Frontiers in Psychiatry最新文献

{"title":"Differences in EEG complexity of cognitive activities among subtypes of schizophrenia.","authors":"Hang Qi, Jilin Zou, Zhenzhen Yao, Gaofeng Zhao, Jing Zhang, Chunlei Liu, Min Chen","doi":"10.3389/fpsyt.2025.1473693","DOIUrl":"10.3389/fpsyt.2025.1473693","url":null,"abstract":"<p><strong>Introduction: </strong>The neural mechanisms that underpin cognitive impairments in patients with schizophrenia remain unclear. Previous studies have typically treated patients as a homogeneous group, despite the existence of distinct symptom presentations between deficit and non-deficit subtypes. This approach has been found to be inadequate, necessitating separate investigation.</p><p><strong>Methods: </strong>This study was conducted at Daizhuang Hospital in Jining City, China, from January 2022 to October 2023. The study sample comprised 30 healthy controls, 19 patients with deficit schizophrenia, and 19 patients with non-deficit schizophrenia, all aged between 18 and 45 years. Cognitive abilities were evaluated using a change detection task. The NeuroScan EEG/ERP System, comprising 64 channels and utilising standard 10-20 electrode placements, was employed to record EEG signals. The multiscale entropy and sample entropy of the EEG signals were calculated.</p><p><strong>Results: </strong>The healthy controls demonstrated superior task performance compared to both the non-deficit (p < 0.001) and deficit groups(p < 0.001). Significant differences in multiscale entropy between the three groups were observed at multiple electrode sites. In the task state, there are significant differences in the sample entropy of the β frequency band among the three groups of subjects. Under simple conditions of difficulty, the performance of the healthy controls exhibited a positive correlation with alpha band sample entropy(r = 0.372) and a negative correlation with beta band sample entropy (r = -0.411). Deficit patients demonstrated positive correlations with alpha band sample entropy (r = 0.370), whereas non-deficit patients exhibited negative correlations with both alpha and beta band sample entropy (r = -0.451, r = -0.362). Under difficult conditions of difficulty, the performance of healthy controls demonstrated a positive correlation with beta band sample entropy (r = 0.486). Deficit patients exhibited a positive correlation with alpha band sample entropy (r = 0.351), while non-deficit patients demonstrated a negative correlation with beta band sample entropy (r = -0.331).</p><p><strong>Conclusion: </strong>The results of this study indicate that cognitive impairment in specific subtypes of schizophrenia may have distinct physiological underpinnings, underscoring the need for further investigation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1473693"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Markers of clinical significance and treatment-seeking of psychotic experiences in non-clinical populations: potential resilience & risk factors.","authors":"Suzanne Ho-Wai So, Peter W Woodruff, Salma M Khaled","doi":"10.3389/fpsyt.2025.1557770","DOIUrl":"10.3389/fpsyt.2025.1557770","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1557770"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep deficiencies and suicidal ideation across the psychosis continuum.","authors":"Heather M Wastler, Alexandra M Blouin, Melissa F V Kilicoglu, Melanie Bozzay","doi":"10.3389/fpsyt.2025.1540497","DOIUrl":"10.3389/fpsyt.2025.1540497","url":null,"abstract":"<p><strong>Objective: </strong>Sleep deficiency, a broad term that encompasses sleep disorder symptoms and other aspects of disturbed sleep, is an established risk factor for suicide. Although several studies have examined the relationship between sleep, suicidal ideation, and suicide attempts among individuals with psychotic disorders, few studies have focused on the early stages of illness. The current study addressed this gap in the literature by examining the relationship between sleep deficiencies, recent suicidal ideation, and lifetime suicidal behavior across the psychosis continuum.</p><p><strong>Method: </strong>A retrospective chart review was used to obtain relevant data for individuals at clinical high-risk for psychosis (CHR-P), individuals with first-episode psychosis (FEP), and individuals with longstanding illness.</p><p><strong>Results: </strong>Results indicate that sleep deficiencies are prevalent across all stages of illness, though individuals at CHR-P have significantly higher rates of sleep deficiency than individuals with FEP and longstanding psychosis. Additionally, there was a strong relationship between sleep deficiencies and suicidal ideation across the entire sample.