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'The end' - or is it? Emergence of SARS-CoV-2 EG.5 and BA.2.86 subvariants. “结束了”——还是结束了？严重急性呼吸系统综合征冠状病毒2型EG.5和BA.2.86亚变体的出现。
IF 3.1 4区 医学
Future Virology Pub Date : 2023-09-01 Epub Date: 2023-09-19 DOI: 10.2217/fvl-2023-0150
Farid Rahimi, Mohammad Darvishi, Amin Talebi Bezmin Abadi
{"title":"'The end' - or is it? Emergence of SARS-CoV-2 EG.5 and BA.2.86 subvariants.","authors":"Farid Rahimi, Mohammad Darvishi, Amin Talebi Bezmin Abadi","doi":"10.2217/fvl-2023-0150","DOIUrl":"https://doi.org/10.2217/fvl-2023-0150","url":null,"abstract":"Having surpassed Alpha","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effects of herpes virus glycoprotein glycosylation on viral infection and pathogenesis 疱疹病毒糖蛋白糖基化对病毒感染和发病的影响
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-22 DOI: 10.2217/fvl-2022-0209
Yijing Chen, Wen Liu, B. Luo
{"title":"The effects of herpes virus glycoprotein glycosylation on viral infection and pathogenesis","authors":"Yijing Chen, Wen Liu, B. Luo","doi":"10.2217/fvl-2022-0209","DOIUrl":"https://doi.org/10.2217/fvl-2022-0209","url":null,"abstract":"Herpes virus is an enveloped virus with many glycoproteins essential for viral infection and immune evasion. Several glycosylation sites exist on the glycoproteins of herpes viruses, including N- and O-glycosylation sites. Glycosylation affects herpes virus infection and pathogenesis in different ways, including the attachment and entry of the herpes virus into host cells, virus replication and the host's immune function. This article summarized the current knowledge on the glycosylation of herpes virus envelope glycoproteins and its impact on viral infection and demonstrated several applications of glycosylation inhibitors.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43664887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered synaptic plasticity: plausible mechanisms associated with viral infections 突触可塑性改变:与病毒感染相关的合理机制
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-22 DOI: 10.2217/fvl-2023-0105
Vaishali Saini, Annu Rani, Amarjeet Kumar, K. Jha, S. Karnati, H. Jha
{"title":"Altered synaptic plasticity: plausible mechanisms associated with viral infections","authors":"Vaishali Saini, Annu Rani, Amarjeet Kumar, K. Jha, S. Karnati, H. Jha","doi":"10.2217/fvl-2023-0105","DOIUrl":"https://doi.org/10.2217/fvl-2023-0105","url":null,"abstract":"Neurotropic viruses target the central nervous system through various mechanisms: they have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking N-methyl d-aspartate receptors; they alter the Ca2+ ion-signaling pathways modulating long-term potentiation, leading to a severe inflammatory response in brain cells, increased reactive oxygen species and lipid peroxidation through mitochondria and peroxisomes. Inflammatory pathways have a key role in modulating the plasticity of neurons, linked to numerous neurological disorders. Advanced neuroimaging techniques facilitate the early diagnosis of impaired synaptic function in viral infections and neurodegenerative disorders. Here we discuss the understanding of the interplay between neurotropic viral infections and their effects on synaptic plasticity and diagnosis through neuroimaging techniques.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48173845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers HTLV-1携带者昼夜节律信号通路中CLOCK和CSNK1D功能的评估
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-16 DOI: 10.2217/fvl-2023-0050
Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani
{"title":"Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers","authors":"Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani","doi":"10.2217/fvl-2023-0050","DOIUrl":"https://doi.org/10.2217/fvl-2023-0050","url":null,"abstract":"Aim: Disruption of the internal circadian rhythm pathway could lead to a range of diseases. In this study, we aim to evaluate the circadian rhythm pathway by assessing the interaction between CLOCK and CSNK1D genes in HTLV-1 carriers in comparison with healthy individuals. Materials & methods: CLOCK and CSNK1D gene expression was assessed using the RT-qPCR. Pathogenesis-related signaling networks were designed and analyzed using the obtained results. Results: There was no significant difference in age between the groups. CLOCK and CSNK1D gene expression levels were significantly higher in carriers than in healthy individuals (p = 0.04, p = 0.03, respectively). Conclusion: In addition to introducing potential biological markers, obtained results could be a good idea to further investigate this signaling pathway in the future.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43477198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LMP1 encoded by Epstein–Barr virus may activate AHR through the ERK pathway in nasopharyngeal carcinoma cells EB病毒编码的LMP1可能通过ERK途径激活鼻咽癌细胞的AHR
