Frontiers in Psychiatry最新文献

{"title":"Fight, flight, freeze, fawn: mapping emergency department staff stress responses to workplace violence - a mixed-methods study.","authors":"Jennifer Davids, Greg de Moore, Martin Brown, Margaret Murphy","doi":"10.3389/fpsyt.2026.1952758","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1952758","url":null,"abstract":"<p><strong>Background: </strong>Workplace violence and aggression are escalating in emergency departments (EDs) globally, yet the self-reported psychological and behavioural responses in clinicians to such stressors remain underexplored. Trauma theory conceptualises stress responses as fight, flight, freeze, and fawn (4Fs); but how these responses manifest in ED staff before, during and after violent incidents has received limited empirical attention.</p><p><strong>Methods: </strong>This mixed-methods study analysed data collected between 2019 and 2023 across four emergency departments within one Australian local health district. Data sources included semi-structured interviews (2019; n = 20), focus groups (2021; n = 30 participants), a cross-sectional survey (2023; n = 61), and follow-up interviews (2023; n = 12). Qualitative data were analysed using Braun and Clarke's six-phase thematic analysis, applying a deductive framework informed by the 4Fs. Quantitative survey data were integrated to examine the distribution of stress responses across reported incidents.</p><p><strong>Results: </strong>Across all data sources, 123 ED staff described 145 coded instances of the 4F stress responses: fight (n=94); flight (n=24), freeze (n=15), and fawn (n=12). Four overarching themes that underpinned these responses were identified: 1) Moral and emotional impact on clinicians, 2) Safety systems interface, 3) Organisational constraints and environment and 4) Patient Complexity. Participants described sustained hyperarousal, anticipatory vigilance, moral distress, emotional withdrawal, and appeasement behaviours arising from repeated exposure to violence. While Code Black responses were viewed as a structured and effective \"organised fight\" mechanism, this was compromised by inconsistent training, role ambiguity, and limited post-incident support which contributed to burnout, disengagement, and workforce attrition.</p><p><strong>Conclusion: </strong>Emergency department clinicians operate in persistently threatening environments that drive recurrent activation of fight, flight, freeze, and fawn responses with cumulative individual and system-level consequences. Behavioural emergencies warrant the same level of preparation, standardisation, and organisational support as other high-risk clinical events, such as a Code Blue - a life-threatening medical event with a responding Medical Emergency Team. Trauma-informed education team-based training, and embedded post-incident support are critical to safeguarding staff wellbeing and sustaining the ED workforce.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1952758"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzodiazepine prescribing in chronic military-related PTSD: real-world patterns and correlates in specialized care.","authors":"Erin Collins, Jenny J W Liu, Mathieu Bilodeau, Amer M Burhan, Murray W Enns, Vicky Lavoie, Natalie Ein, Anthony Nazarov, Edouard Auger, Ken Balderson, Natalie Mota, Sonya Wanklyn, J Don Richardson","doi":"10.3389/fpsyt.2026.1931305","DOIUrl":"10.3389/fpsyt.2026.1931305","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the prevalence of benzodiazepine prescribing among patients with posttraumatic stress disorder (PTSD), identify patient- and practice-level correlates of benzodiazepine use, and examine the clinical rationale underlying prescribing decisions. We aimed to characterize real-world patterns and determinants of benzodiazepine use in a specialized tertiary care military and Veteran PTSD setting, where PTSD is often chronic and treatment-refractory, and to clarify the clinical factors associated with benzodiazepine prescribing.</p><p><strong>Methods: </strong>We conducted a cross-sectional study using clinician-reported data from 13 psychiatrists practicing in Canadian tertiary care Operational Stress Injury clinics. Psychiatrists provided current prescribing information for 438 military personnel and Veterans receiving treatment for a primary diagnosis of PTSD. Multivariable logistic regression examined associations between patient and provider characteristics, treatment history, and benzodiazepine prescribing. Analyses adjusted for age, sex, and clinical site, and accounted for clustering at the provider level.</p><p><strong>Results: </strong>Benzodiazepines were prescribed to 22% of patients. Use was more frequent among patients with longer PTSD duration and greater cumulative pharmacotherapy exposure. Each additional year of PTSD was associated with a 12% increase in adjusted odds of benzodiazepine use (OR 1.12, 95% CI 1.06-1.18). Patients with ≥ 5 years of pharmacotherapy exposure had two- to three-fold greater odds compared with those treated < 5 years. Benzodiazepine monotherapy was rare (< 1%), with most use occurring in combination with other psychotropic medications.