Frontiers in Psychiatry最新文献

{"title":"Depression and musculoskeletal diseases: a framework of systemic mechanisms.","authors":"Xiaoyun Yang, Yang Zhao, Wang Gao, Jinkun Liu, Tao Wang, Jingyu Wang, Feixue Wang","doi":"10.3389/fpsyt.2026.1977499","DOIUrl":"10.3389/fpsyt.2026.1977499","url":null,"abstract":"<p><p>Musculoskeletal disorders (MSDs) encompass a broad spectrum of conditions affecting bones, joints, and muscles, characterized by significant pain and functional impairment, and have become a major global health burden. In recent years, accumulating evidence has revealed complex bidirectional interactions between depression and musculoskeletal health. This review focuses on depression and delineates how it may influence the pathological progression of MSDs through multiple pathways, including neuroendocrine dysregulation, aberrant inflammatory responses, epigenetic modifications, dysregulated extracellular vesicle-mediated communication, abnormal neural activity along the brain-joint axis, and gut microbiota ecological imbalance. Collectively, depression is associated with an increased risk of MSDs and engages intricate interactions across multiple biological systems. Our study underscores that musculoskeletal disorders are by no means confined to isolated joints or local tissues, but rather represent complex diseases with prominent systemic features. Integrated management strategies combining psychosocial interventions, appropriate physical exercise, and dietary modification hold promise as potential multitargeted approaches for the comprehensive treatment of MSDs.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1977499"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).","authors":"Hikaru Hori, Hiroyoshi Takeuchi, Shinji Yoneda, Tadashi Shin, Yusuke Shimada, Minami Umeyama, Masato Ueno, Yoshiteru Takekita","doi":"10.3389/fpsyt.2026.1904119","DOIUrl":"10.3389/fpsyt.2026.1904119","url":null,"abstract":"<p><strong>Background: </strong>Constipation, a common gastrointestinal disorder, impairs quality of life (QOL) and work productivity. This study evaluated constipation severity in individuals with schizophrenia, depression, and the general population and examined its impact on QOL and work productivity, as well as patient education and preferences regarding constipation management.</p><p><strong>Methods: </strong>A cross-sectional web-based survey was conducted. Assessments included the Constipation Scoring System (CSS), Short Form-8, Work Productivity and Activity Impairment questionnaire, and questions regarding prior explanations of constipation risk and changes in bowel habits. CSS scores were stratified as ≤5 and ≥6.</p><p><strong>Results: </strong>In total, 800 participants completed the survey (schizophrenia, n=200; depression, n=200; general population, n=400). CSS scores were higher in the schizophrenia and depression groups than in the general population. Multivariable regression analysis showed that schizophrenia and depression were associated with constipation severity. In the schizophrenia and depression groups, current symptom status and anxiolytic use remained independently associated with CSS scores. Across all groups, participants with CSS scores ≥6 had lower Mental Component Summary scores and higher levels of presenteeism, overall work productivity loss, and activity impairment than those with CSS scores ≤5. Approximately 30% of all participants in each of the schizophrenia and depression groups reported receiving prior explanations regarding psychotropic-related constipation risk, while 40% reported bowel-habit changes after psychotropic drug initiation.</p><p><strong>Conclusions: </strong>Constipation severity was higher in participants with schizophrenia and depression than in the general population; greater severity was associated with lower QOL and greater work productivity impairment. Routine screening, education on constipation, and patient-centered constipation management may be useful clinical approaches for addressing constipation and its associated burden in these populations.</p><p><strong>Trial registration: </strong>This study was registered with the University Hospital Medical Information Network (UMIN000058981).</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1904119"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding non-psychiatric nurses' experiences of caring for patients with mental-physical comorbidity: a descriptive phenomenological study.","authors":"Jingxuan Zhang, Yaping Feng, Hong Luo, Bowen Xue","doi":"10.3389/fpsyt.2026.1737278","DOIUrl":"10.3389/fpsyt.2026.1737278","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore non-psychiatric nurses' experiences of caring for patients with mental-physical comorbidity, the challenges they encounter, and the factors shaping these experiences.