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Motor stereotypies in adult patients with Tourette syndrome 成年抽动秽语综合征患者的运动刻板印象
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2019-0031
Maneeka Ubhi, K. Achinivu, S. Seri, A. Cavanna
{"title":"Motor stereotypies in adult patients with Tourette syndrome","authors":"Maneeka Ubhi, K. Achinivu, S. Seri, A. Cavanna","doi":"10.2217/fnl-2019-0031","DOIUrl":"https://doi.org/10.2217/fnl-2019-0031","url":null,"abstract":"Maneeka Ubhi1, Kanu Achinivu1, Stefano Seri2 & Andrea E Cavanna*,1,2,3 1Michael Trimble Neuropsychiatry Research Group, University of Birmingham & BSMHFT, Birmingham, UK 2School of Life & Health Sciences, Aston University, Birmingham, UK 3Sobell Department of Motor Neuroscience & Movement Disorders, Institute of Neurology & University College London, UK *Author for correspondence: a.e.cavanna@bham.ac.uk","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"15 1","pages":"0031"},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48286097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Interferon beta-1a induces expression of brain-derived neurotrophic factor in human T lymphocytes in vitro and not in vivo 干扰素β-1a在体外和非体内诱导人T淋巴细胞表达脑源性神经营养因子
IF 1.3
Future Neurology Pub Date : 2020-02-01 DOI: 10.2217/fnl-2019-0018
Zarlascht Karmand, H. Hartung, O. Neuhaus
{"title":"Interferon beta-1a induces expression of brain-derived neurotrophic factor in human T lymphocytes in vitro and not in vivo","authors":"Zarlascht Karmand, H. Hartung, O. Neuhaus","doi":"10.2217/fnl-2019-0018","DOIUrl":"https://doi.org/10.2217/fnl-2019-0018","url":null,"abstract":"Aim: To detect IFN β-1a-induced expression of brain-derived neurotrophic factor (BDNF) to undermine the hypothesis of IFN β-1a-associated neuroprotection in multiple sclerosis (MS). Methods: The influence of IFN β-1a on in vitro activated peripheral blood lymphocytes from healthy donors was tested. Proliferation analyses were made to detect T-cell growth. BDNF expression was measured by standard ELISA. To assess the influence of IFN β-1a on BDNF expression in vivo, BDNF serum levels of MS patients treated with IFN β-1a were compared with those of untreated patients. Results: IFN β-1a inhibited T-cell proliferation dose dependently. It induced BDNF expression at middle concentrations. MS patients treated with IFN β-1a exhibited significantly lower BDNF serum levels than untreated patients. Conclusion: IFN β-1a may promote neuroprotection by inducing BDNF expression, but its importance in vivo remains open.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"56 7","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41276594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
How does editing the genome improve targeting DNA and RNA for cerebellar ataxias? 编辑基因组如何改善小脑共济失调的靶向DNA和RNA？
IF 1.3
Future Neurology Pub Date : 2020-02-01 DOI: 10.2217/fnl-2019-0019
J. Gandini, M. Manto
{"title":"How does editing the genome improve targeting DNA and RNA for cerebellar ataxias?","authors":"J. Gandini, M. Manto","doi":"10.2217/fnl-2019-0019","DOIUrl":"https://doi.org/10.2217/fnl-2019-0019","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42307225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic stress, physiological adaptation and developmental programming of the neuroendocrine stress system 慢性应激、神经内分泌应激系统的生理适应与发育规划
IF 1.3
Future Neurology Pub Date : 2020-02-01 DOI: 10.2217/fnl-2019-0014
J. Coffman
{"title":"Chronic stress, physiological adaptation and developmental programming of the neuroendocrine stress system","authors":"J. Coffman","doi":"10.2217/fnl-2019-0014","DOIUrl":"https://doi.org/10.2217/fnl-2019-0014","url":null,"abstract":"Chronic stress undermines physical and mental health, in part via dysregulation of the neuroendocrine stress system. Key to understand this dysregulation is recognizing that the problem is not stress per se, but rather its chronicity. The optimally functioning stress system is highly dynamic, and negative feedback regulation enforces transient responses to acute stressors. Chronic stress overrides this, and adaptation to the chronicity can result in persistent dysregulation by altering sensitivity thresholds critical for control of system dynamics. Such adaptation involves plasticity within the central nervous system (CNS) as well as epigenetic regulation. When it occurs during development, it can have persistent effects on neuroendocrine regulation. Understanding how chronic stress programs development of the neuroendocrine stress system requires elucidation of stress-responsive gene regulatory networks that control CNS plasticity and development.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45988322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
