Frontiers in Psychiatry最新文献

{"title":"Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder and the impact on executive function.","authors":"Anqi Wang, Hua Yang, Yue Yang, Jie Yang, Xiaowen Yang, Qianhui Wen, Qian Wang, Hao Liu, Rong Luo","doi":"10.3389/fpsyt.2025.1475889","DOIUrl":"10.3389/fpsyt.2025.1475889","url":null,"abstract":"<p><strong>Background: </strong>Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. A core cognitive deficit in ADHD is executive function (EF) impairment, which significantly impacts daily life. Methylphenidate (MPH) is a widely used first-line treatment for ADHD, but objective biomarkers to assess treatment response are lacking. The aim of this study was to investigate the effects of MPH on executive function and identify potential neural biomarkers of response in children with ADHD using electroencephalogram (EEG).</p><p><strong>Methods: </strong>A total of 26 boys with ADHD (mean age 8.64 ± 1.30 years) participated in the study. All participants were treated with 18 mg/day of oral extended-release MPH in the morning for 8 weeks. Executive function was assessed using the BRIEF2 and Digit Span Test (DST), and event-related potentials (ERP) were measured at baseline and after 8 weeks of MPH treatment.</p><p><strong>Results: </strong>After 8 weeks of MPH treatment, significant improvements were observed in several executive function domains. BRIEF2 scores, including inhibition, self-monitoring, shifting, emotional control, initiation, working memory, planning/organization, task monitoring, and material organization, were significantly reduced (<i>P</i> < 0.05). Behavioral performance in the Go/NoGo task also improved, with shorter correct response times and higher accuracy rates (<i>P</i> = 0.002, <i>P</i> = 0.009). EEG results revealed a reduction in Nogo-P300 latency at Fz, Cz and Pz compared to baseline (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The normalization of P300 latency following MPH treatment appears to be a reliable neural biomarker of positive treatment response in children with ADHD. MPH was associated with improvements in executive function, particularly in inhibitory control and working memory.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1475889"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model.","authors":"Yiting Kong, Zhewei Su, Rui Wang, Jianyu Tan, Yuancen Zhong, Ming Ai, Wo Wang, Su Hong, Qi Zhang, Li Kuang","doi":"10.3389/fpsyt.2025.1555120","DOIUrl":"10.3389/fpsyt.2025.1555120","url":null,"abstract":"<p><strong>Introduction: </strong>With the rising prevalence of depressive symptoms among younger individuals, depressive symptoms in elementary school students have become a focal issue of concern in society. This study investigated the association between parent-child relationship and depressive symptoms among Chinese elementary school students while testing a moderated mediation model to examine the mediating role of significant study stress and the moderating effect of frequent mobile phone use on this relationship.</p><p><strong>Methods: </strong>We recruited elementary school students from grades 3 to 6 in S district of Chongqing, China, totaling 33,285 participants (51.72% girls; mean age = 10.36 years, SD = 1.24). Data was analyzed using structural equation modeling to assess the mediating and moderating effects of study stress and mobile phone use, respectively, on the relationship between parent-child relationship and depressive symptoms.</p><p><strong>Results: </strong>Depressive symptoms prevalence in our study population was 16.3%. Both fair and poor parent-child relationships were significantly linked to an increased risk of depressive symptoms, with study stress serving as a mediator (indirect effects: fair parent-child relationship = 0.058, poor parent-child relationship = 0.031, p < 0.001). Frequent mobile phone use amplified the impact of fair parent-child relationships on study stress (β=0.024, SE=0.016, p < 0.05) and depressive symptoms (β = 0.021, SE = 0.018, p < 0.05) but did not moderate the relationship between poor parent-child relationships and these outcomes.</p><p><strong>Discussion: </strong>These results emphasize the importance of nurturing parent-child relationship, monitoring study stress, and managing mobile phone usage to support students' mental health. Furthermore, the findings suggest that the impact of mobile phone usage on the mental health of elementary school students varies in complexity across different parent-child relationship contexts, providing valuable insights and recommendations for developing targeted preventive interventions for depressive symptoms in this demographic.