Frontiers in Psychiatry最新文献

{"title":"Latent profiles of death anxiety among young adults: associations with self-esteem, security, and perceived social support.","authors":"Jingxian Yu, Mingjie Wu, Yongqi Liang, Huan Peng, Na Li, Hanjiao Liu","doi":"10.3389/fpsyt.2025.1594720","DOIUrl":"10.3389/fpsyt.2025.1594720","url":null,"abstract":"<p><strong>Introduction: </strong>Death anxiety is a critical mental-health concern among young adults; however, its heterogeneity and underlying psychological mechanisms remain understudied. This study aimed to identify latent profiles of death anxiety in Chinese youth and examine the predictive roles of self-esteem, perceived social support, and security.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of 623 young adults (<i>mean age</i> = 23.62 years, <i>SD</i> = 3.61) aged 18-35 years in mainland China. Latent profile analysis (LPA) was conducted to classify death anxiety subgroups based on responses to the Templer Death Anxiety Scale (C-T-DAS). Self-esteem, perceived social support, and sense of security were assessed using validated scales. Multinomial logistic regression and ANOVA were used to explore predictors and group differences.</p><p><strong>Results: </strong>Three latent death anxiety profiles emerged, High Death Anxiety (56.2%), Moderate Cognition and Low Death Anxiety (8.8%), and Low Cognition and Moderate Death Anxiety (35%). Higher self-esteem (<i>β</i> = -0.46, <i>p</i> <.001), social support (<i>β</i> = -1.12, <i>P = .</i>004), and security (<i>β</i> = -2.87, <i>P</i> <.001) significantly predicted lower death anxiety. The high death anxiety group exhibited the lowest psychological resource scores. Older age (30-35 years) and recent acute illness recovery were associated with higher death anxiety risk (<i>OR</i> = 0.28, 95% <i>CI</i> [0.09, 0.93]). Security showed the strongest inverse association with DA (<i>F =</i> 50.72, <i>P</i> <.001), particularly in the interpersonal and controllability dimensions.</p><p><strong>Conclusion: </strong>Death anxiety among young adults is heterogeneous, influenced by distinct psychological profiles and demographic factors. Interventions should prioritize enhancing self-esteem, social support networks, and security to mitigate death anxiety, especially in high-risk subgroups. Future research should employ longitudinal designs and cross-cultural samples to validate causal pathways and refine targeted strategies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1594720"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating biomarkers of mitochondrial and aging-related genes in major depressive disorder through bioinformatics analysis.","authors":"Zhiyuan Chen, Xiaoxiao Tang, Chao Gu, Shaohong Zou","doi":"10.3389/fpsyt.2025.1653998","DOIUrl":"10.3389/fpsyt.2025.1653998","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a prevalent mental health condition in which mitochondrial dysfunction and cellular senescence contribute to its pathogenesis. This study aims to identify biomarkers related to mitochondria-associated genes (MRGs) and aging-related genes (ARGs) in MDD using bioinformatics.</p><p><strong>Methods: </strong>This study utilized data from GSE201332 and GSE52790, including 1,136 MRGs and 866 ARGs. Initially, candidate genes were selected by intersecting MRGs, ARGs, and differentially expressed genes (DEGs) derived from differential expression analysis in GSE201332. Biomarkers were identified through LASSO regression analysis of the candidate genes. The biomarkers were then evaluated using ROC curves, and artificial neural network (ANN) models were constructed. Subsequently, functional enrichment, immune-related analyses, drug predictions, and molecular docking were performed. Finally, the expression of biomarkers was validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).</p><p><strong>Results: </strong>Seven candidate genes were identified from the intersection of 4,041 DEGs, 1,136 MRGs, and 866 ARGs, with SLC25A5, ALDH2, CPT1C, and IMMT identified as potential biomarkers for MDD through LASSO regression analysis. ROC curve analysis in both GSE201332 and GSE52790 showed that these biomarkers effectively distinguished between MDD and control samples, with AUC values exceeding 0.7. ANN models further confirmed the diagnostic potential of these biomarkers. Gene set enrichment analysis (GSEA) revealed significant enrichment of SLC25A5, CPT1C, and IMMT in pathways related to cellular protein complex assembly and chromatin organization. Immune infiltration analysis demonstrated significant positive correlations between SLC25A5, ALDH2, and IMMT and most of the 18 immune cell types. Molecular docking predictions identified ALDH2 and SLC25A5 as potential targets for specific drugs, with NITROGLYCERIN showing the best binding affinity to ALDH2 (-6.4 kcal/mol). RT-qPCR validation showed significantly lower expression of SLC25A5 and IMMT, and higher expression of CPT1C, in patients with MDD compared to controls (p < 0.05), consistent with bioinformatics predictions.