Frontiers in Psychiatry最新文献

{"title":"Expanding the phenotypic spectrum of Xq28 duplication involving MECP2: a familial case report.","authors":"Katerina Gaberova, Iliyana Hristova Pacheva, Ralitsa Yordanova, Tihomir Todorov, Albena Todorova, Liliyana Grozdanova, Margarita Panova, Mariyana Georgieva, Ivan Stefanov Ivanov","doi":"10.3389/fpsyt.2026.1810637","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1810637","url":null,"abstract":"<p><p>X-linked intellectual disability (XLID) is a well-recognized group of neurodevelopmental disorders, with pathogenic variants in X-chromosomal genes accounting for approximately 16% of intellectual disability cases in males. Clinical expression in females is variable and depends on patterns of X-chromosome inactivation. We describe three affected individuals from a single family with XLID caused by a confirmed duplication of the Xq28 region, including the genes <i>SLC6A8, L1CAM, MECP2, TKTL1, FLNA</i>, and <i>GDI1</i>. Two male siblings presented with severe phenotypes, including profound intellectual disability, severe speech impairment, behavioral issues, facial dysmorphism, spastic cerebral palsy, epilepsy, and cutaneous abnormalities. Their mother showed mild intellectual disability and skin manifestations. Family history suggested additional affected male relatives with a similar or even more severe clinical presentation. The duplication of multiple dosage-sensitive genes within the Xq28 region likely explains the multisystem involvement and the marked phenotypic variability observed between male and female family members. This report highlights the importance of considering Xq28 duplication, the most common X-linked copy number variation associated with intellectual disability, in the differential diagnosis of families with X-linked intellectual disability, especially if it is accompanied by additional neurological impairment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1810637"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver strain modulates the association between attention deficit and alpha oscillations in children with ADHD.","authors":"Xiangsheng Luo, Mengqi Liu, Hanbo Zhang, Junhui Qi, Yanjie Qi, Huanhuan Huang, Yiwei Lin, Yin Tian, Lichong Luo, Tianyu Qu, Li Qin, Longjun Cai, Li Sun, Xiaojie Guo, Xu Chen","doi":"10.3389/fpsyt.2026.1811824","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1811824","url":null,"abstract":"<p><strong>Introduction: </strong>The neurobiological mechanisms underlying Attention-Deficit/Hyperactivity Disorder (ADHD) remain incompletely understood. Existing research has identified abnormalities in alpha rhythm among individuals with ADHD; however, its association with core symptoms lacks consistency, suggesting that enhanced alpha activity may represent a state-dependent compensatory manifestation. The family environment, particularly caregiver stress, is recognized as an important external factor influencing the development of children with ADHD, yet its potential role as a mediator between clinical symptoms and neural brain activity has yet to be systematically explored.</p><p><strong>Methods: </strong>The study included 59 children with ADHD. Correlations among attention deficit scores (ADS), hyperactivity/impulsivity scores (HIS), various dimensions of caregiver strain, and posterior alpha power were analyzed, with Bonferroni correction applied to control for multiple comparisons. Subsequently, hierarchical regression and mediation modeling were employed to examine the mediating effect of caregiver strain.</p><p><strong>Results: </strong>No direct correlation was found between ADS and alpha power. A triangular pattern among symptoms, stress, and brain activity emerged: ADS showed strong positive correlations with all dimensions of caregiver strain, and subjective internalized strain (SIS) remained significantly positively correlated with alpha power even after correction. The mediation model indicated a suppression pattern, wherein the statistical association between ADS and alpha power was consistent with a positive indirect pathway via SIS, alongside a masked direct association, resulting in a non-significant total effect.