Frontiers in Psychiatry最新文献

{"title":"Impact of online health education on attention-deficit/hyperactivity disorder screening results and parenting stress among school-aged children.","authors":"Jing Tan, Wenxia Yi, Jianna Shen, Bin Peng, Min Gong, Feng Li, Li Chen","doi":"10.3389/fpsyt.2025.1522263","DOIUrl":"10.3389/fpsyt.2025.1522263","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the effects of an online health education lecture on the positive screening rate of attention-deficit/hyperactivity disorder (ADHD) and parenting stress among parents of children diagnosed with or screened positive for ADHD.</p><p><strong>Methods: </strong>Using stratified proportional random cluster sampling, 14 primary schools in Chongqing were selected to conduct an online lecture about ADHD for parents and teachers. A total of 2,611 questionnaires were collected (1,508 intervention group, 1,103 control group).</p><p><strong>Results: </strong>The lecture did not significantly affect the positive screening rate of ADHD (parents: β=-0.37, p=0.208; teachers: β=0.53, p=0.338); however, the positive screening rate increased post-intervention. Inattention scores were higher in the intervention group (β=0.42, p=0.040). Parents as primary caregivers were associated with lower ADHD symptom scores (β=-0.61, p=0.022). Lower parental education levels were associated with higher ADHD screening rates (β=0.49, p=0.039) and symptom scores (β=0.60, p=0.022). Teachers with 10-19 years of experience had higher positive screening rates (β=1.26, p=0.005) and symptom scores (β=2.60, p<0.001). The intervention did not affect parenting stress (Z=-1.413, p=0.158).</p><p><strong>Conclusions: </strong>The lecture's effects were relatively weak, using questionnaires may have facilitated health communication. Individual characteristics of parents and teachers should be considered in assessments (ClinicalTrial.gov ID: NCT05231902).</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1522263"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot of a team-based quality improvement strategy to improve cardiovascular risk factors care in community mental health centers.","authors":"Karly A Murphy, Joseph Gennusa, Arlene T Dalcin, Courtney Cook, Stacy Goldsholl, Tyler Fink, Gail L Daumit, Nae-Yuh Wang, David Thompson, Emma E McGinty","doi":"10.3389/fpsyt.2025.1446985","DOIUrl":"10.3389/fpsyt.2025.1446985","url":null,"abstract":"<p><strong>Introduction: </strong>Populations with serious mental illness are less likely to receive evidence-based care for cardiovascular disease (CVD) risk factors. We sought to characterize the implementation of an adapted team-based quality improvement strategy to improve mental health providers' delivery of evidence-based CVD risk factor care.</p><p><strong>Methods: </strong>In a 12-month, single arm pre/post pilot study in four behavioral health homes embedded within psychiatric rehabilitation programs, sites implemented an adapted Comprehensive Unit Safety Program (CUSP). Primary measures examined changes in organizational quality improvement culture and provider self-efficacy for CVD risk factor care. Secondary measures examined changes in acceptability, appropriateness, and feasibility of CUSP and receipt of guideline-concordant care for hypertension, dyslipidemia, and diabetes.</p><p><strong>Results: </strong>Provider self-efficacy to coordinate care for hypertension and diabetes improved, but organizational quality improvement culture did not change. Acceptability, appropriateness, and feasibility were rated highly but did not change pre/post CUSP. The percentage who reached goals per national guidelines improved for those with dyslipidemia but not for those with hypertension or diabetes. CUSP teams implemented processes to build staff capacity, standardize communication, elicit feedback, and deliver education on coordination for CVD risk factors.</p><p><strong>Conclusion: </strong>This pilot study showed no effects of CUSP on organizational quality improvement culture or provider self-efficacy, the mechanisms by which CUSP is expected to improve care processes. Long term investments are needed to support organizational quality improvement work and providers' efficacy to delivery - evidence-based CVD risk factor care delivery.</p><p><strong>Clinical trial registration: </strong>http://www.ClinicalTrials.gov, identifier NCT04696653.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1446985"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of methamphetamine, cannabis, and polysubstance use on oral health.","authors":"Osman Hasan Tahsin Kılıç, Duygu Kürklü Arpaçay, Onur Çağdaş Gezen, Zehra Nur Bayram, Aysel Başer","doi":"10.3389/fpsyt.2025.1510228","DOIUrl":"10.3389/fpsyt.2025.1510228","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the clinical oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PS) use disorders to healthy controls, and assess the impact of substance type, usage duration, quantity, and oral health behaviors on dental health outcomes through comprehensive oral examinations.