Frontiers in Psychiatry最新文献

{"title":"GPT-4 generated psychological reports in psychodynamic perspective: a pilot study on quality, risk of hallucination and client satisfaction.","authors":"Namwoo Kim, Jiseon Lee, Sung Hyeon Park, Yoonseo On, Jieun Lee, Musung Keum, Sanghoon Oh, Yoojin Song, Junhee Lee, Geun Hui Won, Joon Sung Shin, Silvia Kyungjin Lho, Yoon Jung Hwang, Tae-Suk Kim","doi":"10.3389/fpsyt.2025.1473614","DOIUrl":"10.3389/fpsyt.2025.1473614","url":null,"abstract":"<p><strong>Background: </strong>Recently, there have been active proposals on how to utilize large language models (LLMs) in the fields of psychiatry and counseling. It would be interesting to develop programs with LLMs that generate psychodynamic assessments to help individuals gain insights about themselves, and to evaluate the features of such services. However, studies on this subject are rare. This pilot study aims to evaluate quality, risk of hallucination (incorrect AI-generated information), and client satisfaction with psychodynamic psychological reports generated by GPT-4.</p><p><strong>Methods: </strong>The report comprised five components: psychodynamic formulation, psychopathology, parental influence, defense mechanisms, and client strengths. Participants were recruited from individuals distressed by repetitive interpersonal issues. The study was conducted in three steps: 1) Questions provided to participants, designed to create psychodynamic formulations: 14 questions were generated by GPT for inferring psychodynamic formulations, while 6 fixed questions focused on the participants' relationship with their parents. A total of 20 questions were provided. Using participants' responses to these questions, GPT-4 generated the psychological reports. 2) Seven professors of psychiatry from different university hospitals evaluated the quality and risk of hallucinations in the psychological reports by reading the reports only, without meeting the participants. This quality assessment compared the psychological reports generated by GPT-4 with those inferred by the experts. 3) Participants evaluated their satisfaction with the psychological reports. All assessments were conducted using self-report questionnaires based on a Likert scale developed for this study.</p><p><strong>Results: </strong>A total of 10 participants were recruited, and the average age was 32 years. The median response indicated that quality of all five components of the psychological report was similar to the level inferred by the experts. The risk of hallucination was assessed as ranging from unlikely to minor. According to the median response in the satisfaction evaluation, the participants agreed that the report is clearly understandable, insightful, credible, useful, satisfying, and recommendable.</p><p><strong>Conclusion: </strong>This study suggests the possibility that artificial intelligence could assist users by providing psychodynamic interpretations.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1473614"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of anesthesiologists in postpartum depression: current perspectives and future directions.","authors":"Weijia Du, Xiaozhe Qian, Zhendong Xu, Zhiqiang Liu","doi":"10.3389/fpsyt.2025.1511817","DOIUrl":"10.3389/fpsyt.2025.1511817","url":null,"abstract":"<p><p>Postpartum depression is a common complication of childbirth that can seriously affect women, infants, and families. In 2020, the National Health Commission of the People's Republic of China mandated depression and anxiety screenings during pregnancy and postpartum visits to ensure timely medical intervention and referrals to appropriate behavioral health resources. Anesthesiologists are indispensable members in obstetric practice. Optimal peripartum pain control can reduce stress response; promote breastfeeding; and lower maternal anxiety and depression. Recently, the discovery of the rapid and sustained antidepressant properties of ketamine and emerging evidence supporting the effectiveness of anesthetic drugs in the treatment of depressive disorders have positioned anesthesiologists on a new frontier for treating neuropsychiatric disorders. This review aimed to explore the impact of labor epidural analgesia, obstetric anesthesia, and anesthetic drugs on postpartum depression while discussing the emerging role of anesthesiologists in its prevention and treatment based on recent evidence.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1511817"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between significant head injury and cognitive function, disability, and crime in adult men in prison in Scotland UK: a cross-sectional study.","authors":"Tom M McMillan, Hira Aslam, Abi McGinley, Vicky Walker, Sarah J E Barry","doi":"10.3389/fpsyt.2025.1544211","DOIUrl":"10.3389/fpsyt.2025.1544211","url":null,"abstract":"<p><strong>Background: </strong>Although a history of head injury is common in prisoners, little is known about its impact in relation to disability and potential associations with other health problems. This is relevant to the development of effective management and interventions targeted towards health or reducing recidivism. This study investigates effects of significant head injury (SHI) on disability, cognitive function, and offending in adult male prisoners and considers relationships with common comorbidities.