Frontiers in Psychiatry最新文献

{"title":"Corrigendum: Conceptual competence in medicine: promoting psychosomatic awareness in clinics, research and education.","authors":"Dirk von Boetticher","doi":"10.3389/fpsyt.2025.1575091","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1575091","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2025.1500638.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1575091"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture therapies for post-stroke depression: the evidence mapping of clinical studies.","authors":"Zhuo Zhou, Chao Ke, Wenying Shi, Yang Cao, Zhengrong Xie, Xi Zhao, Zeli Hu, Yilin Zhou, Wei Zhang","doi":"10.3389/fpsyt.2025.1523050","DOIUrl":"10.3389/fpsyt.2025.1523050","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture-related therapies have been widely used in previous studies, of which the ones for post-stroke depression (PSD) is on the rise. This study aims to map the current clinical research landscape and identifies gaps to provide direction and information for future research.</p><p><strong>Methods: </strong>Eight databases were searched on acupuncture-related therapies for PSD from inception until April 2024. The publication profile, study objects, intervention categories, outcome indexes were graphically displayed. The Cochrane Collaboration's bias risk assessment tool was used to independently assess randomized controlled trials (RCTs) quality, and the methodological quality of the systematic reviews were assessed using the AMSTAR 2 checklist.</p><p><strong>Results: </strong>A total of 666 clinical studies and 34 systematic reviews/Meta-analyses (SRs/MAs) were included in the evidence map, and the earliest report was found in 1996. The studies were mostly from China, and 89% of the evidence of the studies were of the RCTs. Body acupuncture and electroacupuncture were the most commonly used interventions. Most of the intervention durations were 2-4 weeks, and few patients were followed up. The main outcome was measured by effective rate and the Hamilton Rating Scale for Depression (HAMD). Evidences from clinical studies and SRs/MAs suggest that acupuncture has significant advantages in improving PSD, but the overall quality of studies could be improved.</p><p><strong>Conclusions: </strong>Acupuncture-related therapies have great prospect in relieving the clinical symptoms of PSD, although there are some design and methodological defects in the current studies. In the future, the quality of research needs to be improved for the robustness of clinical evidence.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1523050"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The recovery experiences of individuals with schizophrenia in northwestern Ethiopia.","authors":"Selamawit Kassa, Setareh Ghahari, Rosemary Lysaght, Carrie Anne Marshall, Missaye Mulatie Mengstie","doi":"10.3389/fpsyt.2025.1470656","DOIUrl":"10.3389/fpsyt.2025.1470656","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia recovery is perceived as a one-time symptom remission. However, it is a process that may continue throughout an individual's life. Understanding the recovery experience of a person with schizophrenia is an essential component of filling the mental health service gap and enhancing a smooth recovery process. The objective of this study was to explore the recovery experience of individuals with schizophrenia in a developing country.</p><p><strong>Methods: </strong>To understand these experiences, we used qualitative research. Seventeen participants were purposefully selected from two hospitals in Northwestern Ethiopia. Semi-structured, in-depth interviews were conducted, and data was analyzed using Interpretive Phenomenological Analysis.</p><p><strong>Results: </strong>Finally, four themes were generated: the first theme was the meaning of recovery. The definition of schizophrenia recovery differs from person to person based on their personal experience. For some, recovery means becoming free of symptoms, and for others, helping their family and being economically independent. The second theme was obstacles to recovery. The obstacles included limited understanding from family members, decreased social engagement, financial dependency, hopelessness, and suicidal thoughts. The third theme was support by family and employers. Participants received support from people around them. Family members mainly provided support by feeding, clothing, giving medications, and taking them to spiritual places. The fourth theme was coping strategies used to manage illness, which included medication adherence, visiting holy water sites and traditional healers, and listening to spiritual lessons.</p><p><strong>Conclusion: </strong>Generally, participants focused on recovery from illness by emphasizing being free from symptoms to start their regular life. However, some of them were interested in pursuing education and engaging in work. The meaning given for recovery determines the kind of recovery process individuals have. Accepting that schizophrenia is a lifelong disorder, following medical treatments, finding ways to be active in their social life, and engaging in day-to-day activities are crucial components of recovery. In addition, since support from family members is vital, creating awareness creation programs for family members and the community is essential. Finally, psychosocial support and vocational training are important strategies that need to be considered to support recovery.