</p><p><strong>Methods: </strong>This cross-sectional clinical study was conducted at İzmir Democracy University Buca Seyfi Demirsoy Education and Research Hospital between April 2024 and August 2024. A total of 190 individuals with substance use disorders (MA, THC, and PS users) and 91 healthy controls participated. Sociodemographic data, substance use history, and oral health behaviors were collected using a researcher-developed questionnaire and the Turkish version of the Hiroshima University Dental Behavior Inventory (HU-DBI). Oral health status was assessed through clinical oral examinations using the Decayed, Missing, and Filled Teeth (DMFT) index. Statistical analyses were performed using SPSS 26.0, applying t-tests, ANOVA, Chi-square tests, and Pearson correlation to evaluate group differences and relationships between variables. A p-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The study revealed significant differences in oral health among substance users compared to the control group. MA users had the highest DMFT scores (11.04 ± 5.56), followed by THC users (9.49 ± 5.87), and PS users (8.40 ± 4.52), with the control group showing the lowest scores (6.08 ± 4.18) (p<0.001). The study also found a moderate positive correlation between MA use and DMFT scores, indicating that longer and higher usage leads to poorer oral health, while no significant association was observed between THC use and DMFT scores. Additionally, significant disparities in education levels were observed, with substance users having lower education compared to controls (p=0.001). HU-DBI scores indicated poorer oral health behaviors in substance users, though the difference was not statistically significant (p=0.053).</p><p><strong>Discussion: </strong>The study reveals that all substance use groups, including MA, THC, and PS users, exhibit significantly poorer oral health outcomes, with higher DMFT scores and worse oral health behaviors compared to the control group, highlighting the critical need for comprehensive dental care interventions for individuals with substance use disorders.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov/study/NCT06640712, identifier NCT06640712.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1510228"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual adaptation of digital wellbeing interventions for young people: insights from a project in Saudi Arabia.","authors":"Dahlia Aljuboori, Laura K Clary, Saud Abdulaziz Alomairah, Michelle Colder Carras, Nazmus Saquib, Juliann Saquib, Fahad Albeyahi, Antonius J Van Rooij, Anouk Tuijnman, Vincent G Van der Rijst, Michelle R Kaufman, Johannes Thrul","doi":"10.3389/fpsyt.2024.1455962","DOIUrl":"10.3389/fpsyt.2024.1455962","url":null,"abstract":"<p><p>In today's world, the internet is seamlessly woven into every facet of our existence. This constant engagement with digital media has generated concerns about the negative effects of digital media use, especially among adolescents. These concerns have led to the development and testing of numerous digital wellbeing interventions that focus on adolescents' digital media use. However, these interventions are lacking in the Middle East and North Africa, and specifically in Saudi Arabia, where digital media use is highly prevalent and frequent. Our research team is conducting a series of studies - literature reviews, stakeholder engagement work, and a nationwide survey of adolescent digital media use - to inform, develop, and ultimately test school-based digital wellbeing intervention for high school students in Saudi Arabia. The goal of this manuscript is to explain our process of informing and creating an intervention that builds on previously established, evidence-based approaches, and is also tailored to a particular context (e.g., Saudi Arabia). Moreover, we distill the lessons learned from each study and provide recommendations to assist others in developing tailored digital wellbeing interventions for contexts that have not been the focus of previous intervention development.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1455962"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Well-being balance and lived experiences: understanding the impact of life situations on human flourishing.","authors":"Christopher R Brydges, Alexandra Thérond, Troy W Norris","doi":"10.3389/fpsyt.2024.1516729","DOIUrl":"10.3389/fpsyt.2024.1516729","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the most significant indicators of positive well-being and understand differences in sources of well-being across different life situations, age groups, genders, and income levels, utilizing a novel measure of positive well-being, the Well-being Balance and Lived Experiences (WBAL) Assessment, which evaluates the frequency of various positive experiences and feelings across a range of activation and arousal levels that have previously been demonstrated to affect subjective well-being and human flourishing.