</p><p><strong>Methods: </strong>In this cross-sectional study, adult male prisoners in Scotland were recruited from Her Majesty's Prisons Low Moss and Shotts. To be included, prisoners had to be men in adult custody, fluent in English, able to participate in assessment, provide informed consent, and not have a severe acute disorder of cognition or communication. History of head injury, cognition, disability, history of abuse, health, and problematic substance use were assessed by interview and questionnaire. Comparisons were made between prisoners with and without a history of SHI.</p><p><strong>Results: </strong>The sample of 286 was demographically representative of approximately 8,000 adult men in prison in Scotland. Severe head injury (SHI) was found in 245/286 (86%) and was repeated over periods of time in 151/245 (62%). Disability was associated with SHI in 85/245 (35%) and was significantly associated with problematic drug or alcohol use, clinical anxiety, and clinical depression. Significant associations between SHI and cognitive test outcomes were not found. Prisoners with SHI had more arrests, charges, and convictions and at younger ages, and were at greater risk of involvement in violent and property offences.</p><p><strong>Conclusions: </strong>A history of repeated SHI is very common in adult men in prison and is associated with a greater risk of crime including violence. Disability after SHI often affects social relationships and is associated with multiple health problems. There is a need for policy and interventions to account for the \"weave\" of multiple health needs of people in prison, which includes history of SHI.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1544211"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The age of trauma: the prevalence and psychological impact of potentially traumatic exposures in South Korea.","authors":"Gaeun Son, Jihee Jang, Euntaek Hong, Subin Park, Yun-Kyeung Choi, Kee-Hong Choi","doi":"10.3389/fpsyt.2025.1558085","DOIUrl":"10.3389/fpsyt.2025.1558085","url":null,"abstract":"<p><strong>Background: </strong>Exposure to potentially traumatic events (PTE) is associated with a range of negative mental health outcomes, including post-traumatic stress disorder (PTSD) and complex PTSD (cPTSD). Although exposure to PTEs is highly prevalent, and their impact on mental health is pervasive, research is mostly limited to diagnosed populations or specific trauma cohorts in the post-pandemic era.</p><p><strong>Methods: </strong>We conducted an online survey of 1,000 Seoul residents from October 6-12, 2023, using a stratified sampling method. Participants were asked about their traumatic experiences, mental health outcomes, and experiences with mental health services.</p><p><strong>Results: </strong>Most participants (98.8%) reported that they had experienced at least one PTE. The average number of PTEs reported was 9.19 (SD=7.908). Ninety participants (9%) were categorized as having probable PTSD (2.8% with PTSD only, and 6.2% with cPTSD). The sum of direct and indirect exposures to PTEs of individuals was associated with mental health outcomes, including PTSD symptom severity. Only 34.4% of patients with probable PTSD reported that they had received appropriate mental health services.</p><p><strong>Conclusion: </strong>Our results suggest that PTE exposures are highly prevalent, and self-awareness of mental health conditions and utilization of mental health services are low in South Korea. Given the lasting effects of traumatic events and the large number of untreated cases, this study highlights the need for proactive responses to traumatic events and better access to short- and long-term services for traumatized individuals.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1558085"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of suicidal ideation among South African Health Sciences students at the onset of the COVID-19 pandemic.","authors":"Samhaa Seedat, Muhle Sengwayo, Salma Gani, Lesedi Mashego, Jordan Ochayon, Ashleigh Shepard, Caleb Vergie, Mxolisi Masango, Lerato P Makuapane, Fezile Wagner, Ryan G Wagner","doi":"10.3389/fpsyt.2025.1492620","DOIUrl":"10.3389/fpsyt.2025.1492620","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation is an important mental health concern amongst university students who are exposed to multiple stressors. Furthermore, those studying towards degrees in the field of Health Sciences are exposed to additional and unique stressors. This quantitative cross-sectional study aimed to define the prevalence of suicidal ideation and its determinants amongst undergraduate students within the Faculty of Health Sciences at a large, urban South African University.</p><p><strong>Materials and methods: </strong>An online questionnaire was administered to the 4089 students registered in the Faculty of Health Sciences, with 1211 students submitting responses between March and April 2020. The distribution of this survey coincided with the onset of the national lockdown due to the Covid-19 pandemic. The survey was comprised of validated tools measuring depression (with an included indicator of suicidal ideation), anxiety and resilience. Data analysis was completed using the STATA statistical software (version 14). Both a bivariate analysis and a multivariate logistic regression adjusted for gender were performed.