Frontiers in Psychiatry最新文献

{"title":"<i>N</i>-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder.","authors":"Etna J E Engeli, Katrin H Preller, Nathalie M Rieser, Johanna Klar, Philipp Staempfli, Lea M Hulka, Matthias Kirschner, Erich Seifritz, Marcus Herdener","doi":"10.3389/fpsyt.2024.1489194","DOIUrl":"10.3389/fpsyt.2024.1489194","url":null,"abstract":"<p><strong>Background: </strong>Individuals with cocaine use disorder experience heightened motivation to pursue rewards tied to cocaine, often triggered by associated cues. Cue reactivity and subsequent craving significantly elevate the risk of substance use, creating a pressing need for treatments that can help alleviate cravings. However, no pharmaceutical therapies for treating cocaine use disorder have been approved. Preclinical findings reveal dysfunctions in the glutamatergic pathway connecting prefrontal regions with the nucleus accumbens, which are correlated with cue-induced substance-seeking behaviour. These alterations, at both molecular and behavioural levels, can be reversed in rodents with <i>N</i>-acetylcysteine, a modulator of glutamatergic signalling. In contrast, the therapeutic potential for humans remains uncertain.</p><p><strong>Methods: </strong>Here, we assessed the impact of a short-term challenge with <i>N</i>-acetylcysteine on neural responses to cocaine cues and cue-induced craving in a randomised, placebo-controlled cross-over trial using a fMRI cue reactivity paradigm. In total, 44 fMRI cue reactivity scans of 22 individuals with cocaine use disorder were recorded-once after the administration of 2,400 mg of <i>N</i>-acetylcysteine/day for 2 days and once after placebo intake.</p><p><strong>Results: </strong>In the placebo condition, participants showed increased cue reactivity towards cocaine pictures, accompanied by significantly higher cravings as compared to neutral images. In accordance with recent meta-analyses, cue reactivity was evident in parietal regions such as the posterior cingulate and precuneus, temporal regions like the hippocampus, the bilateral insula, and medial prefrontal regions, namely the inferior, middle, and superior frontal gyrus. Cue-induced activity in the superior frontal gyrus was strongly predicted by the individual duration of cocaine use. While <i>N</i>-acetylcysteine showed no impact on subjectively rated cocaine craving, neural cue reactivity in the superior frontal gyrus was significantly decreased under <i>N</i>-acetylcysteine compared to placebo.</p><p><strong>Conclusions: </strong>Our findings show that prefrontal reactivity to cocaine cues can be reduced even by a brief pharmacological challenge with <i>N</i>-acetylcysteine. Since neural drug cue reactivity has been shown to be a precursor of relapse behaviour, <i>N</i>-acetylcysteine's therapeutic potential should be further investigated in future studies by extending treatment periods.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov, identifier NCT02626494.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1489194"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health amidst multiple crises: trends and sociodemographic risk factors in Austria's general population.","authors":"Elke Humer, Christoph Pieh, Thomas Probst, Carina Dinhof, Yvonne Schaffler, Marina Zeldovich","doi":"10.3389/fpsyt.2025.1534994","DOIUrl":"10.3389/fpsyt.2025.1534994","url":null,"abstract":"<p><strong>Background: </strong>In recent years, mental health in Austria has faced substantial challenges due to a series of both global and regional crises.</p><p><strong>Objective: </strong>This study aimed to assess changes in mental health indicators within the Austrian population over time from April 2022 to October 2024 and to identify sociodemographic correlates of poor mental health.</p><p><strong>Methods: </strong>Two cross-sectional online surveys on representative samples of the Austrian general population were conducted at two timepoints: April 2022 (n = 1,032) and October 2024 (n = 2,025). Mental health indicators, including depression, anxiety, insomnia, alcohol misuse, and stress, were measured using validated scales. Sociodemographic data were collected to examine associations with mental health indicators. Chi-squared tests and t-tests were conducted to compare mental health indicators between 2022 and 2024, and multivariable logistic regression models were applied to examine associations with sociodemographic data.</p><p><strong>Results: </strong>Clinically relevant symptoms of depression and high stress decreased from 2022 to 2024 (depression from 28.3% to 21.6%, stress from 56.3% to 51.0%; p < 0.01), while other symptoms remained stable. Sociodemographic analysis revealed that female gender, younger age, lower income, unemployment, migration background and lack of partnership were associated with higher odds for several mental health issues.</p><p><strong>Conclusions: </strong>Findings suggest small improvements in mental health from 2022 to 2024 and identified sociodemographic risk factors linked to mental health vulnerabilities.