IF 5 3区化学

Gels Pub Date : 2024-07-11 DOI: 10.3390/gels10070455

Laura Giuliani, Chiara Genova, V. Stagno, Luca Paoletti, Andrea Louise Matulac, A. Ciccola, Melania Di Fazio, Silvia Capuani, Gabriele Favero

{"title":"Multi-Technique Assessment of Chelators-Loaded PVA-Borax Gel-like Systems Performance in Cleaning of Stone Contaminated with Copper Corrosion Products","authors":"Laura Giuliani, Chiara Genova, V. Stagno, Luca Paoletti, Andrea Louise Matulac, A. Ciccola, Melania Di Fazio, Silvia Capuani, Gabriele Favero","doi":"10.3390/gels10070455","DOIUrl":"https://doi.org/10.3390/gels10070455","url":null,"abstract":"Currently, one of the most important challenges for the conservation of stone artworks is the removal of metal corrosion products on their surfaces. Traditional cleaning methods, which typically involve the application of aqueous solutions containing chelating agents capable of complexing these metal ions, have shown some weaknesses. These weaknesses become apparent when such methods are applied to statues and other vertical surfaces or when aiming to limit the cleaning process to a specific area with controlled application times. Furthermore, the porosity of the stone surface plays a role concerning the cleaning efficiency. To address these issues, chelating agents can be incorporated into gel-like materials. This study is a proof of concept to evaluate the cleaning efficacy of various gel formulations composed of polyvinyl alcohol (PVA), borax (B), and agarose (AG), loaded with two chelators: ethylenediaminetetraacetic acid (EDTA) and potassium sodium tartrate (PST or Rochelle salt). Three types of carbonate stones (travertine, Lecce stone, and Carrara marble) characterized by different porosities were artificially stained with copper sulphates and treated with the different PVA-B-AG formulations. The effectiveness of the treatment was directly monitored on the stones using a multi-technique approach that included scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) and non-invasive portable nuclear magnetic resonance (NMR). Additionally, the rheological properties of the gels were investigated, and the Fourier transform infrared attenuated total reflection spectroscopy (FTIR ATR) was used to analyse the chemical structure of the gel before and after treatment, aiming to understand the changes induced by the cleaning process.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic Gas-Permeable Mold Fabrication Using Sol–Gel Polymerization for Nano-Injection Molding 利用溶胶-凝胶聚合技术制造阳离子透气模具，用于纳米注塑成型

IF 5 3区化学

Gels Pub Date : 2024-07-11 DOI: 10.3390/gels10070453

Sayaka Miura, Rio Yamagishi, Mano Ando, Arisa Teramae, Yuna Hachikubo, Yoshiyuki Yokoyama, Satoshi Takei

引用次数: 0

Coenzyme-A-Responsive Nanogel-Coated Electrochemical Sensor for Osteoarthritis-Detection-Based Genetic Models 用于骨关节炎检测的辅酶 A 反应性纳米凝胶涂层电化学传感器--基于基因模型