</p><p><strong>Results: </strong>The total prevalence of suicidal ideation adjusted for gender and race in this sample was found to be 21.8% (CI: 18.6-25.3; p<0.001). Females had significantly higher suicidal ideation than males (24.1% versus 17.8%; p=0.011). In the multivariate model adjusted for gender, having depressive (aOR 10.8; CI: 7.9-14.8; p<0.001) or anxiety (aOR 5.1: CI: 3.8-6.8; P<0.001) symptoms, only sometimes (aOR 2.7: CI 1.8-4.0; p<0.001) or never (aOR 2.7; CI: 1.8-4.0; p<0.001) having anyone to talk to and being of colored race (aOR 2.0; CI: 1.1-3.4; p=0.019) were significantly associated with suicidal ideation, whilst higher resilience (aOR 0.3; CI: 0.3-0.4; p<0.001) was associated with lower levels of suicidal ideation.</p><p><strong>Conclusion: </strong>The prevalence of suicidal ideation found in this study was higher than that found in the general South African adult population and highlights the need to further investigate and address student mental health, especially students in the field of Health Sciences. Interventions aimed at mitigating the determinants, including depression and anxiety, and promoting the development of protective factors such as resilience and social support may lead to a reduction in suicidal ideation in this population group. Institutional initiatives aimed at improving access to and the quality of mental health services offered to students should be widely advocated for and implemented.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1492620"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte-microglia co-culture model.","authors":"Timo Jendrik Faustmann, Franco Corvace, Pedro M Faustmann, Fatme Seval Ismail","doi":"10.3389/fpsyt.2025.1522128","DOIUrl":"10.3389/fpsyt.2025.1522128","url":null,"abstract":"<p><p>Schizophrenia is a severe mental disorder with a strong lifetime impact on patients' health and wellbeing. Usually, symptomatic treatment includes typical or atypical antipsychotics. Study findings show an involvement of low-grade inflammation (blood, brain parenchyma, and cerebrospinal fluid) in schizophrenia. Moreover, experimental and neuropathological evidence suggests that reactive microglia, which are the main resident immune cells of the central nervous system (CNS), have a negative impact on the differentiation and function of oligodendrocytes, glial progenitor cells, and astrocytes, which results in the disruption of neuronal networks and dysregulated synaptic transmission, contributing to the pathophysiology of schizophrenia. Here, the role of microglial cells related to neuroinflammation in schizophrenia was discussed to be essential. This review aims to summarize the evidence for the influence of antipsychotics on microglial inflammatory mechanisms in schizophrenia. Furthermore, we propose an established astrocyte-microglia co-culture model for testing regulatory mechanisms and examining the effects of antipsychotics on glia-mediated neuroinflammation. This could lead to a better understanding of how typical and atypical antipsychotics can be used to address positive and negative symptoms in schizophrenia and comorbidities like inflammatory diseases or the status of low-grade inflammation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1522128"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot implementation of a telehealth safety planning group intervention for suicidal rural Veterans enhanced by lived experience veteran peer participation.","authors":"Marianne Goodman, Madison Strouse, Caroline Boucher, Sofie Glatt, James Jacobs, Angie Waliski, Emilia Fonseca, Terra Osterberg, Sapana Patel","doi":"10.3389/fpsyt.2025.1512523","DOIUrl":"10.3389/fpsyt.2025.1512523","url":null,"abstract":"<p><p>Despite the Veterans Administration (VA) designating suicide prevention as the number one clinical priority, Veteran suicide rates continue to rise. One sub-population at elevated risk are Veterans living in rural communities given their heightened availability of firearms coupled with more limited access to mental health services. Telehealth delivery of treatment is a potential solution for the provision of critical services to rural areas. Despite the expansive growth of virtual treatment after the pandemic, there exist few suicide-specific telehealth health services. Our community case study aims to address this gap by piloting a manualized suicide safety planning and firearm safety group, titled Project Life Force (PLF), delivered virtually to rural Arkansas. The project's goal was to specifically enhance rural Veteran engagement with telehealth delivery through the use of community-based lived-experience rural peers. We present the rationale and details of the PLF intervention with a focus on the community Veteran peer enhancement component. This case study presents an innovative treatment design of a group led by a clinician augmented by a peer recovery leader that facilitated detailed conversations of how to limit suicide risk, encouraged disclosure about suicide symptoms, and promoted suicide related coping including encouragement of help-seeking behavior and safer storage of firearms. While the inclusion of a peer recovery leader was felt to be instrumental to the PLF-PE group's success, special attention to the peer recovery leader is essential and includes specific training, regular supervision as well as attention and support regarding the psychological impacts of self-disclosure and assuming a leadership role. This case study highlights the invaluable role that lived experience peers can play in suicide prevention treatment efforts and lethal means safety and paves the way for continued development of this effort.