Frontiers in Psychiatry最新文献

{"title":"The regulative role and mechanism of BNST in anxiety disorder.","authors":"Mingjun Xie, Ying Xiong, Haijun Wang","doi":"10.3389/fpsyt.2024.1437476","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1437476","url":null,"abstract":"<p><p>Anxiety disorders, common yet impactful emotional disturbances, significantly affect physical and mental health globally. Many neuron circuits are associated with anxiety regulation like septo-hippocampal loop, amygdala(AMYG), bed nucleus of the stria terminalis (BNST), ventral hippocampus (vHPC), and brain regions like medial prefrontal cortex (mPFC). However, the concrete mechanism of anxiety disorder in BNST is relatively unknown. Recent research showed BNST plays a critical role in modulating anxiety owing to its anatomical location and special circuit characteristics, which are considered to be a hub in the limbic system regulating anxiety. BNST consists with multiple subregions, which can project separately into different brain regions and exert projecting independently to various brain regions with distinct regulatory effects. Moreover, multiple signal pathways in BNST are reported to play significant roles in regulating anxiety and stress behavior. This review briefly describes anxiety disorders and subdivisions and functions of BNST, focusing on the main neural circuits that serve as fundamental pathways in both the genesis and potential treatment of anxiety disorders and the molecular mechanism of BNST on anxiety. The complexity of structures and mechanisms has facilitated the development of imaging techniques. Innovative multimodal imaging techniques, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), have non-invasively illuminated BNST activities and their functional connections with other brain areas. These methodologies provide a deeper understanding of how BNST responds to anxiety-inducing stimuli, offering invaluable insights into its complex role in anxiety regulation. The continued exploration of BNST in anxiety research promises not only to elucidate fundamental neurobiological mechanisms but also to foster advancements in clinical treatments for anxiety disorders.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1437476"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological distress in biliary tract malignancy patients: influencing factors and development of a predictive nomogram model.","authors":"Zhennan Gou, Yuhua Liu, Wenjie Tang, Changming Zhou, Zhenqi Lu, Lu Wang, Wei Feng, Weiqi Xu, Jun Wang","doi":"10.3389/fpsyt.2024.1450860","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1450860","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the psychological distress and its influencing factors in patients with biliary tract malignant tumors, alongside the development of a predictive model.</p><p><strong>Methods: </strong>A total of 219 patients diagnosed with biliary tract malignant tumors who were admitted to the Department of Liver Surgery at Fudan University Shanghai Cancer Center from July 2021 to May 2023, were selected using a convenience sampling method. Research tools involve psychological distress management screening tools, a demographic questionnaire, self-rating anxiety and depression scales, and the Chinese version of the Memorial Symptom Assessment Scale. Bootstrap method was utilized for repeated sampling to identify relevant factors influencing psychological distress in biliary tract cancer patients. The R software was employed to create a nomogram model, and the model's accuracy and predictive performance were assessed using the receiver operating characteristic curve (ROC) and the Hosmer-Lemeshow test.</p><p><strong>Results: </strong>The average score of psychological distress among the 219 patients was (3.91 ± 2.44), with a psychological distress detection rate of 54.8%. Regression model results indicated that factors such as the presence of distant metastasis, comorbidity with other major diseases, poor sleep quality, anxiety, and severity of anxiety and depression were the primary influencers of psychological distress.</p><p><strong>Conclusion: </strong>The detection rate of psychological distress in patients with biliary tract malignant tumors is notably high. The predictive model constructed in this study exhibits good predictive efficacy and clinical value, providing valuable reference for healthcare professionals in developing targeted intervention strategies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1450860"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and solving strategies of drug-related problems in adult psychiatric inpatients - a systematic review.","authors":"Katharina Wien, Pamela Reißner, Gudrun Hefner, Julia Thern, Stefan Borgwardt","doi":"10.3389/fpsyt.2024.1460098","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1460098","url":null,"abstract":"<p><strong>Introduction: </strong>Most psychiatric inpatients receive psychopharmacological treatment indicated for their mental diseases. The aim of this systematic review is to give clinical pharmacists and physicians a comprehensive summary of common drug-related problems (DRPs) in adult psychiatric inpatients and of potential interventions to solve them in clinical practice.</p><p><strong>Methods: </strong>Six databases and registers were searched for English, German and French articles published between 1999 and 2023 with content regarding the prevalence and/or type or interventions to solve DRPs in adult psychiatric inpatients. Studies were categorized based on types of DRPs and clinical interventions. The prevalence rates of DRPs and subtypes were compared quantitatively and the tested interventions were summarized qualitatively.