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-08 DOI: 10.2217/fvl-2023-0093
Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, B. Luo
{"title":"LMP1 encoded by Epstein–Barr virus may activate AHR through the ERK pathway in nasopharyngeal carcinoma cells","authors":"Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, B. Luo","doi":"10.2217/fvl-2023-0093","DOIUrl":"https://doi.org/10.2217/fvl-2023-0093","url":null,"abstract":"Aim: To investigate the role of AHR in nasopharyngeal carcinoma (NPC) and explore the relationship between Epstein–Barr virus (EBV) infection and the AHR pathway. Methods: The effect of LMP1 on the expression of AHR was analyzed using real-time PCR and western blot. Proliferation and migration of cells were assessed using CCK8 and Transwell analysis. Results: EBV infection downregulated the expression of AHR in NPC cells, possibly through activation of the ERK pathway by LMP1 thereby accelerating AHR proteasomal degradation following translocation to the nucleus. Cell proliferation, migration and autophagy are promoted by activating the AHR pathway. Conclusion: In NPC cells, LMP1 increases the phosphorylation of ERK, which may activate the AHR pathway.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42362963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and identification of dominant B-cell epitopes of human cytomegalovirus UL138 and its clinical applications 人巨细胞病毒UL138显性b细胞表位的筛选鉴定及其临床应用
4区 医学
Future Virology Pub Date : 2023-08-01 DOI: 10.2217/fvl-2023-0052
Hua Zhu, Xuanlu Xu, Jing Jiang, Xiangyang Xue, Wenmiao Zhang, Ruanmin Zou
{"title":"Screening and identification of dominant B-cell epitopes of human cytomegalovirus <i>UL138</i> and its clinical applications","authors":"Hua Zhu, Xuanlu Xu, Jing Jiang, Xiangyang Xue, Wenmiao Zhang, Ruanmin Zou","doi":"10.2217/fvl-2023-0052","DOIUrl":"https://doi.org/10.2217/fvl-2023-0052","url":null,"abstract":"Aim: To predict the dominant B-cell epitope of the human cytomegalovirus UL138 gene and to provide a new assay for its latent infection. Methods: Recombinant plasmids were constructed with the predicted dominant epitopes, induced to be expressed and immunized in mice as a way to identify peptide antigenicity, immunogenicity and human serum. Results: Five potentially dominant B-cell epitopes were obtained. The positive rate of detection was found to be significantly higher in neonatal, adult and mouse serum specimens than in human cytomegalovirus (HCMV) (IgG, IgM) and UL138 gene DNA and cDNA assays (p < 0.05). Conclusion: The predicted dominant B-cell epitope is highly sensitive for the detection of human serum HCMV latent infection and can replace the traditional HCMV IgG assay.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135053252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical transmission and maternal passive immunity post-SARS-CoV-2. 严重急性呼吸系统综合征冠状病毒2型后的垂直传播和母体被动免疫。
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-01 Epub Date: 2023-10-04 DOI: 10.2217/fvl-2023-0089
Hanie Karimi, Vahid Mansouri, Nima Rezaei
{"title":"Vertical transmission and maternal passive immunity post-SARS-CoV-2.","authors":"Hanie Karimi,&nbsp;Vahid Mansouri,&nbsp;Nima Rezaei","doi":"10.2217/fvl-2023-0089","DOIUrl":"10.2217/fvl-2023-0089","url":null,"abstract":"<p><p>Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2 have rendered the pandemic interminable. Vertical transmission (VT) through the placenta and breast milk, which is frequent for certain virus types, is thought to exist for SARS-CoV-2 and is hypothesized by many researchers. Conversely, antibodies are produced to counteract the effect of viruses. Since newborns' immunologic system cannot produce proper antibodies, maternal antibodies are usually transferred from mother to infant/fetus to meet the need. This theory leads to the hypothesis of transmission of antibodies through the placenta and breast milk following SARS-CoV-2 infection or vaccination. This paper further discusses these hypotheses, considering consequences of fetus/infant harm versus benefit.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564388/pdf/fvl-2023-0089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41197546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy. 靶向宿主钙通道和病毒蛋白:一种有前途的SARS-CoV-2治疗策略