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1512523"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two in one: a randomized controlled trial on an internet-based intervention (Lenio) for management of both chronic pain and depressive symptoms.","authors":"Swantje Borsutzky, Anna-Sophie Wilke, Josefine Gehlenborg, Steffen Moritz","doi":"10.3389/fpsyt.2025.1528128","DOIUrl":"10.3389/fpsyt.2025.1528128","url":null,"abstract":"<p><p>The high prevalence of chronic pain and comorbid depression, along with their negative impacts on individuals and society, highlights the need for accessible and effective interventions. This study examined the feasibility, efficacy, and acceptability of Lenio, an Internet-based self-help intervention, combined with the COGITO smartphone application for managing these conditions. The randomized controlled trial involved an intervention group (IG) using Lenio and COGITO, an active control group (ACG) using a transdiagnostic app, and a wait-list control group (WCG) receiving usual treatment. Lenio incorporates cognitive behavioral therapy and third-wave techniques, supported by COGITO's gamified daily exercises to enhance adherence. Across 263 participants assessed at three intervals over 16 weeks, the IG showed significant improvement in somatic-affective depressive symptoms compared to the WCG post-intervention and both control groups at follow-up. However, the ACG outperformed the IG in managing pain at post-intervention though these effects did not persist until follow-up. The interventions were well-received and feasible, with older participants benefiting more from the Lenio/COGITO combination. Lenio and COGITO could bridge gaps to conventional therapy, potentially easing pain by enhancing psychological well-being and coping strategies. Future studies should investigate tailored interventions for chronic pain and their long-term effectiveness.</p><p><strong>Protocol: </strong>Full trial protocol can be accessed via DOI: 10.1186/s13063-023-07440-8.</p><p><strong>Clinical trial registration: </strong>https://drks.de/register/de/trial/DRKS00026722/preview, identifier DRKS-IDDRKS00026722.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1528128"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Treatment resistant depression (TRD): epidemiology, clinic, burden and treatment.","authors":"Andrea Fiorillo, Koen Demyttenaere, Vassilis Martiadis, Giovanni Martinotti","doi":"10.3389/fpsyt.2025.1588902","DOIUrl":"10.3389/fpsyt.2025.1588902","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1588902"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of the Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability in individuals with subjective cognitive decline: paving the way towards brain health clinics in Greece.","authors":"Panagiotis Alexopoulos, Panagiotis Felemegkas, Xanthi Arampatzi, Evdokia Billis, Eleni Dimakopoulou, Polychronis Economou, George A Dimakopoulos, Themis P Exarchos, Maria Frounta, Parthenia Giannakopoulou, Kalliopi Kalaitzi, Maria-Lamprini Koula, Eftyhia Nastou, Maria Skondra, Paraskevi Sakka, Faidra Kalligerou, Nikolaos Skarmeas, Marianna Tsatali, Magdalini Krommyda, Maria Karala, Nikolaos Mastoras, Panagiotis Vlamos, Mary Yannakoulia, Ioannis Zaganas, Maria Karataraki, Maria Basta, Constantine Lyketsos","doi":"10.3389/fpsyt.2025.1514227","DOIUrl":"10.3389/fpsyt.2025.1514227","url":null,"abstract":"<p><p>The pilot phase of the Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability (GINGER) aims to assess the feasibility of a multi-level dementia risk reduction intervention in individuals with subjective cognitive decline (SCD) over a six-month period. The study design incorporates a comprehensive set of trans-disciplinary assessments and interventions in multiple centers across Greece. Individuals 55 years or older with subjective cognitive complaints who do not fulfill criteria for either mild cognitive impairment or dementia are screened for dementia risk factors in the following domains: nutrition, physical activities, vision and hearing, vascular and metabolic parameters, anxiety and depressive symptoms, and insomnia. All GINGER participants receive a cognitive empowerment intervention. Using a precision medicine approach, they receive up to three additional domain-specific interventions based on their individual risk factor profiles. Changes in cognition, dementia risk factors, quality of life and other measures compared to baseline are assessed at three- and six months after the initiation of the intervention. The GINGER protocol was designed and is run by a multi-disciplinary team of dieticians, neurologists, psychiatrists, psychologists, and physiotherapists, while computer scientists oversee data management. The objectives of this pilot phase are (i) evaluation of the protocol's feasibility, (ii) assessment of intervention effects on the individual risk domains targeted by the interventions, (iii) estimation of the overall effects of the intervention on cognitive function, dementia risk and quality of life. The GINGER findings will provide a solid foundation for paving the way towards a network of evidence-based brain health clinics in Greece.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1514227"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}