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1534994"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-suicidal self-injury in adolescence: a validation of the Chinese version of the Inventory of Statements About Self-Injury in student populations.","authors":"Xinhe Tian, Hebin Huang, Weicong Lu, Ruoxi Zhang, Runhua Wang, Xiaoyue Li, Danping Li, Yanling Gao, Shiyun Wu, Guiyun Xu, Robin Shao, Kangguang Lin","doi":"10.3389/fpsyt.2025.1510681","DOIUrl":"10.3389/fpsyt.2025.1510681","url":null,"abstract":"<p><strong>Background: </strong>The Inventory of Statements About Self-Injury (ISAS) is a widely utilized scale for evaluating the 13 potential functions that motivate non-suicidal self-injury(NSSI) behaviors. However, its validation for assessing such motivation in a Chinese context is still lacking.</p><p><strong>Aims: </strong>The main objective was to access the validation of ISAS as an instrument in Chinese young population.</p><p><strong>Method: </strong>A total of 1,106 completed online self-report questionnaires were collected, with 167 reporting a history NSSI. The age range of these individuals was 12 to 24 years old, comprising 74 female and 93 male participants. The factor structure and construct validity were calculated using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The correlations of the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Brief Self-Control Scale (BSCS), the Self-Rating Idea of Suicide Scale (SIOSS), and the Chinese version of the ISAS were tested using bivariate correlation analyses.</p><p><strong>Results: </strong>The internal consistencies of the Chinese version of the ISAS were good to excellent, with 0.788- 0.950 and 0.80-0.949 in the sports group and the junior high school group, respectively. EFA and CFA exhibited a good two-factor structure model (NFI = 0.942, CFI = 0.974, IFI = 0.974, RMSEA = 0.068, SRMR = 0.043, CMIN/DF = 1.762). Moreover, the scores of the functions of the ISAS were correlated with depression (r=0.208, p<0.01), anxiety (r=0.223, p<0.01), suicidal ideation (r=0.322, p<0.01), and low self-control (r=-0.230, p<0.01).</p><p><strong>Conclusion: </strong>This study validates the Chinese ISAS as a reliable NSSI measure, identifies a two-factor structure, and aims to inform targeted interventions and future research on self-injury behaviors among Chinese adolescents.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1510681"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explore autophagy-related lncRNA-miRNA-mRNA ceRNA networks for diagnosis of early-onset schizophrenia through transcriptome analysis.","authors":"Wei Hu, Xinzhe Du, Xinxia Wang, Kexin Zhang, Junxia Li, Yao Gao, Ting An, Hong Zhang, Yu Zhang, Zhiyong Ren, Yong Xu, Sha Liu","doi":"10.3389/fpsyt.2025.1567148","DOIUrl":"10.3389/fpsyt.2025.1567148","url":null,"abstract":"<p><strong>Background: </strong>The severe functional impairment and poor prognosis of early-onset schizophrenia (EOS) create a great need to identify effective biomarkers for early diagnosis in young psychiatric patients. Current research indicates a potential link between loss of autophagy function and emotional and behavioral abnormalities in individuals with psychiatric disorders.</p><p><strong>Materials and methods: </strong>This study aimed to explore diagnostic autophagy-related endogenous competitive RNA (ceRNA) networks for EOS patients. The messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) expression profiles were obtained from peripheral blood mononuclear cells of 18 EOS patients and 12 healthy controls (HC). A co-expression analysis was performed between 365 core lncRNAs and 55 differentially expressed autophagy-related genes (ARGs) to identify differentially expressed autophagy-related lncRNAs. Subsequently, five diagnostic autophagy-related lncRNAs were identified as candidate genes to construct a ceRNA regulatory network using least absolute shrinkage and selection operator (LASSO) Cox regression, and receiver operating characteristic (ROC) curve analysis was performed to evaluate their predictive accuracy. Then, putative interactions among lncRNA-microRNAs (miRNAs)-mRNA were determined based on the lncRNASNP2 and TarBase databases.</p><p><strong>Results: </strong>Three lncRNAs, twenty miRNAs, and ten mRNAs were selected to construct an autophagy-associated ceRNA network associated with EOS occurrence. Through protein-protein interaction network analysis, five hub mRNAs were identified, which exhibited good predictive ability in distinguishing EOS patients from healthy individuals. ROC curve analysis demonstrated that integrating three diagnostic lncRNAs (RP1-135L22.1, RP5-884C9.2, RP11-390F4.3) along with five hub mRNAs (<i>EIF4G1</i>, <i>AKT1</i>, <i>BAX</i>, <i>WIPI2</i>, <i>MAPT</i>) appeared to yield better diagnostic accuracy compared to using either lncRNAs or mRNAs alone. Furthermore, all three diagnostic lncRNAs and five hub mRNAs were positively correlated with at least two types of immune infiltration.</p><p><strong>Conclusion: </strong>Through transcriptome analysis, we searched for diagnostic autophagy-related ceRNA networks, which provided valuable candidates for the early diagnosis of EOS.