Frontiers in Psychiatry最新文献

{"title":"Referrals for suicidality to a UK child and adolescent mental health service: an evaluation of the policy and practice context of response to suicidal young people.","authors":"Fhionna Moore, Iolanda Salonia, Ayesha Ali, Alissa Mann, Lynne Gilmour","doi":"10.3389/fpsyt.2026.1863579","DOIUrl":"10.3389/fpsyt.2026.1863579","url":null,"abstract":"<p><strong>Aims and method: </strong>We reviewed referrals mentioning suicidality to a Scottish CAMHS. The referrals were from January to June 2019 and 2022. We recorded the referral reason and outcome and compared these to the National CAMHS Service Specification (2020).</p><p><strong>Results: </strong>Of 2,753 referrals, 560 (20.34%) mentioned suicidality. Of these, 82.4% were accepted. The majority of those rejected were from outside the region, already in the CAMHS, or provided insufficient information. The majority did not include any risk assessment (43.6%) or safety planning (67.7%). We identified lack of clarity in the National CAMHS Service Specification around the requirement for evidence of a serious mental illness and the meaning of \"suicidal behaviours\".</p><p><strong>Clinical implications: </strong>We require clearer language concerning \"rejected referrals\", better communication between the CAMHS and referrers, improved pathways for referral re-direction, and support for referrers to assess risk and safety plan. We require clarity in national guidelines over where suicidal young people should be supported.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1863579"},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The developmental dopamine trajectory hypothesis of ADHD across the lifespan.","authors":"Raly James Perez Custodio, Stephan Getzmann, Edmund Wascher, Michael C Pan, Florence Ingred Samante, Fred Lawrence Samante, Bung-Nyun Kim, Hee Jin Kim, Eugene C Yi, Jae Hoon Cheong","doi":"10.3389/fpsyt.2026.1944446","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1944446","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) is increasingly recognized as a lifespan neurodevelopmental disorder, yet the mechanisms underlying its changing clinical presentation across development remain poorly understood. Although childhood ADHD is typically characterized by hyperactivity, impulsivity, and inattention, symptom expression frequently evolves during adolescence and adulthood toward greater reward dysregulation, executive dysfunction, motivational impairment, internal restlessness, and changing manifestations of emotional dysregulation. Existing neurobiological models have substantially advanced understanding of ADHD pathophysiology but provide limited explanation for how symptom continuity can coexist with developmental changes in clinical expression. Here, we propose the Developmental Dopamine Trajectory Hypothesis, which posits that DAT related dopaminergic dysregulation may interact with the sequential maturation of frontostriatal, mesolimbic, and mesocortical circuits to contribute to developmental changes in ADHD symptom expression across the lifespan. A central proposition of the framework is that the functional consequences of DAT related dopaminergic dysregulation depend on the developmental state of the neural circuits on which it acts. Within this framework, childhood manifestations may arise primarily from interactions between dopaminergic vulnerability and developing frontostriatal networks, adolescent manifestations from increasing involvement of reward and emotion related circuitry, and adult manifestations from interactions with mature executive control and motivational systems. By integrating evidence from longitudinal clinical studies, neuroimaging, electrophysiology, pharmacology, genetics, and translational DAT models, the proposed framework provides a mechanistic model for how developmental changes in neural circuit state may contribute to changing symptom expression despite continuity of underlying neurobiological vulnerability. The hypothesis generates testable predictions regarding longitudinal symptom trajectories, developmental biomarker changes, potential developmental differences in treatment responsiveness, and adolescence as a proposed critical neurodevelopmental transition period. Reconceptualizing ADHD through a developmental dopaminergic framework places developmental timing and neural circuit maturation at the center of the relationship between dopaminergic vulnerability and clinical phenotype, providing a basis for future longitudinal, mechanistic, and developmentally informed research across the lifespan.