</p><p><strong>Design: </strong>A descriptive phenomenological design was used, with data collected through face-to-face, semi-structured interviews.</p><p><strong>Methods: </strong>Between March and April 2025, 20 registered nurses from non-psychiatric departments of a tertiary hospital in Hangzhou, China, participated in in-depth interviews. Data were analysed using Colaizzi's seven-step phenomenological method, with NVivo 12.0 used to support data management.</p><p><strong>Results: </strong>Nurses described difficulty recognising psychiatric symptoms, balancing mental and physical care, managing safety concerns, communicating with patients, and providing care during night shifts. They also reported limited intervention options and reliance on experiential knowledge. Factors shaping these experiences included stigma-related concealment of mental illness, difficulty engaging some patients in care, limited mental health knowledge and communication skills, lack of standardised guidance, weak collaboration with psychiatric services, and workload and time pressure.</p><p><strong>Conclusion: </strong>Non-psychiatric nurses described caring for patients with mental-physical comorbidity as challenging when psychiatric symptoms were difficult to recognise, mental and physical priorities competed, and access to guidance or psychiatric support was limited. Training in mental health assessment and communication, practical care protocols, and accessible psychiatric consultation may help address these difficulties.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1737278"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caution before canonisation: a clinical and implementation science perspective on psychedelics.","authors":"Andreas Paris, Foteini Thoma, Aikaterini Velentza, Panagiota Pavlopoulou, Giorgos Metaxas","doi":"10.3389/fpsyt.2026.1922928","DOIUrl":"10.3389/fpsyt.2026.1922928","url":null,"abstract":"<p><p>Recent advances in psychedelic research have renewed interest in the potential therapeutic role of psychedelic-assisted interventions in psychiatry. Early clinical trials suggest that compounds such as psilocybin and MDMA, administered within structured therapeutic frameworks, may produce rapid symptom improvements for conditions including depression, post-traumatic stress disorder, and substance use disorders. While these findings are scientifically promising, the current evidence base remains characterized by methodological and translational limitations. Many studies involve small samples, short follow-up periods, functional unblinding, and heterogeneous safety reporting, which complicate causal interpretation and generalizability. In the present paper, we examine psychedelic therapies through clinical, methodological, ethical, and implementation science lenses. We argue that current trials primarily demonstrate proof-of-concept efficacy under controlled conditions rather than readiness for large-scale clinical adoption. Responsible translation therefore requires stronger evidence regarding durability, safety monitoring, comparative effectiveness, and real-world implementation. Psychedelic therapies represent an important emerging research direction, but continued rigorous evaluation and improved implementation of established evidence-based interventions remain central to addressing mental disorders.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1922928"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG signature in psychiatrist's subjective experience: a pilot study.","authors":"Giovanni Videtta, Elena Bondi, Chiara Colli, Gabriele Enrico, Luca Sperti, Mauro Pallagrosi, Laura Fonzi, Ylenia Barone, Giandomenico Schiena, Eleonora Maggioni, Angelo Picardi, Paolo Brambilla","doi":"10.3389/fpsyt.2026.1933800","DOIUrl":"10.3389/fpsyt.2026.1933800","url":null,"abstract":"<p><strong>Introduction: </strong>The Assessment of Clinician's Subjective Experience (ACSE) is a self-report questionnaire developed to evaluate clinicians' subjective experiences during patient interactions. While its psychometric properties and clinical validity have been supported, its neurobiological correlates have not yet been investigated.</p><p><strong>Methods: </strong>In this pilot study, two clinicians and ten patients participated in a three-phase protocol comprising: (1) a first clinical interview, (2) ACSE administration, and (3) listening to the audio recording of the first clinical interview. EEG activity was recorded from clinicians during both the first clinical interview and questionnaire administration. Neural data were analyzed in terms of relative power spectral density, node strength, and global efficiency computed from imaginary coherence.