Frontiers in Psychiatry最新文献

{"title":"Identifying relevant EEG channels for subject-independent emotion recognition using attention network layers.","authors":"Camilo E Valderrama, Anshul Sheoran","doi":"10.3389/fpsyt.2025.1494369","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1494369","url":null,"abstract":"<p><strong>Background: </strong>Electrical activity recorded with electroencephalography (EEG) enables the development of predictive models for emotion recognition. These models can be built using two approaches: subject-dependent and subject-independent. Although subject-independent models offer greater practical utility compared to subject-dependent models, they face challenges due to the significant variability of EEG signals between individuals.</p><p><strong>Objective: </strong>One potential solution to enhance subject-independent approaches is to identify EEG channels that are consistently relevant across different individuals for predicting emotion. With the growing use of deep learning in emotion recognition, incorporating attention mechanisms can help uncover these shared predictive patterns.</p><p><strong>Methods: </strong>This study explores this method by applying attention mechanism layers to identify EEG channels that are relevant for predicting emotions in three independent datasets (SEED, SEED-IV, and SEED-V).</p><p><strong>Results: </strong>The model achieved average accuracies of 79.3% (CI: 76.0-82.5%), 69.5% (95% CI: 64.2-74.8%) and 60.7% (95% CI: 52.3-69.2%) on these datasets, revealing that EEG channels located along the head circumference, including <i>Fp</i> ₁, <i>Fp</i> ₂, <i>F</i> ₇, <i>F</i> ₈, <i>T</i> ₇, <i>T</i> ₈, <i>P</i> ₇, <i>P</i> ₈, <i>O</i> ₁, and <i>O</i> ₂, are the most crucial for emotion prediction.</p><p><strong>Conclusion: </strong>These results emphasize the importance of capturing relevant electrical activity from these EEG channels, thereby facilitating the prediction of emotions evoked by audiovisual stimuli in subject-independent approaches.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1494369"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the relative predictive validity of measures of self-referential processing for depressive symptom severity.","authors":"Ethel Siew Ee Tan, Hong Ming Tan, Kah Vui Fong, Sheryl Yu Xuan Tey, Nikita Rane, Chong Wei Ho, Zhao Yuan Tan, Rachel Jing Min Ong, Chloe Teo, Jerall Yu, Maxine Lee, An Rae Teo, Sin Kee Ong, Xin Ying Lim, Jin Lin Kee, Jussi Keppo, Geoffrey Chern-Yee Tan","doi":"10.3389/fpsyt.2024.1463116","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1463116","url":null,"abstract":"<p><strong>Introduction: </strong>The self-referential encoding task (SRET) has a number of implicit measures which are associated with various facets of depression, including depressive symptoms. While some measures have proven robust in predicting depressive symptoms, their effectiveness can vary depending on the methodology used. Hence, understanding the relative contributions of population differences, word lists and calculation methods to these associations with depression, is crucial for translating the SRET into a clinical screening tool.</p><p><strong>Methods: </strong>This study systematically investigated the predictive accuracy of various SRET measures across different samples, including one clinical population matched with healthy controls and two university student populations, exposed to differing word lists. Participants completed the standard SRET and its variations, including Likert scales and matrix formats. Both standard and novel SRET measures were calculated and compared for their relative and incremental contribution to their associations with depression, with mean squared error (MSE) used as the primary metric for measuring predictive accuracy.</p><p><strong>Results: </strong>Results showed that most SRET measures significantly predicted depressive symptoms in clinical populations but not in healthy populations. Notably, models with task modifications, such as Matrix Endorsement Bias and Likert Endorsement Sum Bias, achieved the lowest mean squared error (MSE), indicating better predictive accuracy compared to standard Endorsement Bias measures.</p><p><strong>Discussion: </strong>These findings imply that task modifications such as utilising Likert-response options and the use of longer word lists may enhance the effectiveness of screening methods in both clinical and research settings, potentially improving early detection and intervention for depression.