</p><p><strong>Discussion: </strong>The findings suggest a model in which SIS is a key statistical mediator in the relationship between ADHD symptoms and specific neural oscillatory patterns, and highlight the plasticity of brain function in response to the family emotional environment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1811824"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating pediatric OCD with group metacognitive therapy in a naturalistic setting: a preliminary investigation of treatment effects and metacognitive change in light of comorbid disorders.","authors":"Marie Louise Reinholdt-Dunne, Anne Rosenfeldt, Odin Hjemdal, Marie Tolstrup, Henrik Nordahl","doi":"10.3389/fpsyt.2026.1766674","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1766674","url":null,"abstract":"<p><strong>Introduction: </strong>Studies suggest that metacognitive therapy (MCT) is a promising treatment for pediatric OCD, but less is known about its mechanisms and effects in light of comorbid disorders. The aim of this study was therefore to explore the magnitude of effects, response and remission rates, and trajectories of change associated with MCT for pediatric OCD in a sample presenting both with and without comorbid neurodevelopmental and anxiety disorders.</p><p><strong>Methods: </strong>In total, 37 participants aged 9-17 years received eight sessions of group MCT, accompanied by two parental workshops. Participants were diagnostically assessed at pre- and post-treatment, and completed self-report measures before, during, and after treatment.</p><p><strong>Results: </strong>For the total sample, results showed significant and large reductions in OCD symptoms (Hedges' <i>g =</i> 2.3) and response and remission rates of 81.1% and 51.4%, respectively. Moderate to large improvements were also found in comorbid symptoms, trait worry, and metacognitive beliefs and strategies. When provisionally exploring three types of diagnostic presentations (i.e., OCD only, OCD with comorbid neurodevelopmental disorder[s], and OCD with comorbid anxiety disorder[s]), slightly lower response rates were observed for the two subgroups with comorbid disorders, accompanied by indications of delayed, but steeper trajectories of change in thought-fusion beliefs.</p><p><strong>Discussion: </strong>Overall, the results indicate that group MCT for pediatric OCD is a feasible treatment in naturalistic settings with high rates of comorbidity, but that the presence of comorbid disorders may be associated with lower response rates and different trajectories of metacognitive change. However, these observations should be considered preliminary and evaluated further in larger samples with more stringent study designs.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1766674"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal depression impairs placental angiogenesis and fetal growth in mice: protective effects of betaine supplementation.","authors":"Shuqin Jia, Guangjun Zhu, Hui Yang, Jing Chen, Tao Zou","doi":"10.3389/fpsyt.2026.1769596","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1769596","url":null,"abstract":"<p><strong>Introduction: </strong>Perinatal depression (PND) is the most common psychiatric disorder experienced during pregnancy and postpartum and is characterized by persistent low mood, difficulty adapting to gestational changes, helplessness, social withdrawal, and, in severe cases, suicidal or infanticidal thoughts. In this study, using a mouse model of PND, we examined the impact of PND on placental angioneurotrophic signaling, namely vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGFR1), and brain-derived neurotrophic factor (BDNF), and determined whether placental hypoxia precipitates impaired angiogenesis and fetal growth restrictions (FGR). Additionally, we evaluated the therapeutic potential of betaine in restoring placental function and fetal growth.</p><p><strong>Methods: </strong>To establish a PND model, pregnant C57BL/6 mice (n = 40) underwent 6 weeks of pre-mating chronic unpredictable mild stress (CUMS) combined with social isolation, continued until gestational day (GD) 14; non-stressed littermates served as controls (n = 10). Model dams were randomized to receive physiological saline vehicle (10 mL/kg/day, DD, n = 10), low-dose betaine (50 mg/kg/day, DD+LB, n = 10), high-dose betaine (200 mg/kg/day, DD+HB, n = 10), or escitalopram (10 mg/kg/day, DD+ESC, n = 10). Stress and treatments continued until gestational day (GD) 17. On GD 18, fetal and placental weights were recorded and placental efficiency calculated. Placental levels of VEGF, VEGFR1, BDNF, and hypoxia-inducible factor-1α (HIF-1α) were quantified using reverse transcription quantitative polymerase chain reaction and western blot. Microvascular density (MVD) and vascular architecture were assessed using CD34 immunohistochemistry and hematoxylin-eosin staining.