Frontiers in Psychiatry最新文献

{"title":"Intergenerational differences in turnover intention of nurses: a cross-sectional survey in Jiangsu province, China.","authors":"Guangyu Hu, Zhen Wang, Chaoran Zhang, Jingwen Xu, Ziheng Shen, Lixin Peng, Haibo Xu","doi":"10.3389/fpsyt.2025.1550623","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1550623","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to learn the turnover intention of nurses in the workplace and analyze the influencing factors, commonalities, and differences from the perspective of intergenerational differences.</p><p><strong>Methods: </strong>Between 4 September and 5 October 2023, a stratified cluster sampling was conducted among 2299 nurses at 16 tertiary hospitals in Jiangsu Province in China, using the questionnaire composited of General sociodemographic information, Work-Family Conflict Scale, Perceived Social Support Scale, Resilience Scale, and Turnover Intention Scale. SPSS v26.0 was performed to analyze data.</p><p><strong>Results: </strong>A total of 2112 participants were included. The turnover intention of \"Generation X\" (born between 1965 and 1980) nurses was lower than that of \"Generation Y\" (born between 1981 and 1996) and \"Generation Z\" (born between 1997 and 2012). Work-family conflict was a common influencing factor on the turnover intention of three generations of nurses (P < 0.05). Family-work conflict (β = 0.099, P < 0.001), other support (β = -0.169, P < 0.001), resilience (β = -0.103, P < 0.001), night shifts (β = 0.047, P = 0.033), the number of children (β = -0.054, P = 0.041) and occupational diseases (β = -0.108, P < 0.001) were specific influencing factors of turnover intention among \"Generation Y\" nurses. Resilience (β= -0.172, P = 0.001) and family support (β = -0.188, P = 0.001) were specific factors of turnover intention in \"Generation Z\" nurses.</p><p><strong>Conclusion: </strong>This study reveals the intergenerational differences in the turnover intention of nurses and its influencing factors. The turnover intention of \"Generation Y\" and \"Generation Z\" nurses is higher than that of \"Generation X\", and work-family conflict is the common factor of their turnover intention. It is suggested that hospital managers formulate targeted intervention strategies to reduce turnover intention according to the intergenerational characteristics of nurses.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1550623"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel opportunities for treating complex neuropsychiatric and neurocognitive conditions based on recent developments with xanomeline.","authors":"Valentin A Pavlov","doi":"10.3389/fpsyt.2025.1593341","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1593341","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1593341"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Deep brain stimulation and suicide attempts in treatment-resistant patients: a case report and neuroethical analysis.","authors":"Ambra D'Imperio, Marcello Ienca","doi":"10.3389/fpsyt.2025.1619883","DOIUrl":"10.3389/fpsyt.2025.1619883","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2024.1398777.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1619883"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging studies of acupuncture for depressive disorder: a systematic review of published papers from 2014 to 2024.","authors":"Dezhi Lin, Qiang Ren, Yangxu Ou, Longlong Li, Dezhong Peng, Sha Yang","doi":"10.3389/fpsyt.2025.1536660","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1536660","url":null,"abstract":"<p><strong>Background: </strong>Several neuroimaging studies have confirmed that acupuncture can elicit alterations in brain networks and regions associated with depressive disorder (DD). This review provides an overview of the methodologies and results of neuroimaging investigations into the efficacy of acupuncture in treating DD, with the intention of guiding future research objectives.</p><p><strong>Methods: </strong>Neuroimaging studies of acupuncture for DD being published between February 2, 2014 and February 2, 2024, were gathered from PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure, Chongqing VIP Database, WanFang Database, and Chinese Biomedical Literature Database. The methodological quality of the studies was assessed utilizing the Risk of Bias 2.0 and Risk of Bias in Non-Randomized Studies of Interventions tools. Following a qualitative analysis of the studies, relevant information regarding acupuncture interventions and brain imaging data was extracted.</p><p><strong>Results: </strong>A total of 26 studies met the inclusion criteria. These studies featured a combined sample size of 1138 participants. All studies employed magnetic resonance imaging. Our findings indicate that acupuncture can affect neural activity in the cingulate gyrus, precuneus, insula, prefrontal lobe, etc. The neuroimaging results of most DD patients were correlated with the Hamilton Rating Scale for Depression scores.