</p><p><strong>Results: </strong>A total of 88 articles with an overall sample of over 95.425 adult psychiatric inpatients were included in this review. DRPs were reported with a prevalence range of 0.32 to 9.48 per patient. The most frequently reported DRPs were caused by prescribing errors (1.91 per patient), the most frequent subtype was drug interaction (0.77 per patient). Clinical pharmacists were involved in interventions in 7 of 13 included articles. Interventions consisted of clinical pharmacy services on the ward, educational classes, medication reviews, and the implementation of digital tools such as dispensing cabinets and prescribing tools.</p><p><strong>Discussion: </strong>The included studies were heterogeneous. The most frequent DRPs in psychiatry are related to prescribing errors and drug interactions. Clinical pharmacists may support the drug therapy by identifying and effectively solving DRPs in psychiatric inpatients using interdisciplinary approaches.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42022354958.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1460098"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model-informed precision dosing of quetiapine in bipolar affective disorder patients: initial dose recommendation.","authors":"Zi-Qiang Zheng, Ying-Wei Jin, Di Yin, Xiao Chen, Su-Mei He, Chen-Xu Liu, Cun Zhang, Dong-Dong Wang","doi":"10.3389/fpsyt.2024.1497119","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1497119","url":null,"abstract":"<p><strong>Objective: </strong>Bipolar affective disorder (BAD) is a mood disorder with high morbidity and mortality. Quetiapine can be used in the treatment of patients with BAD; however, the precise administration regimen of quetiapine in these patients is still unknown. In this study, a population pharmacokinetic (PPK) model of quetiapine in patients with BAD was constructed based on model-informed precision dosing (MIPD) and real-world clinical data and an optimal initial dose of quetiapine in these patients was recommended.</p><p><strong>Methods: </strong>A total of 99 patients with BAD treated with quetiapine were included. At the same time, the quetiapine concentrations, the physical and chemical indices of the patients, and the drug combination information were collected. A quetiapine PPK model for patients with BAD was then constructed and an initial dose based on Monte Carlo simulation was recommended.</p><p><strong>Results: </strong>In the final model of quetiapine for patients with BAD, the apparent oral clearance (CL/F) and the apparent volume of distribution (V/F) were 76.1 L/h and 530 L, respectively. For patients with BAD weighing 40-66 kg, the initial dose recommendation was 16 mg kg^-1 day^-1, the probability of reaching the therapeutic window was 78.8%-82.2%, and the probability of exceeding the upper limit of the therapeutic window was 5.2%-10.3%. For patients with BAD weighing 66-120 kg, the initial dose recommendation was 12 mg kg^-1 day^-1, the probability of reaching the therapeutic window was 81.5%-85.5%, and the probability of exceeding the upper limit of the therapeutic window was 3.6%-8.1%.</p><p><strong>Conclusion: </strong>The present study, for the first time, recommended an initial dose of quetiapine in patients with BAD based on MIPD and real-world data, providing an individualized reference for the administration of quetiapine in these patients.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1497119"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between sedentary behavior and non-suicidal self-injury behavior among adolescents in China.","authors":"Yaru Guo, Xiaojian Yin, Jianyi Xu, Fule Chen, Feng Zhang, Yuan Liu, Pengwei Sun, Jun Hong, Yanyan Hu","doi":"10.3389/fpsyt.2024.1489707","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1489707","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to explore the relationship between sedentary behavior and non-suicidal self-injury (NSSI), and to provide a theoretical basis for preventing and reducing the occurrence of NSSI behavior and the development of intervention measures.</p><p><strong>Methods: </strong>Between September and December 2021, a sedentary behavior and NSSI survey was administered to 10327 Chinese adolescents aged 12-17 who had been randomly selected using the stratified cluster random sampling method. The results were analyzed using the chi-square test and logistic regression analysis to explore the relationship between sedentary behavior and NSSI in this population.</p><p><strong>Results: </strong>The study found an overall NSSI detection rate among the participants of 25.1%, with occasional NSSI and frequent NSSI detection rates of 11.0% and 14.1%, respectively. The NSSI detection rate is higher in girls than in boys. After controlling for related influencing factors, the NSSI detection rates among adolescents with sedentary behavior duration ≥8 hours and screen time ≥2 hours were 1.393(<i>β</i>= 0.332, <i>P</i> <0.01) and 1.569(<i>β</i>= 0.451, <i>P</i> <0.01) times higher than those with sedentary behavior duration <8 hours and screen time <2 hours, respectively.</p><p><strong>Conclusion: </strong>Sedentary behavior, especially that related to screen time is closely related to the occurrence of NSSI in adolescents. To reduce the occurrence of NSSI, we should therefore pay attention to the harmful effects of sedentary behavior on the physical and mental health of teenagers, take corresponding measures to limit sedentary behavior and screen time, and guide teenagers to use electronic devices correctly.