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1944446"},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13684815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compulsive sexual behavior disorder and paraphilic disorders in a large Brazilian community sample: an online investigation.","authors":"Gustavo Cambraia Do Canto, João Guilherme Almeida Jordani, Nino Cesar Marchi, Daniel Ingrisani Branco, Thiago Henrique Roza, Karine Schwarz, Klaus Michael Beier, Beáta Bőthe, Maria Inês Rodrigues Lobato","doi":"10.3389/fpsyt.2026.1807692","DOIUrl":"10.3389/fpsyt.2026.1807692","url":null,"abstract":"<p><strong>Background: </strong>The International Classification of Diseases 11th Revision (ICD-11) includes Compulsive Sexual Behavior Disorder (CSBD) among impulse control disorders, aiming to standardize diagnostic criteria and improve the understanding of problematic sexual behaviors across cultures. However, few large-scale studies have investigated CSBD and its association with Paraphilic Disorders (PD) in Latin American populations.</p><p><strong>Objective: </strong>To investigate the occurrence of high-risk CSBD in a large Brazilian community sample, examine its association with paraphilic interests and disorders, and evaluate associated sociodemographic and clinical factors.</p><p><strong>Methods: </strong>This cross-sectional online study included 5,227 Brazilian adults recruited through convenience sampling between September 2022 and April 2023. Participants completed sociodemographic questionnaires, a Brazilian Portuguese version of the CSBD-19, and a translated inventory assessing paraphilic interests and disorders based on DSM-5-TR criteria. Descriptive statistics, chi-squared tests, linear discriminant analysis, and multivariate backward stepwise logistic regression were performed.</p><p><strong>Results: </strong>The prevalence of high-risk CSBD (CSBD-19 > 50) was 5.4% (n = 282). The mean CSBD-19 score was 30.4 (SD = 9.7), increasing to 56.4 (SD = 6.1) among individuals classified as high risk. Male sex was strongly associated with high-risk CSBD (OR = 3.32, 95%CI: 2.45-4.50, p < 0.001). Significant associations were also identified for sexual sadism disorder (OR = 2.69, 95%CI: 1.79-4.07), paraphilic disorder involving specific body characteristics (OR = 2.46, 95%CI: 1.49-4.04), zoophilic interest (OR = 2.39, 95%CI: 1.70-3.37), partialism disorder (OR = 2.00, 95%CI: 1.17-3.42), and paraphilia-related distress (OR = 1.94, 95%CI: 1.44-2.61). Linear discriminant analysis demonstrated that the Negative Consequences domain showed the strongest discriminative contribution for high-risk CSBD classification (ω = 1.23).</p><p><strong>Conclusions: </strong>This study contributes to more inclusive research on compulsive sexual behavior disorder (CSBD) by investigating a large Brazilian sample, including individuals with diverse sexual orientations and gender identities. Using the ICD-11 framework, the estimated prevalence of high-risk CSBD was 5.4%, a rate comparable to those reported for other common mental health conditions. The study also supports the psychometric applicability of the Brazilian Portuguese version of the CSBD-19 for future epidemiological and cross-cultural research in Latin American populations. Further longitudinal and nationally representative studies are needed to clarify causal pathways, psychiatric comorbidities, minority stress influences, and the neurobiological and psychosocial mechanisms underlying the relationship between CSBD and paraphilic disorders.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1807692"},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of naltrexone-accelerated versus sublingual buprenorphine in opioid withdrawal management and initiating injectable naltrexone treatment: study protocol for a randomized controlled trial.","authors":"Saeede Jafari, Afarin Rahimi-Movaghar, Alireza Noroozi, Pooneh Malekifar, Akbar Fotouhi","doi":"10.3389/fpsyt.2026.1933443","DOIUrl":"10.3389/fpsyt.2026.1933443","url":null,"abstract":"<p><strong>Background: </strong>Extended-release injectable naltrexone (XR-NTX), a long-acting opioid antagonist, is an effective relapse prevention strategy in the treatment of opioid use disorder (OUD). However, standard XR-NTX initiation requires completion of opioid withdrawal management and a 1-2 week opioid-free period. This interval is associated with heightened vulnerability to lapse and relapse, and many patients fail to initiate XR-NTX treatment successfully. Therefore, alternative strategies that enable rapid XR-NTX initiation are needed. This study aimed to compare the effectiveness and safety of naltrexone-accelerated (NA) versus sublingual buprenorphine (SB) withdrawal management in facilitating XR-NTX initiation among patients with OUD.