</p><p><strong>Conclusions: </strong>The results of the current study indicate that acupuncture treatment may have a regulatory effect on the abnormal functioning of neural regions and networks in individuals diagnosed with DD. These networks are predominantly localized within various brain regions, including the default mode network, limbic system, emotion regulation and cognitive network, reward network, central executive network, salience network, and sensorimotor network. It is essential to conduct additional high-quality and multimodal neuroimaging research to expand upon these findings and elucidate the mechanisms by which acupuncture impacts patients with DD.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42023400557.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1536660"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study.","authors":"Yao Ni, Juanmei Li, Zitian Tang, Youqian Zhang, Yanyan Feng","doi":"10.3389/fpsyt.2025.1411587","DOIUrl":"10.3389/fpsyt.2025.1411587","url":null,"abstract":"<p><strong>Background: </strong>Rapid changes in attitudes, legality, and patterns of cannabis use (CU) underscore the importance of understanding its impact on mental health. Although links between CU and personality disorders (PDs) are documented, their causality remains uncertain.</p><p><strong>Methods: </strong>Employing Genome-Wide Association Studies (GWAS) data, this study investigated the causal relationship between cannabis use disorder (CUD) and lifetime cannabis use (LCU) with 9 types of PD risk through Mendelian randomization (MR) analysis. The primary method was the inverse variance weighted (IVW) method, supplemented by multivariable MR to assess direct effects independent of mental, social, and substance use factors, and mediation MR to explore mediating factors.</p><p><strong>Results: </strong>Corrections for the false discovery rate revealed significant causal associations between CUD and an increased risk of emotionally unstable PD (EUPD; OR_IVW = 1.228, 95% CI 1.069-1.411), overall PD (OR_IVW = 1.186, 95% CI 1.065-1.321), and schizoid PD (SPD; OR_IVW = 1.644, 95% CI 1.131-2.390). Mediation analysis identified schizophrenia (SCZ), major depressive disorder (MDD), neuroticism, and smoking initiation (SmkInit) as shared mediating factors between CUD and both EUPD and overall PD, with an additional mediating factor, household income (HI), specific to the CUD-to-overall PD pathway. In contrast, no mediating factors were found between CUD and SPD. Notably, a bidirectional causal relationship was observed between overall PD and CUD (OR_IVW = 1.399, 95% CI 1.033-1.895). Suggestive evidence indicated a causal link between lifetime cannabis use (LCU) and overall PD risk (OR_IVW = 1.074, 95% CI 1.008-1.146).</p><p><strong>Conclusion: </strong>This study offers new insights into the potential impact of CU on the development and progression of various PDs, laying the groundwork for targeted interventions to mitigate its effects on mental health.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1411587"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing loneliness in emerging adults in primary care: a pilot feasibility study.","authors":"Kris Pui Kwan Ma, Brennan Keiser, Melissa Garcia, Chialing Hsu, Karina Cortez, Ashley Johnson, Ajla Pleho, Mary C Curran, Kelly Schloredt, Kwun C G Chan, Kari A Stephens, Sebastian T Tong","doi":"10.3389/fpsyt.2025.1470725","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1470725","url":null,"abstract":"<p><strong>Introduction: </strong>Loneliness among emerging adults is common and is associated with poor physical and mental health. Most loneliness interventions have not been adapted nor tested in primary care that can broadly reach this population. This study aims to pilot test the feasibility, acceptability, and preliminary impact of two adapted interventions -cognitive behavioral therapy (CBT) and social prescribing (SP) - on reducing loneliness in emerging adults in primary care.</p><p><strong>Methods: </strong>Participants aged 18-25, who were seen in primary care and met the cut-off score on the UCLA-3 loneliness, were assigned to either CBT (N=6) or SP (N=9). Both group interventions were delivered virtually for five weeks. Outcomes included the 20-item UCLA loneliness scale, PHQ-9 depression, and GAD-7 anxiety. Ten qualitative interviews were conducted to understand participants' experience of the interventions and effects on their loneliness.</p><p><strong>Results: </strong>Of 15 participants (11 women, mean age = 22), 14 of them completed either intervention. Results from paired T-tests showed pre-post reductions in loneliness, depression, and anxiety for both CBT and SP interventions, though they were statistically non-significant. Four themes described participants' i) experience of loneliness, ii) changes in self and behavior, iii) barriers and facilitators to participation, and iv) suggestions for intervention adaptations.</p><p><strong>Discussions: </strong>The results suggest that it may be feasible to treat loneliness in emerging adults in primary care with adapted interventions like CBT and SP. Further research with larger sample sizes and pragmatic, randomized controlled trial designs are needed to test the effectiveness of these interventions in primary care settings.