Frontiers in Psychiatry最新文献

{"title":"The attentional boost effect in individuals prone to depression: a Remember/Know analysis based on emotional valence and material type.","authors":"Qinling Xie, Meina Zhang, Yiyuan Wang, Di Wang, Fajie Huang","doi":"10.3389/fpsyt.2025.1661870","DOIUrl":"10.3389/fpsyt.2025.1661870","url":null,"abstract":"<p><p>This study provides the first comprehensive investigation of the attentional boost effect (ABE) in individuals prone to depression under varying conditions of emotional valence and material type. It further examines whether ABE is driven primarily by enhanced recall of target information or by the inhibition of distractor processing. A four-factor mixed design (Group × Material Type × Emotional Valence × Stimulus Type) was employed with 60 university students (30 individuals prone to depression, 30 healthy controls). Participants completed a classical ABE paradigm combined with the Remember/Know (R/K) memory task to assess recognition performance and ABE effect sizes across conditions. The results revealed that: (1) both groups demonstrated significant ABE, supporting its cross-group robustness; (2) under the \"positive-picture\" condition, the ABE effect in the depression-prone group tended to be weaker than in healthy controls, suggesting a condition-specific attenuation under the interaction of emotion and material type; (3) ABE primarily emerged in Remember responses rather than Know responses, reflecting an advantage for conscious recollection of target stimuli, while the depression-prone group additionally exhibited \"reversed ABE\" in certain conditions, where distractors elicited greater familiarity; and (4) the modulatory roles of material type and emotional valence were stage-dependent, with picture stimuli-characterized by higher arousal-being more sensitive to emotional modulation, whereas word stimuli showed greater semantic stability. These findings suggest that although individuals prone to depression generally retain ABE, their conscious recollection of targets is selectively weakened under positive emotional contexts, accompanied by reduced efficiency in distractor inhibition. This study extends the applicability of ABE theory to subclinical populations and provides novel empirical evidence for understanding attention-memory coupling and depression-related cognitive biases.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1661870"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situational xylophagia from chronic anemia: case report.","authors":"Jonathan Credo, Sumra Mubarik, Lorin M Scher","doi":"10.3389/fpsyt.2025.1646188","DOIUrl":"10.3389/fpsyt.2025.1646188","url":null,"abstract":"<p><strong>Background: </strong>Xylophagia is a rare subtype of pica involving consumption of paper or wood products. It is unknown why an individual may choose non-food items for consumption; however, pica has higher co-occurrence in those with schizophrenia, intellectual disability, or mineral deficiency.</p><p><strong>Case presentation: </strong>We present a case of a patient with severe abdominal pain and a small bowel obstruction due to a paper bezoar (xylobezoar). Evaluation led to a diagnosis of xylophagia in the context of chronic symptomatic microcytic anemia and not due to an underlying primary psychiatric etiology. Anemia manifested in variable sensory experiences for the patient, including changes in the perception of smell, touch, and taste. The patient's specific preference for books of a particular era could be influenced by changes in printing practices. Additionally, familial practices delayed recognition of xylophagia as an odd, learned behavior. Once recognized as untreated anemia and confirmed to have iron and zinc deficiency, oral supplementation was initiated throughout hospitalization with surgical surveillance following discharge.</p><p><strong>Conclusion: </strong>The presented patient developed a xylobezoar in the setting of severe symptomatic anemia precipitated by a combination of regular menses and a history of Roux-en-Y gastric bypass, leading to both monthly blood loss and chronic iron and zinc malabsorption, respectively. Although pica and xylophagia are frequently linked to primary psychiatric disorder or intellectual disability, and sometimes familial predisposition, the underlying trigger for these behaviors may, in some cases, stem from an unrecognized or untreated medical condition rather than a primary psychiatric disorder.