Frontiers in Psychiatry最新文献

{"title":"Do interpersonal trust and social avoidance mediate the association between psychotic symptoms and social functioning in chronic schizophrenia patients?","authors":"Hongyang Liu, Xinming Pan, Xinxin Huang, Haijia Tian, Xueke Shao, Dandan Wang, Lu Wen, Chenxi Bao, Xinyu Fang, Zhenghui Yi","doi":"10.3389/fpsyt.2025.1433763","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1433763","url":null,"abstract":"<p><strong>Objective: </strong>Schizophrenia is a complex mental disorder that significantly impacts social functioning. The present study aimed to investigate the relationship between psychotic symptoms and social functioning in individuals with chronic schizophrenia. Specifically, we examined the mediating roles of social avoidance and impaired interpersonal trust in this relationship, as these factors are most worrisome in individuals with schizophrenia.</p><p><strong>Methods: </strong>A total of 223 outpatients with chronic schizophrenia and 201 unrelated healthy controls were included. The Positive and Negative Syndrome Scale (PANSS), the Interpersonal Trust Scale (ITS), the Social Avoidance and Distress Scale (SAD), and the simplified Chinese version of the Social Disability Screening Schedule (SDSS) were used for evaluation. Mediation analysis was performed using the PROCESS macro in SPSS23.0.</p><p><strong>Results: </strong>Our results showed that individuals with chronic schizophrenia scored significantly lower on the ITS total and two index scores but higher on the SAD total and two index scores than healthy controls. The ITS score was significantly associated with the psychotic symptoms (both PANSS total score and subscale score) and social functioning in those patients. Interestingly, we further found that interpersonal trust had a significantly mediating effect on the relationship between psychotic symptoms (including positive, negative, cognitive, excited, and depressed symptoms) and social functioning in individuals with schizophrenia.</p><p><strong>Conclusion: </strong>Our preliminary findings suggest that improving interpersonal trust may be a promising approach to enhance social functioning and improve prognosis in individuals with schizophrenia. This insight underscores the importance of incorporating trust-building interventions into clinical practice, which could potentially lead to better social outcomes for patients.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1433763"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Disaster-related psychiatric disorders: assessment, recovery, intervention.","authors":"Samuel F Law","doi":"10.3389/fpsyt.2025.1586458","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1586458","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1586458"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic study of electroacupuncture in the treatment of insomnia: study protocol for a clinical trial of serum metabolomics based on UPLC-Q/TOF-MS and UPLC-QQQ-MS/MS.","authors":"Yuting Zhang, Ziqiong Cao, Junlan Ye, Guoliang Dai, Shan Qin, Xiaoqiu Wang, Wenzhong Wu, Chengyong Liu","doi":"10.3389/fpsyt.2025.1499361","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1499361","url":null,"abstract":"<p><strong>Background: </strong>Insomnia is the most prevalent sleep disorder worldwide. Electroacupuncture is effective in improving sleep quality, daytime fatigue status, and anxiety and depression in patients with insomnia, and this study aimed to investigate the metabolic pathways and their possible mechanisms in response to the efficacy of electroacupuncture in the treatment of insomnia.</p><p><strong>Methods: </strong>A single-center, double-blind, clinical trial was the study's design. For this study, a total of 99 participants were enrolled, and they will be split into two groups: one for insomnia and the other for health. There are 33 healthy people in the healthy group and 66 insomnia patients in the insomnia group. Acupuncture treatment will be administered to the intervention group three times a week for four weeks, for a total of twelve treatments, and will be followed up for 3 months. A combination of UPLC-Q/TOF-MS and UPLC-QQQ-MS/MS was used to qualitatively and quantitatively examine the serum of 99 participants. The Pittsburgh Sleep Quality Index (PSQI) and serum metabolomics provided the primary findings. The Insomnia Severity Index (ISI), Hyperarousal Scale (HAS), Fatigue Feverity Scale (FSS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Sleep Diary and The Montreal Cognitive Assessment (MoCA) were the secondary outcomes. For the insomnia group, serum will be collected at baseline, at the end of treatment, and the scale will be collected at baseline, after 4 weeks of treatment, and at 3 months of follow-up. For the healthy group, serum will be collected at baseline.</p><p><strong>Discussion: </strong>This study aimed to assess the modulatory effects of electroacupuncture on relevant metabolic markers using serum metabolomics, to explore the potential mechanisms and relevant metabolic pathways of electroacupuncture for the treatment of insomnia, and to provide strong scientific evidence for the treatment of insomnia by electroacupuncture.