GelsPub Date : 2025-06-23DOI: 10.3390/gels11070486
Paweł J Piszko, Michał Kulus, Aleksandra Piszko, Jan Kiryk, Sylwia Kiryk, Julia Kensy, Agata Małyszek, Mateusz Michalak, Wojciech Dobrzyński, Jacek Matys, Maciej Dobrzyński
{"title":"The Influence of Calcium Ions and pH on Fluoride Release from Commercial Fluoride Gels in an In Vitro Study.","authors":"Paweł J Piszko, Michał Kulus, Aleksandra Piszko, Jan Kiryk, Sylwia Kiryk, Julia Kensy, Agata Małyszek, Mateusz Michalak, Wojciech Dobrzyński, Jacek Matys, Maciej Dobrzyński","doi":"10.3390/gels11070486","DOIUrl":"10.3390/gels11070486","url":null,"abstract":"<p><p>Fluoride gels are widely used in dental prophylaxis due to their proven ability to prevent demineralization and promote remineralization of hard dental tissues. However, the effectiveness of fluoride release from such gels may be significantly influenced by environmental factors such as pH and the presence of calcium ions. This in vitro study aimed to evaluate how these variables affect fluoride ion release from three commercially available fluoride gels-Clarben, Flairesse, and Lunos. The gels were incubated in artificial saliva of varying pH levels (4.5, 6.0, 7.0, and 7.5) with and without the addition of calcium, as well as in other water-based media-tap water, deionized water, and 0.9% NaCl solution. Fluoride release and changes in pH were measured and statistically analyzed using a multifactorial ANOVA. The results revealed that fluoride release was highest in calcium-free environments and at neutral to slightly alkaline pH, while the presence of calcium significantly reduced fluoride availability. Among the tested products, Flairesse and Lunos exhibited sensitivity to calcium's presence, unlike Clarben. Fluoride release was generally higher in water than in artificial saliva. Additionally, all gels induced a decrease in pH, which varied depending on the initial pH and calcium content. These findings underline the importance of environmental conditions in optimizing the clinical efficacy of fluoride gel applications.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-23DOI: 10.3390/gels11070485
Justyna Pawlik, Klaudia Borawska, Piotr Wieczorek, Kamil Kamiński
{"title":"Green Minimalistic Approach to Synthesize Chitosan-Based Durable Polymer Hydrogel Materials for Supporting Cell Growth.","authors":"Justyna Pawlik, Klaudia Borawska, Piotr Wieczorek, Kamil Kamiński","doi":"10.3390/gels11070485","DOIUrl":"10.3390/gels11070485","url":null,"abstract":"<p><p>In this work, we present an innovative, crosslinker-free method for preparing chitosan-based hydrogel precursors, fully aligned with green chemistry principles and composed of only five non-toxic, readily available reagents. The key novelty lies in the use of glycerin, which, during thermal annealing, evaporates and triggers a surface or bulk chemical transformation of chitosan, depending on its concentration. This process significantly enhances the material's mechanical properties after swelling-with up to a 35% increase in tensile strength and a notable reduction in water uptake compared to systems containing AMPS-based crosslinkers. FTIR analysis indicates a partial re-acetylation of chitosan, shifting its structure toward that of chitin, which correlates with improved hydrophobicity (as shown by increased contact angles up to 92°) and greater structural integrity. These improvements are particularly pronounced at glycerin concentrations of 10-20%, whereas higher concentrations (50%) result in brittle, non-moldable films. Importantly, preliminary biological tests confirm that the resulting hydrogels are effectively colonized by mammalian cells, making them promising candidates for bioimplant or tissue engineering applications. Surface morphology and compatibility were further assessed via SEM, AFM, and contact angle measurements.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-22DOI: 10.3390/gels11070481
Marian Ilie Luca, Mădălina Ungureanu-Iuga, Ana Batariuc, Silvia Mironeasa
{"title":"Physical Characteristics of Durum Wheat Dough and Pasta with Different Carrot Pomace Varieties.","authors":"Marian Ilie Luca, Mădălina Ungureanu-Iuga, Ana Batariuc, Silvia Mironeasa","doi":"10.3390/gels11070481","DOIUrl":"10.3390/gels11070481","url":null,"abstract":"<p><p>Carrot pomace is a valuable, underutilized by-product suitable for obtaining novel foods. The durum wheat dough and pasta network structure is affected by fiber-rich ingredients like carrot pomace, leading to changes in rheological and texture parameters. In this context, this paper aimed to evaluate the rheological, textural, and color properties of durum wheat dough and pasta as affected by different varieties and addition levels of carrot pomace. For this purpose, oscillatory dynamic rheological tests, compression mechanical texture evaluation, cooking behavior observation, and reflectance color measurements were made. The results indicated that carrot pomace has a strengthening effect on the durum wheat dough