</p><p><strong>Results: </strong>CUMS with social isolation evoked robust depression- and anxiety-like behaviors and attenuated maternal weight gain, thereby validating the PND model. PND resulted in significant fetal growth restriction, decreased placental efficiency, and marked reductions in placental BDNF and VEGF. These alterations coincided with elevated HIF-1α, indicating placental hypoxia. High-dose betaine reversed these deficits, restoring fetal weight and placental efficiency to control levels while upregulating placental BDNF and VEGF expression. Histologically, high-dose betaine increased MVD and improved vascular perfusion.</p><p><strong>Conclusions: </strong>These findings highlight betaine as a promising, low-risk intervention for preventing PND-associated fetal complications.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1769596"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Treatment and management of stimulant use disorder and co-occurring disorders.","authors":"Jeremy Weleff, Mohit Singh, David Crockford","doi":"10.3389/fpsyt.2026.1848661","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1848661","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1848661"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with depression in older adults during the COVID-19 pandemic: findings from The Irish Longitudinal Study on Ageing.","authors":"Xiang Jiao, Wei Wang, Lina Zhou","doi":"10.3389/fpsyt.2026.1799213","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1799213","url":null,"abstract":"<p><strong>Objectives: </strong>The coronavirus disease 2019 (COVID-19) pandemic has adversely affected the physical and mental health of older adults worldwide. This study aimed to identify the factors associated with depression among older adults during the pandemic and to develop strategies to enhance their psychological well-being.</p><p><strong>Methods: </strong>Data from The Irish Longitudinal Study on Ageing (TILDA) collected during the COVID-19 pandemic were compared with pre-pandemic data (Wave 5). We examined the impact of the pandemic on depressive symptoms in older adults and investigated potential influencing factors related to depression, including lifestyle changes, COVID-19 concern and protective behaviors, and psychological assessments.</p><p><strong>Results: </strong>The prevalence of clinically significant depressive symptoms in older adults was significantly higher after the onset of the COVID-19 pandemic than in the pre-pandemic Wave 5 (p < 0.001). The rates of difficulty falling asleep and early awakening increased significantly, whereas the time spent on anaerobic exercise, aerobic exercise, and slow walking decreased markedly (all p < 0.001). Hierarchical multiple linear regression analysis revealed that the model including predictors such as age, gender, Perceived Stress Scale score, UCLA Loneliness Scale score, difficulty falling asleep, early awakening, sleep duration, days of anaerobic exercise, days of aerobic exercise, and days of slow walking was statistically significant (F = 165.241, p < 0.001, R = 0.734, R² = 0.539, adjusted R² = 0.536), explaining 53.9% of the variance in depressive symptoms.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic might be associated with an increase in depressive symptoms among older adults. This exacerbation is closely linked to lifestyle changes (sleep disturbances and reduced physical activity), psychological factors (heightened stress and loneliness), and certain information-seeking behaviors. These findings underscore the need for integrated interventions that target these modifiable risk factors.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1799213"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From stigma to support: the mediating role of sympathy between nurses' perceived stigma and helping behavior tendency for alcohol use disorder.","authors":"Shufen Wang, Yanhua Qu, Qingyan Yang, Lei Lei Wang, Jing Shao","doi":"10.3389/fpsyt.2026.1811126","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1811126","url":null,"abstract":"<p><strong>Background: </strong>The detrimental effect of stigma on healthcare for individuals with alcohol use disorders (AUDs) is well-established, often resulting in social distance and diminished helping behavior tendencies. However, contemporary neuroscience reconceptualizes addiction as a brain disease, potentially altering emotional responses to stigma. This study examines a seemingly paradoxical possibility: that under specific conditions, perceived stigma is primarily associated with sympathy (rather than anger or fear), which in turn is linked to helping behavior tendencies among nurses.</p><p><strong>Methods: </strong>A cross-sectional survey was administered to 348 clinical nurses from tertiary hospitals in China. Participants completed standardized scales assessing perceived stigma of patients with AUDs, causal attributions, emotional responses (including sympathy, anger, and fear), and helping behavior tendencies. Data were analyzed using Pearson correlation and mediation analysis (PROCESS macro, Model 4) with 5,000 bootstrap samples to test the mediating role of sympathy.