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1489707"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregabalin treatment in a 30-year-old patient with Bainbridge-Ropers syndrome: a case-report.","authors":"Marie Geiser, Jean-Marc Good, Vincent Guinchat","doi":"10.3389/fpsyt.2024.1502773","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1502773","url":null,"abstract":"<p><p>Mr. X is a Swiss patient with Bainbridge-Ropers syndrome clinically and genetically diagnosed at the age of 28. He is also known to have severe intellectual disability, autism spectrum disorder and epilepsy since the age of 18. At the age of 30, he was admitted for the first time to a psychiatric crisis unit dedicated to mental disabilities for challenging behavior such as self-aggression (forceful vomiting, scratching himself, pulling out his toe and fingernails or banging his head against the wall), agitation, screaming, dropping to the ground, damaging electronic items, or even displaying hetero-aggressive gestures (trying to bite or pull hair, scratching, kicking, or punching) associated with a drop in mood, withdrawal from usual activities, a drop in social interaction and a tendency to doze off during the day. The introduction of Pregabalin leads to rapid stabilization of the clinical state, almost complete improvement in challenging behavior and gradual withdrawal of other treatments (class 2 analgesics, neuroleptics, antidepressants, and benzodiazepines). At the neurological check-up 9 months after discharge from hospital, clinical stability was confirmed by the surrounding team and the medical observation, with almost complete disappearance of auto-aggressive gestures.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1502773"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-invasive brain stimulation on emotion regulation in patients with attention deficit hyperactivity disorder: a systematic review.","authors":"Fang Shen, Hui Zhou","doi":"10.3389/fpsyt.2024.1483753","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1483753","url":null,"abstract":"<p><strong>Background and objective: </strong>A growing body of research evidence suggests that many patients with attention deficit hyperactivity disorder (ADHD) have difficulties with emotion regulation. Non-invasive brain stimulation (NIBS), which mainly includes transcranial electrical stimulation (tES) and repetitive transcranial magnetic stimulation (rTMS), has been considered a potential new direction in the treatment of emotion dysregulation in ADHD patients. The key components of tES are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS). However, there is no systematic evaluation exploring the effects of non-invasive brain stimulation on emotion regulation in ADHD patients. Therefore, this systematic review aimed to summarize the effects of NIBS on emotion regulation in ADHD patients.</p><p><strong>Methods: </strong>This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched PubMed, Embase, Web of Science, and the Cochrane Library electronic databases up to 1 July 2024. We also hand-searched the reference lists of retrieved articles and reviews. Assessing risk of bias using the Cochrane Assessment Tool.</p><p><strong>Results: </strong>Through database search, we obtained a total of 1134 studies, of which 5 met the inclusion criteria. Statistically significant improvements in emotion regulation in children with ADHD were observed in 1 study after treatment with tDCS. In the remaining 4 studies (2 with tDCS and 2 with rTMS), there were no statistically significant changes in emotion regulation in ADHD patients after treatment with either tDCS or rTMS.</p><p><strong>Conclusions: </strong>The data from our preliminary study do not allow us to draw definitive conclusions that non-invasive brain stimulation improves emotion regulation in ADHD patients. This is because there is a paucity of literature on the effects of tES or rTMS on emotion regulation in ADHD patients and a limited number of randomized controlled trials. More high-quality multicenter randomized controlled trials exploring the efficacy of non-invasive brain stimulation on emotion regulation in ADHD patients are needed in the future to provide strong evidence for definitive conclusions before it can be considered as a potential treatment option.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024569041.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1483753"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of metalloestrogens exposure with depression in women across reproductive lifespan.","authors":"Junjie Ren, Wanxin Wu, Jia Li, Qifang Hu, Mi Zhang, Jing Wang, Xiaoming Li, Yanwen Li, Binbin Huang","doi":"10.3389/fpsyt.2024.1486402","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1486402","url":null,"abstract":"<p><strong>Background: </strong>Exposure to metal could impact women's depression risk. However, the connection and mechanisms between metalloestrogens exposure and depression are still not fully understood. We aim to explore the associations between metalloestrogens and the risk of depression in women across reproductive lifespan.</p><p><strong>Methods: </strong>Using data from NHANES 2011-2018, we employed logistic regression and baknernel machine regression (BKMR) to study links between metalloestrogen exposure and depression in US women. We analyzed how contraceptive use affects this relationship.