protein-starch matrix, while the maximum creep compliance decreased with the addition level increase. A delay in starch gelatinization was suggested by the evolution of visco-elastic moduli during heating. Dough hardness and gumminess increased (from 2849.74 for the control to 5080.67 g for 12% Baltimore, and from 1073.73 for the control to 1863.02 g for 12% Niagara, respectively), while springiness and resilience exhibited a reduction trend (from 100.11% for the control to 99.50% for 12% Sirkana, and from 1.23 for the 3% Niagara to 0.87 for 12% Belgrado respectively) as the amount of carrot pomace raised. An increasing tendency of pasta solids loss during cooking and fracturability was observed with carrot pomace addition level increase. Color properties changed significantly depending on carrot pomace variety and addition level, indicating a reduction in lightness from 71.71 for the control to 63.12 for 12% Niagara and intensification of red nuance (0.05 for the control vs. 2.85 for 12% Sirkana). Cooked pasta elasticity, chewiness, gumminess, hardness, and resilience increased, while adhesiveness and stickiness decreased as the level of carrot pomace was higher. These results can represent a starting point for further industrial development of pasta enriched with fiber-rich ingredients like carrot pomace. The study highlights the possibility of using a fiber-rich waste stream (carrot pomace) in a staple product like pasta, providing a basis for clean-label pasta formulations. In addition, the novelty of the study consists in highlighting how compositional differences of different carrot pomace varieties lead to distinct effects on dough rheology, texture, color, and cooking behavior.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and Interfacial Mechanism of Epoxy Soybean Oil-Based Semi-Liquid Gel Materials for Wellbore Sealing Applications.","authors":"Yuexin Tian, Yintao Liu, Haifeng Dong, Xiangjun Liu, Jinjun Huang","doi":"10.3390/gels11070482","DOIUrl":"10.3390/gels11070482","url":null,"abstract":"<p><p>In this study, a novel semi-liquid gel material based on bisphenol A-type epoxy resin (E51), methylhexahydrophthalic anhydride (MHHPA), and epoxidized soybean oil (ESO) was developed for high-performance wellbore sealing. The gel system exhibits tunable gelation times ranging from 1 to 10 h (±0.5 h) and maintains a low viscosity of <100 ± 2 mPa·s at 25 °C, enabling efficient injection into the wellbore. The optimized formulation achieved a compressive strength exceeding 112.5 ± 3.1 MPa and a breakthrough pressure gradient of over 50 ± 2.8 MPa/m with only 0.9 PV dosage. Fourier transform infrared spectroscopy (FTIR) confirmed the formation of a dense, crosslinked polyester network. Interfacial adhesion was significantly enhanced by the incorporation of 0.25 wt% octadecyltrichlorosilane (OTS), yielding an adhesion layer thickness of 391.6 ± 12.7 nm-approximately 9.89 times higher than that of the unmodified system. Complete degradation was achieved within 48 ± 2 h at 120 °C using a γ-valerolactone and p-toluenesulfonic acid solution. These results demonstrate the material's potential as a high-strength, injectable, and degradable sealing solution for complex subsurface environments.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-21DOI: 10.3390/gels11070480
Md Murshed Bhuyan, Nahid Hasan, Jae-Ho Jeong
{"title":"Single- and Multi-Network Hydrogels for Soft Electronics-A Review.","authors":"Md Murshed Bhuyan, Nahid Hasan, Jae-Ho Jeong","doi":"10.3390/gels11070480","DOIUrl":"10.3390/gels11070480","url":null,"abstract":"<p><p>Soft or flexible electronics is a rapidly growing and pioneering research field, as it makes devices comfortable to use, especially in biomedical engineering. Both single- and multi-network hydrogels have diverse applications where the most significant one is in the building of soft electronics, including soft circuits, displays, sensors, batteries, and supercapacitors, electronic storage, electric skin, health monitoring devices, soft robots, and automotive. Three-dimensional printing of conductive gels/hydrogels facilitates the construction of soft electronics. This review illustrates the design, mechanism, and application of hydrogel in soft electronics. The current progress, scope of improvement, and future prospects of hydrogel-based soft electronics are also discussed. This review will provide a clear concept of the topic to researchers.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-21DOI: 10.3390/gels11070479
Shaik Gouse Peera, Myunghwan Byun