</p><p><strong>Results: </strong>Perceived stigma showed a significant positive correlation with sympathy (r= .160, p<.05), which was in turn positively correlated with helping behavior tendencies (r= .269, p<.05). Critically, mediation analysis revealed that sympathy fully mediated the relationship between perceived stigma and helping behavior tendencies. The standardized indirect effect was significant (β= 0.15, 95% CI [0.08, 0.23]), accounting for the total observed relationship, as the direct effect was non-significant. Additionally, compared to non-psychiatric nurses, psychiatric nurses perceived patients as significantly less dangerous and reported lower levels of fear and anger, along with a stronger intention to help and a lower tendency to avoid patients.</p><p><strong>Conclusion: </strong>Challenging conventional perspectives, this study supports a dual-pathway model in which perceived stigma can indirectly associated with professional helping behavior tendencies through the elicitation of sympathy. While other emotions like anger and fear were also measured, the findings highlight the pivotal role of cognitive-affective processes, shaped by neurobiological understandings of addiction, in determining nursing care. Specifically, sympathy, but not anger or fear, was found to mediate the stigma-helping relationship. Enhancing neuroscience-informed education and targeted empathy training, particularly for general nurses, could transform stigmatizing attitudes into supportive care, ultimately improving outcomes for patients with AUDs.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1811126"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis.","authors":"Wenxin Xu, Yu Huang, Chi Su, Zhibin Zhou, Shiying Wang, Haolin Ye, Yueshan Xu, Yanli Wang, Kezhi Liu, Jing Chen, Wei Lei","doi":"10.3389/fpsyt.2026.1785472","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1785472","url":null,"abstract":"<p><strong>Introduction: </strong>Social media addiction (SMA) is often comorbid with anxiety and depression. This study examined the temporal stability of core SMA symptoms and the bridging symptoms with anxiety and depression.</p><p><strong>Methods: </strong>A total of 1,240 adolescents (179 males, 1,061 females; mean age = 15.46 ± 0.63 years, age range: 14 - 18) completed the Bergen Social Media Addiction Scale (BSMAS), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) on two separate occasions in 2023 (T1) and 2024 (T2). The four symptom networks, including the BSMAS networks, two comorbidity networks (the BSMAS-GAD and the BSMAS-PHQ), and the integrated BSMAS-GAD-PHQ network, were estimated using Gaussian graphical models. Core symptom centrality was assessed using Expected Influence (EI), whereas bridge symptoms were identified using Bridge Expected Influence (BEI).</p><p><strong>Results: </strong>1) Although SMA, anxiety, and depression levels of respondents rose significantly over the year, all four networks showed strong temporal stability, with the edge weights (<i>r</i> = .892 -.973, <i>p</i> < .001), the EI (<i>r</i> = .806 - .961, <i>p</i> ≤ .002), and the BEI (<i>r</i> = .699 - .804, <i>p</i> ≤ .008) highly correlated between T1 and T2; network comparison tests showed no significant changes in overall structures of all four networks, with most edges showing stable weights. 2) Within the BSMAS network, BSMAS2 (tolerance) and BSMAS6 (conflict) exhibited the highest EI at both time points. 3) In the comorbidity networks, BSMAS3 (mood modification), BSMAS5 (withdrawal), and BSMAS6 (conflict) consistently served as bridge symptoms on the SMA side at both T1 and T2. 4) Across both time points, PHQ1 (anhedonia) and PHQ7 (concentration problems) exhibited the highest BEI on the depression side, whereas GAD1 (nervousness) and GAD5 (restlessness) did so on the anxiety side. 5) These bridge symptoms were also confirmed in the integrated network.</p><p><strong>Discussion: </strong>These findings illuminate the temporal persistence and development of symptom relationships, offering a more dynamic understanding of SMA-depression-anxiety comorbidity in adolescents.