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1646188"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Mass social media-induced illness presenting with Tourette-like behavior.","authors":"Carolin Fremer, Natalia Szejko, Anna Pisarenko, Martina Haas, Luise Laudenbach, Claudia Wegener, Kirsten R Müller-Vahl","doi":"10.3389/fpsyt.2025.1687567","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1687567","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2022.963769.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1687567"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of child abuse and prolonged grief in adulthood - results from a population-based study.","authors":"Anna-Maria Rummel, Hannah Comtesse, Rita Rosner, Cedric Sachser, Jörg M Fegert, Bettina K Doering, Anna Vogel","doi":"10.3389/fpsyt.2025.1606183","DOIUrl":"10.3389/fpsyt.2025.1606183","url":null,"abstract":"<p><strong>Background: </strong>In recent years, various risk factors for the development of prolonged grief disorder (PGD) have been discussed. While it is well established that child abuse increases the risk of various mental disorders in later life, the relationship between child abuse, including its subtypes, and PGD is barely examined.</p><p><strong>Objective: </strong>The aim of this study was to assess the impact of child abuse and distinct abuse patterns on PGD symptoms in a population-based German sample.</p><p><strong>Methods: </strong>We used self-reported data from 911 individuals (54.3 ± 17.9 years, 59.2% women) who had experienced the loss of a loved one. Participants completed demographic, loss-related and child abuse-related questions. To investigate PGD symptoms we utilized the Prolonged Grief Disorder-13+9 (PG13+9). The Childhood Trauma Questionnaire (CTQ) was employed to assess both overall child abuse severity as well as child abuse subtypes: child emotional abuse, child physical abuse, child sexual abuse. We used k-means cluster analysis to identify distinct child abuse patterns. Two hierarchical regression analyses were conducted to examine the associations between PGD symptom severity and child abuse and the identified child abuse clusters.</p><p><strong>Results: </strong>The prevalence rate for experiencing any child abuse was 13.5%. The occurrence of the child abuse subtypes was 7.9% for emotional abuse, 7.6% for physical abuse, and 5.9% for sexual abuse. <i>A priori</i>, we defined an \"extreme abuse\" cluster from the outliers and identified three clusters \"no/low abuse\", \"moderate abuse\" and \"high abuse\" in our sample through the cluster analysis. Overall child abuse severity (<i>ß</i>=.13, <i>p</i><0.001), \"high abuse\" cluster (<i>ß</i>=.12, <i>p</i>=0.001) and the <i>a priori</i> \"extreme abuse\" cluster (<i>ß</i>=.07, <i>p</i>=0.040) were significant predictors of PGD symptoms.</p><p><strong>Conclusion: </strong>Our study indicates that child abuse impacts PGD symptoms. Possible hypotheses for this connection and their implications are discussed.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1606183"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotope-specific lithium bioactivity - physiological reality or laboratory oddity?","authors":"Cecile Delacour, Marshall Deline, Hildigunnur Hermannsdóttir, Zhaoqi Lu, Michel J P Gingras, Tobias Fromme","doi":"10.3389/fpsyt.2025.1664092","DOIUrl":"10.3389/fpsyt.2025.1664092","url":null,"abstract":"<p><p>The efficacy of lithium in treating bipolar disorder is well established, yet its precise molecular mechanisms remain elusive. A frequently overlooked dimension is the natural occurrence of two stable lithium isotopes (⁶Li and ⁷Li), which differ significantly in mass and nuclear spin and may therefore exhibit distinct bioactivity within living systems. Evidence from multiple rodent studies demonstrates isotope-dependent behaviour effects, suggesting translational relevance. Mechanistic exploration indicates that while classical lithium targets such as glycogen synthase kinase-3 beta and myo-inositol monophosphatase do not discriminate between isotopes, differential effects emerge at the level of mitochondrial calcium handling. Lithium isotopes modulate the calcium storage capacity of brain mitochondria, potentially via incorporation into amorphous calcium phosphate structures, which form crucial calcium depots within the mitochondrial matrix. The physical basis may involve isotope-dependent differences in mass or nuclear spin, possibly interacting with amorphous calcium phosphate or influencing radical pair formation, situating these findings within the rapidly expanding field of quantum biology. However, critical experimental gaps remain, particularly regarding whether isotope-specific mitochondrial effects translate to changes in neuronal signaling. Addressing these gaps through targeted physiological and clinical studies could clarify whether lithium isotope bioactivity is a laboratory curiosity or a tractable quantum biological phenomenon with therapeutic potential.