普萘洛尔联合和不联合瑞舒伐他汀对偏头痛发作的影响：一项三盲随机临床试验

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2020-05-01 DOI:10.2217/fnl-2019-0029

M. Mazdeh, Rihane Mahmudian, S. Vafaei, M. Taheri, S. Ghafouri-Fard

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引用次数: 2

摘要

目的：观察瑞舒伐他汀联合普萘洛尔治疗偏头痛的疗效。患者与方法：采用普查法进行临床试验研究，纳入120例偏头痛患者。患者被随机分配（使用分组随机化）普萘洛尔（每天两次，每次10 mg）和瑞舒伐他汀（每天10 mg；干预组[n=60]）或普萘洛尔和安慰剂（对照组[n=60]）。结果：在干预开始后的第二、第三和第四周末，干预组的发作次数显著减少（p<0.05）。结论：偏头痛患者同时服用普萘洛尔（每天两次，每次10mg）和瑞舒伐他汀（每天10mg）可有效减少偏头痛发作。

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Effect of propranolol with and without rosuvastatin on migraine attacks: a triple blind randomized clinical trial

Aim: To investigate the effect of rosuvastatin in combination with propranolol in reducing migraine attacks. Patients & methods: In a clinical trial study with census method, 120 patients with migraine headache were included. Patients were randomly assigned (using block randomization) to either propranolol (10 mg twice a day) with rosuvastatin (10 mg daily; intervention group [n = 60]) or propranolol (10 mg twice a day) with placebo (control [n = 60]). Results: The numbers of attacks were significantly decreased in the intervention group at the end of second, third and fourth weeks from the beginning of the intervention (p < 0.05). Conclusion: In patients with migraine, concomitant administration of propranolol (10 mg twice a day) and rosuvastatin (10 mg daily) is effective in reducing migraine attacks.

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.