Anticonvulsant drugs effects on sex hormone levels and sexual function in men with epilepsy

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2020-05-01 DOI:10.2217/fnl-2019-0028

M. Mazdeh, M. Heidari, M. Taheri, S. Ghafouri-Fard

引用次数: 5

Abstract

Aim: Sexual dysfunction is common in patients with epilepsy. The aim of this quasi-experimental study was to evaluate the effect of anticonvulsant drugs on hormonal and sexual function in men with epilepsy. Methods: Newly diagnosed patients with epilepsy were divided into three groups of 23 subjects who received monotherapy with sodium valproate, carbamazepine and levetiracetam, respectively. Findings: At the beginning of the study, sexual function and sexual hormones were comparable between the control group and the patient group (p > 0.05). After 6 months of treatment, patients who received sodium valproate had the weakest sexual function. Conclusion: According to the present findings, levetiracetam appears to be a good choice for sexually active patients compared with other conventional anticonvulsants.

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抗惊厥药物对男性癫痫患者性激素水平和性功能的影响

目的:性功能障碍在癫痫患者中很常见。本准实验研究的目的是评估抗惊厥药物对男性癫痫患者激素和性功能的影响。方法:将新诊断的癫痫患者分为三组，每组23例，分别给予丙戊酸钠、卡马西平和左乙拉西坦单药治疗。结果:研究开始时，对照组和患者组的性功能和性激素水平相当(p < 0.05)。治疗6个月后，服用丙戊酸钠的患者性功能最弱。结论:根据目前的研究结果，与其他常规抗惊厥药相比，左乙拉西坦似乎是性活跃患者的良好选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.