</p><p><strong>Conclusions: </strong>In these specialized clinics, benzodiazepine use was more common among patients with persistent illness and extensive treatment histories. These patterns suggest use occurs primarily in the context of chronic and complex care, underscoring the importance of clear clinical guidance for real-world practice.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1931305"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between timing of psychological intervention and reconstruction of worldview, life perspective, and values in adolescents with depression.","authors":"Lin Chen","doi":"10.3389/fpsyt.2026.1786690","DOIUrl":"10.3389/fpsyt.2026.1786690","url":null,"abstract":"<p><strong>Background: </strong>Timely access to structured psycho-educational intervention is crucial for cognitive-motivational recovery in adolescents with depression, a population in a critical developmental stage of consolidating core belief systems. Drawing upon the theory of educational timing, the initiation of these interventions may represent a critical window for reshaping worldview, life perspective, and values. Therefore, this study aimed to examine the association between intervention timing and the reconstruction of these existential constructs, thereby providing an empirical basis for optimizing psycho-educational strategies in adolescent depression care.</p><p><strong>Methods: </strong>This retrospective cohort study included 244 adolescents with depressive disorder treated between January 2022 and December 2024. To operationalize the concept of \"optimal educational timing,\" the cohort was stratified based on intervention initiation: early intervention, defined as initiation of structured psycho-educational intervention within 14 days of the index clinical encounter, and delayed intervention, defined as initiation after 14 days. Outcomes were assessed using the Worldview, Life Perspective, and Values Reconstruction Questionnaire (WLVQ-22). Linear and logistic regression models were used to evaluate changes in WLVQ-22 scores and responder outcomes.</p><p><strong>Results: </strong>The cohort included 126 adolescents in the early-intervention group and 118 in the delayed-intervention group. Baseline WLVQ-22 scores were comparable between groups. After adjustment, early intervention initiation was associated with greater changes in worldview (β = 4.43, 95% confidence interval [CI]: 2.89 to 5.98; <i>p</i> < 0.001), life perspective (β = 3.93, 95% CI: 2.45 to 5.41; <i>p</i> < 0.001), and values total score (β = 2.07, 95% CI: 1.27 to 2.87; <i>p</i> < 0.001). Early intervention was also associated with higher odds of response for worldview (odds ratio [OR] = 2.96, 95% CI: 1.71 to 5.11), life perspective (OR = 2.51, 95% CI: 1.46 to 4.33), and values reconstruction (OR = 2.90, 95% CI: 1.37 to 6.13).</p><p><strong>Conclusions: </strong>Earlier initiation of structured psychological intervention was associated with more favorable short-term WLVQ-22-assessed reconstruction indicators in adolescents with depression. These findings highlight the need for prospective studies to further evaluate the role of intervention timing in adolescent depression care.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1786690"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Treatment of subthreshold bipolar disorder in pregnancy: a report on the effectiveness of the Zamar Protocol^® in three treatment-resistant depression cases.","authors":"Antonios C Zamar, Theodoros Koutsomitros, Georgios Mikellides, Angelos Halaris, George P Chrousos","doi":"10.3389/fpsyt.2026.1872443","DOIUrl":"10.3389/fpsyt.2026.1872443","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Subthreshold bipolar disorder (SBD), also referred to as unspecified bipolar disorder, is frequently encountered in patients with treatment-resistant depression. It presents with depressive and subthreshold manic and mixed symptoms. Sustained remission with full functional recovery is the aim of treatment in mood disorders as residual symptoms may cause disability, while relapse may be associated with increased morbidity or mortality. To date, evidence for achieving sustained remission in SBD is absent, with no studies reporting sustained remission outcomes. The only available evidence to remission is at level 2 in a previous study by the author employing combined high-dose levothyroxine (HDT) and repetitive transcranial magnetic stimulation (rTMS). The management of SBD during pregnancy is particularly challenging due to the absence of evidence-based guidance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;We describe a retrospective case series of three women with longstanding treatment-resistant depressive presentations with a threat to life, later conceptualized within the bipolar