Frontiers in Psychiatry最新文献

{"title":"Single video games improve cognitive functioning in college students: evidence from behavioral and fNIRS assessments.","authors":"Chuangtao Li, Xiaodan Guo, Jingsong Wang, Shen Wang","doi":"10.3389/fpsyt.2025.1640142","DOIUrl":"https://doi.org/10.3389/fpsyt.2025.1640142","url":null,"abstract":"<p><strong>Objective: </strong>In the digital intelligence era, video games have become highly popular among college students, with the duration of playtime escalating rapidly. There is a growing research interest in video games to improve cognitive function, and video games have shown great potential in improving cognitive function. However, most of the current studies have focused on the effects of long-term gaming experience or short-period gaming training on cognitive functioning, and it remains unknown whether a single session of video gaming is equally effective. The primary aim of this study was to evaluate the impact of a single gaming session on the cognitive functions of college students and to explore its underlying mechanisms.</p><p><strong>Methods: </strong>Forty-three college students from a university in Fuzhou City were recruited and randomly assigned to either the VG group (video game) or the nVG group (non-video game). Pre- and post-test behavioral and functional near-infrared spectroscopy (fNIRS) data were collected from the participants. The statistics were analyzed using repeated measures ANOVA, with simple effects analysis conducted if interaction effects were significant, and corrections applied using the Bonferroni method.</p><p><strong>Results: </strong>(1) Following the video game session, the VG group exhibited shorter RT (reaction times), higher ACC (accuracy), and greater RCS (response correctness scores), whereas the nVG group experienced longer RT, lower ACC, and lower RCS. (2) In the VG group, post-test concentrations of Oxy-Hb in channels 6, 9, and 29 were elevated, particularly in the bilateral orbitofrontal cortex (OFC) and left dorsolateral prefrontal cortex (DLPFC), while there was minimal change in prefrontal cortex (PFC) activation levels in the nVG group.</p><p><strong>Conclusions: </strong>Cognitively engaging video games can effectively enhance the cognitive abilities of male college students. The underlying mechanism may be closely related to the promotion of prefrontal lobe activation by video games, which in turn improves reflective ability, processing speed, and decision-making levels.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1640142"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Community series in mental-health-related stigma and discrimination: prevention, role, and management strategies, volume III.","authors":"Renato de Filippis, Samer El Hayek, Mohammadreza Shalbafan","doi":"10.3389/fpsyt.2025.1704050","DOIUrl":"10.3389/fpsyt.2025.1704050","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1704050"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depression symptoms and cognitive frailty in chronic kidney disease patients: a cross-sectional study.","authors":"Peng Zhang, Aiqing Fan, Nian Xie, Jing Jiang, Shuzhi Peng","doi":"10.3389/fpsyt.2025.1648424","DOIUrl":"10.3389/fpsyt.2025.1648424","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive frailty (CF) and depressive symptoms are prevalent in patients with chronic kidney disease (CKD) and may synergistically exacerbate adverse health outcomes. This study examined their association to inform early intervention strategies.</p><p><strong>Methods: </strong>Demographic and clinical data were collected from CKD patients across three hospitals in Shanghai. Depressive symptoms and CF status were assessed via standardized questionnaires. A logistic regression model and restricted cubic spline (RCS) analysis were employed to evaluate the association between depressive symptoms and CF.</p><p><strong>Results: </strong>CF was diagnosed using the Frailty Phenotype (FP), Montreal Cognitive Assessment (MoCA), and Clinical Dementia Rating (CDR). Among 800 participants, 317 exhibited CF (prevalence: 39.6%). The adjusted logistic regression model revealed a significant positive association between Center for Epidemiologic Studies Depression (CES-D) scores and CF (OR=1.124, 95% <i>CI</i>: 1.094-1.15<i>6, p</i><0.001). RCS analysis demonstrated a nonlinear dose-response relationship: CF prevalence increased with rising CES-D scores until plateauing at a score of 9. The odds ratio (OR) exceeded the statistical significance threshold when CES-D scores reached 12. Subgroup analyses consistently supported this dose-response pattern.</p><p><strong>Conclusion: </strong>Depressive symptoms are significantly associated with CF in CKD patients. Routine CES-D screening and provision of psychological support for patients scoring ≥12 may mitigate CF risk.