Frontiers in Psychiatry最新文献

{"title":"Prevalence and determinants of suicidal ideation among South African Health Sciences students at the onset of the COVID-19 pandemic.","authors":"Samhaa Seedat, Muhle Sengwayo, Salma Gani, Lesedi Mashego, Jordan Ochayon, Ashleigh Shepard, Caleb Vergie, Mxolisi Masango, Lerato P Makuapane, Fezile Wagner, Ryan G Wagner","doi":"10.3389/fpsyt.2025.1492620","DOIUrl":"10.3389/fpsyt.2025.1492620","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation is an important mental health concern amongst university students who are exposed to multiple stressors. Furthermore, those studying towards degrees in the field of Health Sciences are exposed to additional and unique stressors. This quantitative cross-sectional study aimed to define the prevalence of suicidal ideation and its determinants amongst undergraduate students within the Faculty of Health Sciences at a large, urban South African University.</p><p><strong>Materials and methods: </strong>An online questionnaire was administered to the 4089 students registered in the Faculty of Health Sciences, with 1211 students submitting responses between March and April 2020. The distribution of this survey coincided with the onset of the national lockdown due to the Covid-19 pandemic. The survey was comprised of validated tools measuring depression (with an included indicator of suicidal ideation), anxiety and resilience. Data analysis was completed using the STATA statistical software (version 14). Both a bivariate analysis and a multivariate logistic regression adjusted for gender were performed.</p><p><strong>Results: </strong>The total prevalence of suicidal ideation adjusted for gender and race in this sample was found to be 21.8% (CI: 18.6-25.3; p<0.001). Females had significantly higher suicidal ideation than males (24.1% versus 17.8%; p=0.011). In the multivariate model adjusted for gender, having depressive (aOR 10.8; CI: 7.9-14.8; p<0.001) or anxiety (aOR 5.1: CI: 3.8-6.8; P<0.001) symptoms, only sometimes (aOR 2.7: CI 1.8-4.0; p<0.001) or never (aOR 2.7; CI: 1.8-4.0; p<0.001) having anyone to talk to and being of colored race (aOR 2.0; CI: 1.1-3.4; p=0.019) were significantly associated with suicidal ideation, whilst higher resilience (aOR 0.3; CI: 0.3-0.4; p<0.001) was associated with lower levels of suicidal ideation.</p><p><strong>Conclusion: </strong>The prevalence of suicidal ideation found in this study was higher than that found in the general South African adult population and highlights the need to further investigate and address student mental health, especially students in the field of Health Sciences. Interventions aimed at mitigating the determinants, including depression and anxiety, and promoting the development of protective factors such as resilience and social support may lead to a reduction in suicidal ideation in this population group. Institutional initiatives aimed at improving access to and the quality of mental health services offered to students should be widely advocated for and implemented.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1492620"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte-microglia co-culture model.","authors":"Timo Jendrik Faustmann, Franco Corvace, Pedro M Faustmann, Fatme Seval Ismail","doi":"10.3389/fpsyt.2025.1522128","DOIUrl":"10.3389/fpsyt.2025.1522128","url":null,"abstract":"<p><p>Schizophrenia is a severe mental disorder with a strong lifetime impact on patients' health and wellbeing. Usually, symptomatic treatment includes typical or atypical antipsychotics. Study findings show an involvement of low-grade inflammation (blood, brain parenchyma, and cerebrospinal fluid) in schizophrenia. Moreover, experimental and neuropathological evidence suggests that reactive microglia, which are the main resident immune cells of the central nervous system (CNS), have a negative impact on the differentiation and function of oligodendrocytes, glial progenitor cells, and astrocytes, which results in the disruption of neuronal networks and dysregulated synaptic transmission, contributing to the pathophysiology of schizophrenia. Here, the role of microglial cells related to neuroinflammation in schizophrenia was discussed to be essential. This review aims to summarize the evidence for the influence of antipsychotics on microglial inflammatory mechanisms in schizophrenia. Furthermore, we propose an established astrocyte-microglia co-culture model for testing regulatory mechanisms and examining the effects of antipsychotics on glia-mediated neuroinflammation. This could lead to a better understanding of how typical and atypical antipsychotics can be used to address positive and negative symptoms in schizophrenia and comorbidities like inflammatory diseases or the status of low-grade inflammation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1522128"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot implementation of a telehealth safety planning group intervention for suicidal rural Veterans enhanced by lived experience veteran peer participation.","authors":"Marianne Goodman, Madison Strouse, Caroline Boucher, Sofie