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1555120"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring autistic traits in parents of autistic children: a pilot study on the broader autism phenotype.","authors":"Antonio Narzisi, Elena Maria Busuoli, Maddalena Fabbri-Destro, Martina Pinzino, Sara Calderoni, Raffaella Tancredi, Michael Vincent Lombardo, Gabriele Masi","doi":"10.3389/fpsyt.2025.1537487","DOIUrl":"10.3389/fpsyt.2025.1537487","url":null,"abstract":"<p><strong>Background: </strong>Biological parents of autistic children often exhibit characteristics associated with the broader autism phenotype (BAP), a subclinical expression of autism-related traits. While BAP traits are known to be prevalent among first-degree relatives of autistic individuals, the relationship between parental traits and children's characteristics remains under-explored.</p><p><strong>Objectives: </strong>This pilot study examines the presence and extent of BAP traits in an Italian sample of both biological mothers and fathers of autistic children, exploring also the correlations between parental BAP traits and children's autistic traits.</p><p><strong>Methods: </strong>Seventy-six autistic children (ages 4-11) and their biological parents were recruited for the study. Parental and child traits were evaluated using the Autism Quotient (AQ) and the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2).</p><p><strong>Results: </strong>Of the recruited sample of parents, 29% fell within the BAP, with 12% of fathers and 17% of mothers meeting the criteria. A significant difference was found in AQ scores between fathers and mothers, with fathers scoring higher on average. Fathers' AQ scores were significantly correlated with their children's AQ scores, while no significant correlation was observed between mothers' AQ scores and children's scores. Additionally, children's AQ scores correlated significantly with all Vineland Adaptive Behavior Scale (VABS) subscales but not with ADOS scores.</p><p><strong>Conclusions: </strong>This study highlights the significance of parental BAP traits in relation to autism characteristics in children. The findings suggest that paternal BAP traits, in particular, may have a stronger association with child characteristics. Understanding these associations may contribute to refining psycho-educational strategies tailored to the specific traits of parents, ultimately enhancing intervention approaches.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1537487"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation, attempt and associated factors among adult cancer patients at Jimma University Medical Center, Jimma, Ethiopia, 2023.","authors":"Kunuya Kunno, Asmare Belete, Tamrat Anbesaw, Monenus Teshome, Shimelis Girma Kassaye, Badiru Dawud, Zelalem Birhan","doi":"10.3389/fpsyt.2025.1461071","DOIUrl":"10.3389/fpsyt.2025.1461071","url":null,"abstract":"<p><strong>Background: </strong>Cancer has been associated with an increased risk of suicidal behaviors and suicide has been one of the leading causes of non-cancer-related mortality among cancer patients in recent years. However, there is limited evidence on suicidal behaviors in patients diagnosed with cancer at Jimma University Medical Center.</p><p><strong>Objective: </strong>This study aimed to assess the magnitude and associated factors of suicidal ideation and attempts among cancer patients at Jimma University Medical Center, Ethiopia, in 2023.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted among 271 cancer patients at Jimma University Medical Center from 1 to 30 November 2023. Data were collected using interviewer-administered questionnaires and a consecutive sampling technique was employed. Suicidal ideation and attempts were assessed by the Composite International Diagnostic Interview Module. Logistic regression analysis was used to evaluate the significance of the association between the dependent and independent variables. Variables with a p-value <0.25 were candidates for the multivariable logistic regression so that predictors of suicidal ideation and attempt were identified at a p-value < 0.05, with a 95% confidence interval (CI), in the final model.</p><p><strong>Results: </strong>This study reported that 24% and 10.7% of the patients with cancer had suicide ideation and attempted suicide in the previous 12 months, respectively. Being female [adjusted odds ratio (AOR) = 5.35; 95% CI, 2.48-11.54] and having anxiety (AOR = 4.09; 95% CI, 1.85-9.03), psychological distress (AOR = 4.19, 95% CI, 1.61-10.87), and stage IV cancer (AOR = 5.81, 95% CI, 1.73-19.51) were significantly associated with suicidal ideation while having depression [AOR = 3.25, 95% CI, 1.05- 10.06] and anxiety [AOR = 3.50, 95% CI, 1.19-10.32] were significantly associated with attempting suicide.</p><p><strong>Conclusion: </strong>Nearly one-quarter and one-tenth of the patients with cancer had suicide ideation and attempted suicide in the previous 12 months, respectively. Being female, advanced cancer stage, anxiety, and psychological distress were statistically significantly associated with suicidal ideation. Anxiety and depression were statistically associated with attempting suicide. It is important that oncology professionals routinely perform patient suicidal risk assessment. Consultation services need to be strengthened with psychiatric professionals in cancer treatment centers.