IF 5 3区化学

Gels Pub Date : 2024-07-10 DOI: 10.3390/gels10070451

Akhmad Irhas Robby, Songling Jiang, Eun-Jung Jin, Sung Young Park

{"title":"Coenzyme-A-Responsive Nanogel-Coated Electrochemical Sensor for Osteoarthritis-Detection-Based Genetic Models","authors":"Akhmad Irhas Robby, Songling Jiang, Eun-Jung Jin, Sung Young Park","doi":"10.3390/gels10070451","DOIUrl":"https://doi.org/10.3390/gels10070451","url":null,"abstract":"An electrochemical sensor sensitive to coenzyme A (CoA) was designed using a CoA-responsive polyallylamine–manganese oxide–polymer dot nanogel coated on the electrode surface to detect various genetic models of osteoarthritis (OA). The CoA-responsive nanogel sensor responded to the abundance of CoA in OA, causing the breakage of MnO2 in the nanogel, thereby changing the electroconductivity and fluorescence of the sensor. The CoA-responsive nanogel sensor was capable of detecting CoA depending on the treatment time and distinguishing the response towards different OA genetic models that contained different levels of CoA (wild type/WT, NudT7 knockout/N7KO, and Acot12 knockout/A12KO). The WT, N7KO, and A12KO had distinct resistances, which further increased as the incubation time were changed from 12 h (R12h = 2.11, 2.40, and 2.68 MΩ, respectively) to 24 h (R24h = 2.27, 2.59, and 2.92 MΩ, respectively) compared to the sensor without treatment (Rcontrol = 1.63 MΩ). To simplify its application, the nanogel sensor was combined with a wireless monitoring device to allow the sensing data to be directly transmitted to a smartphone. Furthermore, OA-indicated anabolic (Acan) and catabolic (Adamts5) factor transcription levels in chondrocytes provided evidence regarding CoA and nanogel interactions. Thus, this sensor offers potential usage in simple and sensitive OA diagnostics.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocomposite Perfluorosulfonic Acid/Montmorillonite-Na+ Polymer Membrane as Gel Electrolyte in Hybrid Supercapacitors 纳米复合全氟磺酸/蒙脱石-Na+聚合物膜作为混合超级电容器中的凝胶电解质

IF 5 3区化学

Gels Pub Date : 2024-07-10 DOI: 10.3390/gels10070452

Borislava Mladenova, Galin Borisov, Mariela Dimitrova, Desislava Budurova, Maya Staneva, Filip Ublekov, Antonia Stoyanova

{"title":"Nanocomposite Perfluorosulfonic Acid/Montmorillonite-Na+ Polymer Membrane as Gel Electrolyte in Hybrid Supercapacitors","authors":"Borislava Mladenova, Galin Borisov, Mariela Dimitrova, Desislava Budurova, Maya Staneva, Filip Ublekov, Antonia Stoyanova","doi":"10.3390/gels10070452","DOIUrl":"https://doi.org/10.3390/gels10070452","url":null,"abstract":"Solid-state supercapacitors with gel electrolytes have emerged as a promising field for various energy storage applications, including electronic devices, electric vehicles, and mobile phones. In this study, nanocomposite gel membranes were fabricated using the solution casting method with perfluorosulfonic acid (PFSA) ionomer dispersion, both with and without the incorporation of 10 wt.% montmorillonite (MMT). MMT, a natural clay known for its high surface area and layered structure, is expected to enhance the properties of supercapacitor systems. Manganese oxide, selected for its pseudocapacitive behavior in a neutral electrolyte, was synthesized via direct co-precipitation. The materials underwent structural and morphological characterization. For electrochemical evaluation, a two-electrode Swagelok cell was employed, featuring a carbon xerogel negative electrode, a manganese dioxide positive electrode, and a PFSA polymer membrane serving as both the electrolyte and separator. The membrane was immersed in a 1 M Na2SO4 solution before testing. A comprehensive electrochemical analysis of the hybrid cells was conducted and compared with a symmetric carbon/carbon supercapacitor. Cyclic voltammetric curves were recorded, and galvanostatic charge–discharge tests were conducted at various temperatures (20, 40, 60 °C). The hybrid cell with the PFSA/MMT 10 wt.% exhibited the highest specific capacitance and maintained its hybrid profile after prolonged cycling at elevated temperatures, highlighting the potential of the newly developed membrane.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Effect of CO2 Response Gel for Plugging Low-Permeability Reservoirs 用于堵塞低渗透储层的二氧化碳响应凝胶的制备及其效果