Glatt, James Jacobs, Angie Waliski, Emilia Fonseca, Terra Osterberg, Sapana Patel","doi":"10.3389/fpsyt.2025.1512523","DOIUrl":"10.3389/fpsyt.2025.1512523","url":null,"abstract":"<p><p>Despite the Veterans Administration (VA) designating suicide prevention as the number one clinical priority, Veteran suicide rates continue to rise. One sub-population at elevated risk are Veterans living in rural communities given their heightened availability of firearms coupled with more limited access to mental health services. Telehealth delivery of treatment is a potential solution for the provision of critical services to rural areas. Despite the expansive growth of virtual treatment after the pandemic, there exist few suicide-specific telehealth health services. Our community case study aims to address this gap by piloting a manualized suicide safety planning and firearm safety group, titled Project Life Force (PLF), delivered virtually to rural Arkansas. The project's goal was to specifically enhance rural Veteran engagement with telehealth delivery through the use of community-based lived-experience rural peers. We present the rationale and details of the PLF intervention with a focus on the community Veteran peer enhancement component. This case study presents an innovative treatment design of a group led by a clinician augmented by a peer recovery leader that facilitated detailed conversations of how to limit suicide risk, encouraged disclosure about suicide symptoms, and promoted suicide related coping including encouragement of help-seeking behavior and safer storage of firearms. While the inclusion of a peer recovery leader was felt to be instrumental to the PLF-PE group's success, special attention to the peer recovery leader is essential and includes specific training, regular supervision as well as attention and support regarding the psychological impacts of self-disclosure and assuming a leadership role. This case study highlights the invaluable role that lived experience peers can play in suicide prevention treatment efforts and lethal means safety and paves the way for continued development of this effort.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1512523"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two in one: a randomized controlled trial on an internet-based intervention (Lenio) for management of both chronic pain and depressive symptoms.","authors":"Swantje Borsutzky, Anna-Sophie Wilke, Josefine Gehlenborg, Steffen Moritz","doi":"10.3389/fpsyt.2025.1528128","DOIUrl":"10.3389/fpsyt.2025.1528128","url":null,"abstract":"<p><p>The high prevalence of chronic pain and comorbid depression, along with their negative impacts on individuals and society, highlights the need for accessible and effective interventions. This study examined the feasibility, efficacy, and acceptability of Lenio, an Internet-based self-help intervention, combined with the COGITO smartphone application for managing these conditions. The randomized controlled trial involved an intervention group (IG) using Lenio and COGITO, an active control group (ACG) using a transdiagnostic app, and a wait-list control group (WCG) receiving usual treatment. Lenio incorporates cognitive behavioral therapy and third-wave techniques, supported by COGITO's gamified daily exercises to enhance adherence. Across 263 participants assessed at three intervals over 16 weeks, the IG showed significant improvement in somatic-affective depressive symptoms compared to the WCG post-intervention and both control groups at follow-up. However, the ACG outperformed the IG in managing pain at post-intervention though these effects did not persist until follow-up. The interventions were well-received and feasible, with older participants benefiting more from the Lenio/COGITO combination. Lenio and COGITO could bridge gaps to conventional therapy, potentially easing pain by enhancing psychological well-being and coping strategies. Future studies should investigate tailored interventions for chronic pain and their long-term effectiveness.</p><p><strong>Protocol: </strong>Full trial protocol can be accessed via DOI: 10.1186/s13063-023-07440-8.</p><p><strong>Clinical trial registration: </strong>https://drks.de/register/de/trial/DRKS00026722/preview, identifier DRKS-IDDRKS00026722.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1528128"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Treatment resistant depression (TRD): epidemiology, clinic, burden and treatment.","authors":"Andrea Fiorillo, Koen Demyttenaere, Vassilis Martiadis, Giovanni Martinotti","doi":"10.3389/fpsyt.2025.1588902","DOIUrl":"10.3389/fpsyt.2025.1588902","url":null,"abstract":"","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1588902"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of the Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability in individuals with subjective cognitive decline: paving the way towards brain health clinics in Greece.","authors":"Panagiotis Alexopoulos, Panagiotis Felemegkas, Xanthi Arampatzi, Evdokia Billis, Eleni Dimakopoulou, Polychronis Economou, George A Dimakopoulos, Themis P Exarchos, Maria