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1470725"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of digital self-care device for at risk drinking problems: focus on individuals at risk for alcohol-related issues.","authors":"Yong Chan Jeong, Yong Jin Kim, Sung Won Roh, Eun Seon Seo, Hong Seok Oh, In Suk Lee, Eun Ji Lee, Hyeon Ji Cho, Sang Kyu Lee","doi":"10.3389/fpsyt.2025.1485940","DOIUrl":"10.3389/fpsyt.2025.1485940","url":null,"abstract":"<p><strong>Aims: </strong>This study was conducted to verify the effectiveness of using digital self-care devices in reducing alcohol-related problems among high-risk alcohol users in community addiction-related institutions.</p><p><strong>Methods: </strong>Data were collected from 257 adults in Korea aged 18 and over (157 men and 60 women), examining their level of alcohol use disorder and the usage of digital self-care devices (such as the number of days alcohol consumption was logged, continuous days of sobriety, feeling, alcohol cravings, alcohol probability, etc.).</p><p><strong>Results: </strong>The results confirmed that the severity of alcohol use disorder significantly decreased before and after the use of digital self-care devices, as analyzed by a t-test (M = 5.239, SD = 10.121, t = 6.945, df = 179, P = .000***). Additionally, a machine learning analysis (random forest) was conducted to explore the factors that most influence the reduction in alcohol risk levels among participants. The analysis revealed that the factor \"continuous days of sobriety\" had the most significant impact on the reduction of alcohol risk levels. The predictive accuracy of this factor was demonstrated using an ROC curve (AUC = 0.724). Subsequently, a multiple regression analysis was conducted to explore the factors influencing continuous days of sobriety. The results indicated that age and the logging of sobriety days had a significant impact, with the logging of sobriety days emerging as the most influential factor.</p><p><strong>Conclusion: </strong>These results suggest that in reducing alcohol consumption and achieving successful sobriety, it may be more important to maintain continuous sobriety rather than the total number of sober days. Additionally, it is necessary to identify the key factors that help maintain continuous sobriety. Understanding which elements need to be fulfilled through digital self-care devices to sustain continuous sobriety is also essential.</p><p><strong>Clinical trial registration: </strong>https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=EM&focus=reset_12&search_page=M&pageSize=10M&page=undefinedM&seq=16267M&status=5M&seq_group=16267, identifier, KCT0005135.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1485940"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qifuyin alleviates anxiety and depression in 3×Tg-AD mice by modulating neuroendocrine function.","authors":"Tianhao Yu, Ying Yu, Junqi Zhao, He Li, Hui Lu, Yangyi Li, Yuqi Peng, Shixue Wang, Wendi Wei, Xiaorui Cheng","doi":"10.3389/fpsyt.2025.1554866","DOIUrl":"10.3389/fpsyt.2025.1554866","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Alzheimer's disease (AD) is frequently accompanied by behavioral and psychological symptoms of dementia (BPSD). Studies have shown that 3×Tg-AD mice, a classical animal model of AD, exhibit anxiety and depression-like behaviors characteristic of BPSD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study investigated the effects of Qifuyin on anxiety and depression-like behaviors in 3×Tg-AD mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The 20 male and female C57BL/6 mice at 10.3 months of age were used as the control group, while the 82 male and female 3×Tg-AD mice of the same age were divided into five groups. The control and model groups were gavaged with solvent, the positive medicine group received a combination of donepezil and memantine, and the Qifuyin (QFY) groups were divided into three doses: low, medium, and high. The effects of QFY on anxiety-like behaviors in mice were assessed using the open field test (OFT) and elevated plus maze (EPM) test, while depression-like behaviors were evaluated through the forced swim test (FST) and sucrose splash test (ST). Plasma levels of corticosterone (CORT), testosterone (T), and estradiol (E2) were measured using ELISA, while adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH) were quantified via radioimmunoassay. Differences in plasma hormone levels among groups were analyzed using principal component analysis (PCA). Pearson correlation analysis was conducted to explore the relationships between plasma hormones and behavioral phenotypes, and multiple linear regression was employed to identify the hormones most strongly correlated with anxiety and depression-like behaviors in mice following QFY treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In 3×Tg-AD mice, anxiety-like behaviors were characterized by reduced the duration, number of visits, and total distances in central area during the OFT. The EPM revealed reduced the duration and frequency in the open arms for both sexes. Depression-like behaviors were evident in the FST, with increased immobility, and in the ST, with prolonged grooming latency in both sexes and reduced grooming frequency in females. The treatment of QFY alleviated these behaviors. In males, In the model group, plasma ACTH, GnRH, and FSH levels were significantly decreased. In the QFY-treated group, plasma CRH levels were significantly reduced, while GnRH levels were significantly increased. In the model group of females, plasma ACTH levels were significantly elevated, while FSH and LH levels were markedly reduced. In the QFY-treated group, plasma CORT levels were significantly decreased, whereas FSH and LH levels were significantly increased. Multiple linear regression indicated QFY mainly mitigates anxiety and depression-like symptoms through modulating GnRH in males and T and ACTH in females.