IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060398

Nina G Mikusheva, Ivan M Zorin, Alexander S Gubarev, Alexandr V Ievlev, Olga V Volina, Nikolai V Tsvetkov

{"title":"Influence of Reduced Molar Mass of Low-Acyl Gellan Gum on Weak Gel Formation and Rheological Properties.","authors":"Nina G Mikusheva, Ivan M Zorin, Alexander S Gubarev, Alexandr V Ievlev, Olga V Volina, Nikolai V Tsvetkov","doi":"10.3390/gels11060398","DOIUrl":"10.3390/gels11060398","url":null,"abstract":"Reduced-molar-mass low-acyl gellan gum was obtained by the centrifugation of an aqueous solution of commercially available food-grade gellan gum. The derived sample was characterized by NMR, FTIR, ICPE, and viscometry methods. The characteristics were compared with commercially available gellan gum Gelzan™. The main focus of the investigation is on the rheological properties of low-molar-mass-gellan ion-induced gels and the influence of reduced molar mass on gelling of gellan. The gels were prepared by adding 0.2-0.3 M of NaCl or KCl to the 0.6 g/dL gellan gum aqueous solution in a 1:1 ratio. The kinetics of gelling at room temperature, studied by rheological methods, strongly depends on molar mass and is practically independent of the temperature (up to 37 °C) and the type of ions. Analysis of the mechanical spectra characterized the obtained gels as weak gels. The gelling temperature achieved upon cooling for low-molar-mass gellan with a 0.1 M NaCl concentration was 39.0 °C (rheology) and 43.5-42.5 °C (visual observation). In summary, this study complements the existing knowledge about how the reduced molar mass of low-acyl gellan gum influences its rheological properties and gelling behavior in ion-induced systems and provides insights into the formulation of gellan-based gels, which can be effectively utilized in various food and pharmaceutical applications.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Optimization of Kunzea ericoides Nanoemulgel Using a Quality by Design Approach for Transdermal Anti-Inflammatory Therapy. 采用质量设计法制备中药透皮抗炎纳米乳并对其进行优化。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060400

Koushik Yetukuri, Marakanam Srinivasan Umashankar

{"title":"Development and Optimization of Kunzea ericoides Nanoemulgel Using a Quality by Design Approach for Transdermal Anti-Inflammatory Therapy.","authors":"Koushik Yetukuri, Marakanam Srinivasan Umashankar","doi":"10.3390/gels11060400","DOIUrl":"10.3390/gels11060400","url":null,"abstract":"This study investigates the Quality by Design (QbD)-driven development and optimization of a nanoemulgel incorporating Kunzea ericoides oil for transdermal therapy. Nanoemulgels enhance percutaneous drug delivery, sustain release profiles, and improve bioavailability. A central composite design was employed to optimize critical formulation parameters, with ANOVA confirming a statistically significant impact on particle size and drug release kinetics (p < 0.05). The optimized formulation exhibited a particle size of 112.38 nm, a polydispersity index of 0.203, and a zeta potential of -29.0 mV, ensuring colloidal stability. In vitro drug release followed the Higuchi model (R2 = 0.989, kH = 4.776), indicating diffusion-controlled kinetics, while the Korsmeyer-Peppas model (n = 0.88) suggested an anomalous transport mechanism. Antibacterial studies determined minimum inhibitory concentrations of 250 µg/mL for Staphylococcus aureus and 500 µg/mL for Escherichia coli, indicating greater susceptibility in S. aureus. In vivo anti-inflammatory evaluation using a carrageenan-induced paw edema model demonstrated a statistically significant reduction in inflammation (p = 0.005 at 60 min), with a near-complete resolution by 240 min. These findings underscore the potential of Kunzea ericoides nanoemulgel as a promising transdermal therapeutic, integrating controlled drug release with potent anti-inflammatory and antibacterial properties for dermatological and inflammatory conditions.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Calcination Temperature and Strontium Addition on the Properties of Sol-Gelled Bioactive Glass Powder. 煅烧温度和锶添加量对溶胶-凝胶生物活性玻璃粉性能的影响。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060401

Pei-Jung Chang, Jia-Yu Chen, Chi-Han Cheng, Kazuhiro Aoki, Cherng-Yuh Su, Chung-Kwei Lin