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1470656"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenting style patterns and their longitudinal impact on mental health in abused and nonabused adolescents.","authors":"Wassilis Kassis, Aikaterini Vasiou, Dilan Aksoy, Céline Anne Favre, Sibylle Talmon-Gros Artz, Doug Magnusson","doi":"10.3389/fpsyt.2025.1548549","DOIUrl":"10.3389/fpsyt.2025.1548549","url":null,"abstract":"<p><strong>Background: </strong>While the impact of parenting styles on adolescents' mental health is well documented, no study has used latent person-oriented methods to analyze the effects of parenting style trajectories, experienced by physically abused and nonabused adolescents from early to middle adolescence, on mental health outcomes.</p><p><strong>Method: </strong>In this longitudinal study, we used latent transition analysis (LTA) to detect parenting patterns and their trajectories among 1,709 adolescents from 44 high schools in Switzerland across three data waves (2021-2023) by applying a multigroup comparison between physically nonabused and abused adolescents. Using multinomial regression, we tested the effects of the detected parenting patterns on adolescents' mental health.</p><p><strong>Results: </strong>Along with the two known patterns, termed \"supportive\" and \"negative\" parenting, two new parenting patterns which we termed \"absent\" (low levels on all tested parenting styles) and \"ambiguous\" (middle to high levels on all tested parenting styles) emerged as playing a key role in the perceptions of adolescents with and without parental abuse experience longitudinally. These four patterns developed in diverse ways: Supportive parenting decreased for abused adolescents over time but remained stable for the nonabused adolescents. The absent parenting level was stable over time among abused adolescents when compared to the outcomes experienced by adolescents subjected to the negative parenting pattern. Furthermore, we found a remarkable decline in the number of nonabused adolescents in the absence pattern from Wave 1 to Wave 3. Further, we also found that abused adolescents reported more negative parenting than nonabused adolescents. Additionally, we found that supportive parenting was beneficial for adolescents' mental health whereas negative, ambiguous, and absent parenting all had detrimental effects.</p><p><strong>Conclusions: </strong>These findings highlight the beneficial association of supportive parenting and the detrimental effects of negative, ambiguous, and absent parenting. This also suggests that we must consider a more complex approach that involves examining a blend of different parenting styles when analyzing adolescent mental health.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1548549"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of attention deficit hyperactivity disorder and incidence rate forecast in China from 1990 to 2021.","authors":"Ningyu Li, Junqiang Zhao, Fujun Zhou","doi":"10.3389/fpsyt.2025.1532156","DOIUrl":"10.3389/fpsyt.2025.1532156","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the temporal trends and future projections of attention-deficit/hyperactivity disorder (ADHD) burden among children and adolescents in China from 1990 to 2021, and to identify age-, period-, and cohort-specific drivers of disease progression.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease Study 2021, we conducted joinpoint regression to detect trend transitions in ADHD incidence and age-standardized rates. Age-period-cohort (APC) modeling was applied to disentangle the effects of age, calendar period, and birth cohort on disease burden. Projections up to 2046 were generated using demographic forecasts from the GBD 2017 population database.</p><p><strong>Results: </strong>Crude ADHD prevalence declined by 21.17% (2168.055 to 1723.307 per 100,000), yet age-standardized prevalence increased by 9.86% (AAPC=0.272%, 95%CI:0.173-0.372, P<0.001). Similarly, age-standardized DALY rates rose by 10.15% (AAPC=0.262%, 95%CI:0.160-0.364,P<0.001), with females showing faster growth than males (AAPC for DALY: 0.294% vs. 0.229%,P<0.001). Adolescents aged 10-14 years bore the highest burden, with prevalence (5,727.28/100,000) and DALY rates (70.55/100,000) twice the global average. APC projections indicated a peak incidence in 2029 for this age group, linked to cohort effects from China's \"Double Reduction\" education policy and rising digital exposure.</p><p><strong>Conclusion: </strong>China faces a rising ADHD burden driven by sociodemographic transitions and diagnostic advancements. Targeted interventions-particularly for adolescents and females-are urgently needed. Strengthening school-based screening, integrating AI-driven diagnostic tools, and prioritizing mental health in national policies could mitigate long-term impacts. These findings underscore the necessity of dynamic surveillance systems to address ADHD's evolving epidemiology in transitioning societies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1532156"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure and response prevention versus risperidone for the treatment of tic disorders: a randomized controlled trial.","authors":"Jolande M T M van de Griendt, Danielle C Cath, Agnes A A C M Wertenbroek, Cara W J Verdellen, Judith J G Rath, Irene G Klugkist, Sebastiaan F T M de Bruijn, Marc J P M Verbraak","doi":"10.3389/fpsyt.2024.1360895","DOIUrl":"10.3389/fpsyt.2024.1360895","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to directly compare behavior therapy (exposure & response prevention; ERP) with pharmacotherapy (risperidone) with respect to tic severity and quality of life in patients with Tourette's disorder or tic disorders.</p><p><strong>Method: </strong>A total of 30 participants were randomly assigned to either ERP (12 weekly 1-hour sessions) or risperidone (flexible dosage of 1-6 mg) with follow-up at 3 and 9 months after end of treatment. Outcome measures included tic severity as measured by the Yale Global Tic Severity Scale, quality of life and side effects. Predefined informative hypotheses were evaluated using Bayes factors (BF), a Bayesian alternative for null hypothesis testing with p-values, that provides a more reliable and powerful method in the case of small samples. A BF larger than one indicates support for the informative hypothesis and the larger the BF, the stronger the support, with a BF between 3 and 10 being considered to provide moderate evidence.