</p><p><strong>Trial registration: </strong>ChiCTR2400085660 (China Clinical Trial Registry, http://www.chictr.org.cn, registered on June 14, 2024).</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1499361"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between estimated glucose disposal rate and diabetic depression: a population-based study.","authors":"Xiangzhi Shao, Huifang Dai, Lielie Zhu","doi":"10.3389/fpsyt.2025.1507280","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1507280","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence has identified a correlation between depression and insulin resistance (IR). This study aims to explore the correlation between estimated glucose disposal rate (eGDR)-a noninvasive and practical measure of IR-and depression in patients with diabetes mellitus (DM).</p><p><strong>Methods: </strong>In this cross-sectional study, the data from 3,080 adults aged 18 years old or older with DM obtained from NHANES 1999-2018 were analyzed. The correlation between eGDR and depression were examined through multivariate logistic regression, subgroup analyses, restricted cubic spline (RCS) analysis, and interaction tests. Additionally, mediation analysis was conducted to assess whether leukocytes and neutrophils could mediate the effects of eGDR on depression.</p><p><strong>Results: </strong>Multivariate logistic regression and RCS analyses demonstrate that eGDR was negative linearly correlated with diabetic depression (OR= 0.89; 95% CI: 0.84, 0.95). Patients with DM in Q3 and Q4 of eGDR exhibited a reduced risk of 28% and 54%, respectively, in depression, compared to those in Q1. Subgroup analyses, stratified by variables such as gender, BMI, age, education level, and medical comorbidities, consistently showed a negative correlation. Mediation analysis further indicates that neutrophils and leukocytes accounted for 4.0% and 3.6% of the correlation between eGDR and depression, respectively.</p><p><strong>Conclusions: </strong>The results of this study demonstrated a statistically significant inverse linear correlation between eGDR and the prevalence of depression in patients with DM, with leukocytes and neutrophils acting as mediating factors in this correlation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1507280"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseen dualities: underdiagnosis of substance use disorders in borderline personality disorder.","authors":"Jana Nabel, Sebastian Bertele, Britta Stapel, Nicole Scharn, Kai G Kahl","doi":"10.3389/fpsyt.2025.1539611","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1539611","url":null,"abstract":"<p><strong>Introduction: </strong>Borderline personality disorder (BPD) patients exhibit high rates of co-occurring mental disorders. Though literature reports varying prevalence of substance use disorders (SUD) in BPD, they are frequent with prevalence rates of approximately 45%. This study examines the 12-month prevalence of SUDs in a German sample of BPD patients by semi-structured interviews and compared to medical records.</p><p><strong>Methods: </strong>N=126 BPD patients were included. Twelve-month SUD prevalence was obtained by semi-structured clinical interview (SCID) and compared to reported prevalence in the general population and to diagnoses from medical records.</p><p><strong>Results: </strong>Mean age of the sample was 37.5 (SD ± 11.5) years and N=61 (48%) patients were female. Compared to the general population, increased 12-month prevalence based on SCID was found for alcohol abuse (22.2%, +7.9-times), alcohol dependence (17.5%, +5.6-times), cannabis abuse (15.1%, +30.2-times), cannabis dependence (19.0%, +31.7-times), sedative abuse (3.2%, +4.6-times) and sedative dependence (3.2% +4.6-times). N=43 (34.1%) patients presented at least one diagnosis of substance abuse and N=43 (34.1%) presented at least one diagnosis of substance dependence. N=51 (40.1%) patients were diagnosed with at least one substance use or dependence disorder. On average, prevalence based on SCID exceeded prevalence obtained from medical records. Particularly, alcohol abuse (3.5-times), cannabis abuse (2.4-times) and dependence (2.2-times), and sedative- and stimulant abuse (both no diagnosis in medical record <i>vs</i>. 3.2% in SCID) were underrecognized. Furthermore, concordance rates between diagnoses based on medical record and SCID were below 30% for all substances.</p><p><strong>Conclusion: </strong>Our data confirm high prevalence of SUDs in BPD patients. Of note, medical records underrecognized alcohol abuse and cannabis abuse and dependence. Substance abuse and dependence are primary risk factors of suicidal behaviors and completed suicide. SUDs have been shown to be amenable to psychotherapeutic interventions. Therefore, careful diagnosis of SUD by e.g. expert structured interviews and integration of SUDs in a multimodal treatment plan is recommended.