Frontiers in Psychiatry最新文献

{"title":"Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study.","authors":"Jianqing Qiu, Cheng Yu, Yalan Kuang, Yao Hu, Ting Zhu, Ke Qin, Wei Zhang","doi":"10.3389/fpsyt.2024.1481006","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1481006","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric illness is thought to be a brain somatic crosstalk disorder. However, the existing phenomenology-based Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic framework overlooks various dimensions other than symptoms. In this study, we investigated the associations between peripheral blood test indexes with various symptom levels of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) to explore the availability of peripheral blood test indexes.</p><p><strong>Methods: </strong>We extracted cases diagnosed with MDD, BD, and SCZ at West China Hospital from 2009 to 2021, translated their main complaints into Research Domain Criteria (RDoC) symptom severity scores using nature language processing (NLP), and collected their detailed psychiatric symptoms and peripheral blood test results. Then, generalized linear models were performed between seven types of peripheral blood test values with their transformed RDoC scores and detailed symptom information adjusted for age, gender, smoking, and alcohol history.</p><p><strong>Results: </strong>Several inflammatory-related indexes were strongly associated with the negative valence system (NVS) domain (basophil percentage adjusted <i>β</i> = 0.275, lymphocyte percentage adjusted <i>β</i> = 0.271, monocyte percentage adjusted <i>β</i> = 0.223, neutrophil percentage adjusted <i>β</i> = -0.310, neutrophil count adjusted <i>β</i> = -0.301, glucose adjusted <i>β</i> = -0.287, leukocyte count adjusted <i>β</i> = -0.244, NLR adjusted <i>β</i> = -0.229, and total protein adjusted <i>β</i> = -0.170), the positive valence system (PVS) domain (monocyte percentage adjusted <i>β</i> = 0.228, basophil count adjusted <i>β</i> = 0.176, and glutamyl transpeptidase adjusted <i>β</i> = 0.171), and a wide range of mood, reward, and psychomotor symptoms. In addition, glucose, urea, urate, cystatin C, and albumin showed considerable associations with multiple symptoms. In addition, based on the direction of associations and the similarity of symptoms in terms of RDoC thinking, it is suggested that \"positive\" mood symptoms like mania and irritability and \"negative\" mood symptoms like depression and anxiety might be on a continuum considering their opposite relationships with similar blood indexes.</p><p><strong>Limitations: </strong>The cross-sectional design, limited symptoms record, and high proportion of missing values in some other peripheral blood indexes limited our findings.</p><p><strong>Conclusion: </strong>The proportion of high inflammatory indexes in SCZ was relatively high, but in terms of mean values, SCZ, BD, and MDD did not differ significantly. Inflammatory response showed a strong correlation with NVS, PVS, and a range of psychiatric symptoms especially mood symptoms, psychomotor symptoms, and cognitive abilities.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1481006"},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of combined cognitive training and non-invasive brain stimulation to modulate impulsivity in adult populations: a systematic review and meta-analysis of existing studies.","authors":"Najat R Khalifa, Yousef Alabdulhadi, Pilar Vazquez, Charlotte Wun, Peng Zhang","doi":"10.3389/fpsyt.2024.1510295","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1510295","url":null,"abstract":"<p><strong>Introduction: </strong>Impulsivity, a tendency to act rashly and without forethought, is a core feature of many mental disorders that has been implicated in suicidality and offending behaviours. While research supports the use of non-invasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS), to modulate brain functions, no studies specifically reviewed the use of combined cognitive training and NIBS to modulate impulsivity.</p><p><strong>Methods: </strong>We aimed to conduct a systematic review and meta-analysis to synthesise the literature on the use of combined cognitive training and NIBS to modulate impulsivity and its subdomains (motor, delay discounting, reflection). We searched Scopus, PsychInfo, Medline, and Cinahl electronic databases, dissertations database, and Google scholar up to September 2024.</p><p><strong>Results: </strong>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, four randomised controlled studies involving the use of combined cognitive training and tDCS in 127 subjects were included in the study. These studies included subjects with substance use disorders, obesity, and Parkinson's disease. Meta-analysis showed that combined cognitive training and tDCS had no statistically significant effects on motor impulsivity as measured using reaction times on the Stop Signal Task and Go/No Go tasks. One study that measured impulsiveness scores on a delay discounting task also showed no significant results. No studies measured reflection or cognitive impulsivity.