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1463116"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association analysis of suicide risk assessed with Mini International Neuropsychiatric Interviews' Suicidality Module in adolescents with non suicidal self injury disorder.","authors":"Shuo Geng, Wen Zhang, Xiang Gao, Lele Qu, Xueping Zheng, Jian Sun, Mingdong Xu, Hua Lin, Xueyu Jia, Xu Zhang","doi":"10.3389/fpsyt.2025.1546039","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1546039","url":null,"abstract":"<p><strong>Objective: </strong>Many adolescents with non suicidal self injury disorder have suicidal ideation. However, the specific characteristics of adolescents with NSSI-D that contribute to high suicide risk remain unclear. This study observes the association between depressive and anxiety symptoms and suicide risk among adolescents with non suicidal self injury disorder, and explores the mechanism underlying the high risk of suicide in this population.</p><p><strong>Method: </strong>Adolescents with non suicidal self injury disorder and their parents from a psychiatric outpatient clinic were selected to conduct paper questionnaires to measure their sociodemographic conditions. The Mini International Neuropsychiatric Interviews' Suicidality Module(MINISM) was used to assess suicide risk of participants. The Self-Rating Depression Scale(SDS), Self-Rating Anxiety Scale(SAS), and Piers-Harris Children's Self-Concept Scale(PHCSS) were used to measure depressive and anxiety symptoms, and self-concept of adolescents with non suicidal self injury disorder. According to the high suicide risk cutoff value of MINISM, the sample was divided into high suicide risk group and non-high suicide risk group. We performed descriptive and correlation statistical and network analysis to study the types of depressive and anxiety symptoms associated with suicide risk and the mechanism underlying suicide risk among non suicidal self injury disorder adolescents.</p><p><strong>Results: </strong>A total of 112 non suicidal self injury disorder adolescent participants were included in this study. Severe depressive symptoms(OR=8.205, 95%CI=3.454-19.490) and severe anxiety symptoms(OR=3.926, 95%CI=1.613-9.554) are associated with a high risk of suicide. The father's college/university education(p<0.01) is associated with severe anxiety symptoms, and low self-concept(p<0.01) is associated with severe depressive symptoms. Network analysis suggests the centrality of anxiety symptoms and father's education level.</p><p><strong>Conclusion: </strong>The results of statistical analysis suggest that severe depressive symptoms are related to the high risk of suicide (based on MINISM) in adolescents with NSSI-D statistical significantly, and anxiety symptoms and low self-concept are associated with depressive symptoms in NSSI-D adolescents. Interventions targeting anxiety symptoms in adolescents with NSSI-D may help reduce their suicide risk.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1546039"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between resilience and mental health of adolescents and young adults: a systematic review and meta-analysis.","authors":"Shulai Luo, Jiangtao Hu, Junshuai Zhang, Zhengyang Mei, Zhongjian Tang, Shi Luo","doi":"10.3389/fpsyt.2025.1536553","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1536553","url":null,"abstract":"<p><strong>Background: </strong>Adolescents and young adults (AYAs) aged 10-25 exhibit an increased prevalence of mental health disorders. Resilience has been well established as a positive factor in promoting and protecting mental health. This systematic review and meta-analysis aimed to quantify the correlation between resilience and mental health in AYAs by including relevant observational studies. Additionally, it explored potential moderators such as percentage of female participants, sample regions, and resilience measurements.</p><p><strong>Methods: </strong>A comprehensive search of the PubMed, Embase, Cochrane Library, Web of Science and Scopus databases was conducted until September 2024. CMA 3.0 software was used to perform meta-analysis, publication bias and sensitivity analysis of the included studies, and the moderating effect was verified by meta-analysis of variance (ANOVA).</p><p><strong>Result: </strong>Nineteen studies involving a total of 17,746 participants were included, and the summary effect sizes from the random effect model showed that resilience among AYAs had a correlation coefficient of -0.391 with negative indicators of mental health (95% CI: - 0.469, - 0.308, p < 0.001), and a correlation coefficient of 0.499 with positive indicators of mental health (95% CI: 0.400, 0.586, p < 0.001). Additionally, sample regions and resilience measurements significantly moderated the correlation between resilience and positive indicators of mental health.