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The administ","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1554866"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression.","authors":"Hao Yu, Chengji Wang, Yao Wu, Changxing He, Shaohong Zou","doi":"10.3389/fpsyt.2025.1574391","DOIUrl":"10.3389/fpsyt.2025.1574391","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is a prevalent feature throughout the course of bipolar disorder (BD) and may contribute to recurrent episodes and poor prognosis. Despite its significant clinical impact, the biological mechanisms underlying cognitive impairment in BD remain poorly understood, complicating treatment efforts. The NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor, encoded by the GRIN2B gene, plays a critical role in cognitive functions.</p><p><strong>Methods: </strong>In this study, we measured the methylation levels of the promoter region of the GRIN2B gene in peripheral blood samples from patients with bipolar depression and healthy controls using the MassARRAY method. Cognitive performance was assessed through a series of standardized neuropsychological tests. Subsequently, we analyzed the correlation between GRIN2B gene promoter methylation levels and cognitive performance in patients with bipolar depression.</p><p><strong>Results: </strong>We identified aberrant methylation levels at multiple CpG sites within the GRIN2B gene promoter region in patients with bipolar depression compared to healthy controls. These methylation changes were significantly associated with impairments in several cognitive domains, including attention and executive function, even after adjusting for potential confounding factors. These findings suggest that aberrant methylation in the GRIN2B gene promoter region may play a critical role in cognitive impairment in bipolar depression.</p><p><strong>Conclusions: </strong>DNA methylation levels in the GRIN2B gene promoter region may represent a potential therapeutic target for addressing cognitive impairment in bipolar depression. These findings provide a theoretical foundation for future clinical diagnosis and the development of targeted treatment strategies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1574391"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex associations between anxiety, depression, and resilience in a college student sample: a network analysis.","authors":"Hui Wang, Min Wang, Xiuchao Wang, Tingwei Feng, Xufeng Liu, Wei Xiao","doi":"10.3389/fpsyt.2025.1502252","DOIUrl":"10.3389/fpsyt.2025.1502252","url":null,"abstract":"<p><strong>Background: </strong>Anxiety and depression have significant impacts on individuals' mental health and social functioning, particularly among college students. Psychological resilience is considered a crucial resource for coping with adversity and stress and may play a key role in alleviating anxiety and depression symptoms. The aim of this study is to explore the finer-grained potential relationships between psychological resilience, anxiety, and depression among college students.</p><p><strong>Methods: </strong>This study employed network analysis to examine the psychological resilience, anxiety, and depression status of a randomly sampled cohort of 855 college students (51.8% female; M = 18.70, SD = 1.13). Statistical analyses and network visualization were conducted using R version 4.2.2 and the qgraph package. Bridge centrality indices of variables within the network were computed, with particular emphasis on the significance of bridge symptoms within the network structure.</p><p><strong>Results: </strong>Significant covariation was observed between anxiety and depression symptoms. Psychological resilience exhibited a negative correlation with both anxiety and depression, with a negative bridge expected influence value for R10 \"Can handle unpleasant feelings\", indicating a potential protective role of psychological resilience in mitigating these mental health issues. R10 \"Can handle unpleasant feelings\" occupies the most central position within the psychological resilience network, with the smallest BEI value (-0.01), indicating its protective role in the overall network. To some extent, it can regulate anxiety and depression symptoms.</p><p><strong>Conclusion: </strong>This study highlights the complex interrelationships between psychological resilience, anxiety, and depression among college students through network analysis. Bridge expected influence analysis identified \"R10\" as a protective factor and \"A7\" as a key risk factor. The findings suggest that interventions targeting bridge symptoms and enhancing resilience may help alleviate anxiety and depression. Prioritizing these two symptoms in future research could yield greater intervention benefits.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1502252"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}