</p><p><strong>Discussion: </strong>There is a dearth of literature on the use of combined cognitive training and NIBS for impulsivity. This in conjunction of clinical heterogeneity across studies makes it difficult to draw definitive conclusions about the neuromodulation of impulsivity and its subdomains using combined cognitive training and NIBS. The findings of this study highlight the need to conduct more studies in the field.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD 42024511576.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1510295"},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between polypharmacy and the long-term prescription of hypnotics in Japan: a retrospective cross-sectional study.","authors":"Munehiro Komatsu, Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Mizuki Kudo, Eru Miyakoshi, Yu Itoh, Nana Shibata, Naoko Ayabe, Kazuo Mishima","doi":"10.3389/fpsyt.2024.1471457","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1471457","url":null,"abstract":"<p><strong>Introduction: </strong>Hypnotic polypharmacy and its long-term prescriptions constitute the inappropriate use of hypnotics. However, the relationship between hypnotic polypharmacy and prolonged prescriptions remains unclear. This study aimed to elucidate the association between hypnotic polypharmacy and the duration of hypnotic prescriptions.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study utilized a large dataset from the Japan Medical Data Center. The study population included adults who had been prescribed hypnotics between April 2020 and March 2021, with a focus on those receiving hypnotics in March 2021. Hypnotic polypharmacy was defined as the concurrent prescription of two or more hypnotics in March 2021. The duration of hypnotic prescriptions was measured by calculating the number of months between April 2019 and March 2021 during which hypnotics were prescribed. A binary logistic regression analysis was conducted to assess the relationship between hypnotic polypharmacy and long-term hypnotic prescriptions, adjusting for relevant covariates.</p><p><strong>Results: </strong>We included 112,256 patients (mean age: 49.5 years, females: 47.1%). Among them, 67.9% received hypnotic monotherapy, and 32.1% received hypnotic polypharmacy. Compared with adults who were prescribed hypnotics for 1 month, the association with polypharmacy was stronger in those who were prescribed hypnotics for ≥4 months as the duration of the prescription increased (adjusted odds ratio [aOR]: 1.15, 95% confidence interval [CI]: 1.04-1.27, p=0.006 for 4-6 months; aOR 1.35, 95% CI 1.23-1.49, p<0.001 for 7-9 months; aOR 1.58, 95% CI 1.43-1.73, p<0.001 for 10-12 months; and aOR 3.24, 95% CI 2.99-3.52 for 13-24 months).</p><p><strong>Conclusions: </strong>This study demonstrated a significant association between hypnotic polypharmacy and long-term prescriptions of hypnotics. Initiating insomnia treatment with hypnotic monotherapy may reduce the likelihood of long-term prescriptions, and limiting the duration of hypnotic prescriptions could potentially prevent polypharmacy.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1471457"},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health and attitudes toward suicide amongst individuals with gender dysphoria in Iran.","authors":"Maryam Assareh, Vahid Rashedi, Mehrdad Eftekhar Ardebili, Razieh Salehian, Mohammadreza Shalbafan","doi":"10.3389/fpsyt.2024.1443638","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1443638","url":null,"abstract":"<p><strong>Introduction: </strong>Gender dysphoria (GD) is associated with profound mental health challenges, including heightened suicide risk. This study aimed to explore the mental health status and attitudes toward suicide among individuals with GD in Iran.</p><p><strong>Methods: </strong>A comprehensive assessment was conducted using three validated tools: the General Health Questionnaire (GHQ-28) to gauge emotional distress and psychological well-being, the Beck Depression Inventory (BDI-II) to evaluate the severity of depressive symptoms, and the Predicament Questionnaire (PQ) to measure attitudes toward suicide in the context of social crises.</p><p><strong>Results: </strong>Among the 78 participants, 43 (55.1%) were identified as experiencing significant mental health issues, while 21 (26.9%) were found to suffer from severe depression. The average PQ score was 57.92, which aligns with findings from similar populations in previous studies, highlighting a concerning trend in suicide-related attitudes. Further statistical analysis revealed significant correlations between psychological distress (GHQ-28 scores) and attitudes toward suicide (PQ scores), as well as between depressive symptoms (BDI-II scores) and suicide-related attitudes.