</p><p><strong>Conclusion: </strong>This study identified SLC25A5, ALDH2, CPT1C, and IMMT as biomarkers associated with MDD, offering insights into its molecular mechanisms.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1653998"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of family function in the relationship between stressful life events and depressive symptoms in mid-pregnancy women: a birth cohort study in Wuhan, China.","authors":"Yihan He, Hui Zhou, Jiyu Luo, Ao Xu, Dongmei Qiu, Haiyun Huang, Xiaorui Peng, Yujia Zhou, Lingyun Xu, Yang Li, Yuanyuan Li, Xiang Hu, Hongling Zhang","doi":"10.3389/fpsyt.2025.1588065","DOIUrl":"10.3389/fpsyt.2025.1588065","url":null,"abstract":"<p><strong>Background: </strong>In current research on prenatal depression among pregnant women, the role of family functioning is crucial yet often overlooked. Specifically, in the field of maternal mental health, relatively limited attention has been given to the psychological well-being of women during the second trimester of pregnancy. This study aims to assess the depression, family functioning, and stressful life events of women in their second trimester, and to explore whether family functioning mediates the relationship between stressful events and depressive symptoms.</p><p><strong>Methods: </strong>A questionnaire survey was conducted with 3,386 pregnant women from the Wuhan Healthy Baby Birth Cohort. Participants completed the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), the Family APGAR Index, and the 18-item Stressful Life Events Scale. Structural equation modeling was applied to analyze the data.</p><p><strong>Results: </strong>The findings revealed significant interrelationships among depression, family functioning, and stressful life events. Family functioning was found to partially mediate the relationship between stressful life events and depressive symptoms during the second trimester, explaining 21.9% of the variance.</p><p><strong>Conclusions: </strong>These findings suggest that improving family functioning and fostering communication can help reduce depressive symptoms during the second trimester, supporting maternal mental health.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1588065"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Twice-daily 15mA transcranial alternating current stimulation for adolescent major depressive disorder with suicidal ideation.","authors":"Dan-Dan Cheng, Yi-Lin Yang, Zi-Yi Yuan, Su Hong, Li Kuang","doi":"10.3389/fpsyt.2025.1669966","DOIUrl":"10.3389/fpsyt.2025.1669966","url":null,"abstract":"<p><strong>Background: </strong>Adolescent major depressive disorder with suicidal ideation (MDD-SI) poses significant treatment challenges and carries substantial mortality risk, while existing interventions often demonstrate limited acute efficacy for suicidal ideation (SI).</p><p><strong>Methods: </strong>This two-week prospective case series investigated the feasibility and preliminary therapeutic effects of high-frequency transcranial alternating current stimulation (tACS) administered twice daily. Seven adolescents with MDD-SI underwent 40-minute tACS sessions (77.5 Hz, 15 mA) twice-daily over a two weeks for a total of 20 sessions, in conjunction with stable pharmacotherapy.</p><p><strong>Results: </strong>The accelerated tACS protocol was well-tolerated with no adverse events. It demonstrated significant reductions in both depressive symptoms and SI within two weeks (all <i>P</i> < 0.05), predominantly in the first week. Treatment response varied based on psychiatric and medical comorbidities, indicating potential moderators.</p><p><strong>Conclusion: </strong>These preliminary findings suggest the potential of accelerated high-frequency tACS as a potential crisis intervention for adolescent MDD-SI, while highlighting the need for controlled clinical trials to establish efficacy and optimize stimulation parameters.