</p><p><strong>Conclusion: </strong>Resilience in AYAs showed a moderately negative correlation with negative indicators of mental health and a moderately strong positive correlation with positive indicators of mental health. The findings strengthened the basis for future resilience research in AYAs aged 10-25, highlighting the potential of resilience to help mitigate the increasing mental health challenges faced by this population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1536553"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Women in psychiatry 2023: aging psychiatry.","authors":"Elizabeta B Mukaetova-Ladinska, Stella-Maria Paddick","doi":"10.3389/fpsyt.2025.1556398","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1556398","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1556398"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between digital technology use and depression among older people in China: a moderated mediation model.","authors":"Qinmei Wu, Wei He, Jinfu Wang, Litao Du, Xiangli Xue, Qiang He, Yang Pan, Si Chen, Xianliang Zhang","doi":"10.3389/fpsyt.2025.1457967","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1457967","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association among multidimensional (Digital engagement, DE; Digital devices, DD; and Digital purpose, DP) digital technology use and depression in older Chinese, considering social participation as a mediator and physical activity level (PAL) as a moderator.</p><p><strong>Methods: </strong>Data on 5,744 participants (aged≥60) were extracted from the China Health and Retirement Longitudinal Study 2020 dataset. Depression was assessed using the 10-item Center for Epidemiologic Studies Depression Scale. Logistic regression examined the association between digital technology use and depression. The PROCESS program's Model 4 evaluated the mediating role of social participation, while Model 7 assessed the moderating role of PAL.</p><p><strong>Results: </strong>Digital technology use was negatively associated with depression (DE, <i>OR=</i> 0.722, 95%CI: 0.609, 0.858; DD, <i>OR=</i> 0.739, 95%CI: 0.634, 0.860; DP, <i>OR=</i> 0.916, 95%CI: 0.881, 0.952). Various dimensions of digital technology use exerted direct effects on depression scores of 85.87% (DE, <i>OR=</i> -0.638, 95%CI: -1.036, -0.240), 86.09% (DD, <i>OR=</i> -0.526, 95%CI: -0.844, -0.208), and 87.82% (DP, <i>OR=</i> -0.173, 95%CI: -0.259, -0.087), respectively, and social participation mediated 14.13%, 13.91%, 12.18%. PAL exerted a positive moderating effect on the first half path of mediation, especially with the vigorous PAL (DE, <i>OR=</i> 0.591, 95%CI: 0.230, 0.952; DD, <i>OR=</i> 0.515, 95%CI: 0.206, 0.824; DP, <i>OR=</i> 0.157, 95%CI: 0.075, 0.239).</p><p><strong>Conclusions: </strong>Multidimensional digital technology use showed an association with depression in older adults. Promoting social participation through digital technology use is associated with lower depressive symptom scores, and vigorous PAL further strengthens this association, leading to improved mental health.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1457967"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dose-effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis.","authors":"Xiaoni Zhang, Yue Wang, Chengyong Liu, Shan Qin, Liyu Lin, Can Dong, Wenzhong Wu, Zhaoming Chen","doi":"10.3389/fpsyt.2025.1501321","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1501321","url":null,"abstract":"<p><strong>Background: </strong>The benefits of acupuncture on primary insomnia (PI) have been well established in previous studies. However, different acupuncture dosages may lead to controversy over its efficacy. Therefore, this systematic review and meta-analysis was conducted to assess the relationship between the dose and efficacy of acupuncture for the treatment of PI.</p><p><strong>Methods: </strong>Seven databases were searched from inception until May 30, 2024. The included randomized controlled trials (RCTs) with acupuncture for PI on the Pittsburgh Sleep Quality Index (PSQI) scores were divided into three categories according to the therapeutic dose of acupuncture (frequency, session, and course): low dosage, medium dosage, and high dosage. The correlation between the dose and the effect of treatment was analyzed. Risk of bias was assessed using Cochrane Collaboration's risk of bias tool. Meta-analyses were performed using RevMan v.5.4 and Stata 16.0 software.