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1664092"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of self-transcendence status and influencing factors in gastric cancer patients undergoing chemotherapy: a random forest model-based study.","authors":"Qin Wang, Guoqin Ren, Li Sun, Xumiao Zhang, Hongxia Hua, Yanglin Gu","doi":"10.3389/fpsyt.2025.1641453","DOIUrl":"10.3389/fpsyt.2025.1641453","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the current status and determinants of self-transcendence in gastric cancer patients undergoing chemotherapy and to establish a foundation for clinical development of interventions.</p><p><strong>Methods: </strong>A convenience sampling method was employed to select 507 gastric cancer patients undergoing chemotherapy in the oncology department of a tertiary hospital in Wuxi City, Jiangsu Province, from October 2024 to May 2025. Questionnaire surveys were carried out using the Demographic Characteristics Questionnaire, Brief Illness Perception Questionnaire, Herth Hope Index, Medical Coping Modes Questionnaire, and Self-Transcendence Scale. A random forest model and LASSO regression were used to rank the importance of influencing factors and select characteristic variables. Then, multiple linear regression analyses were combined to determine the main influencing factors.</p><p><strong>Results: </strong>The mean value of the self-transcendence score of gastric cancer patients undergoing chemotherapy was 44.08. The random forest model results demonstrated that prioritizing the key variables was most effective at a lambda (λ) value of 0.048, which aligned with five influencing factors. The independent variables with the top five importance rankings were the degree of confrontation, the self-rated health status, the degree of resignation, the level of hope, and the degree of avoidance. Multiple linear regression analysis revealed that self-transcendence in gastric cancer patients undergoing chemotherapy was predominantly affected by confrontation degree, self-rated health status, resignation degree, hope level, and avoidance degree (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The self-transcendence level of gastric cancer patients undergoing chemotherapy is observed to be in the moderate to low spectrum. Healthcare personnel can improve this level by targeting the relevant influencing factors, thereby enhancing quality of life during chemotherapy.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1641453"},"PeriodicalIF":3.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: From learned helplessness to learned controllability: cognitive and neurobiological aspects involved in the development of trauma or resilience.","authors":"Gustavo E Tafet","doi":"10.3389/fpsyt.2025.1692598","DOIUrl":"10.3389/fpsyt.2025.1692598","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1692598"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recruiting marijuana-exposed maternal-infant dyads for longitudinal study: a feasibility assessment.","authors":"Nayana A Sojin, Rhea Parimoo, Lauren A Agliano, Amie J Goodin, Deepthi S Varma, Bruce A Goldberger, Ibrahim Tuna, Reem Abu-Rustum, Kay Roussos-Ross","doi":"10.3389/fpsyt.2025.1637076","DOIUrl":"10.3389/fpsyt.2025.1637076","url":null,"abstract":"<p><strong>Introduction: </strong><i>In-utero</i> marijuana exposures are correlated with adverse neurodevelopmental outcomes in exposed neonates. As rates of marijuana use in pregnancy and postpartum reportedly increase, it is crucial to obtain conclusive, pregnancy-specific safety data through well-designed clinical research studies. The objective of this study is to assess feasibility of recruitment and retention of marijuana-exposed pregnant women for longitudinal study involving biospecimen and imaging collection.</p><p><strong>Methods: </strong>Participants self-reporting marijuana use in pregnancy and controls with no self-reported exposure were recruited from routine prenatal care in a large health-system. Consented participants completed imaging and biological specimen collections during pregnancy, at delivery, and postpartum. Proportions of collected samples/images at each data collection interval were calculated and compared for exposed versus unexposed.