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1648424"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music-based interventions in the treatment of eating disorders: a scoping review.","authors":"Annie Heiderscheit, Julia Gawronska, Jodie Bloska, Anya Ragnhildstveit, Thandi Milton, Sharon A S Neufeld","doi":"10.3389/fpsyt.2025.1660696","DOIUrl":"10.3389/fpsyt.2025.1660696","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Eating disorders (EDs) are potentially life-threatening conditions characterized by persistent eating- and body-related disturbances that negatively impact nutritional intake, psychological well-being, and physical health. While psychological therapies remain the primary treatment for patients with EDs, music-based interventions (MBIs) show significant promise for addressing symptoms in clinical practice. However, little is known about the methods employed in these interventions or their effectiveness in addressing or improving ED outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Following PRISMA-ScR guidelines, we conducted a scoping review of the literature. Eight electronic databases were systematically queried from inception to May 2025 for studies evaluating MBIs in patients engaged in ED treatment. Data regarding study design, sample characteristics, intervention components, and primary outcomes were extracted and analysed utilising either reflexive thematic analysis or descriptive statistics. The quality of intervention reporting was additionally examined utilising the established MBI reporting guidelines.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 114 articles screened, 21 met inclusion criteria. The final sample comprised 10 case studies, 6 qualitative studies, 4 quantitative studies, and 1 mixed methods study, with all but one conducted in high-income countries. Settings included inpatient (&lt;i&gt;n&lt;/i&gt; = 12), outpatient (&lt;i&gt;n&lt;/i&gt; = 7), and combined (&lt;i&gt;n&lt;/i&gt; = 2) ED programs. Most MBIs involved music therapy (&lt;i&gt;n&lt;/i&gt; = 18), while others incorporated vibroacoustic therapy (&lt;i&gt;n&lt;/i&gt; = 1), background music during mealtimes (&lt;i&gt;n&lt;/i&gt; = 1), and group singing (&lt;i&gt;n&lt;/i&gt; = 1). Delivery formats encompassed individual (&lt;i&gt;n&lt;/i&gt; = 14), group (&lt;i&gt;n&lt;/i&gt; = 5), and hybrid (&lt;i&gt;n&lt;/i&gt; = 1) sessions, or were not indicated. Qualitative synthesis identified seven themes reflecting symptom management, self-development, and treatment engagement. Quantitative studies reported improvements in anxiety, mood, ED symptoms and increased food eaten and weight gain. However, robust conclusions were limited by small sample sizes, a lack of control group, non-randomisation, or another intervention being implemented with the MBI. Overall, reporting of MBI components was inconsistent, with a mean completeness of 45-100%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;To our knowledge, this is the largest scoping review to map the breadth and depth of studies assessing MBIs in ED treatment. Preliminary evidence supports positive psychological and behavioural outcomes for patients with EDs. However, conclusions are limited by lack of methodological rigor, variable outcome measures, and inconsistent reporting of intervention components or theoretical framework. The complex and multifaceted nature of EDs and high rates of comorbidities and trauma histories further complicates interpretations. To advance research and clinical application of MBIs in ED care, standardiz","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1660696"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Chinese Version of the Frequency, Intensity, and Burden of Side Effects Rating.","authors":"Jie Zhao, Junyu Ji, Aiai Cao, Jing Ni, Tongdan Cao","doi":"10.3389/fpsyt.2025.1613331","DOIUrl":"10.3389/fpsyt.2025.1613331","url":null,"abstract":"<p><strong>Background: </strong>The Frequency, Intensity, and Burden of Side Effects Rating (FIBSER) Scale is a brief tool developed to assess side effects in patients with major depressive disorder (MDD). This study aims to evaluate the reliability and validity of the Chinese version of the FIBSER in Chinese patients with MDD.</p><p><strong>Methods: </strong>A total of 162 MDD patients were enrolled to assess the Chinese version of FIBSER, the self-report version of the Quick Inventory of Depressive Symptoms (QIDS-SR16), and the Rating Scale for Side Effects (SERS). Reliability and validity were evaluated using Cronbach's α coefficient, test-retest reliability, Spearman correlation analysis, and Principal component analysis.</p><p><strong>Results: </strong>The Cronbach's α coefficient for the Chinese version of the FIBSER was 0.945. The test-retest reliability coefficients for the three domains were 0.799, 0.821, and 0.897, respectively. The correlation coefficients between FIBSER and SERS ranged from 0.765 to 0.817. The correlation coefficients with QIDS-SR16 ranged from 0.187 to 0.270. Principal component analysis found one significant principal component, highlighting the prominence of side effect frequency as a factor. The Composite Reliability and Average Variance Extracted values in the confirmatory factor analysis showed excellent convergent validity.</p><p><strong>Conclusions: </strong>The study suggests that the Chinese version of the FIBSER tool exhibits good reliability and validity in patients with MDD. It is suitable for the rapid clinical assessment of side effects in patients receiving antidepressant treatment.