Frounta, Parthenia Giannakopoulou, Kalliopi Kalaitzi, Maria-Lamprini Koula, Eftyhia Nastou, Maria Skondra, Paraskevi Sakka, Faidra Kalligerou, Nikolaos Skarmeas, Marianna Tsatali, Magdalini Krommyda, Maria Karala, Nikolaos Mastoras, Panagiotis Vlamos, Mary Yannakoulia, Ioannis Zaganas, Maria Karataraki, Maria Basta, Constantine Lyketsos","doi":"10.3389/fpsyt.2025.1514227","DOIUrl":"10.3389/fpsyt.2025.1514227","url":null,"abstract":"<p><p>The pilot phase of the Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability (GINGER) aims to assess the feasibility of a multi-level dementia risk reduction intervention in individuals with subjective cognitive decline (SCD) over a six-month period. The study design incorporates a comprehensive set of trans-disciplinary assessments and interventions in multiple centers across Greece. Individuals 55 years or older with subjective cognitive complaints who do not fulfill criteria for either mild cognitive impairment or dementia are screened for dementia risk factors in the following domains: nutrition, physical activities, vision and hearing, vascular and metabolic parameters, anxiety and depressive symptoms, and insomnia. All GINGER participants receive a cognitive empowerment intervention. Using a precision medicine approach, they receive up to three additional domain-specific interventions based on their individual risk factor profiles. Changes in cognition, dementia risk factors, quality of life and other measures compared to baseline are assessed at three- and six months after the initiation of the intervention. The GINGER protocol was designed and is run by a multi-disciplinary team of dieticians, neurologists, psychiatrists, psychologists, and physiotherapists, while computer scientists oversee data management. The objectives of this pilot phase are (i) evaluation of the protocol's feasibility, (ii) assessment of intervention effects on the individual risk domains targeted by the interventions, (iii) estimation of the overall effects of the intervention on cognitive function, dementia risk and quality of life. The GINGER findings will provide a solid foundation for paving the way towards a network of evidence-based brain health clinics in Greece.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1514227"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD, stress, and anxiety.","authors":"Petr Bob, Michal Privara","doi":"10.3389/fpsyt.2025.1536207","DOIUrl":"10.3389/fpsyt.2025.1536207","url":null,"abstract":"<p><p>Recent findings on stress and anxiety in attention deficit hyperactivity disorder (ADHD) suggest that specific processes related to brain developmental disorganization could create a vulnerable background that increases sensitivity to stress stimuli from the psychosocial environment. These basic neurodevelopmental processes are closely related to the developmental mechanisms of primitive functions and their integration or disintegration. In this context, the psychopathological processes that manifest in ADHD are linked to the mechanisms of disturbed inhibitory functions that may cause incongruent neural interactions (\"neural interference\") between the more primitive functions and the higher levels of attentional and cognitive neural processes. These disturbed developmental processes may also determine increased sensitivity to stressful experiences that, in ADHD cases, could lead to the manifestations of various psychopathological symptoms such as disturbed attentional and motor functions, anxiety, and depression, among other cognitive and affective disturbances. These findings, based on previous research, suggest novel framework and hypothesis on how this neurodevelopment-based increased sensitivity to stress stimuli could manifest in the etiopathogenesis of ADHD in its relationship with cognitive, affective, and motor deficits.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1536207"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge graph and its application in the study of neurological and mental disorders.","authors":"Qizheng Wang, Fan Yang, Lijie Quan, Mengjie Fu, Zhongli Yang, Ju Wang","doi":"10.3389/fpsyt.2025.1452557","DOIUrl":"10.3389/fpsyt.2025.1452557","url":null,"abstract":"<p><p>Neurological disorders (e.g., Alzheimer's disease and Parkinson's disease) and mental disorders (e.g., depression and anxiety), pose huge challenges to global public health. The pathogenesis of these diseases can usually be attributed to many factors, such as genetic, environmental and socioeconomic status, which make the diagnosis and treatment of the diseases difficult. As research on the diseases advances, so does the body of medical data. The accumulation of such data provides unique opportunities for the basic and clinical study of these diseases, but the vast and diverse nature of the data also make it difficult for physicians and researchers to precisely extract the information and utilize it in their work. A powerful tool to extract the necessary knowledge from large amounts of data is knowledge graph (KG). KG, as an organized form of information, has great potential for the study neurological and mental disorders when it is paired with big data and deep learning technologies. In this study, we reviewed the application of KGs in common neurological and mental disorders in recent years. We also discussed the current state of medical knowledge graphs, highlighting the obstacles and constraints that still need to be overcome.