IF 5 3区化学

Gels Pub Date : 2024-07-09 DOI: 10.3390/gels10070449

Huipeng Wang, Changhua Yang, Yongwei Zhang, Chen Wang

{"title":"Preparation and Effect of CO2 Response Gel for Plugging Low-Permeability Reservoirs","authors":"Huipeng Wang, Changhua Yang, Yongwei Zhang, Chen Wang","doi":"10.3390/gels10070449","DOIUrl":"https://doi.org/10.3390/gels10070449","url":null,"abstract":"In order to solve the problem of gas channeling during CO2 flooding in low-permeability reservoirs, a novel CO2 responsive gel channeling system was prepared by using carrageenan, branched polyethylene imide and ethylenediamine under laboratory conditions. Based on the Box–Behnken response surface design method, the optimal synthesis concentration of the system was 0.5 wt% carrageenan, 2.5 wt% branchized polyethylenimide and 6.5 wt% ethylenediamine. The micromorphology of the system before and after response was characterized by scanning electron microscopy. The rheology and dehydration rate were tested under different conditions. The channeling performance and enhanced oil recovery effect of the gel system were simulated by a core displacement experiment. The experimental results show that the internal structure of the system changes from a disordered, smooth and loosely separated lamellae structure to a more uniform, complete and orderly three-dimensional network structure after exposure to CO2. The viscosity of the system was similar to aqueous solution before contact with CO2 and showed viscoelastic solid properties after contact with CO2. The experiment employing dehydration rates at different temperatures showed that the internal structure of the gel would change at a high temperature, but the gel system had a certain self-healing ability. The results of the displacement experiment show that the plugging rate of the gel system is stable at 85.32% after CO2 contact, and the recovery rate is increased by 17.06%, which provides an important guide for the development of low-permeability reservoirs.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Sulfation Degree of Glycosaminoglycan-Functionalized 3D Collagen I Networks on Cytokine Profiles of In Vitro Macrophage–Fibroblast Cocultures 糖胺聚糖功能化三维胶原蛋白 I 网络硫酸化程度对体外巨噬细胞-成纤维细胞共培养物细胞因子谱的影响

IF 5 3区化学

Gels Pub Date : 2024-07-09 DOI: 10.3390/gels10070450

Franziska Ullm, Alexander Renner, U. Freudenberg, Carsten Werner, T. Pompe

{"title":"The Influence of Sulfation Degree of Glycosaminoglycan-Functionalized 3D Collagen I Networks on Cytokine Profiles of In Vitro Macrophage–Fibroblast Cocultures","authors":"Franziska Ullm, Alexander Renner, U. Freudenberg, Carsten Werner, T. Pompe","doi":"10.3390/gels10070450","DOIUrl":"https://doi.org/10.3390/gels10070450","url":null,"abstract":"Cell–cell interactions between fibroblasts and immune cells, like macrophages, are influenced by interaction with the surrounding extracellular matrix during wound healing. In vitro hydrogel models that mimic and modulate these interactions, especially of soluble mediators like cytokines, may allow for a more detailed investigation of immunomodulatory processes. In the present study, a biomimetic extracellular matrix model based on fibrillar 3D collagen I networks with a functionalization with heparin or 6-ON-desulfated heparin, as mimics of naturally occurring heparan sulfate, was developed to modulate cytokine binding effects with the hydrogel matrix. The constitution and microstructure of the collagen I network were found to be stable throughout the 7-day culture period. A coculture study of primary human fibroblasts/myofibroblasts and M-CSF-stimulated macrophages was used to show its applicability to simulate processes of progressed wound healing. The quantification of secreted cytokines (IL-8, IL-10, IL-6, FGF-2) in the cell culture supernatant demonstrated the differential impact of glycosaminoglycan functionalization of the collagen I network. Most prominently, IL-6 and FGF-2 were shown to be regulated by the cell culture condition and network constitution, indicating changes in paracrine and autocrine cell–cell communication of the fibroblast–macrophage coculture. From this perspective, we consider our newly established in vitro hydrogel model suitable for mechanistic coculture analyses of primary human cells to unravel the role of extracellular matrix factors in key events of tissue regeneration and beyond.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-Linked COL–rGO Biocomposite Hydrogels 加速伤口愈合的创新方法：酶交联 COL-rGO 生物复合水凝胶的合成与验证

IF 5 3区化学

Gels Pub Date : 2024-07-06 DOI: 10.3390/gels10070448

Luisbel González, Víctor Espinoza, Mauricio Tapia, Valentina Aedo, Isleidy Ruiz, Manuel Meléndrez, Claudio Aguayo, L. Atanase, Katherina Fernández