</p><p><strong>Results: </strong>Both ERP and Risperidone were found to be effective with respect to tic severity at end of treatment (BF 5.35). At 9 months follow-up, results remained stable (BF 4.59), with an advantage of ERP over Risperidone at 3 months follow-up (BF 3.92). With respect to quality of life, an effect was found for ERP (BF 3.70 at 3 months follow up; BF 3.08 at 9 months follow-up). Dropout rates were higher in the medication condition, mainly due to significantly more side effects halfway during treatment, fading out towards end of treatment.</p><p><strong>Discussion: </strong>Behavior therapy and medication are equally viable options in the treatment of tic disorders, with a slight preference for ERP based on follow-up results on tic severity and quality of life, and side effects.</p><p><strong>Clinical trial registration: </strong>https://onderzoekmetmensen.nl/nl/node/23410/pdf, identifier NL-OMON23410.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1360895"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From work to community: how social participation and retirement can benefit older adults' depression.","authors":"Yiyu Zhan, He Ning, Yuchen Zhang","doi":"10.3389/fpsyt.2025.1522222","DOIUrl":"10.3389/fpsyt.2025.1522222","url":null,"abstract":"<p><strong>Objectives: </strong>The retirement phase and social participation influence the depressive symptoms of older individuals. Nonetheless, the fundamental mechanisms connecting these factors remain unclear. This analysis examined mediating social participation in the relationship between older adults' retirement and depressive symptoms.</p><p><strong>Methods: </strong>The study analyzed 9,103 Chinese individuals aged 60 and above utilizing the 2020 China Health and Retirement Longitudinal Study (CHARLS). Researchers evaluated participants' depression utilizing the Center for Studies in Epidemiology Depression Scale (CESD-10). The hierarchical multiple regression models were utilized to evaluate the link between retirement and depression, through cross-sectional analyses, along with the possible influence of social participation on this relationship.</p><p><strong>Results: </strong>Retirement significantly reduce older individuals' depression and improves their mental health state. In addition, social participation as a mediating variable further enhanced the beneficial impacts of retirement on the mental health state.</p><p><strong>Conclusion: </strong>This research discovered that retirement indirectly influences older adults' depression, with social participation playing a significant impact. Thus, it establishes a foundation for mitigating psychological issues in this demographic. Engaging in or sustaining social activities during later life enhances the mental well-being of older individuals. Promoting social participation among older individuals is a viable approach to reduce depression and facilitating successful aging initiatives in this demographic.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1522222"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a peer advisory board in a mental health ethics research group - challenges, benefits, facilitators and lessons learned.","authors":"Mirjam Faissner, Esther Braun, Simone Agnes Efkemann, Anne-Sophie Gaillard, Iris Haferkemper, Christin Hempeler, Imke Heuer, Ursula Lux, Sarah Potthoff, Matthé Scholten, Sylvia Spiegel, Christina Stefaniak, Madeleine Thesing, Anna Werning, Jakov Gather","doi":"10.3389/fpsyt.2025.1516996","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1516996","url":null,"abstract":"<p><p>While participatory methods are regarded as beneficial in many areas of psychiatric research, they are still rarely considered in the field of mental health ethics. Yet, there are several epistemic and ethical reasons why participatory research is particularly important in this field, such as the high relevance of experiential knowledge for ethical analyses. In this article, we report our experiences with establishing a peer advisory board for an existing mental health ethics research group. We demonstrate how a peer advisory board can provide low-threshold opportunities for various forms of participation, which can occur simultaneously within one research project. We first describe how we established the peer advisory board and explain its structure. We then give an overview of several research projects that involved various forms of participation by members of the peer advisory board, such as the development of a template for a psychiatric advance directive, the co-writing of articles, and the organization of scientific events. We discuss the challenges, benefits, and facilitators of a peer advisory board from our different vantage points as service users, relatives, clinicians, and researchers. Challenges included organizational barriers such as time constraints and rigid bureaucratic structures within academic institutions and funding bodies as well as the persistence of power imbalances between members of the research group and the peer advisory board. Benefits included the opportunity for personal development and capacity building among both peer advisory board members and members of the research group, and the multiplication of research results among the relevant communities. Based on a reflection on our own experiences, we argue that participatory research in mental health ethics is not only ethically and epistemically desirable but also practically feasible. We close by formulating several lessons learned from our experiences.