{"title":"Effect of Calcination Temperature and Strontium Addition on the Properties of Sol-Gelled Bioactive Glass Powder.","authors":"Pei-Jung Chang, Jia-Yu Chen, Chi-Han Cheng, Kazuhiro Aoki, Cherng-Yuh Su, Chung-Kwei Lin","doi":"10.3390/gels11060401","DOIUrl":"10.3390/gels11060401","url":null,"abstract":"Strontium-added bioactive glass (SBG) has been widely used in bone tissue engineering. SBG can be prepared by conventional high-temperature melt-quenching or calcining sol-gelled powder at 700 °C or above. In the present study, the effects of calcination temperature (400-650 °C) and the amount of strontium addition (0-7 mol.%) were investigated simultaneously. The sol-gel process and post-calcination were used to prepare the Sr-added 58S bioactive glass (SBG) powders. The bioactivity of the SBG powder was assessed by immersing it in simulated body fluid, while biocompatibility and cytotoxicity were evaluated using L929 and MG63 cells, and a zebrafish animal model. The calcination temperatures were determined by thermogravimetric analysis based on the weight loss at various stages. X-ray diffraction was used to reveal the crystalline structure of calcined or SBF-immersed SBG powders. Meanwhile, the texture characteristics of SBG powders were examined by the BET method. Fourier-transformed infrared spectroscopy and scanning electron microscopy were used to investigate the absorption bands and powder morphology of SBG powders before and after SBF immersion. The experimental results showed that all SBG powders were mesoporous with a high specific surface area larger than 200 m2/g. SBG powder calcined at 650 °C with 5% Sr addition possessed a major Ca14.92(PO4)2.35(SiO4)5.65 phase, the smallest pore size of 5.86 nm, and the largest specific surface area of 233 m2/g. It was noncytotoxic and exhibited good bioactivity and biocompatibility.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alginate/k-Carrageenan Interpenetrated Biopolymeric Aerogels for Nutraceutical Drug Delivery. 海藻酸盐/k-卡拉胶互穿生物聚合物气凝胶用于营养药物输送。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060393

Alessandra Zanotti, Lucia Baldino, Ernesto Reverchon, Stefano Cardea

{"title":"Alginate/k-Carrageenan Interpenetrated Biopolymeric Aerogels for Nutraceutical Drug Delivery.","authors":"Alessandra Zanotti, Lucia Baldino, Ernesto Reverchon, Stefano Cardea","doi":"10.3390/gels11060393","DOIUrl":"10.3390/gels11060393","url":null,"abstract":"Bioactive compounds of natural origin are central to the development of nutraceutical formulations. To improve their stability and to target their delivery to the intestinal or colonic tract, alginate/k-carrageenan spherical gels have been produced at different volumetric ratios (100/0, 70/30, 50/50, 30/70, and 0/100 v/v), by means of solution dripping and external gelation. Different drying methods were compared, and only through supercritical technologies was it possible to achieve interpenetrated networks that feature nanometric pore size distribution. Hybrid aerogels inherited the most relevant characteristics of alginate and k-carrageenan: they showed remarkable water uptake capacity (e.g., 50.60 g/g), and stability in aqueous media over large timespans. Naringin release tests in simulated intestinal and colonic fluids proved that it is possible to target drug delivery by choosing intermediate alginate/k-carrageenan ratios. Overall, by means of supercritical gel drying, it is possible to generate advanced biopolymeric aerogels, yielding fully natural interpenetrated networks that valorize the most compelling properties of each species involved.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Different Dual-Modified Jujube Juicing Residue Dietary Fibers on the Properties of Egg Protein Gels Induced by Alkalinity and Heat. 不同双改性枣榨汁渣饲粮纤维对碱度和热致鸡蛋蛋白凝胶性能的影响

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060399

Xinyu Zheng, Ling Dang, Yichan Zhang, Xinyu Liu, Hui Wang, Yajun Zheng, Xinling Song, Zhihui Wei, Jiayao Zhang, Xiaoyang Guo