{"title":"Engineering Gel-Based Precursors into Advanced ORR Catalysts for Zn-Air Batteries and Fuel Cells: Insights into Hydrogels, Aerogels, Xerogels, Metal-Organic Gels, and Metal Aerogels.","authors":"Shaik Gouse Peera, Myunghwan Byun","doi":"10.3390/gels11070479","DOIUrl":"10.3390/gels11070479","url":null,"abstract":"<p><p>Efficient electrocatalysts for the oxygen reduction reaction (ORR) are essential for numerous energy storage and conversion systems, including zinc-air batteries and fuel cells. Cutting-edge Pt/C catalysts remain the most efficient ORR catalysts to date; however, their high cost and inadequate stability impede their use in commercial devices. Recently, transition metal-based electrocatalysts are being pursued as ideal alternatives for cost-effective and efficient materials with a promising future. This review provides an in-depth analysis of the principles, synthesis, and electrocatalytic assessment of noble metal and transition metal-based catalysts derived from diverse gel precursors, including hydrogels, aerogels, xerogels, metal-organic gels, and metal aerogels. Electrocatalysts derived from gel precursors have garnered significant interest due to their superior physicochemical properties, including an exceptionally high surface area, adjustable porosity, adaptability, and scalability. Catalysts obtained from gel precursors offer numerous advantages over conventional catalyst synthesis methods, including the complete utilization of precursors, precise control over surface area and porosity, and uniform distribution of ORR active sites. Among the various types, metal aerogels are distinguished as the superior catalysts, exceeding the Department of Energy's (DoE) 2025 targets for the mass and specific activities of ORR catalysts. In contrast, hydrogel- and aerogel-derived catalysts excel in terms of ORR activity, specific surface area, and the potential to incorporate high loadings of single-atom catalysts composed of transition metals. Ultimately, we unequivocally categorized the electrocatalysts into high-, moderate-, and low-performance tiers, identifying the most promising catalyst candidate within each gel classification. Concluding insights, future outlooks, and recommendations were provided for the advancement of cost-effective, scalable electrocatalysts derived from gels for fuel cells and zinc-air batteries.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-20DOI: 10.3390/gels11070478
Andreea Pușcaș, Anda Elena Tanislav, Andruța Elena Mureșan, Vlad Mureșan
{"title":"Emulgels as Fat-Replacing Systems in Biscuits Developed with Ternary Mixtures of Pea and Soy Protein Isolates and Gums.","authors":"Andreea Pușcaș, Anda Elena Tanislav, Andruța Elena Mureșan, Vlad Mureșan","doi":"10.3390/gels11070478","DOIUrl":"10.3390/gels11070478","url":null,"abstract":"<p><p>Hydrogels (Hy) were obtained with a ternary system of proteins (pea (P) or soy isolate (S) 2%), guar (0.5%), and xanthan gums (0.5%) and were subjected to thermal treatment (70 °C/20 min or 85 °C/15 min, or not) prior to structure formation. The FTIR spectra of the hydrogels and the turbidity test (spectrophotometrically red at 600 nm) were used for studying protein-polysaccharide interactions. Amplitude sweeps (0.01-100%) and flow behavior tests (0.1-100 s<sup>-1</sup>) were conducted for structure analysis. Emulgels were obtained by emulsification of the Hy with 40% or 60% sunflower oil. The centrifugal stability and texture (TPA test) of the emulgels were assessed and SND_40% exhibited the highest hardness (5.30 ± 0.23 N). Based on the results, SND_40%, PND_40%, SD70_40%, and PD_70% were chosen as fat-replacing systems in biscuit formulation. The textural, color, and stability attributes of the reformulated samples were compared with a reference containing margarine. Increased hardness and fracturability were determined for the emulgel-based biscuits, while the color parameters were statistically similar to the reference. Thermal treatments applied to enhance protein-polysaccharide interactions increased the structural performances of some emulgels, while their application as fat-replacing systems should be further evaluated since no statistical differences were recorded in the sensory evaluation of the reference and reformulated biscuits. Emulgels with tuned technological properties have the potential to replace saturated fats in foods.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research and Performance Evaluation of Low-Damage Plugging and Anti-Collapse Water-Based Drilling Fluid Gel System Suitable for Coalbed Methane Drilling.","authors":"Jian Li, Zhanglong Tan, Qian Jing, Wenbo Mei, Wenjie Shen, Lei Feng, Tengfei Dong, Zhaobing Hao","doi":"10.3390/gels11070473","DOIUrl":"10.3390/gels11070473","url":null,"abstract":"<p><p>Coalbed methane (CBM), a significant unconventional natural gas resource, holds a crucial position in China's ongoing energy structure transformation. However, the inherent low permeability, high brittleness, and strong sensitivity of CBM reservoirs to drilling fluids often lead to severe formation damage during drilling operations, consequently impairing well productivity. To address these challenges, this study developed a novel low-damage, plugging, and anti-collapse water-based drilling fluid gel system (ACWD) specifically designed for coalbed methane drilling. Laboratory investigations demonstrate that the ACWD system exhibits superior overall performance. It