</p><p><strong>Conclusions: </strong>Further research is needed to clarify the specific nature of these sleep deficiencies and to elucidate the mechanisms by which sleep deficiencies might increase risk for suicide in this population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1540497"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A transdiagnostic approach to investigate of the relationships between anxiety sensitivity and health anxiety: the mediated roles of distress tolerance and emotion regulation.","authors":"Hamid Mohsenabadi, Mohammadreza Pirmoradi, Komeil Zahedi Tajrishi, Banafsheh Gharraee","doi":"10.3389/fpsyt.2025.1478442","DOIUrl":"10.3389/fpsyt.2025.1478442","url":null,"abstract":"<p><strong>Background: </strong>Emotion regulation (ER) and distress tolerance (DT) are considered transdiagnostic risk factors for a range of anxiety disorders. This study investigated the relationship between anxiety sensitivity (AS) and health anxiety (HA) in the general population, focusing on the mediating roles of DT and ER.</p><p><strong>Methods: </strong>The study was conducted as a cross-sectional survey from October to December 2023 in Tehran Province, Iran. A total of 971 individuals participated in this study (52.8% female; mean age 39.04 years, SD=10.64). Participants completed self-report questionnaires to assess HA (The Short Health Anxiety Inventory), AS (The Anxiety Sensitivity Index-3), DT (The 15-item Distress Tolerance Scale) and ER (The 10-item Emotion Regulation Questionnaire). We used structural equation modeling (SEM) to examine the hypothesis that DT and ER would mediate the relationship between AS and the HA.</p><p><strong>Results: </strong>AS was modestly related to all measures (r from -0.40 to 0.55). According to the SEM analysis, AS (β = 0.45, 95%CI [0.34, 0.56]) had a significant direct effect on HA. However, the analysis of the indirect effects revealed that both DT (β = 0.10, 95% CI [0.06, 0.16]) and emotion regulation strategies-cognitive reappraisal (β = 0.06, 95% CI [0.01, 0.11]) and expressive suppression (β = 0.11, 95% CI [0.06, 0.18])-act as partial mediators in the relationship between AS and HA.</p><p><strong>Conclusions: </strong>AS plays a crucial role in predisposing individuals to HA. The mediating roles of DT and ER provide insight into the link between AS and HA. Nevertheless, the study's cross-sectional design and reliance on a non-clinical sample limit the applicability of the results. Further research involving different samples and intervention studies is needed to validate and expand upon these findings.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1478442"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study.","authors":"Annemieke C Kamstra, Sybolt O de Vries, Maarten F Brilman, Petty Vasilev, Manna A Alma, Antoinette D I van Asselt, Mia De Wolf, Robert A Schoevers, Frederike Jörg","doi":"10.3389/fpsyt.2025.1538267","DOIUrl":"10.3389/fpsyt.2025.1538267","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood traumatization can result in physical and mental health problems in adulthood, such as post-traumatic stress disorder (PTSD), which negatively influences quality of life and social functioning. Although evidence based trauma treatments benefit clients with PTSD after childhood abuse and comorbid personality disorders, they are less effective than in clients who were traumatized in adulthood, and drop-out is substantial. The current study aims to assess the effects of inpatient dialectical behavior therapy combined with prolonged exposure (DBT-PTSD) on severity of PTSD, dissociation, parasuicidal behavior and borderline personality disorder (BPD) in clients with severe PTSD and comorbid psychiatric disorders. Secondary outcomes are social functioning, quality of life, borderline and cluster C personality disorder symptoms as treatment predictors, treatment trajectories, clients' experiences and health economic consequences.</p><p><strong>Methods: </strong>The naturalistic, longitudinal Trauma Therapy Study is conducted from January 2019 until May 2025 in a mental healthcare center in the Netherlands. Clients with severe PTSD and comorbid conditions who are referred to inpatient DBT-PTSD are included into the study. Based on power analyses a total sample size of N=56 is needed. Measurements take place before the waiting list period, at pre- and posttreatment and at six- and twelve-months follow-up. Clients fill in a daily DBT-PTSD diary, which gives insight into individual symptom trajectories.</p><p><strong>Results: </strong>Statistical analyses include two-sided paired samples t-tests, linear mixed model analyses and cost-effectiveness analyses. Qualitative interviews are conducted within two years posttreatment and analyzed using a phenomenological approach. We correct for chance capitalization by using a conservative α-level of.01. Multiple imputation is used to handle missing data.