What is the role of post acute EEG in prediction of late neurological outcome in severe disorders of consciousness? 急性后脑电图在预测严重意识障碍的晚期神经系统结果中的作用是什么？
IF 1.3
Future Neurology Pub Date : 2020-02-01 DOI: 10.2217/fnl-2019-0017
M. Scarpino, F. Lolli, G. Lanzo, A. Grippo
{"title":"What is the role of post acute EEG in prediction of late neurological outcome in severe disorders of consciousness?","authors":"M. Scarpino, F. Lolli, G. Lanzo, A. Grippo","doi":"10.2217/fnl-2019-0017","DOIUrl":"https://doi.org/10.2217/fnl-2019-0017","url":null,"abstract":"Causes of development of severe disorders of consciousness Hypoxic-ischemic encephalopathy, traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage and brain infarction are common causes of mortality and morbidity [1–8]. Many patients affected by these acquired brain injuries (ABIs) die in the acute stages during their stay in the intensive care unit; others, after a coma phase, usually develop a severe disorder of consciousness (DoC), characterized by an unresponsive wakefulness syndrome or a minimally conscious state (MCS). In some cases, consciousness level improves, transitioning to an emergence from MCS (E-MCS); however, patients with E-MCS often show a severe neurological disability [9]. In recent years, improvements both in intensive care technology and in neurosurgical procedures have reduced the mortality rate; however, as a result, many patients discharged from the acute setting exhibit severe DoCs.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45045734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Welcome to the 15th volume of Future Neurology 欢迎来到《未来神经学》第15卷
IF 1.3
Future Neurology Pub Date : 2020-02-01 DOI: 10.2217/fnl-2019-0027
Kate Lovesey
{"title":"Welcome to the 15th volume of Future Neurology","authors":"Kate Lovesey","doi":"10.2217/fnl-2019-0027","DOIUrl":"https://doi.org/10.2217/fnl-2019-0027","url":null,"abstract":"To all our readers, we are delighted to welcome you to the fifteenth volume of Future Neurology. We are also excited to welcome you to the second Open Access issue of the journal. Since the launch of this title, we have continued to publish high-quality scientific research and commentary, and the open access model will allow us to share our great content with an even bigger audience. 2019 was another exciting year for Future Neurology with the continued publication of timely, high quality manuscripts. We are proud to present some of our content highlights within this article. We would also like to take this opportunity to thank all of our valued Editorial Board members, readers and contributors for their continued support. As we move into 2020, we very much look forward to seeing the journals continuous progression and development.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48819257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strength and physical functions in people with Parkinson's disease 帕金森病患者的力量和身体功能
IF 1.3
Future Neurology Pub Date : 2019-11-01 DOI: 10.2217/fnl-2019-0009
Sacha Clael, L. Bezerra
{"title":"Strength and physical functions in people with Parkinson's disease","authors":"Sacha Clael, L. Bezerra","doi":"10.2217/fnl-2019-0009","DOIUrl":"https://doi.org/10.2217/fnl-2019-0009","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43380526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pharmacology and potential therapeutic uses of some cannabinoids 一些大麻素的药理学和潜在的治疗用途
IF 1.3
Future Neurology Pub Date : 2019-11-01 DOI: 10.2217/fnl-2019-0010
R. Pertwee
