Aging and eye tracking: in the quest for objective biomarkers

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2019-11-01 DOI:10.2217/fnl-2019-0012

R. Z. Marandi, P. Gazerani

引用次数: 22

Abstract

Recent applications of eye tracking for diagnosis, prognosis and follow-up of therapy in age-related neurological or psychological deficits have been reviewed. The review is focused on active aging, neurodegeneration and cognitive impairments. The potential impacts and current limitations of using characterizing features of eye movements and pupillary responses (oculometrics) as objective biomarkers in the context of aging are discussed. A closer look into the findings, especially with respect to cognitive impairments, suggests that eye tracking is an invaluable technique to study hidden aspects of aging that have not been revealed using any other noninvasive tool. Future research should involve a wider variety of oculometrics, in addition to saccadic metrics and pupillary responses, including nonlinear and combinatorial features as well as blink- and fixation-related metrics to develop biomarkers to trace age-related irregularities associated with cognitive and neural deficits.

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衰老和眼动追踪:寻找客观的生物标志物

本文综述了近年来眼动追踪在年龄相关性神经或心理缺陷的诊断、预后和随访治疗中的应用。这篇综述的重点是主动衰老、神经变性和认知障碍。本文讨论了在衰老背景下使用眼动和瞳孔反应特征(眼测)作为客观生物标志物的潜在影响和当前局限性。仔细研究一下这些发现，尤其是关于认知障碍的发现，就会发现眼动追踪是一种非常宝贵的技术，可以用来研究衰老的隐藏方面，而这些方面是其他非侵入性工具无法揭示的。未来的研究应该包括更广泛的眼视测量，除了扫视测量和瞳孔反应，包括非线性和组合特征，以及眨眼和注视相关的指标，以开发生物标志物，追踪与认知和神经缺陷相关的年龄相关的不规则性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.