Dan-Dan Cheng, Yi-Lin Yang, Zi-Yi Yuan, Su Hong, Li Kuang
{"title":"病例报告：每日两次15mA经颅交流电刺激治疗青少年重度抑郁症伴自杀意念。","authors":"Dan-Dan Cheng, Yi-Lin Yang, Zi-Yi Yuan, Su Hong, Li Kuang","doi":"10.3389/fpsyt.2025.1669966","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adolescent major depressive disorder with suicidal ideation (MDD-SI) poses significant treatment challenges and carries substantial mortality risk, while existing interventions often demonstrate limited acute efficacy for suicidal ideation (SI).</p><p><strong>Methods: </strong>This two-week prospective case series investigated the feasibility and preliminary therapeutic effects of high-frequency transcranial alternating current stimulation (tACS) administered twice daily. Seven adolescents with MDD-SI underwent 40-minute tACS sessions (77.5 Hz, 15 mA) twice-daily over a two weeks for a total of 20 sessions, in conjunction with stable pharmacotherapy.</p><p><strong>Results: </strong>The accelerated tACS protocol was well-tolerated with no adverse events. It demonstrated significant reductions in both depressive symptoms and SI within two weeks (all <i>P</i> < 0.05), predominantly in the first week. Treatment response varied based on psychiatric and medical comorbidities, indicating potential moderators.</p><p><strong>Conclusion: </strong>These preliminary findings suggest the potential of accelerated high-frequency tACS as a potential crisis intervention for adolescent MDD-SI, while highlighting the need for controlled clinical trials to establish efficacy and optimize stimulation parameters.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1669966"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502979/pdf/","citationCount":"0","resultStr":"{\"title\":\"Case report: Twice-daily 15mA transcranial alternating current stimulation for adolescent major depressive disorder with suicidal ideation.\",\"authors\":\"Dan-Dan Cheng, Yi-Lin Yang, Zi-Yi Yuan, Su Hong, Li Kuang\",\"doi\":\"10.3389/fpsyt.2025.1669966\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Adolescent major depressive disorder with suicidal ideation (MDD-SI) poses significant treatment challenges and carries substantial mortality risk, while existing interventions often demonstrate limited acute efficacy for suicidal ideation (SI).</p><p><strong>Methods: </strong>This two-week prospective case series investigated the feasibility and preliminary therapeutic effects of high-frequency transcranial alternating current stimulation (tACS) administered twice daily. Seven adolescents with MDD-SI underwent 40-minute tACS sessions (77.5 Hz, 15 mA) twice-daily over a two weeks for a total of 20 sessions, in conjunction with stable pharmacotherapy.</p><p><strong>Results: </strong>The accelerated tACS protocol was well-tolerated with no adverse events. It demonstrated significant reductions in both depressive symptoms and SI within two weeks (all <i>P</i> < 0.05), predominantly in the first week. Treatment response varied based on psychiatric and medical comorbidities, indicating potential moderators.</p><p><strong>Conclusion: </strong>These preliminary findings suggest the potential of accelerated high-frequency tACS as a potential crisis intervention for adolescent MDD-SI, while highlighting the need for controlled clinical trials to establish efficacy and optimize stimulation parameters.</p>\",\"PeriodicalId\":12605,\"journal\":{\"name\":\"Frontiers in Psychiatry\",\"volume\":\"16 \",\"pages\":\"1669966\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502979/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fpsyt.2025.1669966\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpsyt.2025.1669966","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Case report: Twice-daily 15mA transcranial alternating current stimulation for adolescent major depressive disorder with suicidal ideation.
Background: Adolescent major depressive disorder with suicidal ideation (MDD-SI) poses significant treatment challenges and carries substantial mortality risk, while existing interventions often demonstrate limited acute efficacy for suicidal ideation (SI).
Methods: This two-week prospective case series investigated the feasibility and preliminary therapeutic effects of high-frequency transcranial alternating current stimulation (tACS) administered twice daily. Seven adolescents with MDD-SI underwent 40-minute tACS sessions (77.5 Hz, 15 mA) twice-daily over a two weeks for a total of 20 sessions, in conjunction with stable pharmacotherapy.
Results: The accelerated tACS protocol was well-tolerated with no adverse events. It demonstrated significant reductions in both depressive symptoms and SI within two weeks (all P < 0.05), predominantly in the first week. Treatment response varied based on psychiatric and medical comorbidities, indicating potential moderators.
Conclusion: These preliminary findings suggest the potential of accelerated high-frequency tACS as a potential crisis intervention for adolescent MDD-SI, while highlighting the need for controlled clinical trials to establish efficacy and optimize stimulation parameters.
期刊介绍：
Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.
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