</p><p><strong>Methods: </strong>A sample of 496 evaluable subjects aged 20-69 and census-balanced for gender were recruited from a U.S. population panel. Differences in well-being and sources of well-being were analyzed across subgroups via MANOVA analysis followed by <i>post-hoc</i> ANOVA and Tukey's HSD analyses using Cohen's <i>d</i> to determine size and direction of effects between categorical subgroups.</p><p><strong>Results: </strong>Life situations, including relationship, parenting and employment status, were shown to have a more significant effect on overall well-being than the demographic variables of age, gender and household income. Reported well-being improved significantly with life situations, including companionate relationships (<i>d</i>=0.38, <i>p</i><0.001) and parenting (<i>d</i>=0.35, <i>p</i><0.001), that provide greater opportunities for more frequent social connection (<i>d</i>'s=0.25, <i>p</i><0.01 to 0.62, <i>p</i><0.001) and purposeful contribution to others' well-being (<i>d</i>'s=0.34 to 0.71, <i>p</i><0.001), associated with increased feelings of significance (<i>d</i>'s=0.40 to 0.45, <i>p</i><0.001) and efficacy (<i>d</i>'s=0.37 to 0.44, <i>p</i><0.001). An age-related positivity effect was observed, with older adults reporting more frequent positive feelings than younger age groups (<i>d</i>=0.31, <i>p</i><0.01). Measures of mindset positivity, variety of positive experiences and feelings, and frequency and range of positive feelings across arousal levels each corresponded closely with overall well-being.</p><p><strong>Conclusion: </strong>Life situations, including relationship, parenting and employment status, had a more broad and significant effect on wellbeing than age, gender or income. Across life situations, purposeful contribution and social connection, with associated feelings of efficacy and significance were key drivers of differences in well-being. Mindset positivity and variety of positive experiences and feelings correspond closely with overall well-being. Findings from this study can help guide the design and implementation of intervention programs to improve well-being for individuals and targeted subgroups, demonstrating the utility of the WBAL Assessment to evaluate discrete modifiable sources of positive well-being.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1516729"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where you live, what you do: depression differences among diverse Chinese nongmin through cognitive openness.","authors":"Li He, Jiangyin Wang, Yang Yang, Zhilu Tian, Liu Jiang","doi":"10.3389/fpsyt.2025.1433949","DOIUrl":"10.3389/fpsyt.2025.1433949","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the depression levels among Workers with Agricultural Hukou (WAH) in China, considering their varied living environments, types of work, and social discrimination experiences. It specifically addresses the research question: Is there a significant discrepancy in depression levels among different subgroups within WAH?</p><p><strong>Methods: </strong>The study utilizes data from the China Family Panel Studies (CFPS) for the years 2018 and 2020. To estimate the depression levels and their variances across different WAH subgroups, we employed three analytical methods: Ordinary Least Squares, Propensity Score Matching, and Two-Stage Least Squares.</p><p><strong>Results: </strong>Our findings indicate that all WAH subgroups experience higher levels of depression compared to Workers with Non-Agricultural Hukou (WNAH). Among the WAH subgroups, the depression levels, in ascending order, are observed in Rural-to-Urban Migrant Workers (RUMW), Rural Non-Agricultural Workers (RNAW), Subsistence Farmers, and Agricultural Laborers. Notably, these differences in depression levels may be influenced by the mechanism of cognitive openness.</p><p><strong>Conclusion: </strong>The study concludes that there are significant disparities in depression levels among WAH subgroups. Understanding these differences is crucial for targeted mental health interventions and for addressing the broader implications of social discrimination and work-related stress among agricultural workers in China.