Israr Ali, Urwa Shahid, Seon-Hwa Kim, Suganthy Ramamoorthy, Won Han, Minseon Kim, Vishal Gavande, Won-Ki Lee, Joong Ho Shin, Sang-Hyug Park, Kwon Taek Lim
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CMC-Based Injectable Hydrogels Crosslinked by Diels-Alder Chemistry for Wound Healing Applications.
Chronic wounds disrupt natural healing and tissue regeneration, posing a major challenge in healthcare. Conventional wound care often lacks effective drug delivery, tissue integration, infection control, and patient comfort. However, injectable hydrogels offer localized, minimally invasive treatment and conform to irregular wound shapes. This study presents carboxymethyl cellulose (CMC)-based injectable hydrogels, prepared via Diels-Alder click chemistry using highly furan functionalized CMC (45%) and a bismaleimide crosslinker. The hydrogels showed a rapid gelation time (<490 s) under physiological conditions. The hydrogel exhibited favorable physicochemical and mechanical properties, as well as sustained curcumin release (∼80% in 5 days). In vitro studies confirmed excellent biocompatibility with NIH3T3 fibroblasts and notable antibacterial activity against E. coli, supporting its potential for wound healing applications.
期刊介绍：
The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts.
Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.
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