{"title":"Effects of Different Dual-Modified Jujube Juicing Residue Dietary Fibers on the Properties of Egg Protein Gels Induced by Alkalinity and Heat.","authors":"Xinyu Zheng, Ling Dang, Yichan Zhang, Xinyu Liu, Hui Wang, Yajun Zheng, Xinling Song, Zhihui Wei, Jiayao Zhang, Xiaoyang Guo","doi":"10.3390/gels11060399","DOIUrl":"10.3390/gels11060399","url":null,"abstract":"Egg protein gels have relatively poor water-holding capacity, hardness, and freeze-thaw properties. Jujube juicing residue dietary fiber (JJRDF) is available, but it is rarely used in the food industry because of its poor hydration properties. Versions of JJRDF modified via cellulase and xylanase hydrolysis separately coupled with carboxymethylation (JJRDF-CXHC), phosphate crosslinking (JJRDF-CXHPC), and acetylation (JJRDF-CXHA) were prepared, and their effects on heat-induced and alkaline-induced egg protein gels (HA-EPGs) were studied. Smaller particle sizes and higher solubility, viscosity, expansion volume, and ability to retain water were observed in JJRDF-CXHC, JJRDF-CXHPC, and JJRDF-CXHA compared to JJRDF (p < 0.05). JJRDF-CXHC showed the highest viscosity (18.46 cP) and expansion volume (10.40 mL/g). Higher random coil and β-sheet contents resulted in an increase in pH, adhesiveness, hardness, and chewiness, and a decrease in the water-losing rate in freeze-thaw cycles, and gastric digestion was observed in the HA-EPGs as a consequence of adding JJRDF, JJRDF-CXHC, JJRDF-CXHPC, and JJRDF-CXHA at 3-5 g/100 g. Moreover, JJRDF-CXHC and JJRDF-CXHPC were better at improving the textural quality of the unmodified HA-EPG compared to JJRDF-CXHA and JJRDF (p < 0.05). Therefore, to improve egg protein gel quality, JJRDF modified with cellulase and xylanase hydrolysis separately coupled with carboxymethylation and crosslinking is a good choice. However, the functionalities of these modified JJRDFs should be studied.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Temperature Dried Alginate/Silica Hybrid Aerogel Beads with Tunable Surface Functionalities for Removal of Lead Ions from Water. 低温干燥海藻酸盐/硅杂化气凝胶珠具有可调的表面功能，用于去除水中的铅离子。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060397

Jiuqi Wei, Shilong Yang, Zhicheng Zhu, Jialu Lu, Bencong Zhang, Mingmei Zhang, Wei Wei

{"title":"Low-Temperature Dried Alginate/Silica Hybrid Aerogel Beads with Tunable Surface Functionalities for Removal of Lead Ions from Water.","authors":"Jiuqi Wei, Shilong Yang, Zhicheng Zhu, Jialu Lu, Bencong Zhang, Mingmei Zhang, Wei Wei","doi":"10.3390/gels11060397","DOIUrl":"10.3390/gels11060397","url":null,"abstract":"Low-temperature dried alginate/silica hybrid aerogel beads with a large specific surface area (160.8 m2/g), low density (0.160 m2/g), and high degree of sphericity were successfully fabricated. Single networks of silica aerogels beads were synthesized via by calcining hybrid aerogel beads in air. Moreover, alginate-derived carbon/silica aerogel beads were also obtained by the thermal treatment of the hybrid aerogel beads in nitrogen, which were indicative of the double networks of the as-synthesized crack-free hybrid aerogel beads for the first time. The adsorption performances of above aerogel beads were also investigated. Meanwhile, using a common silane coupling agent as a modifying agent, a series of hybrid aerogel beads with tunable functional surfaces were obtained. The results showed that the obtained samples adsorbed Pb2+ well, and the hybrid aerogel beads modified with KH-590 exhibited an experimental maximum adsorption capacity of Pb2+ of 193.73 mg·g-1.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gel-Based Approaches to Vegan Leather: Opportunities and Challenges in Mimicking Leather Properties. 基于凝胶的纯素皮革方法：模仿皮革特性的机遇和挑战。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060395

Soon Mo Choi, Do Hyun Lee, Sun Mi Zo, Ankur Sood, Sung Soo Han

{"title":"Gel-Based Approaches to Vegan Leather: Opportunities and Challenges in Mimicking Leather Properties.","authors":"Soon Mo Choi, Do Hyun Lee, Sun Mi Zo, Ankur Sood, Sung Soo Han","doi":"10.3390/gels11060395","DOIUrl":"10.3390/gels11060395","url":null,"abstract":"Recently, increased global awareness of environmental sustainability and ethical consumerism has amplified the demand for sustainable alternatives to animal-derived leather. Traditional leather manufacturing faces significant ethical and ecological challenges, including greenhouse gas emissions, excessive water consumption, deforestation, and toxic chemical usage. Vegan leather has emerged as a promising solution, predominantly fabricated from petroleum-based synthetic materials such as polyurethane (PU) and polyvinyl chloride (PVC). However, these materials have sustainability limitations due to their non-biodegradability and associated environmental burdens. To overcome these issues, this review critically explores the feasibility of developing vegan leather using gel-based materials derived from natural and synthetic polymers. These materials offer precise structural controllability, excellent biodegradability, and the potential for significantly improved mechanical performance through hybridization and nanocomposite strategies. Despite their promising attributes, gel-based materials face significant limitations, including insufficient tensile strength, poor abrasion resistance, susceptibility to swelling, limited long-term stability, and challenges in scaling up for industrial production. This paper outlines the structural and physical properties required for viable leather substitutes, reviews opportunities provided by gel-based materials, addresses associated technical challenges, and proposes comprehensive strategies for enhancing mechanical properties and developing sustainable, eco-friendly production processes. Future research directions emphasize hybrid composite development, nanoparticle integration, circular manufacturing processes, and multi-disciplinary collaboration to establish gel-based vegan leather as a viable, sustainable, and market-competitive alternative to conventional animal leather.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Collagen on the Rheological and Transport Properties of Agarose Hydrogels. 胶原蛋白对琼脂糖水凝胶流变学和运输特性的影响。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060396