</p><p><strong>Discussion: </strong>Research on the effects of integrated treatment programs for clients with severe PTSD and co-morbid conditions is scarce. This study extends current knowledge on the effects of inpatient DBT-PTSD on PTSD and BPD symptoms, clients' social functioning and quality of life. In addition, it provides insight into individual symptom trajectories and experiences, inspiring future treatment improvements for clients with severe psychopathology.</p><p><strong>Trial registration: </strong>Medical Ethical Committee approval (NL669060018, RTPO1044/01.10.2018). Preregistration: Dutch registration database Centrale Commissie Mensgebonden Onderzoek and International Clinical Trials Registry Platform (NL-OMON46167/01.10.2018/https://trialsearch.who.int/Trial2.aspx?TrialID=NL-OMON46167).</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1538267"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of self-compassion versus mindfulness interventions on autonomic responses to stress in generalized anxiety disorders.","authors":"Xuejun Qi, Yonghui Shen, Xianwei Che, Ying Wang, Xi Luo, Lijun Sun","doi":"10.3389/fpsyt.2025.1483827","DOIUrl":"10.3389/fpsyt.2025.1483827","url":null,"abstract":"<p><strong>Objective: </strong>Although research on psychological interventions in generalized anxiety disorder (GAD) has provided evidence of their effectiveness regarding self-reported outcomes, few studies have examined their psychophysiological effects. Heart rate is emerging as a potential biomarker of efficacy in anxiety disorders. This study aimed to investigate the effects of a self-compassion intervention versus a mindfulness intervention on physiological arousal in response to induced stress.</p><p><strong>Methods: </strong>Forty-seven patients with GAD had heart rate data collected during a stress task before and after a 2-week pharmacological treatment (known as treatment as usual, TAU), a self-compassion intervention + TAU or a mindfulness intervention + TAU. They also reported state anxiety, positive affect, and negative affect at pre- and post- intervention before the stress task. ANOVAs were conducted to analyze the effects on electrocardiogram data self-reported measurements.</p><p><strong>Results: </strong>Self-compassion intervention uniquely decreased heart rate response to a stressor whereas mindfulness intervention did not. Both treatments decreased state anxiety and negative affect to a stressor, while increased positive affect in this context. We also demonstrated a significant correlation between decreased heart rate response and less negative emotions.</p><p><strong>Conclusion: </strong>The Findings provides novel physiological evidence that self-compassion interventions buffer stress reactivity in individuals with GAD. Attention shall be paid to the limitations in small and unequal sample size and a non-randomized study design.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1483827"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy, complexity, and spectral features of EEG signals in autism and typical development: a quantitative approach.","authors":"Aleksandar Tenev, Silvana Markovska-Simoska, Andreas Müller, Igor Mishkovski","doi":"10.3389/fpsyt.2025.1505297","DOIUrl":"10.3389/fpsyt.2025.1505297","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects the brain's function. Electroencephalography (EEG) is a non-invasive technique that measures the electrical activity of the brain and can reveal its dynamics and information processing. This study explores an eyes-opened resting state quantitative EEG analysis of 49 children with ASD and 39 typically developing (TD or Control) children, using various features of entropy and complexity. Time and frequency domain features were applied for all EEG channels, such as the power spectra, brain rate, sample entropy, permutation entropy, spectral entropy, Tsallis entropy, Rényi entropy, Lempel-Ziv complexity, and Higuchi fractal dimension. The features were compared between the ASD and TD groups and tested for statistical significance. The results showed that the ASD group had a lower brain rate, higher Tsallis entropy and Rényi entropy, and lower Lempel-Ziv complexity than the TD group. The entropy results show impaired neural synchronization, increased randomness, and noise in ASD. The Lempel-Ziv complexity results showed that it is a potential indicator of the existence of focal spikes in the EEG signals of ASD. The brain-rate results show a low level of arousal in ASD. The findings suggest that entropy and complexity measures can be useful tools for characterizing the EEG features of ASD and provide insights into the neurophysiological mechanisms of the disorder.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1505297"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The survey of the status of self-stigma of depression and its relationship with demographic factors in Gonabad, Iran.","authors":"Hadi Tehrani, Fatemehzahra Naddafi, Mahbobeh Nejatian, Alireza Jafari","doi":"10.3389/fpsyt.2024.1544260","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1544260","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2024.1463879.