Shuning Hong, Mengjiao Chi, Haisi Chen, Fengfeng Chu, Yuping Zheng, Ming Tao
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引用次数: 0
Abstract
Objective: We aimed to investigate the metacognition of patients with major depressive disorder (MDD) and its correlation with their condition, as well as explore its diagnostic significance in the early stages of the disease, thereby providing a reference for clinical treatment.
Methods: Using a cross-sectional research design, we selected 66 patients diagnosed with MDD and 99 healthy controls for a mental rotation task; we examined their metacognitive performance using a post-decisional confidence assessment paradigm. We evaluated various aspects, including their performance on first-order tasks (d'), metacognitive bias (average confidence), metacognitive sensitivity (meta-d'), metacognitive efficiency (the M Ratio).
Results: In terms of the first-order task performance (d'), the group with MDD scored significantly lower than the healthy controls (t = -4.274, p < 0.001, respectively). Regarding metacognitive bias(average confidence), metacognitive sensitivity (meta-d'), and metacognitive efficiency (the M ratio), the group with MDD performed significantly worse than the healthy controls (t = -4.280, p < 0.001; t = -3.540, p < 0.001; t = -2.104, p = 0.039, respectively). In addition, the Hamilton Rating Scale for Depression (HAMD-17) scores of the patients with MDD were significantly negatively correlated with their d', average confidence levels, meta-d', and M ratio(r = -0.468, p < 0.001; r = -0.601, p < 0.001;r = -0.457, p < 0.001; r = -0.362, p = 0.003), The average confidence levels of MDD patients are significantly positively correlated with d', meta-d', and M ratio. (r = -0.552, p < 0.001; r = 0.738, p < 0.001;r =0.273, p =0.02).
Conclusion: The metacognitive abilities of patients with MDD were significantly impaired, and the degree of metacognitive impairment was related to the severity of clinical depressive symptoms. Moreover, the impairment of their metacognitive abilities was correlated with negative metacognitive bias.
目的：探讨重度抑郁症（MDD）患者的元认知及其与病情的相关性，探讨其在疾病早期的诊断意义，为临床治疗提供参考。方法：采用横断面研究设计，我们选择66名诊断为重度抑郁症的患者和99名健康对照进行心理旋转任务；我们使用决策后信心评估范式检查了他们的元认知表现。我们评估了各个方面，包括他们在一阶任务中的表现（d‘），元认知偏差（平均置信度），元认知敏感性（meta-d’），元认知效率（M比率）。结果：在一阶任务表现（d'）方面，重度抑郁症组显著低于健康对照组（t = -4.274, p < 0.001）。在元认知偏差（平均置信度）、元认知敏感性（meta-d′）和元认知效率（M比）方面，重度抑郁症组的表现显著差于健康对照组(t = -4.280, p < 0.001；T = -3.540, p < 0.001；T = -2.104, p = 0.039)。此外，重度抑郁症患者的汉密尔顿抑郁评定量表（HAMD-17）得分与其d′、平均置信度、meta-d′、M比值呈显著负相关(r = -0.468, p < 0.001；R = -0.601, p < 0.001; R = -0.457, p < 0.001；r = -0.362, p = 0.003)， MDD患者的平均置信水平与d′、meta-d′、M比值呈显著正相关。(r = -0.552, p < 0.001；R = 0.738, p < 0.001; R =0.273, p =0.02)。结论：重度抑郁症患者的元认知能力明显受损，且元认知损害程度与临床抑郁症状的严重程度相关。此外，他们的元认知能力损害与负性元认知偏差相关。临床试验注册：https://www.chictr.org.cn，标识符ChiCTR2400091242。
期刊介绍：
Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.
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