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1567148"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glioblastoma and new-onset criminal behaviors in a geriatric patient: a forensic-psychiatric case report from Switzerland.","authors":"Alexander J Smith, Urs Hagen, Barbara Brela, Anna Buadze, Michael Liebrenz","doi":"10.3389/fpsyt.2025.1553508","DOIUrl":"10.3389/fpsyt.2025.1553508","url":null,"abstract":"<p><p>Organic brain disorders (OBD), including rapid-growth cancerous tumors, can have significant neuropsychiatric effects and in some circumstances have led to the manifestation of deviant behaviors that conflict with societal norms. This report describes the case of a geriatric male patient in Switzerland with no prior history of delinquency who in later life repeatedly committed stalking offences and aggressive acts. An initial forensic-psychiatric evaluation diagnosed this individual with persistent delusional disorder based on pronounced symptoms and rigid personality traits; during this assessment, the patient refused neuroimaging scans but later consented to these examinations. Thereafter, these revealed an isocitrate dehydrogenase wild-type glioblastoma and provided critical insights into his behavioral changes. Specifically, the tumor's location in regions of the brain responsible for executive functioning, emotional regulation, and social cognition likely contributed to the development of delusions and psychosis-like symptoms that ultimately resulted in new-onset delinquency. Thus, this case highlights the multifaceted challenges of OBDs in forensic-psychiatric contexts, accentuating a need for greater awareness and sensitivity towards these conditions, particularly when externalized deviant behaviors emerge in elderly groups that diverge from established patterns.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1553508"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Reviews in psychiatry 2023: personality disorders.","authors":"Massimiliano Beghi, Michele Sanza","doi":"10.3389/fpsyt.2025.1567144","DOIUrl":"10.3389/fpsyt.2025.1567144","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1567144"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep multimodal representations and classification of first-episode psychosis via live face processing.","authors":"Rahul Singh, Yanlei Zhang, Dhananjay Bhaskar, Vinod Srihari, Cenk Tek, Xian Zhang, J Adam Noah, Smita Krishnaswamy, Joy Hirsch","doi":"10.3389/fpsyt.2025.1518762","DOIUrl":"10.3389/fpsyt.2025.1518762","url":null,"abstract":"<p><p>Schizophrenia is a severe psychiatric disorder associated with a wide range of cognitive and neurophysiological dysfunctions and long-term social difficulties. Early detection is expected to reduce the burden of disease by initiating early treatment. In this paper, we test the hypothesis that integration of multiple simultaneous acquisitions of neuroimaging, behavioral, and clinical information will be better for prediction of early psychosis than unimodal recordings. We propose a novel framework to investigate the neural underpinnings of the early psychosis symptoms (that can develop into Schizophrenia with age) using multimodal acquisitions of neural and behavioral recordings including functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), and facial features. Our data acquisition paradigm is based on live face-toface interaction in order to study the neural correlates of social cognition in first-episode psychosis (FEP). We propose a novel deep representation learning framework, Neural-PRISM, for learning joint multimodal compressed representations combining neural as well as behavioral recordings. These learned representations are subsequently used to describe, classify, and predict the severity of early psychosis in patients, as measured by the Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF) scores to evaluate the impact of symptomatology. We found that incorporating joint multimodal representations from fNIRS and EEG along with behavioral recordings enhances classification between typical controls and FEP individuals (significant improvements between 10 - 20%). Additionally, our results suggest that geometric and topological features such as curvatures and path signatures of the embedded trajectories of brain activity enable detection of discriminatory neural characteristics in early psychosis.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1518762"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting satisfaction with vocational status among people with serious mental illness in vocational services: the role of perceived skills and support.","authors":"Gili Hoter Ishay, Gil Goldzweig, Ilanit Hasson-Ohayon, Marc Gelkopf, Efrat Shadmi, David Roe","doi":"10.3389/fpsyt.2025.1533227","DOIUrl":"10.3389/fpsyt.2025.1533227","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the role of perceived skills and support in satisfaction with vocational status to better address the vocational needs and recovery goals of individuals with serious mental illness (SMI). It focuses on three service types: individual placement and support (IPS), sheltered workshops, and vocational support centers.