</p><p><strong>Results: </strong>The study involved 3,374 adult women, with 345 of them experiencing depression. Our research revealed that certain metalloestrogens like Ba, Ca, Pb, Sb, and Sn were linked to higher depression risk in women, while Hg was associated with lower depression risk in older women. For women aged 18-44, a blend of metalloestrogens showed a significant positive correlation with depression risk, and the likelihood of depression in later years notably rose when the metal mixture concentration reached or exceeded the 60th percentile. Oral contraceptives would have an effect on the impact of metalloestrogen mixture exposure on depression in women during the reproductive stage.</p><p><strong>Conclusions: </strong>Our study indicates a significant link between metalloestrogen exposure and a higher risk of depression in adult women in the United States. This finding can aid in identifying the connection and enhancing women's mental well-being.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1486402"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropeptide Y in first-episode schizophrenia: is there any sex differences in the pathogeneses of schizophrenia?","authors":"Jia-Qi Song, Wen Xin, Jian-Jin Yu, Qing Zhao, Hong-Na Li, Da-Chun Chen","doi":"10.3389/fpsyt.2024.1514475","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1514475","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated relationships between Neuropeptide Y levels and severity of psychiatric symptoms in first-episode schizophrenia patients, and explore the sexual heterogeneity in them.</p><p><strong>Methods: </strong>We recruited 115 first-episode schizophrenia patients and 58 matched healthy controls, and measured serum Neuropeptide Y levels of them at baseline and again after 10 weeks of risperidone treatment in patient group. Patients were also evaluated with the Positive and Negative Symptoms Scale (PANSS) to reveal the severity of symptoms.</p><p><strong>Results: </strong>95 patients completed the whole experiment. We find that mean Neuropeptide Y levels at baseline were significantly higher in patients than in controls (p<0.001), no matter in males or females. In males, there are positive correlations between Neuropeptide Y levels and PANSS scores at baseline (p<0.01), and between the change of them (p<0.05). However, we do not find these correlations in female patients. Furthermore, the interaction terms of NPY × sex were highly significant taking PANSS as dependent variable(p<0.001).</p><p><strong>Conclusion: </strong>Neuropeptide Y plays a significant role in the pathogenesis of schizophrenia. In male patients, Neuropeptide Y is positively correlated with the severity of symptoms, while this correlation is not found in females. Continued efforts are needed to determine the sexual dimorphism in pathogeneses of schizophrenia.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1514475"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic relapse prediction via biomarker monitoring: a systematic review.","authors":"Alexandros Smyrnis, Christos Theleritis, Panagiotis Ferentinos, Nikolaos Smyrnis","doi":"10.3389/fpsyt.2024.1463974","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1463974","url":null,"abstract":"<p><strong>Background: </strong>Associating temporal variation of biomarkers with the onset of psychotic relapse could help demystify the pathogenesis of psychosis as a pathological brain state, while allowing for timely intervention, thus ameliorating clinical outcome. In this systematic review, we evaluated the predictive accuracy of a broad spectrum of biomarkers for psychotic relapse. We also underline methodological concerns, focusing on the value of prospective studies for relapse onset estimation.</p><p><strong>Methods: </strong>Following the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, a list of search strings related to biomarkers and relapse was assimilated and run against the PubMed and Scopus databases, yielding a total of 808 unique records. After exclusion of studies related to the distinction of patients from controls or treatment effects, the 42 remaining studies were divided into 5 groups, based on the type of biomarker used as a predictor: the genetic biomarker subgroup (n = 4, or 9%), the blood-based biomarker subgroup (n = 15, or 36%), the neuroimaging biomarker subgroup (n = 10, or 24%), the cognitive-behavioral biomarker subgroup (n = 5, or 12%) and the wearables biomarker subgroup (n = 8, or 19%).</p><p><strong>Results: </strong>In the first 4 groups, several factors were found to correlate with the state of relapse, such as the genetic risk profile, Interleukin-6, Vitamin D or panels consisting of multiple markers (blood-based), ventricular volume, grey matter volume in the right hippocampus, various functional connectivity metrics (neuroimaging), working memory and executive function (cognition). In the wearables group, machine learning models were trained based on features such as heart rate, acceleration, and geolocation, which were measured continuously. While the achieved predictive accuracy differed compared to chance, its power was moderate (max reported AUC = 0.77).</p><p><strong>Discussion: </strong>The first 4 groups revealed risk factors, but cross-sectional designs or sparse sampling in prospective studies did not allow for relapse onset estimations. Studies involving wearables provide more concrete predictions of relapse but utilized markers such as geolocation do not advance pathophysiological understanding. A combination of the two approaches is warranted to fully understand and predict relapse.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1463974"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}