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1452557"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of smartphone addiction on mental health and its relationship with life satisfaction in the post-COVID-19 era.","authors":"Chunyue Zhu, Shuo Li, Lei Zhang","doi":"10.3389/fpsyt.2025.1542040","DOIUrl":"10.3389/fpsyt.2025.1542040","url":null,"abstract":"<p><p>Following the COVID-19 outbreak, smartphone usage among quarantined Chinese college students surged significantly, leading to a growing dependency on their devices and adversely impacting their emotional well-being. Consequently, the negative emotions associated with smartphone addiction have emerged as critical factors influencing students' life satisfaction. However, the psychological mechanisms linking these emotional effects to life satisfaction, as well as potential sustainable educational interventions, remain insufficiently explored. This study assessed a sample of 322 undergraduates (51.6% male) using the Mobile Phone Addiction Index (MPAI), the Depression, Anxiety, and Stress Scale (DASS-21), and the Satisfaction With Life Scale (SWLS) to construct a mediation model. The aim was to examine the relationships between smartphone addiction, negative emotions, and life satisfaction. Results revealed that smartphone addiction was significantly positively correlated with negative emotions (r = 0.332, p < 0.01), while negative emotions were significantly negatively correlated with life satisfaction (r = -0.391, p < 0.01). Among these negative emotions, depression emerged as a key factor, intensifying smartphone dependence and detrimentally affecting overall life satisfaction. The mediation analysis demonstrated that smartphone addiction contributes to the development of negative emotions, which in turn reduce life satisfaction. Students with higher levels of smartphone addiction reported heightened negative emotions, leading to more pessimistic coping strategies and, ultimately, a decline in mental health and life satisfaction. This study provides valuable insights into the impact of smartphone addiction on college students' life satisfaction and offers actionable educational recommendations to mitigate its harmful effects, promoting healthier and more sustainable lifestyles for students.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1542040"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to adopting therapeutic virtual reality: the perspective of clinical psychologists and psychotherapists.","authors":"Anna Felnhofer, Franziska Pfannerstill, Lisa Gänsler, Oswald D Kothgassner, Elke Humer, Johanna Büttner, Thomas Probst","doi":"10.3389/fpsyt.2025.1549090","DOIUrl":"10.3389/fpsyt.2025.1549090","url":null,"abstract":"<p><strong>Background and objective: </strong>Despite evidence supporting the effectiveness of Virtual Reality (VR) for mental disorders, VR adoption in therapy remains low. As VR-technology continues to advance, it is crucial to examine individual and contextual barriers preventing implementation of therapeutic VR.</p><p><strong>Methods: </strong>An online survey with closed and open-ended questions regarding knowledge of VR, VR-usage and barriers to VR adoption was conducted among clinical psychologists and psychotherapists in Austria (M_age=51.71 years, 76% women).</p><p><strong>Results: </strong>Of 694 participants, only 10 reported using therapeutic VR. Chi-square tests revealed significant differences regarding interest in therapeutic VR based on prior experience, employment status, professional training, and therapeutic cluster. Besides a small age effect, no effects of gender or professional experience were found. Participants interested in VR (interest group, IG) frequently cited barriers and other reasons (see thematic analysis) for not having used VR yet. Those not interested in VR (no interest group, NIG) indicated a lack of relevance, no perceived advantage, or disinterest as reasons for not using VR. Thematic analysis identified four themes shared by both IG and NIG, each encompassing group-specific sub-themes: <i>professional barriers</i> (lack of knowledge, training, time, personal reasons), <i>financial barriers</i> (costs, cost-benefit-ratio), <i>therapeutic barriers</i> (clinical applicability, concerns about \"real\" therapeutic relationship), and <i>technological barriers</i> (immature technology, cybersickness, no equipment).</p><p><strong>Conclusions: </strong>Significant barriers to the adoption of therapeutic VR among clinical psychologists and psychotherapists are gaps in knowledge and training, financial constraints, and lack of motivation, all of which highlight the need for training and financial support to enhance VR implementation.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1549090"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}