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1669966"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of seizure worsening after perampanel add-on to oxcarbazepine: possible role of metabolic interaction and pharmacogenetics.","authors":"Xin Fang, Menglu Zhu, Lijiang Wang","doi":"10.3389/fpsyt.2025.1621598","DOIUrl":"10.3389/fpsyt.2025.1621598","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the factors contributing to increased seizure frequency in patients treated with a combination of oxcarbazepine (OXC) and perampanel.</p><p><strong>Methods: </strong>The influence of the combined use of perampanel and oxcarbazepine on pharmacokinetics was analyzed, and the results were further confirmed by scoring the Naranjo Adverse Reaction Scale. The influence of race on antiseizure medications (ASMs) was also analyzed.</p><p><strong>Results: </strong>The concomitant use of perampanel and oxcarbazepine increased the plasma concentration of oxcarbazepine. Scoring with the Naranjo adverse reaction scale indicated that the deterioration of seizures in patients following the addition of perampanel may be associated with the interaction of the two drugs.</p><p><strong>Conclusion: </strong>The exacerbation of epilepsy in patients may be attributed to the increased blood concentration of oxcarbazepine resulting from its combination with perampanel, which potentially triggers a worsening of seizures. Variations in gene mutations related to Asian factors, as well as differences in drug metabolism enzymes and transporters, may also contribute to alterations in the concentration of ASMs.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1621598"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring lived experiences in home-based psychiatric care: a qualitative study of service users, families, and professionals in Spain.","authors":"Ana María Besoaín-Cornejo, Montserrat Gil-Girbau, Mariam Alouali-Moussakhkhar, Luisa Baladón Higueras, Josefina Sáez, Maria Rubio-Valera","doi":"10.3389/fpsyt.2025.1670470","DOIUrl":"10.3389/fpsyt.2025.1670470","url":null,"abstract":"<p><strong>Introduction: </strong>Psychiatric home care provides a wide range of multidisciplinary, user-centered, high-intensity psychiatric interventions to manage mental health crises. Previous studies have found high satisfaction with care, but only assessed user and nurse perspectives. This study aimed to understand the experience of a psychiatric home hospitalization program in Spain from the perspective of all involved (users, families and healthcare professionals).</p><p><strong>Materials and methods: </strong>A qualitative study with a phenomenological approach was conducted to assess \"Crisis Resolution and Home Treatment\" (CRHT), a psychiatric home care program. Semi-structured individual and group interviews were held between 2021 and 2022. The final sample size was determined by saturation and data were analyzed thematically. Analyses were performed by a multidisciplinary team and externally reviewed by a mental health user and an experienced CRHT manager.</p><p><strong>Results: </strong>Four main themes summarizing CRHT experiences emerged: (1) Organizing and operating CRHT programs; (2) Receiving care at home; (3) Caregiver and family involvement and (4) Consequences of the home-based care model. CRHT allows individualized and contextualized treatment. Users and families valued home care and felt safe, although unprepared for the post-discharge situation, especially as care intensity decreases. While home care strengthens family bonds, some caregivers may need additional support to manage a crisis. Along with personalized care, CRHT allows for the development of a comprehensive lifelong treatment plan, although the care burden (for oneself and others) must be considered.</p><p><strong>Conclusion: </strong>CRHT was rated positively as a flexible intervention, facilitating person-centered care and strengthening trust between users, their families, and the CRHT team. It offers personalized treatment and connects individuals to further support, enabling better treatment experiences and strengthening family relationships.