spectrum. All patients had achieved sustained remission before pregnancy using a treatment approach combining HDT with rTMS (the Zamar Protocol), with or without low-dose quetiapine. Following shared decision making and counseling regarding the extremely limited evidence base, treatment was continued during pregnancy due to concerns about the riskof relapse and risk to life. All three patients maintained clinical stability during pregnancy, the postpartum period, and beyond. Across the three cases, five pregnancies occurred while patients remained on HDT-based treatment, with adjunctive rTMS used during selected periods. No maternal, obstetric, neonatal, or early developmental adverse outcomes were reported during the available follow-up. In one case, clinical deterioration followed a dose reduction and improved after re-escalation. The consistent biochemical pattern of elevated FT4 relative to FT3 (low FT3/FT4 ratio) previously reported was observed across cases, which differed from typical thyrotoxic profiles. Variants in the deiodinase-related genes and the thyroid hormone transport pathways were identified, in keeping with previously published literature.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This small retrospective case series suggests that continuation of HDT-based treatment, with or without adjunctive rTMS, may be a feasible option in carefully preselected patients with pre-pregnancy blood and genetic biomarkers and pre-pregnancy clinical response when presenting with severe life-threatening bipolar spectrum disorder presenting as treatment-resistant depression. These findings established safety and efficacy at a low level of evidence (level 4 CEBM) and highlight the need for more robust prospective research. Careful discussion with the patient and spouse exploring the risk-benefit ratio and any evidence-based available acceptable alternatives","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1872443"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors for enteral nutrition intolerance in psychiatric patients with comorbid medical conditions: a retrospective cohort study.","authors":"Pei Zhou, Dongyan Zhang, Ping Zhang, Jiajia Shi, Xiaomin Liu, Shujuan Jiao, Beibei Wang, Xia Xue","doi":"10.3389/fpsyt.2026.1904251","DOIUrl":"10.3389/fpsyt.2026.1904251","url":null,"abstract":"<p><strong>Background: </strong>Critically ill psychiatric patients frequently present with multiple physical comorbidities and poor nutritional status. Enteral nutrition plays a key role in comprehensive critical care, but enteral nutrition intolerance (ENI) is highly prevalent.</p><p><strong>Aims: </strong>To investigate the incidence, independent risk factors, and clinical outcomes of ENI in critically ill psychiatric patients with comorbid physical diseases.</p><p><strong>Methods: </strong>This is a single-center retrospective study. We enrolled 150 consecutive patients admitted between January 2024 and December 2025 who received enteral nutrition for at least 3 days. Data for analysis were sourced from the institutional electronic medical record database. Baseline characteristics, nutritional indicators, psychiatric parameters, comorbidity scores, and treatment-related variables were collected. To detect independent risk factors for ENI, univariate screening was performed first, followed by multivariate logistic regression.</p><p><strong>Results: </strong>The overall incidence of ENI was 54.0% in critically ill psychiatric patients with physical comorbidities. Multivariate logistic regression showed the odds ratio (OR) of serum albumin <25 g/L (OR = 3.26, 95%CI: 2.11-5.04, P<0.001), APACHE II score ≥15 (OR = 2.89, 95%CI: 1.87-4.47, P<0.001), combined use of ≥3 antipsychotic agents (OR = 2.71, 95%CI: 1.75-4.19, P<0.001), schizophrenia (OR = 2.12, 95%CI: 1.43-3.21, P = 0.008), and duration of antibiotic use ≥7 days (OR = 2.18, 95%CI: 1.40-3.38, P = 0.001). ENI was significantly associated with longer hospital stay, lower nutritional goal attainment, more frequent EN interruption, and higher pulmonary infection rates.</p><p><strong>Conclusion: </strong>These findings indicate a high burden of ENI in this vulnerable population. The risk factors include hypoalbuminemia, high APACHE IIscore, combined use of three or more antipsychotic agents, schizophrenia, and prolonged antibiotic therapy.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1904251"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reality shock and mental resilience among adolescent police cadets: meaning, identity, and relational pathways in a Chinese police academy context.","authors":"Hongping Lin","doi":"10.3389/fpsyt.2026.1921313","DOIUrl":"10.3389/fpsyt.2026.1921313","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescent police cadets are trained in an institutional environment where schooling, collective discipline, physical training, peer living, and early occupational socialization are closely intertwined. This environment may provide structure and purpose, but may also expose cadets to a distinctive form of vocational environmental risk. However, the psychological pathways through which environmental risk and personal resources are linked to mental resilience in this population remain underexplored.