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1433949"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder.","authors":"Bin Gong, Chenxu Xiao, Yu Feng, Jing Shen","doi":"10.3389/fpsyt.2025.1414015","DOIUrl":"10.3389/fpsyt.2025.1414015","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bipolar disorder (BD) is a mental illness characterized by alternating episodes of elevated mood and depression, while major depressive disorder (MDD) is a debilitating condition that ranks second globally in terms of disease burden. Pharmacotherapy plays a crucial role in managing both BD and MDD. We investigated the genetic differences in populations of individuals with MDD and BD, and from a genetic perspective, we offered new insights into potential drug targets. This will provide clues to potential drug targets.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study employed genome-wide association studies (GWAS) and summary-data-based Mendelian randomization (SMR) methods to investigate the genetic underpinnings of patients with bipolar disorder (BD) and major depressive disorder (MDD) and to predict potential drug target genes. Genetic variants associated with BD and MDD were identified through large-scale GWAS datasets. For BD, the study utilized a comprehensive meta-analysis comprising 57 BD cohorts from Europe, North America, and Australia, including 41,917 BD cases and 371,549 controls of European ancestry. This dataset included both type 1 and type 2 BD cases diagnosed based on DSM-IV, ICD-9, or ICD-10 criteria through standardized assessments. For MDD, we used data from a meta-analysis by Howard DM et al., which integrated the largest GWAS studies of MDD, totaling 246,363 cases and 561,190 controls. The SMR approach, combined with expression quantitative trait loci (eQTL) data, was then applied to assess causal associations between these genetic variants and gene expression, aiming to identify genetic markers and potential drug targets associated with BD and MDD. Furthermore, two-sample Mendelian randomization (TSMR) analyses were performed to explore causal links between protein quantitative trait loci (pQTL) and these disorders.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The SMR analysis revealed 41 druggable genes associated with BD, of which five genes appeared in both brain tissue and blood eQTL datasets and were significantly associated with BD risk. Furthermore, 45 druggable genes were found to be associated with MDD by SMR analysis, of which three genes appeared simultaneously in both datasets and were significantly associated with MDD risk. &lt;i&gt;NEK4&lt;/i&gt;, a common drug candidate gene for BD and MDD, was also significantly associated with a high risk of both diseases and may help differentiate between type 1 and type 2 BD. Specifically, &lt;i&gt;NEK4&lt;/i&gt; showed a strong association with BD (β brain=0.126, P FDR=0.001; βblood=1.158, P FDR=0.003) and MDD (β brain=0.0316, P FDR=0.022; βblood=0.254, P FDR=0.045). Additionally, &lt;i&gt;NEK4&lt;/i&gt; was notably linked to BD type 1 (βbrain=0.123, P FDR=2.97E-05; βblood=1.018, P FDR=0.002), but showed no significant association with BD type 2.Moreover, TSMR analysis identified four proteins (BMP1, F9, ITIH3, and SIGIRR) affecting the risk of BD, and PSMB4 affecting the risk of MDD.&lt;/p&gt;&lt;p&gt;&lt;st","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1414015"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Holding on to Hope\": follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions.","authors":"Tessa-May Zirnsak, Kristen McCarter, Melissa L McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L Baker, Donita E Baird, Billie Bonevski, Ron Borland, David Castle, Erin Forbes, Peter J Kelly, Catherine Segan, Rohan Sweeney, Alyna Turner, Jill M Williams, Lisa Brophy","doi":"10.3389/fpsyt.2024.1257112","DOIUrl":"10.3389/fpsyt.2024.1257112","url":null,"abstract":"<p><strong>Background: </strong>Mental health service users are more likely to smoke tobacco and are as likely to make quit attempts as people not experiencing SMI, but they are less likely to succeed. Quitting tobacco can be harder for people experiencing SMI due to higher levels of nicotine dependence, more severe withdrawal, and many other complex factors. The Quitlink study was a randomized controlled trial combining a tailored 8-week Quitline intervention delivered by dedicated Quitline counsellors plus combination nicotine replacement therapy for people who experience SMI. The purpose of this paper is to report on the medium- and longer-term findings from interviews conducted at 5 and 8 months.</p><p><strong>Methods: </strong>As a part of the broader Quitlink study, participants were invited to qualitative interviews at 2, 5 and 8 months following recruitment, in line with quantitative follow-up time points. Interviews were conducted with 28 participants in the Quitlink trial (intervention group n = 12, control group n = 16). Interviews were transcribed and analyzed with a thematic analysis methodology using NVivo 12. Key themes were determined using inductive coding.