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-01 DOI: 10.2217/fvl-2022-0203
Mona Fani, Maryam Moossavi, Hasan Bakhshi, Abozar Nasiri Jahrodi, Mohammad Reza Khazdair, Amir Hossein Zardast, Shokouh Ghafari
{"title":"Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy.","authors":"Mona Fani,&nbsp;Maryam Moossavi,&nbsp;Hasan Bakhshi,&nbsp;Abozar Nasiri Jahrodi,&nbsp;Mohammad Reza Khazdair,&nbsp;Amir Hossein Zardast,&nbsp;Shokouh Ghafari","doi":"10.2217/fvl-2022-0203","DOIUrl":"https://doi.org/10.2217/fvl-2022-0203","url":null,"abstract":"<p><p>Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca<sup>2+</sup> is required to enhance the fusion process of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, some important inflammatory factors during SARS-CoV-2 infection are dependent on Ca<sup>2+</sup> level. On the other hand, viroporins have emerged as attractive targets for antiviral therapy due to their essential role in viral replication and pathogenesis. By inhibiting the host calcium channels and viroporins, it is possible to limit the spread of infection. Therefore, calcium channel blockers (CCBs) and drugs targeting Viroporins can be considered an effective option in the fight against SARS-CoV-2.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10229899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single antiviral for a triple epidemic: is it possible? 一种抗病毒药物对付三种流行病:可能吗?
IF 3.1 4区 医学
Future Virology Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0048
N. Sultanoglu, E. Erdag, Cenk Serhan Ozverel
{"title":"A single antiviral for a triple epidemic: is it possible?","authors":"N. Sultanoglu, E. Erdag, Cenk Serhan Ozverel","doi":"10.2217/fvl-2023-0048","DOIUrl":"https://doi.org/10.2217/fvl-2023-0048","url":null,"abstract":"Aim: A triple epidemic of respiratory syncytial virus (RSV), SARS-CoV-2 and influenza variants is on the rise worldwide. It is crucial to identify antiviral agents that can be used against all three viruses associatd with this triple epidemic. Materials & methods: A total of ten antiviral agents were investigated in this study. Using molecular docking and the molecular mechanics/position-Boltzmann surface area technique, an examination of the binding affinity and protein–ligand interactions was conducted. Results: Out of the ten ligands that were compared, three showed the highest affinity for the docking site related to three the viral infections in descending order: AVG-388, remdesivir and nirmatrelvir. Conclusion: In conclusion, AVG-388, remdesivir and nirmatrelvir could be recommended as effective antiviral agents during the triple epidemic.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43237885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma IL-10, IL-19 and IL-32 are potential biomarkers for adenovirus-induced severe pneumonia in pediatric patients 血浆IL-10、IL-19和IL-32是腺病毒诱导的小儿重症肺炎的潜在生物标志物
IF 3.1 4区 医学
Future Virology Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0080
Jing Chen, Guoyun Su, Ruimu Zhang, Jikui Deng, Lifeng Qi
{"title":"Plasma IL-10, IL-19 and IL-32 are potential biomarkers for adenovirus-induced severe pneumonia in pediatric patients","authors":"Jing Chen, Guoyun Su, Ruimu Zhang, Jikui Deng, Lifeng Qi","doi":"10.2217/fvl-2023-0080","DOIUrl":"https://doi.org/10.2217/fvl-2023-0080","url":null,"abstract":"Aim: This study aimed to identify potential plasma biomarkers for severe pediatric adenovirus (AdV) infection. Methods: Thirty-seven inflammatory proteins were measured in the plasma of AdV-infected, influenza H3N2-infected or healthy pediatric participants and the prediction values of selected inflammatory proteins for AdV and severe AdV were assessed. Results: The expression profiles of AdV- and H3N2-infected patients were largely similar, with only IL-2, IL-10, IL-19 and IL-32 showing pathogen-dependent expression. IL-10, IL-19 and IL-32, both individually and in combination, could predict AdV and severe AdV infection. Conclusion: Plasma IL-10, IL-19 and IL-32 are potential biomarkers for AdV, especially severe AdV in pediatric patients.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45568855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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