</p><p><strong>Methods: </strong>Drawing on an environmental risk and resilience framework, this cross-sectional study examined the association between reality shock and mental resilience among 642 adolescent police cadets from three police education institutions in China, and explored whether positive psychological traits were linked to resilience through occupational calling, identity work support, and relational job crafting. The sample was randomly split into an exploratory subsample (n = 321) and a confirmatory subsample (n = 321), resulting in a refined 36-item measurement model. Structural equation modeling and bootstrap mediation analyses (5,000 resamples) were conducted on the full sample.</p><p><strong>Results: </strong>Reality shock was negatively associated with mental resilience (β = -.23, p < .001), whereas positive psychological traits, occupational calling, identity work support, and relational job crafting were positively associated with resilience. Competing nested structural models and directional alternative model tests suggested that a combined parallel-sequential mediation model best fit the data. Bootstrap analyses confirmed that the indirect effects through the three parallel pathways and the sequential pathway were all significant. Multi-group analyses across academic years supported strict measurement invariance and suggested broadly similar structural associations across training stages.</p><p><strong>Discussion: </strong>These findings suggest that resilience in adolescent police cadets is not merely individual toughness; it is deeply linked to occupational meaning, identity support, and relational practices. The results extend environmental risk and resilience frameworks to specialized vocational education settings and offer practical implications for police education programs. Because the data were cross-sectional and self-reported, causal conclusions cannot be drawn.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1921313"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping risk of gambling disorder in older adults: a neural network approach.","authors":"Roser Granero, Fernando Fernández-Aranda, Isabel Baenas, Lucero Munguía, Anahí Gaspar-Pérez, Mónica Gómez-Peña, Jeffrey Derevensky, Sally Gainsbury, Rebeca Rodríguez-García, Susana Jiménez-Murcia","doi":"10.3389/fpsyt.2026.1936618","DOIUrl":"10.3389/fpsyt.2026.1936618","url":null,"abstract":"<p><strong>Background and objectives: </strong>Gambling disorder (GD) in older adults remains insufficiently understood, despite growing concerns about gambling-related harm in older adulthood. Risk profiles and clinical presentations in this age group may differ from those typically described in younger or mixed-age samples, reflecting age-specific psychosocial contexts, health conditions, and life transitions. Traditional statistical approaches may be limited in their ability to model the complex, non-linear interplay among psychological, behavioral, and contextual factors. The present study aimed to apply neural network-based models to predict the presence and severity of GD in older adults.</p><p><strong>Methods: </strong>The study used a cross-sectional, single-center, case-control design. Data were obtained from adults aged 50 to 85 years, with 50 years adopted as a pragmatic lower threshold given the lack of consensus on defining older adulthood, comprising a clinical sample of 745 patients seeking treatment for gambling-related problems at a specialized treatment hospital unit, and a healthy control (HC) group of 136 participants without gambling-related problems, recruited at non-psychiatric hospital outpatient services.</p><p><strong>Results: </strong>A neural network (multilayer perceptron, MLP) with one hidden layer composed of eight neurons showed excellent discrimination between individuals with GD and healthy controls in the complete sample (AUC = 0.987, 90.4% specificity, 97.7% sensitivity, and 96.6% classification accuracy). In the independent holdout subset, the model yielded an AUC of 0.890, with 75.0% specificity, 96.2% sensitivity, and 93.3% classification accuracy (although these estimates should be interpreted cautiously because the holdout included only 12 healthy controls). Novelty seeking emerged as the strongest contributor to the model, followed by emotion regulation difficulties, particularly non-acceptance of emotional responses and reduced impulse control. Focusing exclusively on the clinical GD subsample, a second MLP including six hidden neurons indicated that overall psychological distress was the primary factor associated with disorder severity. Additional relevant contributors to GD included novelty seeking, gambling-related cognitive distortions, and lower self-directedness.