</p><p><strong>Results: </strong>Clinicians were psychiatrists, one male and one female. Seven patients were diagnosed with mixed anxiety and depressive disorder, and three with unspecified anxiety disorders. ACSE scores were highest for the Difficulty in attunement and Engagement dimensions, consistent with previous literature. EEG findings revealed dimension-specific and topographically distinct oscillatory patterns for only two ACSE dimensions: Difficulty in Attunement and Engagement. More limited evidence emerged for Disconfirmation. Functional connectivity analyses indicated different network profiles, characterized by differences in global efficiency patterns. Correlational analyses further identified significant associations between ACSE dimensions and EEG-derived features.</p><p><strong>Discussion: </strong>These preliminary findings provide initial evidence that clinicians' subjective experiences during clinical encounters could be associated with measurable neural signatures, offering a novel perspective on the neurobiological basis of intersubjective processes in clinical settings.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1933800"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and internal validation of machine learning models for identifying suicidal behavior in inpatients with mood disorders.","authors":"Sixiang Liang, Qitong Jiang, Jinhe Zhang, Yannan Deng, Yuxuan Xu, Guangwei Zhao, Xinyu Liu, Yujie Xing, Hongye Yu, Chen Hu, Sha Sha","doi":"10.3389/fpsyt.2026.1950186","DOIUrl":"10.3389/fpsyt.2026.1950186","url":null,"abstract":"<p><strong>Background: </strong>Suicidal behavior (SB) is a major concern in mood disorders. Models developed from retrospective records are vulnerable to ambiguous targets, data leakage, and inappropriate handling of class imbalance. We developed and internally validated a model to identify the risk of suicidal behavior in patients with mood disorders upon admission.</p><p><strong>Methods: </strong>The dataset included 1, 099 inpatients with ICD-10 mood disorders admitted to Beijing Anding Hospital in 2022. Exclusion of 20 records with more than 20% row-level missingness and one record without an outcome left 1, 078 patients, including 126 with SB. Current SB comprised documented suicidal ideation, planning, or attempt within the three months before index admission, including the admission assessment. Previous SB and previous suicide attempt (SA) referred to events more than three months before admission. Elastic Net selected 14 predictors from 65 candidates in the development set. We compared 13 classifiers from six model families. All preprocessing and resampling were confined to training folds, and evaluation used only observed patients. Assessment included repeated fivefold cross-validation, probability calibration, bootstrap confidence intervals, precision-recall and decision-curve analyses, clinical baselines, and sensitivity analyses.</p><p><strong>Results: </strong>The analytic cohort comprised 952 SB-negative and 126 SB-positive patients (11.69%). The development set contained 864 patients (97 SB-positive), and the observed test set contained 214 patients (29 SB-positive). Calibrated linear discriminant analysis (LDA) provided the most consistent balance of discrimination and calibration. In repeated cross-validation, mean AUC was 0.721 ± 0.052, mean AUPRC was 0.268 ± 0.060, and mean Brier score was 0.095. In the observed test set, AUC was 0.704 (0.597-0.803), AUPRC was 0.283 (0.198-0.453), and Brier score was 0.111. At the training-derived threshold of 0.111, sensitivity was 0.552 and specificity was 0.659. The leading SHAP contributions were onset-polarity category, previous SA, age, and previous SB, but all attributions were associational.</p><p><strong>Conclusions: </strong>Model performance was acceptable. These internally validated findings are exploratory and require prospective assessment, standardized outcome measurement, and external validation before clinical use.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1950186"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced contagious yawning in psychiatric disorders: a systematic review of potential social-cognitive mechanisms.","authors":"Roni Boiangiu, Roni Peleg","doi":"10.3389/fpsyt.2026.1879203","DOIUrl":"10.3389/fpsyt.2026.1879203","url":null,"abstract":"<p><strong>Introduction: </strong>Contagious yawning has been proposed to reflect multiple aspects of social cognition, including empathy, emotional contagion, self-processing, Theory of Mind (ToM), and action observation mechanisms such as the human mirror neuron system (hMNS). However, its underlying mechanisms remain debated, with evidence suggesting additional roles for social attention, gaze allocation, social motivation, and neurobiological factors. This systematic review examined evidence for reduced contagious yawning in Autism Spectrum Disorder (ASD), schizophrenia-spectrum disorders, and psychopathic traits, and evaluated potential underlying mechanisms.