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1461071"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-affirmative support for autism, the Double Empathy Problem and monotropism.","authors":"Mark Brosnan, Louis John Camilleri","doi":"10.3389/fpsyt.2025.1538875","DOIUrl":"10.3389/fpsyt.2025.1538875","url":null,"abstract":"<p><p>Conceptualising autism within a neurodiversity approach raises fundamental questions regarding the nature of the goals pursued in autism support and who is responsible for achieving these goals. The Double Empathy Problem considers deficits in social communication as residing between autistic and non-autistic communicators, rather than solely within the autistic individual. This is important as autistic individuals can have different perceptions of what appropriate goals for autism support should be, when compared to (non-autistic) family, friends and professionals. Monotropism highlights the importance of engaging with the interests of the autistic individual when considering support. This perspective considers the extent to which autistic individuals can self-set and self-achieve autism support goals? Social narratives have a specific goal and explicit description of how to achieve this goal and what the outcome of achieving the goal will be. The Stories Online For Autism app (SOFA-app.com) develops and delivers social narratives for autistic individuals. The SOFA-app has proven to be highly acceptable and effective in supporting autistic individuals. Initially our research focussed on family, friends and professionals developing autism support for autistic children. Subsequently we extended this methodology to explore the self-set goals of autistic adults and children as well as capacity to self-achieve these goals successfully. Digital support for the development and delivery of social narratives to support self-set goals for autistic individuals is recommended. Addressing the Double Empathy Problem and supporting self-set goals are also considered alongside the implications of preferences associated with Monotropism to argue this approach can be considered neuro-affirmative.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1538875"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could antidepressants increase mood and immunity at the same time?","authors":"Francis Lavergne, Therese M Jay","doi":"10.3389/fpsyt.2025.1340179","DOIUrl":"10.3389/fpsyt.2025.1340179","url":null,"abstract":"<p><p>A review of scientific literature suggests that the use of antidepressants can be broadly extended to address various forms of stress and inflammation as an adjunctive therapy that enhances host resistance. While the effects of antidepressants on mood are well-documented in terms of their emotional, cognitive, and behavioral impacts, these aspects do not fully explain their cellular mechanisms of action. At the cellular level, antidepressants exert trophic effects that promote neurogenesis and synaptic connectivity. Studies demonstrate that antidepressants improve cell survival, enhance stem cell proliferation, and reduce danger perception (mood effects) in depressed patients and animal models of depression. These trophic properties highlight a deeper biological mechanism beyond their mood-related benefits. The acid sphingomyelinase (ASM) theory of mood offers a more compelling explanation of the cellular effects of antidepressants compared to the monoamine hypothesis. Antidepressants functionally inhibit the ASM enzyme, thereby reducing the production of ceramide, which directs cells toward increased survival, cytoprotection, and reproduction, as well as improved mood. This review also highlights research demonstrating that antidepressants enhance host resistance to infections, immunological challenges, stress, and depression. These findings support the potential use of antidepressants to bolster host resilience in scenarios involving infections, vaccinations, cellular aggression, stress, depression, and even aging.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1340179"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of schizophrenia, depression, and Alzheimer's diseases among older adults: a retrospective study of 271 consecutive admissions.","authors":"Wen Wang, Junrong Ye, Yanheng Wei, Jiawei Huang, Haoyun Wang, Fei Liu, Shengwei Wu, Jialan Wu, Zezhi Li, Jianxiong Guo, Aixiang Xiao","doi":"10.3389/fpsyt.2025.1486626","DOIUrl":"10.3389/fpsyt.2025.1486626","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to identify the clinical characteristics of schizophrenia, depression, and AD among older adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;General information of patients was collected, including diagnosis, age, gender, level of education, marital status, drinking behavior, smoking behavior, course of mental disorder, type of admission, history of modified electroconvulsive therapy (MECT) and hospitalization period. The Brief Psychiatric Rating Scale (BPRS), Geriatric Depression Scale (GDS), Generalized Anxiety Disorder 7-Item Scale (GAD-7), Insight and Treatment Attitudes Questionnaire (ITAQ), and Mini-Mental State Examination (MMSE) were employed to evaluate the participants' mental status. The Functional Activities Questionnaire (FAQ), Social Support Rating Scale (SSRS), Barthel ADL Index, Standardized Swallowing Assessment (SSA), and Mini-Nutritional Assessment (MNA) were applied to measure social and daily living function. The Nurses' Global Assessment of Suicide Risk (NGASR) and The Brøset Violence Checklist (BVC) were used to assess the patients' risk of suicide.