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1670470"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Substance fixation in autism spectrum disorder with resultant anorexia nervosa.","authors":"Lucas Arney, Raymond Uymatiao, Justin White","doi":"10.3389/fpsyt.2025.1630528","DOIUrl":"10.3389/fpsyt.2025.1630528","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) has a long-standing history of being strongly associated with multiple psychiatric comorbidities, including substance use disorders (SUDs) and eating disorders (EDs) like anorexia nervosa (AN). ASD-specific features, including repetitive behaviors, constricted interests, cognitive rigidity, and obsessive fixations, are believed to make patients with ASD vulnerable to SUD and ED development. However, little research attempts to understand the interconnection between ASD and these comorbidities. We present a case of a 26-year-old man with a long-standing diagnosis of ASD who developed SUD and restrictive food intake, culminating in the patient meeting the AN criteria. This patient voluntarily admitted himself to the inpatient psychiatric unit with worsening depression and suicidal ideation following a car accident resulting from sleep deprivation and acute cannabis intoxication. Further investigation revealed a problematic, obsessive pattern of initial alcohol use associated with weight gain, followed by profound food restriction and subsequent transition to daily, near-constant cannabis use. On presentation, he appeared anxious with overt signs of sleep deprivation and malnutrition from substantial weight loss with a body mass index (BMI) decline from 23.6 to 16.98 over the last year. A urine drug screen was positive for cannabinoids, and imaging was unremarkable. Over an 11-day hospitalization, a multidisciplinary team initiated anxiolytics, antidepressants, sleep aids, and cannabis-withdrawal management combined with nutritional rehabilitation under dietitian supervision until acute suicidality was resolved with an improved BMI to 18.75. At discharge, the patient reported eagerness to engage with outpatient psychotherapy, ongoing psychiatric follow-up, and ASD-adapted cognitive behavioral therapy. This case underscores the diagnostic and management implications associated with co-occurring ASD, SUD, and ED. Obsessive fixation and rigidity potentiate maladaptive coping, which, if unaddressed in therapy, may increase the risk of future SUD and ED relapse. Though rapid inpatient stabilization is possible, gaps in both specialty care and ASD-adapted programs may compound relapse risk, especially in underserved regions. Additionally, this case necessitates a comprehensive assessment of patients with neurodevelopmental disorders for more informed and integrated therapeutic intervention. The nuanced interplay between ASD, SUD, and ED has synergistic effects on caloric restriction, requiring multidisciplinary treatment strategies to achieve sustained recovery and reduce morbidity in a vulnerable population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1630528"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the relationship between perceived social support and prenatal distress in pregnant women.","authors":"Somayae Abdollahi Sabet, Samira Ahmadi, Zahra Pakian, Azam Maleki","doi":"10.3389/fpsyt.2025.1514249","DOIUrl":"10.3389/fpsyt.2025.1514249","url":null,"abstract":"<p><strong>Background: </strong>Understanding the link between perceived social support and prenatal distress is vital for improving maternal mental health during pregnancy.</p><p><strong>Objective: </strong>To examine the relationship between perceived social support and prenatal distress among pregnant women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 220 pregnant women at Ayatollah Mousavi Hospital in Zanjan City in 2023. Participants were selected through a convenience sampling method, and data were collected using the Prenatal Distress and social support questionnaires. The analysis involved Spearman's rank correlation, the Mann-Whitney U test, the Kruskal-Wallis test, and backward conditional logistic regression with median cut-off points, all at a 95% confidence level.</p><p><strong>Results: </strong>The average perinatal distress score was 39.38 (SD = 6.04), and the average social support score was 45.66 (SD = 10.91). Total social support was negatively correlated with overall prenatal distress (r = -0.355), childbirth and the baby-related distress (r =-0.472), and emotional/relational issues(r = -0.119), but not with body image-related distress (r = 0.090, p = 0.35). Younger, higher-educated women with more children reported lower distress. Additionally, women aged 18-25, with more children, low income, who were housewives, or had a gestational age of 29-42 weeks, had higher social support scores (p < 0.01).</p><p><strong>Conclusion: </strong>Both perinatal distress and perceived social support were observed at moderate levels among the study population. Parity emerged as the only independent predictor for both prenatal distress and social support, with primiparous women exhibiting higher distress levels, while multiparous women reported higher perceived social support. These findings underscore the importance of developing tailored interventions that address the distinct needs of women according to their parity status.