{"title":"Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-Linked COL–rGO Biocomposite Hydrogels","authors":"Luisbel González, Víctor Espinoza, Mauricio Tapia, Valentina Aedo, Isleidy Ruiz, Manuel Meléndrez, Claudio Aguayo, L. Atanase, Katherina Fernández","doi":"10.3390/gels10070448","DOIUrl":"https://doi.org/10.3390/gels10070448","url":null,"abstract":"In this study, an innovative conductive hybrid biomaterial was synthetized using collagen (COL) and reduced graphene oxide (rGO) in order for it to be used as a wound dressing. The hydrogels were plasticized with glycerol and enzymatically cross-linked with horseradish peroxidase (HRP). A successful interaction among the components was demonstrated by FTIR, XRD, and XPS. It was demonstrated that increasing the rGO concentration led to higher conductivity and negative charge density values. Moreover, rGO also improved the stability of hydrogels, which was expressed by a reduction in the biodegradation rate. Furthermore, the hydrogel’s stability against the enzymatic action of collagenase type I was also strengthened by both the enzymatic cross-linking and the polymerization of dopamine. However, their absorption capacity, reaching values of 215 g/g, indicates the high potential of the hydrogels to absorb fluids. The rise of these properties positively influenced the wound closure process, achieving an 84.5% in vitro closure rate after 48 h. These findings clearly demonstrate that these original composite biomaterials can be a viable choice for wound healing purposes.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradable Gel for Temporary Plugging in High Temperature Reservoir and Its Properties 用于高温储层临时堵塞的可降解凝胶及其特性

IF 5 3区化学

Gels Pub Date : 2024-07-05 DOI: 10.3390/gels10070445

Fan Yang, Jinhua Liu, Renjing Ji, Xiaorong Yu, Huan Yang, Gaoshen Su

{"title":"Degradable Gel for Temporary Plugging in High Temperature Reservoir and Its Properties","authors":"Fan Yang, Jinhua Liu, Renjing Ji, Xiaorong Yu, Huan Yang, Gaoshen Su","doi":"10.3390/gels10070445","DOIUrl":"https://doi.org/10.3390/gels10070445","url":null,"abstract":"Although various degradable gel materials have been developed for temporary plugging in oil fields, they often degrade too quickly in high-temperature environments. To address this issue, an unstable crosslinker was synthesized to prepare a high-temperature degradable gel. This gel does not degrade excessively fast at high temperatures. Temperature and crosslinker concentration are the primary factors influencing gel degradation time, followed by monomer and initiator concentrations. Increased temperature and decreased crosslinker concentration both reduce degradation time, which can be adjusted within the range of 90–130 °C by varying the crosslinker concentration. The molecular structure and thermal stability of the degradable gel were analyzed using FTIR, 13C NMR, and TG. Furthermore, the viscoelastic properties, compressive performance, plugging performance, and core damage performance of the gel were evaluated. Within the test range of 0.1–1000 Pa, the storage modulus is higher than the loss modulus. The gel prepared at 130 °C exhibited a compressive stress of 0.25 MPa at 50% strain. The plugging pressure of the gel in sand-filled tubes with varying permeabilities (538.2–2794.1 mD) exceeded 15 MPa while maintaining a core damage rate below 5%. SEM analysis indicated that the degradation mechanism of the gel may involve the collapse of its three-dimensional network structure due to the hydrolysis of amide groups in the crosslinker. The viscosity of the degradation liquid was below 11 mPa·s, enabling it to be brought back to the surface with the formation fluid without the need for further breaking operations.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Characterization of Hybrid Meat Analogs from Whey Protein-Mushroom Composite Hydrogels 利用乳清蛋白-蘑菇复合水凝胶开发混合肉类模拟物并确定其特性

