Case report: Twice-daily 15mA transcranial alternating current stimulation for adolescent major depressive disorder with suicidal ideation.

IF 3.2 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI:10.3389/fpsyt.2025.1669966

Dan-Dan Cheng, Yi-Lin Yang, Zi-Yi Yuan, Su Hong, Li Kuang

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Abstract

Background: Adolescent major depressive disorder with suicidal ideation (MDD-SI) poses significant treatment challenges and carries substantial mortality risk, while existing interventions often demonstrate limited acute efficacy for suicidal ideation (SI).

Methods: This two-week prospective case series investigated the feasibility and preliminary therapeutic effects of high-frequency transcranial alternating current stimulation (tACS) administered twice daily. Seven adolescents with MDD-SI underwent 40-minute tACS sessions (77.5 Hz, 15 mA) twice-daily over a two weeks for a total of 20 sessions, in conjunction with stable pharmacotherapy.

Results: The accelerated tACS protocol was well-tolerated with no adverse events. It demonstrated significant reductions in both depressive symptoms and SI within two weeks (all P < 0.05), predominantly in the first week. Treatment response varied based on psychiatric and medical comorbidities, indicating potential moderators.

Conclusion: These preliminary findings suggest the potential of accelerated high-frequency tACS as a potential crisis intervention for adolescent MDD-SI, while highlighting the need for controlled clinical trials to establish efficacy and optimize stimulation parameters.

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病例报告：每日两次15mA经颅交流电刺激治疗青少年重度抑郁症伴自杀意念。

背景：青少年重度抑郁症伴自杀意念（MDD-SI）存在显著的治疗挑战和巨大的死亡风险，而现有的干预措施通常对自杀意念（SI）的急性疗效有限。方法：为期两周的前瞻性病例系列研究了高频经颅交流电刺激（tACS）的可行性和初步治疗效果。7名患有MDD-SI的青少年接受了40分钟的tACS治疗（77.5 Hz, 15 mA），每天两次，持续两周，共20次，同时进行稳定的药物治疗。结果：加速tACS方案耐受性良好，无不良事件。两周内抑郁症状和SI均显著减轻（均P < 0.05），主要在第一周。治疗效果因精神病学和医学合并症而异，表明有潜在的调节作用。结论：这些初步研究结果表明，加速高频tACS作为青少年MDD-SI的潜在危机干预措施的潜力，同时强调需要对照临床试验来确定疗效和优化刺激参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.