{"title":"Pharmacology and potential therapeutic uses of some cannabinoids","authors":"R. Pertwee","doi":"10.2217/fnl-2019-0010","DOIUrl":"https://doi.org/10.2217/fnl-2019-0010","url":null,"abstract":"Roger Pertwee speaks to Jennifer Straiton, Assistant Editor, at the BNA 2019 Festival of Neuroscience (14–17 April, Dublin, Ireland), where he gave a talk titled ‘Pharmacological actions and potential novel therapeutic uses of certain plant and synthetic cannabinoids’. Roger Pertwee is an Emeritus Professor at the University of Aberdeen (Scotland, UK), where he has been active in scientific research since 1974. He began his research career at the University of Oxford (UK) where he gained three postgraduate degrees: an MA in biochemistry, a DPhil in pharmacology and a DSc in physiological sciences. His research focuses on the pharmacology of cannabinoids, both on their mechanisms of action and on their potential therapeutic uses. He has held major roles in multiple major discoveries in the field including; the discovery of a cannabinoid CB1 receptor allosteric site, the pharmacological characterization of various phytocannabinoids as well as the co-discovery of endocannabinoids and the co-discovery and characterization of novel synthetic cannabinoids.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47559219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging and eye tracking: in the quest for objective biomarkers 衰老和眼动追踪:寻找客观的生物标志物
IF 1.3
Future Neurology Pub Date : 2019-11-01 DOI: 10.2217/fnl-2019-0012
R. Z. Marandi, P. Gazerani
{"title":"Aging and eye tracking: in the quest for objective biomarkers","authors":"R. Z. Marandi, P. Gazerani","doi":"10.2217/fnl-2019-0012","DOIUrl":"https://doi.org/10.2217/fnl-2019-0012","url":null,"abstract":"Recent applications of eye tracking for diagnosis, prognosis and follow-up of therapy in age-related neurological or psychological deficits have been reviewed. The review is focused on active aging, neurodegeneration and cognitive impairments. The potential impacts and current limitations of using characterizing features of eye movements and pupillary responses (oculometrics) as objective biomarkers in the context of aging are discussed. A closer look into the findings, especially with respect to cognitive impairments, suggests that eye tracking is an invaluable technique to study hidden aspects of aging that have not been revealed using any other noninvasive tool. Future research should involve a wider variety of oculometrics, in addition to saccadic metrics and pupillary responses, including nonlinear and combinatorial features as well as blink- and fixation-related metrics to develop biomarkers to trace age-related irregularities associated with cognitive and neural deficits.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42273904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Seizures in cancer patients: a vast spectrum of etiologies 癌症患者的癫痫发作:广泛的病因
IF 1.3
Future Neurology Pub Date : 2019-11-01 DOI: 10.2217/fnl-2019-0015
Jad Costa, F. Haddad, G. Costa, A. Harb, R. Eid, H. Kourie, J. Helou
{"title":"Seizures in cancer patients: a vast spectrum of etiologies","authors":"Jad Costa, F. Haddad, G. Costa, A. Harb, R. Eid, H. Kourie, J. Helou","doi":"10.2217/fnl-2019-0015","DOIUrl":"https://doi.org/10.2217/fnl-2019-0015","url":null,"abstract":"Aim: This study aims to recognize the distribution of different seizures etiologies in cancer patients, the most common primary tumors responsible for brain metastases, the most epileptogenic primary tumors and the therapeutic modalities. Methods: A retrospective study was conducted at Hotel-Dieu de France Hospital targeting patients admitted to hematology–oncology department between 2005 and 2016 who presented a seizure. Results: Of the 153 included patients, mean age was 57 years (standard deviation = 16 years) and a male predominance (66%). The majority of seizures were due to a primary tumor (49%) or brain metastases (32%). Other reversible (metabolic and drug) or nonreversible causes (carcinomatous meningitis, radiation and cardiovascular complications) formed the remaining causes. Regarding antiepileptic treatments, sodium valproate was mostly used, followed by levetiracetam and phenytoin. Conclusion: Numerous reversible causes are involved in the onset of epileptic seizures, including metabolic disorders, antibiotics and chemotherapies.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48175093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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