</p><p><strong>Conclusions: </strong>These findings indicate a pervasive prevalence of psychological disorders, particularly depression, within this group, and underscore the strong association between depressive states and suicidal ideation. The study underscores the urgent need for targeted mental health interventions and comprehensive healthcare policies tailored to the specific needs of individuals with GD in Iran. Given the substantial mental health burden observed, particularly the risk of suicide, this research highlights the critical importance of integrating mental health care into broader support systems for this population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1443638"},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the pain anxiety symptom scale among postoperative patients in Amol, Iran.","authors":"Hamid Sharif-Nia, Erika Sivarajan Froelicher, João Marôco, Esmaeil Hoseinzadeh, Sima Hejazi, Reza Fatehi, Poorya Nowrozi, Bita Mohammadi","doi":"10.3389/fpsyt.2024.1422346","DOIUrl":"10.3389/fpsyt.2024.1422346","url":null,"abstract":"<p><strong>Introduction: </strong>So far, the psychometric properties of the Persian version of the Pain Anxiety Symptom Scale have not been assessed in Iran. Therefore, this study was conducted to determine the validity and reliability of the Persian version of the Pain Anxiety Symptom Scale among a group of Iranian patients in Amol.</p><p><strong>Methods: </strong>This methodological study was conducted in 2023 with a sample of 400 postoperative patients from Amol, Iran, selected through convenience sampling. The dataset was divided into two groups of 200 for exploratory and confirmatory factor analyses. Construct validity was assessed using maximum likelihood exploratory factor analysis with Promax rotation, supported by Horn's parallel analysis and network analysis to visualize item relationships. Confirmatory factor analysis, convergent and discriminant validity was performed on the second dataset. Reliability was evaluated through various statistical measures, including Cronbach's alpha, McDonald's omega, average inter-item correlation coefficient, composite reliability, and maximal reliability (MaxR).</p><p><strong>Results: </strong>Among the 400 participants, the mean age was 44.38 years (SD = 13.49), with 152 (46.1%) being women and 178 (53.9%) men. Most participants (n = 268, 81.2%) had an education level lower than a diploma, and 93 individuals (28.2%) reported a history of surgery. The results of exploratory factor analysis with Promax rotation developed two factors accounting for 66.29% of the variance comprising 15 items. Also, after necessary modifications during confirmatory factor analysis, the final model was approved. As for reliability, the Cronbach's alpha, composite reliability, and MaxR for all constructs were greater than 0.7, demonstrating good internal consistency and construct reliability.</p><p><strong>Conclusion: </strong>According to the results, the Persian version of the Pain Anxiety Symptom Scale has a valid structure and acceptable reliability. This scale can be used by health professionals in many ways.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1422346"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality among individuals with substance use disorder-does violent criminal behavior have an impact?","authors":"Joakim Jakobsson, Anna Karlsson, Anders Håkansson, Björn Hofvander","doi":"10.3389/fpsyt.2024.1455343","DOIUrl":"10.3389/fpsyt.2024.1455343","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding violent criminality and its impact on health and eventually the risk of premature mortality is important for efficient future interventions. This study aimed to explore the effect violent criminality had on premature mortality (i.e., death before the age of 65) among individuals with substance use disorders (SUDs).</p><p><strong>Methods: </strong>The cohort was created by identifying all Swedish patients diagnosed with SUD between the first of January 2013 and 31st of December 2014. The individuals were split into three age categories.</p><p><strong>Results: </strong>There were significant differences in standard mortality rates (SMR) in the cohort compared to the general Swedish population across the three age categories. We found differences between the SMRs for individuals convicted of violent and nonviolent crimes in the two younger age categories [age 15-29: violent crime (42.4) vs. non-violent crime (36.6), age 30-44: violent crime (28.0) vs. non-violent crime (23.0)]. A Cox regression analysis showed that each conviction of a violent crime increased the hazard ratio (HR) of premature mortality significantly [age 15-29; HR = 1.10 (95% CI: 1.04-1.17), age 30-44; HR =1.06 (95% CI: 1.03-1.09)]. After correcting for non-violent crimes, the increased risk only remained for the youngest group [HR = 1.06 (95% CI: 1.00-1.13)].</p><p><strong>Discussion: </strong>This study suggests that criminal behavior constitutes a proxy for the risk behaviors that increase the risk of premature mortality among young individuals with SUD even after controlling for confounders. Longitudinal studies, examining time-dependent risks and protective influences, are needed to explain the different pathways and processes leading to the amplified premature mortality in the groups.