Veronika Richterová, Alžběta Gjevik, Ondřej Vaculík, Jakub Vejrosta, Miloslav Pekař

引用次数: 0

Gel Electrolytes in the Development of Textile-Based Power Sources. 凝胶电解质在纺织基电源开发中的应用。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060392

Ana Isabel Ribeiro, Cátia Alves, Marta Fernandes, José Abreu, Fábio Pedroso de Lima, Jorge Padrão, Andrea Zille

{"title":"Gel Electrolytes in the Development of Textile-Based Power Sources.","authors":"Ana Isabel Ribeiro, Cátia Alves, Marta Fernandes, José Abreu, Fábio Pedroso de Lima, Jorge Padrão, Andrea Zille","doi":"10.3390/gels11060392","DOIUrl":"10.3390/gels11060392","url":null,"abstract":"The interest in flexible and wearable electronics is increasing in both scientific research and in multiple industry sectors, such as medicine and healthcare, sports, and fashion. Thus, compatible power sources are needed to develop secondary batteries, fuel cells, supercapacitors, sensors, and dye-sensitized solar cells. Traditional liquid electrolytes pose challenges in the development of textile-based electronics due to their potential for leakage, flammability, and limited flexibility. On the other hand, gel electrolytes offer solutions to these issues, making them suitable choices for these applications. There are several advantages to using gel electrolytes in textile-based electronics, namely higher safety, leak resistance, mechanical flexibility, improved interface compatibility, higher energy density, customizable properties, scalability, and easy integration into manufacturing processes. However, it is also essential to consider some challenges associated with these gels, such as lower conductivity and long-term stability. This review highlights the application of gel electrolytes to textile materials in various forms (e.g., fibers, yarns, woven, knit, and non-woven), along with the strategies for their integration and their resulting properties. While challenges remain in optimizing key parameters, the integration of gel electrolytes into textiles holds immense potential to enhance conductivity, flexibility, and energy storage, paving the way for advanced electronic textiles.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the Feasibility of Self-Assembling Peptides as a Three-Dimensional Culture Tool for Drug Screening of Colorectal Adenocarcinoma Cells. 自组装肽作为结直肠癌细胞药物筛选三维培养工具的可行性研究。

IF 5 3区化学

Gels Pub Date : 2025-05-27 DOI: 10.3390/gels11060394

Yu Gao, Di Su, Jiawei Zhao, Zhongli Luo, Xuemei Lin

{"title":"Study on the Feasibility of Self-Assembling Peptides as a Three-Dimensional Culture Tool for Drug Screening of Colorectal Adenocarcinoma Cells.","authors":"Yu Gao, Di Su, Jiawei Zhao, Zhongli Luo, Xuemei Lin","doi":"10.3390/gels11060394","DOIUrl":"10.3390/gels11060394","url":null,"abstract":"In recent years, the incidence of colorectal cancer has been increasing annually. During the research on tumor treatment strategies, the translation of fundamental research findings into clinical applications has often been constrained by the limitations of existing tumor models, with few breakthroughs achieved to date. Therefore, our objective is to explore the feasibility of utilizing self-assembling short peptides (SAPs) to construct a three-dimensional (3D) culture system for colorectal adenocarcinoma cells for anticancer drug screening. By characterizing the physicochemical properties and biocompatibility of SAP SCIOBIO III, we demonstrated that it can rapidly self-assemble into a nanofibrous scaffold under ionic triggers, supporting 3D cell culture. Subsequently, anticancer drug sensitivity tests were conducted on both 2D and 3D culture systems of colorectal adenocarcinoma cells. The results indicate that SCIOBIO III can mimic the extracellular matrix and serves as an ideal scaffold for constructing a 3D cell culture microenvironment. We successfully established a 3D culture model for colorectal adenocarcinoma cells and effectively screened anticancer drugs, which holds promise for advancing the development of personalized anticancer drug screening technologies.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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