</p><p><strong>Results: </strong>Six key themes were identified. These included: internal/external attributions for tobacco smoking, social relationships and relapse, the role of hopefulness in quitting, the role of clinicians in initiating and maintaining a quit attempt, increasing cessation literacy, and efficacy of the study intervention. Overall, findings suggested that participants' quit attempts were often precarious and vulnerable, but active support and feelings of social connectedness were key to supporting participants to initiate a quit attempt and maintain gains.</p><p><strong>Conclusions: </strong>People who experience SMI can make attempts to quit smoking tobacco with support from clinicians and social networks. Connectedness and hope are significant enablers of making and sustaining quit attempts.</p><p><strong>Trial registration: </strong>The Quitlink trial was registered with ANZCTR (www.anzctr.org.au): ACTRN12619000244101 prior to the accrual of the first participant and updated regularly as per registry guidelines.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1257112"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.","authors":"Jenna Langbein, Ujwal Boddeti, Weizhen Xie, Alexander Ksendzovsky","doi":"10.3389/fpsyt.2025.1479240","DOIUrl":"10.3389/fpsyt.2025.1479240","url":null,"abstract":"<p><p>Recent technological advances in intracranial brain stimulation have enhanced the potential of neuromodulation for addressing neuropsychiatric disorders. We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and closed-loop neuromodulation to modulate high-symptom severity states in neuropsychiatric disorders. We searched PubMed, Scopus, Web of Science, Embase, and PsycINFO/PsycNet, followed by the reference and citation lists of retrieved articles. This search strategy yielded a total of 583 articles, of which 5 articles met the inclusion criteria, focusing on depression, obsessive-compulsive disorder, post-traumatic stress disorder, and binge eating disorder. We discuss the methodology of biomarker identification, the biomarkers identified, and the preliminary treatment outcomes for closed-loop neuromodulation. Successful biomarker identification hinges on investigating across various setting. Targeted neuromodulation, either directed at the biomarker or within its associated neural network, offers a promising treatment approach. Future research should seek to understand the mechanisms underlying the effects of neuromodulation as well as the long-term viability of these treatment effects across different neuropsychiatric conditions.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1479240"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cohort-based assessment of drug use trends during the COVID-19 pandemic: relationship with mood and sociodemographic factors in Brazil.","authors":"Nubia Heidrich, Maurício Schüler Nin, Felipe Borges Almeida, Hilda M R M Constant, Luana Freese, Helena M T Barros","doi":"10.3389/fpsyt.2025.1514365","DOIUrl":"10.3389/fpsyt.2025.1514365","url":null,"abstract":"<p><p>The COVID-19 pandemic has brought significant challenges, including severe psychological consequences, especially for vulnerable individuals, such as those with substance use disorders. This study investigated the impact of the pandemic on substance use patterns and psychological health in Brazilians, exploring associations with sociodemographic factors to identify groups at higher risk. Data were collected online to assess self-reported substance use through the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), and psychological state, using the Depression, Anxiety and Stress Scale (DASS-21) and level of social distancing. The research was conducted in three waves: September-October 2020, April-May 2021, and September-November 2022. The ASSIST (alcohol, cannabis, hallucinogens, and cocaine/crack) and DASS-21 (anxiety, depression, and stress) scores decreased over time. Regarding sociodemographic data, being male, single, with less education, lower income and lower social distancing showed associations with alcohol and cannabis scores. All drug scores showed associations with psychological symptoms and time, suggesting a possible adaptation or resilience of the sample to the challenges of the pandemic. These findings highlight the importance of monitoring patterns of substance use and mental health in times of crisis, especially in vulnerable populations. Such knowledge is essential to inform public health strategies and prepare health systems to face future global crises.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1514365"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}