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1613331"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of the Japanese Edinburgh Postnatal Depression Scale for screening postpartum anxiety.","authors":"Ekachaeryanti Zain, Yuichiro Watanabe, Shinpei Takabayashi, Leakhena Por, Saori Fujita, Sachie Moriyama, Aiko Honma, Naoki Fukui, Shuken Boku","doi":"10.3389/fpsyt.2025.1659497","DOIUrl":"10.3389/fpsyt.2025.1659497","url":null,"abstract":"<p><strong>Background: </strong>Despite the acknowledged importance of addressing postpartum anxiety alongside postpartum depression, standardized screening tools specifically developed for this purpose remain limited.</p><p><strong>Objective: </strong>This study aimed to validate the anxiety factor of the Edinburgh Postnatal Depression Scale (EPDS) and to determine optimal cutoff scores for screening postpartum anxiety.</p><p><strong>Methods: </strong>EPDS and the State-Trait Anxiety Inventory (STAI) were collected from 100 Japanese women at one month postpartum at Niigata University Medical and Dental Hospital between May 18, 2021, and December 28, 2022, using random convenience and purposive sampling. Confirmatory factor analysis (CFA) was conducted on data from 84 participants to test six previously proposed EPDS factor models, and receiver operating characteristic (ROC) analysis was performed on data from 83 participants to determine area under the curve (AUC) values and cutoff scores. The EPDS anxiety subscales with three items (EPDS-3A) and four items (EPDS-4A) were separately evaluated as predictor variables, with STAI state and trait anxiety as criterion measures. We assessed accuracy, sensitivity, and specificity.</p><p><strong>Results: </strong>All models with two-factor and three-factor showed a good fit to the data, with two models with EPDS-3A being superior among other models (comparative fit index = 1.000, root mean square error of approximation = 0.001). ROC analyses indicated good testing accuracy of the EPDS anxiety subscales for detecting both state and trait anxiety. For EPDS-3A, the AUCs were 0.832 (95% CI 0.735-0.930) for state anxiety with an optimal cutoff of ≥3 (sensitivity 79.2%, specificity 79.7%), and 0.912 (95% CI 0.837-0.988) for trait anxiety with an optimal cutoff of ≥4 (sensitivity 82.4%, specificity 84.8%). For EPDS-4A, the AUCs were 0.833 (95% CI 0.736-0.930) for state anxiety with an optimal cutoff of ≥4 (sensitivity 79.2%, specificity 71.2%), and 0.935 (95% CI 0.867-1.000) for trait anxiety with an optimal cutoff of ≥5 (sensitivity 88.2%, specificity 87.9%).</p><p><strong>Conclusion: </strong>Both the EPDS-3A and EPDS-4A demonstrated good model fit and screening accuracy for anxiety at one month postpartum. Integrating anxiety screening into routine postpartum care may improve maternal mental health outcomes. Future studies involving clinical settings and larger cohort studies are recommended to improve external validity.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1659497"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between mindful self-care and maternal-fetal attachment in pregnant women: the parallel mediating effects of positive and negative affect.","authors":"Lika Xu, Xueyi Sun, Yifan Liu, Yujie Chen, Caiyun Wang, Ting Li, Hanjiao Liu, Junfan Wei, Meng Li","doi":"10.3389/fpsyt.2025.1672476","DOIUrl":"10.3389/fpsyt.2025.1672476","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between mindful self-care and maternal-fetal attachment (MFA) and parallel mediating effects of positive and negative affect among pregnant women.</p><p><strong>Methods: </strong>A cross-sectional survey using convenience sampling from June 2025 to July 2025 in six tertiary hospitals in Henan and Guangdong province. A total of 351 pregnant women were recruited and a questionnaire including socio-demographic characteristics, positive and negative affect scale and maternal antenatal attachment scale was used. Descriptive statistics, t-tests, one-way ANOVA, Harman's single-factor test, Pearson correlation analysis, and parallel mediation analysis were conducted.</p><p><strong>Results: </strong>Correlation analysis showed that mindful self-care, positive affect, negative affect and MFA were all significantly correlated with each other, respectively. Once positive affect and negative affect were included as mediators, the direct effect of mindful self-care on MFA was no longer significant, suggesting that positive affect and negative affect fully mediated the relationship between mindful self-care and MFA.</p><p><strong>Conclusion: </strong>Positive and negative affect play parallel mediating roles in the relationship between mindful self-care and MFA, emphasizing the critical role of emotion regulation in developing prenatal MFA and underscore the important value of mindful self-care as a psychological resource during pregnancy, which provides new perspectives for future theoretical models and intervention designs.