</p><p><strong>Results: </strong>30 participants were recruited over 20 months: 77% (n=23) self-reported as marijuana-exposed and 23% (n=7) reported as unexposed (control). 70% (n=21) of participants completed the study (n=14 marijuana-exposed; n=7 control), while 30% (n=9 marijuana-exposed; 0%, n=0 control) completed some study visits before becoming lost-to-follow-up (LTFU).</p><p><strong>Discussion: </strong>Preliminary findings suggest that it is feasible to recruit and retain pregnant women using marijuana for longitudinal study. Although marijuana-exposed participants were more likely than control participants to miss postpartum visits, become LTFU, and require rescheduling of study visits, marijuana-exposed participants were still found to complete 68% of study visits.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1637076"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication adherence in obsessive-compulsive disorders and evaluation of effective adherence support strategies.","authors":"Sophia Pöppel, Sina Ziegler, Klara Bednasch, Elisabeth Kohls, Christine Rummel-Kluge","doi":"10.3389/fpsyt.2025.1642622","DOIUrl":"10.3389/fpsyt.2025.1642622","url":null,"abstract":"<p><strong>Introduction: </strong>Medication adherence is a critical component in the treatment of psychiatric conditions such as obsessive-compulsive disorder (OCD). Poor adherence is associated with an increased risk of relapse, subsequent (re)hospitalization, and prolonged remission, which ultimately leads to a worse prognosis. This study aimed to assess medication adherence over time in individuals with OCD, identify predictors, and gather patient-reported strategies to maintain adherence.</p><p><strong>Methods: </strong>This study surveyed <i>N</i> = 100 patients recruited in the outpatient department of a university medical center in Leipzig, Germany, between January 2019 and January 2020 (Ethics Committee approval number: 332/18-ek; date of approval: 25 September 2018). Medication adherence was assessed using indirect (i.e., Drug Attitude Inventory, Medication Adherence Rating Scale) and direct methods (i.e., therapeutic drug monitoring via serum drug concentration). Additionally, the participants reported strategies they found helpful for maintaining adherence.</p><p><strong>Results: </strong>The participants exhibited mild impairments in various aspects of functioning despite relatively functional daily lives. Most were prescribed selective serotonin reuptake inhibitors (SSRIs), with a subset receiving combination therapy for treatment-resistant cases. Medication adherence was classified into three categories: 24.4% of the participants were good adherers, 62.2% were partially adherent, and 13.4% were non-adherent. Therapeutic drug monitoring (TDM) indicated that 84.6% of the participants had drug levels within the therapeutic range. Concerns about side effects and doubts regarding the efficacy of the medication were commonly reported, which might contribute to suboptimal adherence. However, no significant associations were found between adherence and sociodemographic or clinical variables, which suggested the need for a more comprehensive approach considering psychosocial factors. Behavioral strategies for maintaining adherence (e.g., incorporating medication into daily routines) were preferred and rated as helpful, while invasive monitoring methods were largely rejected.</p><p><strong>Discussion: </strong>This study highlights the importance of a multifaceted approach to improving medication adherence in individuals with OCD. While SSRIs remain the primary pharmacological treatment, a significant portion of patients still struggle with adherence. Although TDM provides valuable insights into drug levels, it may not fully capture adherence behavior due to metabolic and behavioral variability. Addressing patient concerns about side effects and medication efficacy, alongside implementing behavioral strategies that integrate medication into daily routines, may improve adherence and enhance treatment outcomes.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1642622"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Research hotspots and frontiers of acceptance and commitment therapy for mental disorders: a bibliometric analysis.","authors":"Xueqing Wang, Mingqi Wang, Huafang Li","doi":"10.3389/fpsyt.2025.1659792","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1659792","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2025.1440755.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1659792"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}