</p><p><strong>Methods: </strong>PubMed, PsycINFO, and Scopus were systematically searched for clinical and mechanistic studies of contagious yawning in psychiatric and healthy populations. Studies were screened using predefined eligibility criteria, and risk of bias was assessed using design-specific Joanna Briggs Institute (JBI) critical appraisal tools. Twenty-three studies met the inclusion criteria.</p><p><strong>Results: </strong>Reduced contagious yawning was reported in ASD, psychopathic traits, and schizophrenia-spectrum disorders, although findings varied across conditions. In ASD, reduced contagious yawning was associated with social attention, gaze allocation, oxytocin-related processes, and broader social-cognitive differences. In psychopathic traits, evidence more consistently implicated affective-interpersonal traits and reduced emotional responsiveness. Evidence for schizophrenia-spectrum disorders was more limited, with proposed mechanisms including impairments in social cognition, ToM, negative symptoms, and possible medication effects. Neuroimaging and electrophysiological findings implicate brain systems involved in social cognition, self-processing, and action observation, although the specific role of the hMNS remains uncertain.</p><p><strong>Discussion: </strong>Reduced contagious yawning may reflect altered social-cognitive processing rather than empathy alone, with contributing mechanisms differing across psychiatric conditions. Interpretation is limited by small sample sizes, methodological heterogeneity, and variation in study design. Further well-powered studies are needed to clarify its neurobiological basis and clinical significance.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1879203"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Sensory processing in autism: mechanisms, impacts and interventions.","authors":"Antonio Narzisi, Temple Grandin, Maddalena Fabbri-Destro, Giulio Valagussa","doi":"10.3389/fpsyt.2026.1994957","DOIUrl":"10.3389/fpsyt.2026.1994957","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1994957"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Comparative efficacy of antidepressants for acute adolescent major depressive disorder: a source-verified systematic review and network meta-analysis.","authors":"Chan Gong, Wengao Zeng, Xiangzhi Xiao, Qing Liu, Yaoyue Luo","doi":"10.3389/fpsyt.2026.2010890","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.2010890","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2026.1881200.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"2010890"},"PeriodicalIF":3.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced serum levels of the pro-resolving lipid mediators resolvin D1 and lipoxin A4 in schizophrenia.","authors":"Muhammet Sancaktar, Ece Yildiz, Bahadir Demir, Gulcin Elboga, Feridun Bulbul, Kenan Ercan, Seyithan Taysi, Abdurrahman Altındag","doi":"10.3389/fpsyt.2026.1943920","DOIUrl":"10.3389/fpsyt.2026.1943920","url":null,"abstract":"<p><p>Schizophrenia is increasingly conceptualized as a disorder of chronic, unresolved neuroinflammation, yet why the inflammatory burden fails to resolve remains unclear. Specialized pro-resolving lipid mediators-including resolvin D1 (RvD1) and lipoxin A4 (LXA4)-actively terminate inflammation but have rarely been examined in schizophrenia. Because no previous study has measured LXA4 in schizophrenia or assessed both mediators concurrently, we compared serum RvD1 and LXA4 levels between patients and controls and assessed their association with illness severity. In this single-center case-control study, fasting serum RvD1 and LXA4 were measured by ELISA in 35 patients with schizophrenia (DSM-5) during an acute psychotic episode and 35 healthy controls of comparable age and sex; severity was rated with the PANSS and the Clinical Global Impression-Severity (CGI-S) scale. Both mediators were significantly lower in patients than controls (RvD1: 3372 ± 863 vs 3981 ± 382 ng/L, p < 0.001, Cohen's d = -0.91; LXA4: p = 0.002), and each remained independently associated with case status after adjustment for age, sex, and body mass index. Lower RvD1 correlated with higher CGI-S scores (ρ = -0.54, p = 0.001), whereas LXA4 did not. This provides preliminary evidence that circulating levels of these pro-resolving lipid mediators are reduced in schizophrenia, consistent with altered pro-resolving signalling rather than a demonstrated failure of the resolution process itself. Overall, they identify RvD1 as a candidate severity-related biomarker in patients during an acute psychotic episode, warranting confirmation in larger, longitudinal, mass spectrometry-based studies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1943920"},"PeriodicalIF":3.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}