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1672476"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of smartphone addiction and its related risk factors among Palestinian high school students: a cross-sectional study.","authors":"Muna Ahmead, Etaf Maqboul, Eman Alshawish, Mohammad Dweib","doi":"10.3389/fpsyt.2025.1636080","DOIUrl":"10.3389/fpsyt.2025.1636080","url":null,"abstract":"<p><strong>Background: </strong>Smartphone addiction is a significant social and health problem. There is limited research on smartphone addiction in Palestine. The current study aimed to assess the prevalence of smartphone addiction and its association with sociodemographic variables, depression, anxiety, and social support among 12th grade students.</p><p><strong>Methods: </strong>The study utilized a cross-sectional research design. A self-reported questionnaire, including the Smartphone Addiction Scale (SPAS), the OSLO Social Support Scale, and the Hospital Anxiety and Depression Scale (HADS), was used to gather data.</p><p><strong>Results: </strong>A total of 1,083 participants were recruited, of whom 27.3% had depression, 50.5% had anxiety, 57.3% experienced smartphone addiction, and 17.6% had strong social support. The study found that students with weak or moderate teacher relationships (AOR: 2.854, p < 0.001), disrupted sleep with smartphones (AOR: 2.143, p < 0.001), negative impact of smartphone usage on studies (AOR: 3.016, p < 0.001), and poor or weak social support (AOR: 3.051, p < 0.001) were at risk of smartphone addiction. Participants who reported no impact on their sleep time (AOR: 0.478, p-value = 0.001), used smartphones for less than 2 hours daily (AOR: 0.347, p < 0.001), and used smartphones for 2 to 3 hours daily (AOR: 0.684, p = 0.037) were less likely to develop smartphone addiction.</p><p><strong>Conclusion: </strong>Smartphone addiction was prevalent in high school students in this study. Weak teacher relationships, sleep disturbances, negative academic effects, and insufficient social support may lead to smartphone addiction. Programs that educate students, parents, and educators on smartphone addiction can prevent it and help detect and manage smartphone use problems.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1636080"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baduanjin as an innovative intervention for mood disorders: evaluating efficacy and mechanisms.","authors":"Jiping Chen, Yanyu Lu","doi":"10.3389/fpsyt.2025.1647619","DOIUrl":"10.3389/fpsyt.2025.1647619","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1647619"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and trends of drug use disorders in young adults: global insights from GBD 2021.","authors":"Xin Su, Teng Fan, Qi Quan, Jun Kan, Zeyu Liu, Bei Zhang, Yuanyuan Huang","doi":"10.3389/fpsyt.2025.1503564","DOIUrl":"10.3389/fpsyt.2025.1503564","url":null,"abstract":"<p><strong>Background: </strong>Drug use disorders (DUDs) is a serious global health crisis, particularly affecting adolescents and young people. The increasing prevalence of DUDs has led to the development of chronic diseases, including cancer, although it has significant impacts on health and life, it is often overlooked in research.</p><p><strong>Method: </strong>This study utilized GBD 2021 data to assess the burden of four drug use disorders in the young adult population. The data, covering 1991 to 2021, included metrics such as age-sex-year incidence, prevalence, deaths, and disability-adjusted life years (DALYs). Age-standardized rates were used for comparing burden across years and regions, and joinpoint analysis evaluated trends. The Bayesian Age-Period-Cohort model was employed to project future burden. The study also examined the relationship between DUDs burden and socio-economic conditions using the Social Development Index (SDI) and stratified data by WHO regions. Additionally, population attributable fractions were calculated within the GBD comparative risk assessment framework.</p><p><strong>Results: </strong>Cannabis use disorder (CUDs) emerged as the most prevalent, the ASPR was 617.22/100,000 in 2021. The highest age-standardized mortality rates (ASMR) and age-standardized DALYs rates (ASDR) was observed in OUDs, at (1.46 [1.37-1.55]) and (236.61[185.21-292.47]), respectively. The region of the Americas accounted for the largest proportion of this burden. Opioid use disorders (OUDs) exhibited a notable rising trend, with the age-standardized prevalence rate (ASPR) of 359.62/100,000 in 2021, with a concentration primarily in the European region and the region of the Americas. Male had a higher burden of DUDs than female in the young adults. The burden of DUDs was mainly concentrated under the age of 25, especially CUDs and OUDs. The ASMR and ASDR of DUDs also showed significant growth trends in high SDI areas. Drug use's contribution to cancer risk, particularly liver cancer due to hepatitis C virus (HCV), had been progressively increasing.</p><p><strong>Conclusions: </strong>The burden of OUDs and CUDs, continued to escalate annually, especially among young adult males who face heightened risks. Notably, drug use is increasingly contributing to liver cancer mortality and DALYs, emphasizing the urgency of interventions. This study provides evidence for evaluating the burden transfer between different demographic data.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1503564"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}