An Advanced Adhesive Electrolyte Hydrogel Intended for Iontophoresis Enhances the Effective Delivery of Glycolic Acid Via Microbeads.

IF 5.3 3区化学 Q1 POLYMER SCIENCE

Gels Pub Date : 2025-08-26 DOI:10.3390/gels11090682

Mariia Kazharskaia, Yu Yu, Chenguang Liu

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引用次数: 0

Abstract

This study presents an innovative iontophoretic delivery system for glycolic acid (GA) based on polysaccharide microbeads embedded within an electrolyte hydrogel. The mi-crobeads, fabricated using a peristaltic pump, exhibited a uniform morphology with an average diameter of 1078 ± 140.38 μm and were successfully integrated into a hydrogel matrix (thickness: 4542.55 ± 337.24 μm). Comprehensive physicochemical characterization (FT-IR, XRD, SEM) confirmed effective component integration. The hydrogel demonstrated optimal mechanical properties with a tensile strength of 0.02 ± 0.003 MPa and reliable adhesion to various substrates, while maintaining excellent self-healing capabili-ties-post-repair conductivity remained sufficient to power an LED indicator. The material demonstrated favorable conductivity under various storage conditions while maintaining non-cytotoxic properties. Notably, microbead incorporation preserved electrochemical performance, as demonstrated by stable behavior in cyclic voltammetry using an Ag/AgCl reference system. Iontophoretic testing revealed significantly enhanced glycolic acid delivery at -1.0 V com-pared to passive diffusion. The system, combining PVA, PAA, alginate, [Bmim]BF₄, and E. prolifera polysaccharides with gellan gum, shows strong potential for advanced cosmetic dermatology applications requiring precise active ingredient delivery.

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一种用于离子导入的高级粘合剂电解质水凝胶增强了通过微珠的乙醇酸的有效递送。

本研究提出了一种基于多糖微珠嵌入电解质水凝胶的新型乙醇酸（GA）离子电泳递送系统。采用蠕动泵法制备的微球形貌均匀，平均直径为1078±140.38 μm，并成功集成到厚度为4542.55±337.24 μm的水凝胶基质中。综合理化表征（FT-IR， XRD， SEM）证实了有效组分的整合。该水凝胶表现出最佳的力学性能，抗拉强度为0.02±0.003 MPa，与各种基材的粘附性能可靠，同时保持优异的自修复能力，修复后的导电性足以为LED指示灯供电。该材料在各种储存条件下均表现出良好的导电性，同时保持非细胞毒性。值得注意的是，微珠的加入保留了电化学性能，在使用Ag/AgCl参比体系的循环伏安法中表现出稳定的行为。离子电泳测试显示，与被动扩散相比，-1.0 V下乙醇酸的传递明显增强。该系统结合了PVA、PAA、海藻酸盐、[Bmim]BF4和巨藻多糖与结冷胶，在需要精确活性成分递送的高级美容皮肤科应用中显示出强大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.