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1514249"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional near-infrared spectroscopy as a diagnostic aid for stable schizophrenia.","authors":"Suzhen Zhang, Ting Li, Liangliang Chen, Tongkuai Cong, Xinping Kuai, Yonggang Mu","doi":"10.3389/fpsyt.2025.1635854","DOIUrl":"10.3389/fpsyt.2025.1635854","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment in schizophrenia (SCZ) is common, but the mechanism remains unclear. This study aimed to investigate whether brain activation during the functional near-infrared spectroscopy (fNIRS) verbal fluency test (VFT) task is associated with cognitive deficits and to evaluate the reliability of fNIRS as a clinical tool for diagnosing stable SCZ.</p><p><strong>Methods: </strong>A total of 45 stable SCZ patients and 30 healthy controls (HC) were included. Demographic information, Positive and Negative Symptom Scale (PANSS), and MATRICS Consensus Cognitive Battery (MCCB) were assessed. During VFT, hemodynamic responses in the frontotemporal cortex were monitored with fNIRS.</p><p><strong>Results: </strong>During VFT, individuals with SCZ demonstrated a reduced number of valid words, lower β value in channel 8, 25-26, 35-36 and 47-48, and decreased integral value (IV) in both the prefrontal lobe and bilateral temporal lobes. IV of the temporal lobes and the β value of channel 48 demonstrated sensitivity for diagnosis of SCZ, with an area under the receiver operating characteristic curve of 0.781 (95% CI: 0.667-0.896), and 0.762 (95% CI: 0.655-0.869), respectively. Moreover, IV of the temporal lobes correlated positively with multi-domain of cognition, including speed of processing, attention/vigilance, social cognition and MCCB total scores. The β value of channel 48 correlated positively with speed of processing.</p><p><strong>Conclusion: </strong>Our findings suggest that fNIRS may serve as a valuable clinical measure of cognition assessment, and IV of bilateral temporal lobes and β value of channel 48 can be used as candidate biomarkers to differentiate individuals with schizophrenia.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1635854"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population pharmacokinetics modelling to predict DDI from zopiclone on clozapine in schizophrenia patients.","authors":"Huan-Huan Han, Yue Zhang, Jie Wang, Xue Tian, Ye Li, Su-Mei He, Cun Zhang, Xiao Chen, Dong-Dong Wang","doi":"10.3389/fpsyt.2025.1664678","DOIUrl":"10.3389/fpsyt.2025.1664678","url":null,"abstract":"<p><strong>Introduction: </strong>Clozapine, as a core drug for the treatment of schizophrenia, is widely used in the drug treatment of schizophrenia patients. However, when multiple drugs are used in combination, it is not clear whether there are drug-drug interactions (DDI) of clozapine in patients with schizophrenia. This study aims to use population pharmacokinetics (PPK) modelling to predict DDI and individualized therapy of clozapine in schizophrenia patients.</p><p><strong>Methods: </strong>We collected 81 patients with schizophrenia and included their physiological data, biochemical data, treatment plans and information on combined medication during the clinical treatment process. Next, PPK modelling was used to analyze drugs with potential DDI when clozapine was used in schizophrenia patients, and dosage adjustments were recommended.</p><p><strong>Results: </strong>Final analysis revealed that weight and coadministration of zopiclone affected clozapine clearance, and there was DDI with clozapine when zopiclone was used concurrently in schizophrenia patients. Further, for schizophrenia patients without zopiclone, 10 mg/kg/day, 9 mg/kg/day, 8 mg/kg/day and 7 mg/kg/day clozapine were recommended for 40-50 kg, 50-67 kg, 67-88 kg, and 88-120 kg patients, respectively. For schizophrenia patients with zopiclone, 6 mg/kg/day and 5 mg/kg/day clozapine were recommended for 40-70 kg and 70-120 kg patients, respectively. This study was the first to systematically analyze DDI when clozapine was used in schizophrenia patients and found DDI when zopiclone and clozapine were taken concurrently.</p><p><strong>Conclusion: </strong>When zopiclone was taken concurrently, clozapine dosage need to be reduced. Based on this, schizophrenia patients individualized dosage adjustment was recommended.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1664678"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}