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1785472"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How family functioning shapes prenatal bonding: a mediation analysis of depressive symptoms and maternal-fetal attachment.","authors":"Silvia Mammarella, Laura Giusti, Laura Camoni, Fiorino Mirabella, Manuela Ludovisi, Rita Roncone","doi":"10.3389/fpsyt.2026.1800384","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1800384","url":null,"abstract":"<p><strong>Objective: </strong>Pregnancy is a period in a woman's life characterized by profound hormonal, psychological, and social changes, which may lead to increased emotional vulnerability, during which depressive symptoms may negatively affect maternal well-being and maternal-fetal attachment. Although family functioning has traditionally been examined mainly in relation to psychopathology, its protective role during pregnancy remains insufficiently explored. This study examined whether depressive symptoms mediate the association between family functioning and antenatal maternal attachment.</p><p><strong>Methods: </strong>The sample consisted of 261 pregnant women enrolled in a multicenter Italian perinatal mental health project. The present add-on study focused specifically on family functioning, social support, and maternal antenatal attachment. Participants completed self-report measures assessing depressive symptoms (Edinburgh Postnatal Depression Scale), maternal-fetal attachment (Maternal Antenatal Attachment Scale), family functioning (Family Functioning Questionnaire), perceived partner support, and social network quality. Structural equation modeling was used to test a mediation model in which depressive symptoms mediated the relationship between family functioning and two attachment dimensions: quality of attachment and intensity of preoccupation. Models were estimated using full-information maximum likelihood with bootstrapped confidence intervals.</p><p><strong>Results: </strong>Higher family functioning was significantly associated with lower depressive symptom severity. Depressive symptoms were negatively associated with attachment quality but not with intensity of preoccupation. A small but significant indirect effect of family functioning on attachment quality, mediated by depressive symptoms, emerged, indicating partial mediation. No mediation effect was observed for intensity of preoccupation, which showed a direct positive association with family functioning. These results remained substantially unchanged after controlling for perceived partner support and social network quality.</p><p><strong>Conclusion: </strong>Depressive symptoms partially mediate the relationship between family functioning and the emotional quality of maternal-fetal attachment, whereas the intensity of preoccupation appears to be more directly linked to the broader family environment. These findings underscore the importance of assessing family functioning during pregnancy and suggest that interventions targeting both family dynamics and maternal depressive symptoms may foster healthier prenatal attachment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1800384"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between internet addiction and daytime sleepiness in nursing students: a moderated mediation model.","authors":"Ying Li, Dan Bu, Keyan Yuan, Piao Xia","doi":"10.3389/fpsyt.2026.1756841","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1756841","url":null,"abstract":"<p><strong>Background: </strong>Internet addiction is highly correlated with daytime sleepiness, but the underlying mechanisms between the variables need to be further explored. The aim of this study was to investigate sleep quality as a mediating factor and depression as a moderating factor to further elucidate the potential risk factors between internet addiction and daytime sleepiness in nursing students.</p><p><strong>Method: </strong>A self-report survey was conducted among 1,578 nursing students from eight universities in China. The survey included measures of internet addiction, sleep quality, daytime sleepiness, and depression. Descriptive and correlation analysis of these variables was performed, and a moderated mediation model was constructed.</p><p><strong>Results: </strong>Internet addiction was positively correlated with sleepiness, sleep quality, and depression between nursing days. Sleep quality played a partial mediating role in the relationship between internet addiction and daytime sleepiness in nursing students, and depression strengthened the relationship between internet addiction and sleep quality pathway in a moderated mediation model.</p><p><strong>Conclusion: </strong>This study further revealed the psychological mechanism of the relationship between internet addiction and sleepiness in nursing. Sleep quality was a mediating factor for this relationship, and depression may enhance the strength of the relationship between internet addiction and sleep quality variables.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1756841"},"PeriodicalIF":3.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}