</p><p><strong>Results: </strong>A total of 56 studies were included. There were 17 sham acupuncture-controlled RCTs that are notable because of their high quality. Overall, the effect on the reduction of the PSQI scores varied across the different acupuncture dosages. For the frequency of acupuncture, the results showed a significant improvement in the moderate frequency (three sessions per week) and high frequency (five to seven sessions per week) categories. With regard to the acupuncture session, it was shown that moderate session (12-20 sessions) and high session (24-30 sessions) had better effects on the reduction of the PSQI scores, with low session (≤10 sessions) being not significant. For the acupuncture course, there were no differences in the short course (≤2 weeks) and the long course (>4 weeks) between the acupuncture group and the control group. Medium course (3-4 weeks) was considered as the optimal course. In addition, there were no differences between acupuncture and SATV (sham acupuncture therapy at verum points) on the same acupuncture points in the PSQI scores. The results of GRADE assessment demonstrated that the level of evidence was very low to moderate, probably due to the poor methodological quality and the substantial heterogeneity among studies.</p><p><strong>Conclusions: </strong>A dose-effect relationship was found between the acupuncture dose and the PSQI scores. Although sham acupuncture needling at the same points as those in acupuncture may not be a true placebo control, this was utilized in a minority of studies. Collectively, the data suggest that at least three sessions per week for 3-4 weeks and a total of at least 12 acupuncture sessions would be the optimal clinical response.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/, identifier CRD42024560078.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1501321"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deviation from the balanced time perspective and depression and anxiety symptoms: the mediating roles of cognitive-behavioral emotion regulation in a cross-cultural model.","authors":"Hamed Abdollahpour Ranjbar, Ayse Altan-Atalay, Mojtaba Habibi Asgarabad, Bulent Turan, Mehmet Eskin","doi":"10.3389/fpsyt.2025.1452455","DOIUrl":"10.3389/fpsyt.2025.1452455","url":null,"abstract":"<p><strong>Background: </strong>Time perspective (TP) influences how individuals perceive and classify their past, present, and future, impacting their cognition, behavior, and psychological outcomes. Deviation from the balanced time perspective (DBTP) is associated with mental health problems (e.g., depression and anxiety). Emotion regulation (ER) encompasses cognitive and behavioral processes to regulate emotions, with maladaptive strategies like rumination and withdrawal linked to depression and anxiety. Despite extensive research on TP and ER, their joint impact, particularly in the context of depression and anxiety, and cultural differences remain underexplored.</p><p><strong>Method: </strong>Participants (<i>N</i> = 513 Iranian, <i>N</i> = 470 Turkish) completed self-report questionnaires on time perspective, cognitive and behavioral ER, anxiety, and depression symptoms. A moderated mediation model was assessed, incorporating the exogenous variable of DBTP, with ER strategies as mediators, and endogenous variables of depressive and anxiety symptoms. The model accounted for cultural variations in the paths as a moderator.</p><p><strong>Results: </strong>Significant associations were found between DBTP, ER strategies, depression, and anxiety symptoms. Mediation analyses revealed that both cognitive and behavioral ER strategies (except for adaptive behavioral ER strategies) significantly mediated the associations between DBTP and depression and anxiety. Additionally, multigroup analyses suggested that these mediating effects were consistent across Iranian and Turkish samples, with exceptions in adaptive cognitive ER strategies.</p><p><strong>Conclusion: </strong>The study highlights the crucial role of TPs and ER strategies in predicting anxiety and depression symptoms, with notable cultural nuances. Specifically, maladaptive strategies exacerbate symptoms, while adaptive strategies mitigate them primarily in Iranian contexts. Cultural subtleties are discussed in detail.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1452455"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with attention-deficit/hyperactivity disorder among Tunisian children.","authors":"Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Randaline Ayoub, Hela Ben Abid, Ahmed Mhalla, Hela Slama","doi":"10.3389/fpsyt.2025.1462099","DOIUrl":"10.3389/fpsyt.2025.1462099","url":null,"abstract":"<p><strong>Introduction: </strong>Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental condition that affects millions of children and adolescents worldwide. Knowledge of risk factors associated with ADHD may reduce its prevalence and its severe impact on patient's quality of life. The aim of this study was to identify risk factors associated with ADHD and to discuss their involvement in the genesis of the disorder.