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1455343"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study of the experiences of young people with severe mental health problems and complex needs regarding youth flexible assertive community treatment.","authors":"Marthe Johansen, Hanne Kilen Stuen, Eva Brekke, Camilla Bergsve Jensen, Anne Landheim","doi":"10.3389/fpsyt.2024.1478345","DOIUrl":"10.3389/fpsyt.2024.1478345","url":null,"abstract":"<p><p>Youth Flexible Assertive Community Treatment (Youth Flexible ACT) is a service model for children and young people with severe mental health problems and complex needs aimed at providing integrated, continuous and holistic care. Studies on young people's experiences of Youth Flexible ACT or similar models are scarce. The present qualitative study aimed to explore and describe how young people with severe mental health problems and complex needs experience follow-up and treatment provided by Youth Flexible ACT teams. Semi-structured interviews were conducted with 14 young people (age range, 15-19 years) who were being followed up by a Youth Flexible ACT team. Qualitative content analysis was used, and the following two overarching themes characterizing the young people's experiences of follow-up and treatment provided by Youth Flexible ACT teams were identified: (1) trusting and collaborative relationships, and (2) organization matters. The participants experienced a more personal relationship with the staff, who behaved more like friends and paid attention to resources, interests, solutions and their context. The participants emphasized and valued components that coincided with the Youth Flexible ACT model, indicating a match between what the young people needed and wanted and what the model was supposed to provide. The team providing these relationships and youth-friendly and developmentally sensitive care appeared to be facilitated by how the service model was organized, with the teams being flexible and accessible while providing integrated, multifaceted help and systemic follow-up.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1478345"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology.","authors":"Shasha Wu, Qing Jiang, Jinhui Wang, Daming Wu, Yan Ren","doi":"10.3389/fpsyt.2024.1485957","DOIUrl":"10.3389/fpsyt.2024.1485957","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Major depressive disorder (MDD) is a severe psychiatric disorder characterized by complex etiology, with genetic determinants that are not fully understood. The objective of this study was to investigate the pathogenesis of MDD and to explore its association with the immune system by identifying hub biomarkers using bioinformatics analyses and examining immune infiltrates in human autopsy samples.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Gene microarray data were obtained from the Gene Expression Omnibus (GEO) datasets GSE32280, GSE76826, GSE98793, and GSE39653. Our approach included differential expression analysis, weighted gene co-expression network analysis (WGCNA), and protein-protein interaction (PPI) network analysis to identify hub genes associated with MDD. Subsequently, gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Cytoscape plugin CluGO, and Gene Set Enrichment Analysis (GSEA) were utilized to identify immune-related genes. The final selection of immune-related hub genes was determined through the least absolute shrinkage and selection operator (Lasso) regression analysis and PPI analysis. Immune cell infiltration in MDD patients was analyzed using CIBERSORT, and correlation analysis was performed between key immune cells and genes. The diagnostic accuracy of the identified hub genes was evaluated using receiver operating characteristic (ROC) curve analysis. Furthermore, we conducted a study involving 10 MDD patients and 10 healthy controls (HCs) meeting specific criteria to assess the expression levels of these hub genes in their peripheral blood mononuclear cells (PBMCs). The Herbal Ingredient Target Database (HIT) was employed to screen for herbal components that target these genes, potentially identifying novel therapeutic agents.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 159 down-regulated and 51 up-regulated genes were identified for further analysis. WGCNA revealed 12 co-expression modules, with modules \"darked\", \"darkurquoise\" and \"light yellow\" showing significant positive associations with MDD. Functional enrichment pathway analysis indicated that these differential genes were associated with immune functions. Integration of differential and immune-related gene analysis identified 21 common genes. The Lasso algorithm confirmed 4 hub genes as potential biomarkers for MDD. GSEA analysis suggested that these genes may be involved in biological processes such as protein export, RNA degradation, and fc gamma r mediated cytotoxis. Pathway enrichment analysis identified three highly enriched immune-related pathways associated with the 4 hub genes. ROC curve analysis indicated that these hub genes possess good diagnostic value. Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) demonstrated significant expression differences of these hub genes in PBMCs between MDD patients and HCs. Immune infiltration analysis revealed significant correlations between immune cells, inc","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1485957"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal hypoxia in patients with sleep disorders: exploring its role as a mediator between neurotic personality traits and psychological symptoms.","authors":"Fei Jiang, Jinsong Huang, Lijun Fan, Xiaoyan Dong, Chunyan Yang, Wenzhu Zhou","doi":"10.3389/fpsyt.2024.1442826","DOIUrl":"10.3389/fpsyt.2024.1442826","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep disorders often coexist with personality and psychological issues, alongside nocturnal hypoxia. This study investigates the potential mediating role of nocturnal hypoxia between personality traits and psychological symptoms in individuals with sleep disorders.</p><p><strong>Methods: </strong>A cohort comprising 171 participants reporting sleep disturbances was recruited from Dalian Seventh People's Hospital. Psychological symptoms were assessed using the Symptom Checklist-90-R (SCL-90-R), while personality traits were evaluated using the Eysenck Personality Questionnaire (EPQ). Nocturnal hypoxia status was determined through overnight polysomnography.</p><p><strong>Results: </strong>Mediation analysis, conducted using SPSS 23.0, demonstrated that the cumulative time of nocturnal peripheral oxygen saturation (SpO2) < 85% (T85) partially mediated the relationship between neuroticism and various psychological symptoms, including somatization (c=0.207, c'=0.164, a*b=0.043, proportion of mediation 20.8%), interpersonal sensitivity (c=0.360, c'=0.326, a*b=0.034, proportion of mediation 9.6%), depression (c=0.277, c'=0.234, a*b=0.042, proportion of mediation 15.3%), anxiety (c=0.240, c'=0.199, a*b=0.041, proportion of mediation 16.9%), hostility (c=0.241, c'=0.205, a*b=0.036, proportion of mediation 14.9%), phobic anxiety (c=0.271, c'=0.241, a*b=0.030, proportion of mediation 11.1%), and psychoticism (c=0.298, c'=0.266, a*b=0.032, proportion of mediation 10.8%).</p><p><strong>Discussion: </strong>These findings underscore the potential mediating role of nocturnal hypoxia in the association between neuroticism personality traits and psychological symptoms among individuals with sleep disorders. Our research holds considerable significance in advancing the quest for personalized treatments targeting psychological symptoms in individuals with sleep disorders.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1442826"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of comprehensive cognitive, affective, and psychomotor competency assessment scales in psychodynamic psychotherapy for borderline personality disorder.","authors":"Petrin Redayani Lukman, Tjhin Wiguna, Diantha Soemantri, Sri Linuwih Menaldi, Sylvia Detri Elvira, Limas Sutanto, Tuti Wahmurti A Sapiie, Aria Kekalih, Reina Rahma Noviasari, Hukma Shabiyya Rizki, Kharisma Zatalini Giyani","doi":"10.3389/fpsyt.2024.1389992","DOIUrl":"10.3389/fpsyt.2024.1389992","url":null,"abstract":"<p><strong>Background: </strong>Psychodynamic psychotherapy is a type of psychotherapy for individuals with borderline personality disorder (BPD). However, competency in conducting effective psychodynamic psychotherapy for BPD is difficult to evaluate. Therefore, this study aimed to identify the psychometric properties of a comprehensive scale to assess cognitive, affective, and psychomotor competencies (CS-CAPC) in psychodynamic psychotherapy for BPD.</p><p><strong>Methods: </strong>This is a qualitative study. The first step used the Delphi technique to gather experts' opinions on the cognitive, affective, and psychomotor competencies necessary to conduct psychodynamic psychotherapy for BPD. The experts comprised three psychotherapists, seven psychiatrists with experience in psychotherapy, and nine teaching staff. A panel discussion was conducted to obtain qualitative data. Thematic data analysis was adopted, and content validity testing was used to analyze the content validity of the CS-CAPC in psychodynamic psychotherapy for BPD.</p><p><strong>Results: </strong>The CS-CAPC comprised two scales assessing two specific competencies in psychodynamic psychotherapy for BPD: The first scale, the psychodynamic formulation competency assessment scale (PF-CAS), comprised six items, including the case description, etiology, and potential course of therapy. The second scale, the practical-competency assessment scale (PC-CAS) for psychodynamic psychotherapy for BPD, comprised 12 items, including building a therapeutic alliance, performing psychodynamic interventions while working through the therapeutic process, and closing the session. The scale-level content validity index (S-CVI) for the PF-CAS was 0.981, and that for the PC-CAS in psychodynamic psychotherapy for BPD was 1.00.</p><p><strong>Conclusion: </strong>The CS-CAPC in psychodynamic psychotherapy for BPD had good validity in assessing individual competency in the cognitive, affective, and psychomotor domains.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"15 ","pages":"1389992"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}