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1539611"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphetamines: a current epidemic.","authors":"Norman Miller","doi":"10.3389/fpsyt.2025.1460341","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1460341","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1460341"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between school bullying involvement and Internet addiction among Chinese Southeastern adolescents: a moderated mediation model with depression and smoking.","authors":"Yuhang She, Liping Li","doi":"10.3389/fpsyt.2025.1557108","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1557108","url":null,"abstract":"<p><strong>Background: </strong>School bullying and Internet addiction are both common public health problems for adolescents. Several studies found an association between school bullying and Internet addiction; however, the underlying mediating and moderating mechanisms of the complex relationship between school bullying and Internet addiction are limited.</p><p><strong>Objective: </strong>This study explored the mediating role of depression in the relationship between school bullying and Internet addiction and whether smoking moderated the relationship between school bullying and depression in Chinese southeastern adolescents.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in Guangdong Province in Southeast China in June 2021. Associations between Internet addiction, school bullying, and depression were estimated using Spearman correlation analysis, the mediation effect and moderation effect were examined using Model 4 and Model 7 in the Hayes' PROCESS macro.</p><p><strong>Results: </strong>The results included 1992 adolescents, 23.5% and 28.0% of participants reported experiences of school bullying and Internet addiction, respectively. There was a significant correlation between school bullying, depression, and Internet addiction (<i>p</i> < 0.01). School bullying direct effects on Internet addiction [<i>β</i> = 0.565, <i>SE</i>= 0.053, 95% <i>CI</i> (0.461, 0.669)], depression partially mediated the association between school bullying and Internet addiction, with the mediation effect size being 36.5%. And smoking played a moderating role between school bullying and depression [<i>β</i> = -0.166, <i>SE</i>= 0.058, 95% <i>CI</i> (-0.280, -0.052)].</p><p><strong>Conclusions: </strong>In Chinese southeastern adolescents, depression mediated the relationship between school bullying and Internet addiction, and smoking moderated the relationship between school bullying and depression.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1557108"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of affective touch in mental illness: a systematic review of CT fiber dysregulation in psychological disorders and the therapeutic potential of CT fiber stimulation.","authors":"Martina Papi, Davide Decandia, Daniela Laricchiuta, Debora Cutuli, Livia Buratta, Maurizio Peciccia, Claudia Mazzeschi","doi":"10.3389/fpsyt.2025.1498006","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1498006","url":null,"abstract":"<p><strong>Introduction: </strong>Over the past few decades, research on affective touch has clarified its impact on key psychological functions essential for environmental adaptation, such as self-awareness, self-other differentiation, attachment, and stress response. These effects are primarily driven by the stimulation of C-tactile (CT) fibers. Despite significant advancements in understanding the fundamental mechanisms of affective touch, its clinical applications in mental health remain underdeveloped. This systematic review aims to rigorously assess the scientific literature on the relationship between CT fiber stimulation and psychological disorders, evaluating its potential as a therapeutic intervention.</p><p><strong>Methods: </strong>This systematic review was conducted in accordance with PRISMA guidelines. A search was performed in the EMBASE, PubMed, and Web of Science databases for articles published in the last 10 years. The review focused on two main aspects: (1) potential dysregulation of CT fibers in individuals with psychological disorders, and (2) psychological treatments based on CT fiber stimulation and their psychological and functional outcomes.</p><p><strong>Results: </strong>Most studies investigating CT fiber dysregulation in psychological disorders reported sensory alterations, with patients rating affective touch as less pleasant than healthy controls. These differences were often associated with dysregulation in the reward network and interoceptive processing, with several studies suggesting reduced insular cortex activation as a contributing factor. Regarding psychological treatments, only a limited number of studies analyzed therapies based on CT fiber stimulation. Despite methodological variations and differences in psychological diagnoses, the available evidence suggests that affective touch therapies can effectively reduce symptom severity and improve interoception across different psychological conditions.