exhibits stable rheological properties, with an initial API filtrate loss of 1.0 mL and a high-temperature, high-pressure (HTHP) filtrate loss of 4.4 mL after 16 h of hot rolling at 120 °C. It also demonstrates excellent static settling stability. The system effectively inhibits the hydration and swelling of clay and coal, significantly reducing the linear expansion of bentonite from 5.42 mm (in deionized water) to 1.05 mm, and achieving high shale rolling recovery rates (both exceeding 80%). Crucially, the ACWD system exhibits exceptional plugging performance, completely sealing simulated 400 µm fractures with zero filtrate loss at 5 MPa pressure. It also significantly reduces core damage, with an LS-C1 core damage rate of 7.73%, substantially lower than the 19.85% recorded for the control polymer system (LS-C2 core). Field application in the JX-1 well of the Ordos Basin further validated the system's effectiveness in mitigating fluid loss, preventing wellbore instability, and enhancing drilling efficiency in complex coal formations. This study offers a promising, relatively environmentally friendly, and cost-effective drilling fluid solution for the safe and efficient development of coalbed methane resources.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GelsPub Date : 2025-06-20DOI: 10.3390/gels11070474
Lucas Carravero Costa, Isabelle Pochard, Cédric C Buron, Florian E Jurin
{"title":"Elaboration of Conductive Hydrogels by 3D Printer for the Development of Strain Sensors.","authors":"Lucas Carravero Costa, Isabelle Pochard, Cédric C Buron, Florian E Jurin","doi":"10.3390/gels11070474","DOIUrl":"10.3390/gels11070474","url":null,"abstract":"<p><p>The development of biocompatible, conductive hydrogels via direct ink writing (DIW) has gained increasing attention for strain sensor applications. In this work, a hydrogel matrix composed of polyvinyl alcohol (PVA) and κ-carrageenan (KC) was formulated and enhanced with polyvinylidene fluoride (PVDF) and silver nanoparticles (AgNPs) to impart piezoelectric properties. The ink formulation was optimized to achieve shear-thinning and thixotropic recovery behavior, ensuring printability through extrusion-based 3D printing. The resulting hydrogels exhibited high water uptake (~280-300%) and retained mechanical integrity. Rheological assessments showed that increasing PVDF content improved stiffness without compromising printability. Electrical characterization demonstrated that AgNPs were essential for generating piezoelectric signals under mechanical stress, as PVDF alone was insufficient. While AgNPs did not significantly alter the crystalline phase distribution of PVDF, they enhanced conductivity and signal responsiveness. XRD and SEM-EDX analyses confirmed the presence and uneven distribution of AgNPs within the hydrogel. The optimized ink formulation (5% PVA, 0.94% KC, 6% PVDF) enabled the successful fabrication of functional sensors, highlighting the material's strong potential for use in wearable or biomedical strain-sensing applications.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing Wound Healing Through Secretome-Loaded 3D-Printed Biomaterials.","authors":"Tithteeya Rattanachot, Yogeswaran Lokanathan, Mh Busra Fauzi, Manira Maarof","doi":"10.3390/gels11070476","DOIUrl":"10.3390/gels11070476","url":null,"abstract":"<p><p>Wound healing remains a significant hurdle within the field of medical practice, especially concerning chronic and non-healing injuries. Conventional interventions, such as skin grafts, wound dressings, and biomaterials, offer structural support for the regenerated tissues but often lack the biological signaling cues essential for tissue regeneration. However, these approaches often lack the biological signals necessary to promote effective tissue repair. An emerging strategy involves incorporating cell-secreted proteins, known as the secretome, into biomaterials. The secretome contains bioactive elements such as cytokines, growth factors, and extracellular vesicles (EVs), which enhance the wound healing process. This review explores the potential of secretome-loaded biomaterials in modulating inflammation, promoting angiogenesis, and assisting in the remodeling of the extracellular matrix (ECM). Recent advancements in biomaterial engineering technology, such as 3-dimensional (3D) bioprinting, have improved the controlled delivery and bioactivity of secretome at the wound site. These gel-based biomaterials enhance wound healing by providing sustained bioactive molecule release, improving cell growth, and tissue repair. Despite these promising outcomes, limitations including variations in secretome composition and difficulties in large-scale production. Hence, secretome-loaded biomaterials offer a promising solution for wound healing, but further research is needed to optimize formulations, ensure stability, and validate clinical applications.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 7","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}