</p><p><strong>Conclusion: </strong>The neural network models effectively classified GD and its severity in older adults, identifying a multifactorial pattern characterized by affective distress, emotion regulation difficulties, and distorted gambling-related beliefs. These findings highlight the potential of non-linear modeling to characterize patterns associated with GD in older adults, while the clinical utility of machine learning tools for age-sensitive detection and intervention remains preliminary and requires further validation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1936618"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical challenges in the clinical translation of anti-amyloid monoclonal antibodies for Alzheimer's disease: a scoping review.","authors":"Alexandra Wicker, Amanda Courtright-Lim, Jon Tilburt","doi":"10.3389/fpsyt.2026.1953954","DOIUrl":"10.3389/fpsyt.2026.1953954","url":null,"abstract":"<p><strong>Background: </strong>The development and evaluation of anti-amyloid beta monoclonal antibodies (mAbs) for the treatment of Alzheimer's disease have been accompanied by extensive ethical debate spanning clinical trials, regulatory processes, prescribing practices, and healthcare delivery. This scoping review examined literature published between 2006 and 2026 to identify and clarify the landscape of ethical considerations surrounding the implementation, prescribing, and delivery of anti-amyloid mAbs across both research and clinical settings.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, Web of Science, Embase, and Ovid EBM Reviews (including CENTRAL and CDSR) from 2006 to March 2026 using a structured search strategy. Eligible publications focused on ethical issues associated with the clinical translation of anti-amyloid mAbs. Two reviewers independently screened titles, abstracts, and full-text articles, with duplicate extraction performed on an initial subset of publications. The review was conducted using JBI guidance and reported according to PRISMA-ScR.</p><p><strong>Results: </strong>We identified 84 publications from 23 countries published between 2014 and 2026, including 12 original research studies, 1 systematic review, and 71 commentaries, narrative reviews, legal analyses, or practice guidelines. Analysis identified 32 subthemes, which were synthesized into 7 overarching themes: (1) beneficence and nonmaleficence, (2) respect for persons, (3) equity and accessibility, (4) evidence and trial integrity, (5) governance and stewardship, (6) relational and social impacts, and (7) health system readiness and sustainability. Among the 32 subthemes, uncertain clinical benefit and risk of harm (both within the beneficence and nonmaleficence theme) were discussed most frequently within the literature, each appearing in 61 publications.</p><p><strong>Conclusions: </strong>The biomedical literature documents a broad range of ethical considerations relating to anti-amyloid mAbs. Despite this growing literature, it is primarily based on commentary, with few empirical studies, and even fewer incorporating the perspectives of patients, families, and clinicians. Doing so may add further context and nuance to ethical discussion about mAbs in the years ahead.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1953954"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Smartphone addiction and self-esteem among university students: a moderated mediation and latent profile analysis.","authors":"Shiyu Zhang, Xiao Zhang, Siyu Yuan, Tianpeng Yang, Liang Li","doi":"10.3389/fpsyt.2026.2009437","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.2009437","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2026.1865079.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"2009437"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aviophobia and its relationship to stress and epileptic-like symptoms: a narrative review.","authors":"Matthew Laker, Petr Bob, Norbert Riethof","doi":"10.3389/fpsyt.2026.1911877","DOIUrl":"10.3389/fpsyt.2026.1911877","url":null,"abstract":"<p><p>Travel by air and global mobility have become essential for an increasing number of people and, in many cases, may cause anxiety symptoms of aviophobia. Although variations exist in estimates of aviophobia prevalence, undeniably large numbers of people suffer consequences that influence their work and personal lives. Despite the existence of effective treatments, a high prevalence, above and below the clinical threshold, plus diagnostic difficulties may complicate therapeutic options for treating aviophobia. Based on current evidence, this article provides an overview of recent findings and future research and treatment perspectives, including novel findings indicating that certain stressful aviophobia experiences may be linked to temporal and limbic epileptiform activity, which may produce epileptic-like symptoms.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1911877"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}