</p><p><strong>Discussion: </strong>The findings underscore the potential of affective touch as a therapeutic avenue for psychological disorders. However, given the dearth of studies on this topic, further analyses are necessary to fully understand its mechanisms and clinical efficacy. Expanding research in this area could provide valuable insights into functional impairments related to CT fiber dysregulation and support the development of targeted interventions for mental health treatment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1498006"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital screen time usage, prevalence of excessive digital screen time, and its association with mental health, sleep quality, and academic performance among Southern University students.","authors":"Kamollada Kaewpradit, Pitchayanont Ngamchaliew, Napakkawat Buathong","doi":"10.3389/fpsyt.2025.1535631","DOIUrl":"10.3389/fpsyt.2025.1535631","url":null,"abstract":"<p><strong>Background: </strong>Excessive digital screen time (EDST), which is defined as screen use that surpasses recommended limits, has been found to have detrimental effects on students' mental health and academic performance. However, there is a paucity of studies investigating EDST in university students in Thailand.</p><p><strong>Objective: </strong>To investigate the prevalence, characteristics, and associations of excessive digital screen time with students' mental health, sleep quality, and academic performance.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Southern University, Thailand, between December 2023 and January 2024. A total of 446 students completed self-administered questionnaires assessing DST characteristics, mental health, sleep quality, and academic performance. The tools used included the Depression Anxiety Stress Scale, Rosenberg Self-Esteem Scale, UCLA Loneliness Scale, and Pittsburgh Sleep Quality Index. DST was analyzed by device type and average weekly usage hours, focusing on smartphones, tablets, and computers. EDST was defined as daily usage exceeding 8 hours for smartphones, 6 hours for tablets, or 5 hours for computers. Participants exceeding these thresholds on any device were classified as having EDST. Sampling was conducted using quota sampling across faculties. Data were analyzed using chi-square tests, rank sum tests, and logistic regression, with significance set at P<0.05.</p><p><strong>Results: </strong>Students' median age was 20 years (67.9% women). Most participants used smartphones for 4-6 hours daily (29.7%), tablets for <4 hours (29.8%), and computers for <4 hours (62.6%). Smartphones were primarily used for social media (73.1%), while tablets (28.4%) and computers (19.3%) were used for educational purposes. The prevalence of EDST was 48.4%, including 29.4% on tablets, 22.9% on smartphones, and 7.6% on computers. EDST was significantly associated with younger age (AOR 0.79; 95% CI 0.66-0.94) and enrollment in health science faculties (AOR 1.7; 95% CI 1.01-2.86).</p><p><strong>Conclusion: </strong>A high prevalence of EDST was observed among university students, particularly on smartphones and tablets. Younger students and those in health science programs were more prone to EDST, potentially due to higher academic demands and social media use. Interventions to enhance self-awareness, regulate screen time, and develop time management skills are recommended to mitigate its negative effects on mental health and academic performance.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1535631"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of Xiaoyao formula as an adjuvant therapy for treating postpartum depression.","authors":"Jing Liu, Anna Rong, Fei Wang","doi":"10.3389/fpsyt.2025.1558505","DOIUrl":"10.3389/fpsyt.2025.1558505","url":null,"abstract":"<p><strong>Background: </strong>Xiaoyao Powder/Pill, as a classical Chinese herbal formula, has been widely used for treating depression. This meta-analysis aims to evaluate the effectiveness of Xiaoyao formula (XYF) as an adjuvant therapy for treating postpartum depression.</p><p><strong>Methods: </strong>We searched studies indexed in international databases (Cochrane Library, Embase, and PubMed) and Chinese databases (SinoMed, CNKI, and Wanfang). Randomized controlled trials (RCTs) assessing the efficacy of XYF in combination with Western therapy compared to Western therapy alone for treating postpartum depression were eligible. The total response rate was defined as a reduction of more than 25% in depression scores, while clinical recovery was defined as a reduction of more than 75% in depression scores.</p><p><strong>Results: </strong>Our analysis included ten RCTs comprising 810 women. The combination of XYF and Western therapy led to a significant improvement in the total response rate (risk ratios [RR] 1.17; confidence intervals [CI] 1.08-1.26) and the clinical recovery rate (RR 1.56; 95% CI 1.27-1.91) compared to Western therapy alone. Additionally, XYF as an adjuvant therapy also significantly decreased Hamilton Depression Scale scores (standard mean difference [SMD] -1.69; 95% CI -2.37 to -1.01).</p><p><strong>Conclusions: </strong>Adjuvant treatment with XYF can effectively alleviate depression in postpartum women. However, further well-designed RCTs are necessary to validate these findings, as the current evidence remains uncertain.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1558505"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}