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Totally 271 participants were recruited, the numbers of participants with schizophrenia, depression, and Alzheimer's diseases (AD), were 81 (29.9%), 85 (31.4%), and 105 (38.7%), respectively. One-way ANOVA was used to compare the variance of the crude score results among three groups of subjects. The results showed that patients with depression had the highest GDS total score, followed by patients with AD, and patients with schizophrenia had the lowest score (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). The total scores of GAD-7 and ITAQ in patients with depression were higher than those in patients with AD and schizophrenia (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). The total score of MMSE in patients with schizophrenia and depression was higher than that in patients with AD (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). The incidence of circulatory system diseases in patients with depression and AD was higher than that in patients with schizophrenia (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The incidence of respiratory system diseases in patients with AD was highest, followed by patients with schizophrenia, and patients with depression had the lowest incidence (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The incidence of nervous system diseases in patients with AD was highest, followed by patients with depression, and patients with schizophrenia had the lowest incidence (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The total scores of FAQ and SSA in patients with AD were higher than those in patients with schizophrenia and depression (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), while patients with depression had statistically lower SSRS scores than patients with schizophrenia and patients with AD (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Furthermore, patients with AD had lower Barthel ADL Index scores and water-swallowing test (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). MNA scores of patients with schizophrenia were higher than those of patients with depression and AD, with statistical significance (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The NGASR sc","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1486626"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dyad approach to understanding relationship satisfaction and health outcomes in military couples following service member and veteran traumatic brain injury.","authors":"Tracey A Brickell, Brian J Ivins, Megan M Wright, Jamie K Sullivan, Louis M French, Rael T Lange","doi":"10.3389/fpsyt.2025.1465801","DOIUrl":"10.3389/fpsyt.2025.1465801","url":null,"abstract":"<p><strong>Objective: </strong>Using a dyadic approach, this study examined health and family outcomes in military couples following service member and veteran (SMV) traumatic brain injury (TBI), within the context of relationship satisfaction.</p><p><strong>Methods: </strong>Participants included 164 dyads (<i>N</i> = 328), composed of US SMVs (<i>n</i> = 164) and their intimate partners (IPs, <i>n</i> = 164). Dyads completed a measure of relationship satisfaction, as well as measures of psychological, social, caregiving, family, neurobehavioral, and/or PTSD outcomes. Dyads were classified into four relationship satisfaction groups: (1) SMV and IP satisfied (Both Satisfied, <i>n</i> = 72 dyads), (2) SMV satisfied and IP dissatisfied (SMV_sat/IP_dis, <i>n</i> = 25 dyads), (3) SMV dissatisfied and IP satisfied (SMV_dis/IP_sat, <i>n</i> = 21 dyads), and (4) SMV and IP dissatisfied (Both Dissatisfied, <i>n</i> = 46 dyads).</p><p><strong>Results: </strong>Within dyads, SMVs reported worse scores than their IPs, except in the SMV_sat/IP_dis group, where their dissatisfied IPs reported worse scores on four measures. Across groups, dissatisfied SMVs reported worse scores compared to satisfied SMVs, and dissatisfied IPs reported worse scores compared to satisfied IPs. Satisfied and dissatisfied SMVs and IPs in the mixed relationship satisfaction groups reported little to no differences across measures compared to their respective SMVs and IPs in the Both Satisfied and Both Dissatisfied groups, with the exception of the family measures for dissatisfied SMVs or IPs.