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1544260"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of meaning in life, perceived social support, and depressive symptoms among vocational undergraduate students.","authors":"Sen Sen Zhang, Wen Hua Zhang, Shao Hong Yong, Jia Tai Chen","doi":"10.3389/fpsyt.2025.1510255","DOIUrl":"10.3389/fpsyt.2025.1510255","url":null,"abstract":"<p><strong>Background: </strong>Depression poses a considerable personal and public health problem, particularly in the post-epidemic era. The present study aimed to investigate the association between meaning in life (MIL) and perceived social support (PSS) with depressive symptoms among vocational undergraduate students, employing a network analysis approach to gain a deeper understanding of the underlying pathways and to prevent the progression of depressive symptoms into disorders.</p><p><strong>Methods: </strong>A total of 1367 Chinese vocational undergraduates (<i>M</i> _age = 20.1, <i>SD</i> = 1.6; 44.7% female) were recruited and were asked to complete a series of questionnaires, including the meaning in life questionnaire, perceived social support scale, and patient health questionnaire. The regularized partial correlation network was estimated. The partial correlations between nodes were calculated as edges. Moreover, network comparison tests were conducted to compare three subnetworks based on different levels of depression (minimal, subthreshold, and moderate/severe).</p><p><strong>Results: </strong>The top strength nodes within each network were identified as <i>sleep</i> and <i>motor</i> in minimal group, <i>anhedonia</i> and <i>concentration</i> in subthreshold group, and <i>anhedonia</i> and <i>sleep</i> in moderate/severe group. Additionally, the bridge strength nodes were determined as <i>MIL-3</i>, <i>MIL-4</i>, <i>sleep</i>, <i>guilt</i>, and <i>school</i> in minimal group; <i>MIL-4</i>, <i>anhedonia</i>, <i>suicide</i>, and <i>friend</i> in subthreshold group; MIL-9, <i>MIL-7</i>, <i>anhedonia</i>, <i>sleep</i>, and <i>family</i> in moderate/severe group. Furthermore, network comparison tests showed significant differences in centrality (all <i>p</i> < 0.05), while network invariance remained constant across groups. Notably, the accuracy and stability coefficients for all network structures were greater than 0.5, indicating stable and reliable results.</p><p><strong>Conclusion: </strong>These findings elucidate specific pathways and potential central nodes for interactions of MIL or PSS with depressive symptoms at different levels of depression, providing valuable insights for targeted prevention and intervention strategies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1510255"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Cerebrotendinous Xanthomatosis masquerading as adult ADHD in psychiatric practice.","authors":"Jongtae Kim, Yun Jeong Hong, Si Baek Lee, Seong Hoon Kim, Myung Ah Lee, Eunbuel Ko, Jeong Wook Park","doi":"10.3389/fpsyt.2025.1528204","DOIUrl":"10.3389/fpsyt.2025.1528204","url":null,"abstract":"<p><strong>Introduction: </strong>This case report details the presentation of a patient who initially sought consultation at a psychiatric outpatient clinic with symptoms suggestive of Attention-Deficit/Hyperactivity Disorder (ADHD); however, further evaluation revealed a diagnosis of Cerebrotendinous Xanthomatosis (CTX). CTX, a genetic disorder impacting lipid metabolism, is often overlooked in differential diagnoses due to its rarity. This case underscores the importance of considering alternative diagnoses in adults exhibiting ADHD-like symptoms without a childhood history of the disorder, adding to the literature on diagnostic complexities in psychiatric practice.</p><p><strong>Case presentation: </strong>A 33-year-old man visited a psychiatric outpatient clinic with symptoms such as increasing distractibility and inattention, requesting an evaluation for adult ADHD. However, the absence of an ADHD history in childhood, coupled with progressive neurological symptoms and tendon xanthomas, led to further investigation. Comprehensive neurological assessments, including neuroimaging and genetic testing, ultimately diagnosed him with CTX. Treatment with chenodeoxycholic acid (CDCA) resulted in stabilization of cognitive function, although improvement in gait disturbances and tremors remained minimal.</p><p><strong>Conclusion: </strong>This case demonstrates that CTX can masquerade as adult ADHD, emphasizing the necessity for thorough assessments in atypical ADHD presentations. Psychiatrists should consider rare metabolic disorders like CTX in similar cases, which may enable timely intervention and improve patient outcomes.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1528204"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}