</p><p><strong>Methods: </strong>This single-center, open-label, randomized controlled trial uses a parallel-group design. Eligible patients aged 18-60 years with moderate to severe OUD who are actively using opioids and are not receiving regular maintenance treatment with methadone or buprenorphine are randomly assigned to one of two groups: (1) NA withdrawal management, comprising one day of adjunctive non-opioid medications, one day of buprenorphine administration, one day of washout, and four days of gradual oral naltrexone titration (1, 3, 12, and 25 mg/day); or (2) SB withdrawal management, comprising one day of adjunctive non-opioid medications, six days of buprenorphine tapering (up to 8 mg on Day 2, 6 mg on Day 3, 4 mg on Days 4-5, 2 mg on Day 6, and 1 mg on Day 7), and a seven-day washout period. Adjunctive non-opioid medications in both groups comprised clonidine, clonazepam, gabapentin, and trazodone. The primary outcomes are the proportions of participants who (1) achieve a negative urine drug test for the assessed opioids and (2) receive XR-NTX at the end of the withdrawal management period. Secondary outcomes include severity of withdrawal symptoms, opioid craving intensity, and adverse effects. All analyses are conducted according to the intention-to-treat principle.</p><p><strong>Discussion: </strong>The findings of this trial may provide clinically relevant evidence to support rapid initiation of XR-NTX treatment in patients with OUD and inform clinical practice.</p><p><strong>Clinical trial registration: </strong>https://en.irct.ir/trial/81525, Iranian Registry of Clinical Trials IRCT20250123064499N1.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1933443"},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy.","authors":"Jinlong Chao, Rui Yang, Hong Peng, Jian Shi, Qiuxia Shi","doi":"10.3389/fpsyt.2026.1907020","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1907020","url":null,"abstract":"<p><p>Major Depressive Disorder (MDD) remains one of the most prevalent psychiatric conditions worldwide, with a marked increase in incidence and severity following the COVID-19 pandemic. Despite its rising burden, clinical diagnosis continues to rely on subjective assessments, lacking objective and reproducible neurobiological markers. Functional Near-Infrared Spectroscopy (fNIRS) has emerged as a promising non-invasive imaging technique capable of capturing the spatiotemporal dynamics of cerebral hemodynamics, particularly within the prefrontal cortex-a key region involved in emotional regulation and cognitive control. In this study, we propose a spatiotemporal feature-based framework for MDD classification and emotion-related brain state recognition. Thirty MDD patients and thirty demographically matched healthy controls underwent fNIRS recording while exposed to emotional auditory stimuli. By analyzing group-level differences in oxyhemoglobin concentrations and <i>β</i>_values derived from a general linear model (GLM), we identified significant prefrontal abnormalities in the MDD group, particularly under negative emotional conditions. These alterations were most prominent in the dorsolateral prefrontal cortex (DLPFC), a region consistently implicated in emotion dysregulation. The classification model, based on fNIRS-derived activation features, achieved 90% accuracy for MDD detection and 85% for emotion recognition. These results demonstrate that integrating spatial and temporal features improves sensitivity to depression-related cortical dysfunction, offering a potential objective biomarker for diagnosis and novel insight into emotion-specific neurocircuitry in MDD. This work supports the clinical feasibility of fNIRS-based biomarkers and advances understanding of affective brain processing in depression.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1907020"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical factors predicting tic persistence into adulthood.","authors":"Ariadne Kaylor, Joshua A Senior, Evan Realbuto, Jenna LaRochelle, Dongmei Yu, Daisy T Noriega-Makarskyy, Angela Essa, Carol A Mathews, Jeremiah M Scharf","doi":"10.3389/fpsyt.2026.1948693","DOIUrl":"10.3389/fpsyt.2026.1948693","url":null,"abstract":"<p><strong>Background: </strong>Despite widespread patient and family interest in long-term outcome prediction at the time of Tourette syndrome (TS) diagnosis, there is limited data on factors associated with disease severity and impairment in adulthood. This study aimed to examine the relationship between childhood and adulthood worst-ever tics and identify predictors of adulthood tic severity and impairment, including the role of significant life events.</p><p><strong>Methods: </strong>In a cross-sectional design, 258 adult participants with TS completed an online questionnaire assessing tic severity and impairment during their worst-ever tic periods in childhood and adulthood, co-occurring obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) symptoms and clinical and demographic characteristics.</p><p><strong>Results: </strong>Worst-ever childhood tic severity and impairment were significantly associated with greater worst-ever adulthood tic severity and impairment. Co-occurring OCD was also associated with greater tic severity and impairment in adulthood. Use of tic medication was a significant predictor of greater worst-ever adulthood tic impairment, but not severity. Overall, 153 (59.3%) participants reported experiencing a significant life event at the time of their worst-ever tics in adulthood, and the presence of a significant life event was associated with greater worst-ever adulthood tic impairment. There was a significant effect of negative and neutral life events, but not positive life events, on adult worst-ever tic severity and impairment, compared to those not reporting a significant life event.