IF 5 3区化学

Gels Pub Date : 2024-07-05 DOI: 10.3390/gels10070446

Ramdattu Santhapur, Disha Jayakumar, D. Mcclements

{"title":"Development and Characterization of Hybrid Meat Analogs from Whey Protein-Mushroom Composite Hydrogels","authors":"Ramdattu Santhapur, Disha Jayakumar, D. Mcclements","doi":"10.3390/gels10070446","DOIUrl":"https://doi.org/10.3390/gels10070446","url":null,"abstract":"There is a need to reduce the proportion of animal-derived food products in the human diet for sustainability and environmental reasons. However, it is also important that a transition away from animal-derived foods does not lead to any adverse nutritional effects. In this study, the potential of blending whey protein isolate (WPI) with either shiitake mushroom (SM) or oyster mushroom (OM) to create hybrid foods with enhanced nutritional and physicochemical properties was investigated. The impact of OM or SM addition on the formation, microstructure, and physicochemical attributes of heat-set whey protein gels was therefore examined. The mushroom powders were used because they have relatively high levels of vitamins, minerals, phytochemicals, and dietary fibers, which may provide nutritional benefits, whereas the WPI was used to provide protein and good thermal gelation properties. A variety of analytical methods were used to characterize the structural and physicochemical properties of the WPI-mushroom hybrids, including confocal microscopy, particle electrophoresis, light scattering, proximate analysis, differential scanning calorimetry, thermogravimetric analysis, dynamic shear rheology, textural profile analysis, and colorimetry. The charge on whey proteins and mushroom particles went from positive to negative when the pH was raised from 3 to 9, but whey protein had a higher isoelectric point and charge magnitude. OM slightly increased the thermal stability of WPI, but SM had little effect. Both mushroom types decreased the lightness and increased the brownness of the whey protein gels. The addition of the mushroom powders also decreased the hardness and Young’s modulus of the whey protein gels, which may be because the mushroom particles acted as soft fillers. This study provides valuable insights into the formation of hybrid whey protein-mushroom products that have desirable physiochemical and nutritional attributes.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated In Vivo and In Vitro Evaluation of a Powder-to-Hydrogel, Film-Forming Polymer Complex Base with Tissue-Protective and Microbiome-Supportive Properties 对具有组织保护和微生物支持特性的粉末水凝胶成膜聚合物复合基料进行体内外综合评估

IF 5 3区化学

Gels Pub Date : 2024-07-05 DOI: 10.3390/gels10070447

D. Banov, Guiyun Song, Zahraa Foraida, Oksana Tkachova, Oleksandr Zdoryk, Maria Carvalho

{"title":"Integrated In Vivo and In Vitro Evaluation of a Powder-to-Hydrogel, Film-Forming Polymer Complex Base with Tissue-Protective and Microbiome-Supportive Properties","authors":"D. Banov, Guiyun Song, Zahraa Foraida, Oksana Tkachova, Oleksandr Zdoryk, Maria Carvalho","doi":"10.3390/gels10070447","DOIUrl":"https://doi.org/10.3390/gels10070447","url":null,"abstract":"The study aimed to perform a comprehensive in vitro and in vivo evaluation of a newly developed, patent-pending, powder-to-hydrogel, film-forming polymer complex base, which possesses tissue-protective and microbiome-supportive properties, and to compare its characteristics with poloxamer 407. The study used a combination of in vitro assays, including tissue viability and cell migration, and in vivo wound healing evaluations in male diabetic mice. Microbiome dynamics at wound sites were also analyzed. The in vitro assays demonstrated that the polymer complex base was non-cytotoxic and that it enhanced cell migration over poloxamer 407. In vivo, the polymer complex base demonstrated superior wound healing capabilities, particularly in combination with misoprostol and phenytoin, as evidenced by the reduced wound area and inflammation scores. Microbiome analysis revealed favorable shifts in bacterial populations associated with the polymer complex base-treated wounds. The polymer complex base demonstrates clinical significance in wound care, potentially offering improved healing, safety and microbiome support. Its transformative properties and efficacy in drug delivery make it a promising candidate for advanced wound care applications, particularly in chronic wound management.","PeriodicalId":12506,"journal":{"name":"Gels","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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