</p><p><strong>Method: </strong>The study is a cross-sectional analysis of the nationwide Israeli PR-PROM project data. A sample of 2,968 participants diagnosed with SMI and their service providers self-reported their perceived skills, support, and satisfaction with vocational status.</p><p><strong>Results: </strong>We found perceived skills and support to be primary predictors of vocational satisfaction across all groups. There were significant differences in satisfaction with vocational status among the three service types: IPS users reported higher satisfaction than sheltered workshop and vocational support center users. The service-provider evaluations reflected similar trends, with higher satisfaction ratings for more integrative services. Additionally, discrepancies were observed between participant and provider satisfaction ratings, varying by vocational service type.</p><p><strong>Discussion: </strong>The study highlights the importance of perceived skills and support in enhancing satisfaction with vocational status for people with SMI regardless of the vocational service type. Whereas objective factors like employment status and salary contribute to vocational rehabilitation and quality of life, subjective perceptions of skills and support play a significant role in satisfaction with vocational status. The results suggest that vocational rehabilitation services should monitor consumers' perceptions of skills and support to improve their vocational satisfaction, which can promote personal well-being and social integration.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1533227"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic symptoms in Chinese patients with somatic symptom disorder: prevalence, risk factors, and associated conditions.","authors":"Jiamei Yuan, Yunhui Zhong, Yibo Li, Yuanping Liao, Hong Tang","doi":"10.3389/fpsyt.2025.1519492","DOIUrl":"10.3389/fpsyt.2025.1519492","url":null,"abstract":"<p><p>Psychotic symptoms are prevalent in individuals with various mental health disorders and frequently lead to adverse outcomes. In this study, we assessed the prevalence of psychotic symptoms and its associated conditions in a large sample of Chinese patients with somatic symptom disorder (SSD), which has not been examined systemically. We recruited 899 patients with SSD. We used the positive subscale of the Positive and Negative Syndrome Scale to assess psychotic symptoms in the participants. We evaluated the participants using the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA) and Perceived Stress Scale (PSS).The prevalence of psychotic symptoms in participants was 10.2%. Compared with participants without psychotic symptoms, participants with psychotic symptoms had higher scores on the HAMD, HAMA and PSS scales and a shorter sleep duration. Based on the results of stepwise binary logistic regression analysis, the HAMA, HAMD and PSS were significantly associated with psychotic symptoms in the participants. Our findings suggest that psychotic symptoms are common in patients with SSD in the Chinese Han population. In addition, greater levels of anxiety, depression, and stress are potentially useful markers for predicting a greater risk of psychotic symptoms.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1519492"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between interpersonal security and social media dependence: a moderated mediation model.","authors":"Jinglin Li, Jiajia Tan, Shang Zhang, Haihong Wang, Xinfa Yi","doi":"10.3389/fpsyt.2025.1536539","DOIUrl":"10.3389/fpsyt.2025.1536539","url":null,"abstract":"<p><strong>Background: </strong>Interpersonal security is an important psychological factor influencing social media use. However, little is known about the mediating and moderating mechanisms linking Interpersonal security and social media dependence.</p><p><strong>Objective: </strong>The present study explored the mediating role of negative rumination between interpersonal safety and social media dependence, as well as cohort differences in sibling conditions as moderators.</p><p><strong>Methods: </strong>A total of 986 college students were surveyed using a cross-sectional design. Participants completed the Interpersonal Security Questionnaire, the Social Media Dependence Scale, and the Negative Rumination Scale.</p><p><strong>Results: </strong>The results showed that a significant interrelationship between interpersonal security, negative rumination, and social media dependence. In addition, the role of negative rumination as a mediator of interpersonal security and social media dependence was supported, and the mediating effects were different between the only-child and non-only-child cohorts.</p><p><strong>Conclusions: </strong>Findings of the study provide a psychological basis for the treatment of social media dependence behavior in college students, with the aim of increasing their interpersonal security and reducing their dependence on social media.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1536539"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}