</p><p><strong>Discussion: </strong>These findings provide insight into characteristics present either in childhood or in adulthood that may help predict the presence and severity of tic symptoms in adulthood.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1948693"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking networks through relatedness - a qualitative study among inpatients in forensic psychiatry.","authors":"Berit Kjærside Nielsen, Lisbeth Uhrskov Sørensen, Caroline Trillingsgaard Mejdahl, Jette Møllerhøj, Morten Deleuran Terkildsen","doi":"10.3389/fpsyt.2026.1870584","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1870584","url":null,"abstract":"<p><strong>Background: </strong>Recovery-oriented approaches in forensic psychiatry increasingly emphasize the importance of social relationships. However, research and practice have primarily approached significant relationships through a family-caregiver lens leaving less knowledge about the broader range of relationships that may be meaningful to patients. Drawing on the concept of relatedness, this study explores how forensic psychiatric inpatients understand and negotiate their networks of significant relations during long-term admission.</p><p><strong>Methods: </strong>A qualitative study was conducted in two medium secure forensic psychiatric units in Denmark. Twenty-four inpatients participated in semi-structured interviews supported by sociograms, which enabled participants to map and reflect on their social networks. Data were analyzed using a combination of descriptive analysis of sociograms and reflexive thematic analysis of interview transcripts.</p><p><strong>Results: </strong>Participants described their networks as fluid and context-dependent, encompassing not only biological relatives but also peers, former partners, professionals, and symbolically or digitally mediated relations. Three overarching themes were identified: (1) temporal trajectories, highlighting how relationships were shaped by past ruptures, present functions, and future hopes; (2) forms of relational presence, including emotional and symbolic connections as well as ambivalence; and (3) relational dynamics and agency, reflecting how participants actively maintained, redefined, or distanced themselves from relationships under institutional constraints. Relationships were characterized by both significance and fragility, with participants navigating tensions between connection, burden, and self-preservation.</p><p><strong>Conclusions: </strong>The findings challenge narrow conceptions of informal caregiving in forensic psychiatry by demonstrating that patients' significant networks extend beyond family-based models. Adopting a relatedness perspective highlights the need for clinical practices that recognize diverse and patient-defined relationships, including symbolic and context-specific forms of connection. Tailoring involvement strategies to patients' own relational priorities, while remaining attentive to ambivalence and potential burden, may support more nuanced and person-centered approaches to recovery in forensic psychiatric care.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1870584"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fight, flight, freeze, fawn: mapping emergency department staff stress responses to workplace violence - a mixed-methods study.","authors":"Jennifer Davids, Greg de Moore, Martin Brown, Margaret Murphy","doi":"10.3389/fpsyt.2026.1952758","DOIUrl":"10.3389/fpsyt.2026.1952758","url":null,"abstract":"<p><strong>Background: </strong>Workplace violence and aggression are escalating in emergency departments (EDs) globally, yet the self-reported psychological and behavioural responses in clinicians to such stressors remain underexplored. Trauma theory conceptualises stress responses as fight, flight, freeze, and fawn (4Fs); but how these responses manifest in ED staff before, during and after violent incidents has received limited empirical attention.</p><p><strong>Methods: </strong>This mixed-methods study analysed data collected between 2019 and 2023 across four emergency departments within one Australian local health district. Data sources included semi-structured interviews (2019; n = 20), focus groups (2021; n = 30 participants), a cross-sectional survey (2023; n = 61), and follow-up interviews (2023; n = 12). Qualitative data were analysed using Braun and Clarke's six-phase thematic analysis, applying a deductive framework informed by the 4Fs. Quantitative survey data were integrated to examine the distribution of stress responses across reported incidents.