</p><p><strong>Conclusions: </strong>Relationship dissatisfaction was related to worse health and family outcomes, even when the other members of the dyad reported satisfaction in their relationship. A dual-goal, dyadic approach to TBI treatment that focuses on how individual, couple, and family factors interact will likely maximize service member recovery and return to duty, as well as outcomes for military families.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1465801"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher levels of total cholesterol/high-density lipoprotein cholesterol ratios are associated with an increased risk of suicidal behavior in children and adolescents with depressive disorders.","authors":"Nana Sun, Zhiwei Liu, Liang Sun, Feng Sun, Longlong Sun, Jingjing Zhang, Rongchun Yang, Gaofeng Yao, Yun Liu","doi":"10.3389/fpsyt.2025.1557451","DOIUrl":"10.3389/fpsyt.2025.1557451","url":null,"abstract":"<p><strong>Objective: </strong>To explore the prevalence of suicidal ideation (SI) and suicidal attempt (SA) in inpatients with childhood and adolescent depressive disorders and the relationship between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratios and SI, SA.</p><p><strong>Methods: </strong>A study was conducted involving 515 pediatric patients diagnosed with depressive disorders at the Third People's Hospital of Fuyang. This research primarily focused on gathering basic demographic and clinical data. Through employing methods such as correlation analysis and logistic regression, the study aimed to identify factors linked to SI and SA among these individuals.</p><p><strong>Results: </strong>The prevalence of SI and SA was 20.0% (103/515) and 9.1% (47/515). Binary logistic regression highlighted several independent predictors for SI. A notable increase in the likelihood of SI was observed with an increase in the number of hospitalizations (Odds Ratio [<i>OR</i>]=1.65, <i>P</i>=0.025), a heightened TC/HDL-C ratio (<i>OR</i>=1.72, <i>P</i>=0.002), an escalated antidepressant dosage (<i>OR</i>=1.02, <i>P</i>=0.029), and elevated HAMD scores (<i>OR</i>=1.04, <i>P</i>=0.003). For SA, critical independent associated factors identified were an increased number of hospitalizations (<i>OR</i>=2.71, <i>P</i><0.001), a higher TC/HDL-C ratio (<i>OR</i>=1.69, <i>P</i>=0.002), and greater HAMD scores (<i>OR</i>=1.06, <i>P</i>=0.003), particularly in children and adolescents diagnosed with depressive disorders.</p><p><strong>Conclusion: </strong>These findings suggest that monitoring lipid profiles, particularly the TC/HDL-C ratio, alongside careful management of antidepressant dosages and close observation of depressive symptoms, could be crucial in mitigating suicidal risks among this vulnerable population.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1557451"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors.","authors":"Jinni Su, Belal Jamil, Kit K Elam, Angel D Trevino, Kathryn Lemery-Chalfant, Eleanor K Seaton, Rick A Cruz, Kevin J Grimm","doi":"10.3389/fpsyt.2025.1505035","DOIUrl":"10.3389/fpsyt.2025.1505035","url":null,"abstract":"<p><strong>Introduction: </strong>There is limited understanding on how polygenic scores derived from genome-wide association studies of adult and child psychopathology may uniquely predict childhood traits. The current study took a developmental approach to examine the interplay between adult-based and child-based polygenic scores with family processes in predicting trajectories of externalizing behaviors from late childhood to early adolescence among racially-ethnically diverse youth.</p><p><strong>Method: </strong>Data were drawn from the non-Hispanic White (N = 5,907), non-Hispanic Black (N = 1,694), and Hispanic youth (N = 2,117) from the adolescent brain cognitive development (ABCD) study. Parents reported on youth externalizing behaviors at baseline (T1, age 9/10), 1-year (T2, age 10/11), 2-year (T3, age 11/12), and 3-year (T4, age 12/13) follow-up assessments. Youth reported on parenting and family environment at T1 and provided saliva or blood samples for genotyping.</p><p><strong>Results: </strong>Both polygenic scores for adult externalizing and childhood aggression predicted greater likelihood of following trajectories with higher externalizing behaviors. Among non-Hispanic White youth, polygenic scores also predicted greater family conflict, which in turn predicted higher externalizing behavior trajectories.</p><p><strong>Discussion: </strong>Our findings indicated that both adult-based and child-based polygenic scores for externalizing behaviors are useful in predicting trajectories of externalizing behaviors, highlighting developmental continuity in genetic influences. Family processes, especially family conflict, play an important role in adolescent externalizing behaviors across racial-ethnic groups, suggesting the need to target family conflict in intervention efforts. Findings also highlight the importance of conducting research in diverse populations, including improving diversity in genetically informed studies.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1505035"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}