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1516996"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulnerabilities in migrant live-in care arrangements for people with dementia: a comparative analysis of experts' insights from Germany and Israel.","authors":"Natalie Ulitsa, Anna Eva Nebowsky, Liat Ayalon, Mark Schweda, Milena von Kutzleben","doi":"10.3389/fpsyt.2025.1485270","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1485270","url":null,"abstract":"<p><strong>Background: </strong>The global rise in dementia among older adults has led to an increased reliance on migrant live-in caregivers, particularly in countries like Germany and Israel. This triadic care arrangement, involving persons with dementia, their families, and migrant live-in caregivers, presents unique challenges and vulnerabilities. These vulnerabilities, deeply intertwined with ethical concerns, are shaped by the socio-cultural and legal contexts of each country. This study aims to explore these vulnerabilities through a comparative analysis of expert experiences in Germany and Israel.</p><p><strong>Method: </strong>A qualitative study was conducted using semi-structured interviews with 24 experts-14 from Israel and 10 from Germany-who have extensive experience in dementia care or migrant caregiving. The interviews were analyzed through qualitative content analysis, focusing on six dimensions of vulnerability: physical, psychological, relational/interpersonal, moral, socio-cultural-political-economic, and existential/spiritual.</p><p><strong>Results: </strong>The analysis revealed that all parties in the care triad-persons with dementia, migrant live-in caregivers, and family members-experience distinct yet interconnected vulnerabilities. These vulnerabilities are deeply entangled, manifesting in complex, interrelated ways both within each party and between the different parties in this triadic arrangement. The study also highlighted both similarities and differences in expert experiences between Germany and Israel, reflecting the unique socio-cultural and legal contexts of each country.</p><p><strong>Conclusions: </strong>The study underscores the multifaceted and interdependent nature of vulnerabilities in migrant live-in care arrangements for people with dementia. By comparing expert insights from Israel and Germany, the research highlights the critical role of national policies and cultural contexts in shaping these vulnerabilities, leading to distinct experiences and challenges in each country. Addressing these vulnerabilities is essential for improving the quality of care and the well-being of all parties involved in the triadic care arrangement.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1485270"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interplay of mental health knowledge, stigma, and social distance among clinical nurses: a study in Liaoning, China.","authors":"Weiwei Wang, Junhong Xia, Wei Chen, Junhua Ye, Kun Xie, Zhuona Zhang, Siti Mardhiana Binti Mohamad, Ahmad Naqib Shuid","doi":"10.3389/fpsyt.2025.1478690","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1478690","url":null,"abstract":"<p><strong>Background: </strong>Stigma related to mental health conditions has a negative impact on both the nursing staff and their patients. Most of the current research on stigma explores the impact of single factors on stigma and does not explore the relationship between knowledge, social distance and stigma among clinical nurses.</p><p><strong>Methods: </strong>A convenience sampling method was used to conduct a questionnaire survey among 628 nurses from five hospitals in Liaoning Province in March 2021 and June 2021 using a combination of online and offline methods. To study the negative attitudes toward patients with mental illness among clinical nurses and to analyze the relationship between mental ill health stigma, social distancing, and mental health knowledge among nurses. The questionnaire includes Sociodemographic data, Scale for Assessing the Stigma of Mental Illness in Nursing (score range: 20~100, the higher the score, the less stigma attached to mental ill health), Mental Illness Social Distance Scale (score range: 6~30, the higher the score, the greater the social distance) and Mental Health and Mental Health Knowledge Questionnaire (score range: 0~25, the higher the score, the higher the knowledge level).</p><p><strong>Results: </strong>The nurses' mental ill health stigma score was 58.96 ± 9.38 points, the mean scores of psychiatric and general nurses were 58.86 ± 9.33 and 59.41 ± 9.58 points, respectively. Willingness to become a psychiatric nurse is a factor influencing the stigma of mental illness. The stigma of mental ill health, social distance and mental health knowledge of nurses are positively correlated (P<0.01). The mediation analysis demonstrated that mental health stigma significantly mediated the relationship between mental health knowledge and social distance (a= 0.599, P<0.001; b= -0.194, P<0.001). After accounting for stigma, the direct effect of mental health knowledge on social distance was no longer significant (c'=-0.007, P=0.078), highlighting the central role of stigma in this relationship.</p><p><strong>Conclusions: </strong>Nurses mental ill health stigma is moderate and is the main mediating effect between mental health knowledge and social distancing. The pivotal role of mental health knowledge in shaping nurses' attitudes and behaviors pertaining to social distancing in the context of mental illness. By combating stigma and enhancing mental health literacy among healthcare practitioners, we can foster environments that promote inclusive and compassionate care practices, thereby ameliorating patient outcomes and redressing disparities in mental health treatment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1478690"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}