</p><p><strong>Results: </strong>Across all data sources, 123 ED staff described 145 coded instances of the 4F stress responses: fight (n=94); flight (n=24), freeze (n=15), and fawn (n=12). Four overarching themes that underpinned these responses were identified: 1) Moral and emotional impact on clinicians, 2) Safety systems interface, 3) Organisational constraints and environment and 4) Patient Complexity. Participants described sustained hyperarousal, anticipatory vigilance, moral distress, emotional withdrawal, and appeasement behaviours arising from repeated exposure to violence. While Code Black responses were viewed as a structured and effective \"organised fight\" mechanism, this was compromised by inconsistent training, role ambiguity, and limited post-incident support which contributed to burnout, disengagement, and workforce attrition.</p><p><strong>Conclusion: </strong>Emergency department clinicians operate in persistently threatening environments that drive recurrent activation of fight, flight, freeze, and fawn responses with cumulative individual and system-level consequences. Behavioural emergencies warrant the same level of preparation, standardisation, and organisational support as other high-risk clinical events, such as a Code Blue - a life-threatening medical event with a responding Medical Emergency Team. Trauma-informed education team-based training, and embedded post-incident support are critical to safeguarding staff wellbeing and sustaining the ED workforce.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1952758"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between affective temperaments and thalamic nuclei volumes.","authors":"Hirofumi Hirakawa, Hina Kohno, Masaaki Muronaga, Toshihiko Izumi, Takuya Ogawa, Yudai Nagano, Takahiro Abeyama, Kentaro Kohno","doi":"10.3389/fpsyt.2026.1947058","DOIUrl":"https://doi.org/10.3389/fpsyt.2026.1947058","url":null,"abstract":"<p><strong>Introduction: </strong>Affective temperaments are stable, biologically based traits that may represent subclinical manifestations or premorbid phenotypes of mood disorders. The thalamus is increasingly recognized as an active component of distributed neural networks involved in cognition, emotion, and behavioral regulation. We focused on the thalamus and conducted an exploratory analysis of the associations between affective temperaments and the volumes of thalamic nuclei in healthy participants.</p><p><strong>Method: </strong>This study included 43 healthy right-handed participants. Affective temperament was assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire. T1-weighted structural magnetic resonance imaging data were acquired using a 3T scanner and processed with FreeSurfer version 7.1.1 to obtain the estimated total intracranial volume (eTIV) and the volumes of 52 thalamic regions, comprising 25 bilateral thalamic nuclei and the bilateral whole thalamus. The primary analyses were partial Spearman correlations adjusted for age, sex, and eTIV. Given that 52 thalamic regions and five affective temperaments were examined, Bonferroni correction was applied to control the family-wise error rate for multiple comparisons. Statistical significance was defined as a Bonferroni-corrected threshold of P < 0.00019 (0.05/[52 × 5]). Additional analyses adjusted for age, sex, and ipsilateral whole thalamus volume were performed as sensitivity analyses.</p><p><strong>Results: </strong>In the primary analysis, higher cyclothymic temperament scores were significantly associated with smaller left paratenial nucleus (Pt) volume (partial ρ = -0.57, P = 0.00015, 95% CI [-0.72, -0.36]). In the sensitivity analysis adjusting for age, sex, and left whole thalamus volume, the association was attenuated (partial ρ = -0.42, P = 0.007, 95% CI [-0.62, -0.17]) and did not meet the Bonferroni-corrected significance threshold. None of the other affective temperaments were significantly associated with left Pt volume. Several other associations of comparable magnitude were observed, but none met the corrected threshold.</p><p><strong>Discussion: </strong>Higher cyclothymic temperament scores were associated with smaller left Pt volume in the primary analysis. However, the association only narrowly met the corrected significance threshold and was attenuated in the sensitivity analysis. Thus, its regional specificity and statistical robustness remain uncertain, and replication in larger independent samples is warranted.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1947058"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Case Report: The intersection of psychiatry and medicine: diagnostic and ethical insights from case studies.","authors":"Francesco Monaco, Annarita Vignapiano, Martina D'Angelo, Fabiola Raffone, Valeria Di Stefano, Antonella Boccia, Anna Longobardi, Benedetta Di Gruttola, Michele Fornaro, Giulio Corrivetti, Iolanda Martino, Luca Steardo, Luca Steardo","doi":"10.3389/fpsyt.2026.1992650","DOIUrl":"10.3389/fpsyt.2026.1992650","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fpsyt.2025.1576179.].</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1992650"},"PeriodicalIF":3.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}