</p><p><strong>Methods: </strong>This is a case-control study involving a first group of 74 children (mean age = 9 years) diagnosed with ADHD. The second group included 80 healthy control children. They were randomly selected and matched for age and gender. A literature-based questionnaire assessing the socio-demographic data, biological and environmental factors associated with ADHD was administered to the parents. The diagnosis of ADHD group was made by a trained child psychiatrist according to the DSM-5 criteria supplemented by the Conners scales of parents and teachers. For the control group, we added to the questionnaire the MINI-kid section of ADHD to screen for possible presence of ADHD symptoms. Univariate then multivariate analyses were conducted to identify factors associated with ADHD.</p><p><strong>Results: </strong>Several factors were more prevalent in children with ADHD than in controls: disturbed family dynamics, low socio-economic status, family history of psychiatric and organic pathologies, and particularly several early environmental factors, including passive smoking during pregnancy, prematurity, fetal distress, caesarean delivery and low birth weight. In the early childhood period, early exposure to television was also strongly associated with ADHD. However, the multivariate model conducted to determine the variables independently associated with ADD/ADHD revealed only three determining factors: passive smoking during pregnancy (OR = 4.60 [2.14, 9.94]; p < 0.001), acute fetal distress (OR = 5.08 [1.47, 17.52]; p = 0.01), and familial psychiatric history (OR = 9.37 [2.46, 35.59]; p = 0.001).</p><p><strong>Discussion: </strong>The recognition of factors involved in the genesis of ADHD within different ethnic populations may help understanding and broaden our knowledge of this disorder to develop targeted strategies for prevention and early intervention. Further participants with more robust statistical output are required to confirm our findings to a more generalized population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1462099"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DAILY - A personalized circadian <i>Zeitgeber</i> therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial.","authors":"Naomi Springer, Lisa Echtler, Paul Volkmann, Anisja Hühne-Landgraf, Jasmin Hochenbleicher, Eva Hoch, Gabi Koller, Dominic Landgraf","doi":"10.3389/fpsyt.2025.1477895","DOIUrl":"10.3389/fpsyt.2025.1477895","url":null,"abstract":"<p><strong>Background: </strong>Disturbances of circadian rhythms and everyday structures are hallmarks of alcohol use disorder (AUD). Recurring activities such as sleep, activity, and meals represent time cues, so called <i>Zeitgebers</i>, that synchronize the circadian system. With our newly developed therapy approach for AUD patients, we aim to reduce relapses and alcohol consumption in AUD patients undergoing a withdrawal program by strengthening their circadian rhythms.</p><p><strong>Methods/design: </strong>We aim to achieve the improvement of circadian rhythms with personalized structure plans for daily <i>Zeitgeber</i> activities, which are used in parallel with the standard therapy at our clinic. The DAILY pilot study is a six-week monocentric trial with a controlled, randomized, single-blinded, parallel-group design. 41 AUD patients participated in the pilot study and were randomly assigned to an intervention group (IG) or a control group (CG).</p><p><strong>Results: </strong>The variability of daily activities was significantly lower in the IG group than in the CG group. Of the IG participants, two had relapsed during the study (<12%), whereas ten relapsed in the CG group (>60%). The relapsing IG participants recorded a total of three alcohol consumption days, while the CG participants recorded 52 consumption days. Abstinent participants showed significantly less variability in the times of their daily activities than relapsed participants. In addition, our analyses indicate that craving for alcohol is related to variability in the time of getting up and that craving and temporal variability increase before relapses. Moreover, the general well-being of the IG participants improved more than that of the CG participants.</p><p><strong>Discussion: </strong>The data from this pilot study show that following a personalized daily structure plan helps AUD patients to remain abstinent during withdrawal therapy. The analyses indicate that temporal variability of daily activities and the risk of relapse are correlated. On the one hand, adherence to the daily structure may prevent relapse, on the other hand, an increase in variability may be a helpful predictor of approaching relapse. In our view, these data justify a continuation of the DAILY study with the addition of further measurements such as the determination of endogenous circadian rhythms.</p><p><strong>Clinical trial registration: </strong>https://drks.de, identifier DRKS00019093.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1477895"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}