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An update on long-acting agents in HIV therapy HIV治疗中长效药物的最新进展
4区 医学
Future Virology Pub Date : 2023-09-01 DOI: 10.2217/fvl-2023-0097
Laura Pezzati, Giada Canavesi, Stefano Rusconi
{"title":"An update on long-acting agents in HIV therapy","authors":"Laura Pezzati, Giada Canavesi, Stefano Rusconi","doi":"10.2217/fvl-2023-0097","DOIUrl":"https://doi.org/10.2217/fvl-2023-0097","url":null,"abstract":"Since the advent of highly active antiretroviral therapy, many efforts have been made to broaden the spectrum of possible regimens. Long-acting antiretrovirals, are particularly attractive, since they allow for less frequent dosing and can potentially overcome difficulties associated with daily tablet consumption, including the need for flexibility and privacy. In this article, we present a summary and update on currently available long-acting antiretrovirals and those under development and discuss issues related to their effective implementation.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of miR-203 and its target genes in condyloma acuminatum and their relationships with clinical recurrence miR-203及其靶基因在尖锐湿疣组织中的表达及其与临床复发的关系
4区 医学
Future Virology Pub Date : 2023-09-01 DOI: 10.2217/fvl-2023-0086
Beilei He, Yangfan Wu, Qingyun Yang, Enyi Ye, Tingkai Xiang, Xinyi Wang, Lin Deng, Kune Lu, Jue Liu, Xiaohong Yu, Zhangyu Bu
{"title":"Expression of miR-203 and its target genes in condyloma acuminatum and their relationships with clinical recurrence","authors":"Beilei He, Yangfan Wu, Qingyun Yang, Enyi Ye, Tingkai Xiang, Xinyi Wang, Lin Deng, Kune Lu, Jue Liu, Xiaohong Yu, Zhangyu Bu","doi":"10.2217/fvl-2023-0086","DOIUrl":"https://doi.org/10.2217/fvl-2023-0086","url":null,"abstract":"Aim: To examine the expression of miR-203 and its target genes survivin and p63 in condyloma acuminatum (CA) and to determine their relationships with clinical recurrence. Methods: Case and control groups were assessed for general data and the expression levels of miR-203, survivin and p63. The case group received carbon dioxide laser treatment, had a 3-month follow-up period, and was then divided into recurrence and non-recurrence groups. The relevant data were analyzed using SPSS v. 25.0 software. Results: miR-203 was identified as an independent protective factor against the recurrence of CA, while wart number, survivin and p63 were independent risk factors for CA recurrence. Conclusion: miR-203 could be a specific clinical bioindicator for the prognosis and recurrence of CA.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'The end' - or is it? Emergence of SARS-CoV-2 EG.5 and BA.2.86 subvariants. “结束了”——还是结束了？严重急性呼吸系统综合征冠状病毒2型EG.5和BA.2.86亚变体的出现。
IF 3.1 4区 医学
Future Virology Pub Date : 2023-09-01 Epub Date: 2023-09-19 DOI: 10.2217/fvl-2023-0150
Farid Rahimi, Mohammad Darvishi, Amin Talebi Bezmin Abadi
{"title":"'The end' - or is it? Emergence of SARS-CoV-2 EG.5 and BA.2.86 subvariants.","authors":"Farid Rahimi, Mohammad Darvishi, Amin Talebi Bezmin Abadi","doi":"10.2217/fvl-2023-0150","DOIUrl":"https://doi.org/10.2217/fvl-2023-0150","url":null,"abstract":"Having surpassed Alpha","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effects of herpes virus glycoprotein glycosylation on viral infection and pathogenesis 疱疹病毒糖蛋白糖基化对病毒感染和发病的影响
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-22 DOI: 10.2217/fvl-2022-0209
Yijing Chen, Wen Liu, B. Luo
{"title":"The effects of herpes virus glycoprotein glycosylation on viral infection and pathogenesis","authors":"Yijing Chen, Wen Liu, B. Luo","doi":"10.2217/fvl-2022-0209","DOIUrl":"https://doi.org/10.2217/fvl-2022-0209","url":null,"abstract":"Herpes virus is an enveloped virus with many glycoproteins essential for viral infection and immune evasion. Several glycosylation sites exist on the glycoproteins of herpes viruses, including N- and O-glycosylation sites. Glycosylation affects herpes virus infection and pathogenesis in different ways, including the attachment and entry of the herpes virus into host cells, virus replication and the host's immune function. This article summarized the current knowledge on the glycosylation of herpes virus envelope glycoproteins and its impact on viral infection and demonstrated several applications of glycosylation inhibitors.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43664887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered synaptic plasticity: plausible mechanisms associated with viral infections 突触可塑性改变:与病毒感染相关的合理机制
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-22 DOI: 10.2217/fvl-2023-0105
Vaishali Saini, Annu Rani, Amarjeet Kumar, K. Jha, S. Karnati, H. Jha
{"title":"Altered synaptic plasticity: plausible mechanisms associated with viral infections","authors":"Vaishali Saini, Annu Rani, Amarjeet Kumar, K. Jha, S. Karnati, H. Jha","doi":"10.2217/fvl-2023-0105","DOIUrl":"https://doi.org/10.2217/fvl-2023-0105","url":null,"abstract":"Neurotropic viruses target the central nervous system through various mechanisms: they have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking N-methyl d-aspartate receptors; they alter the Ca2+ ion-signaling pathways modulating long-term potentiation, leading to a severe inflammatory response in brain cells, increased reactive oxygen species and lipid peroxidation through mitochondria and peroxisomes. Inflammatory pathways have a key role in modulating the plasticity of neurons, linked to numerous neurological disorders. Advanced neuroimaging techniques facilitate the early diagnosis of impaired synaptic function in viral infections and neurodegenerative disorders. Here we discuss the understanding of the interplay between neurotropic viral infections and their effects on synaptic plasticity and diagnosis through neuroimaging techniques.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48173845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of influenza A virus: current molecular tools 甲型流感病毒的诊断：当前的分子工具
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-16 DOI: 10.2217/fvl-2023-0091
Sanjit Boora, Anishkumar Khan, S. Kaushik
{"title":"Diagnosis of influenza A virus: current molecular tools","authors":"Sanjit Boora, Anishkumar Khan, S. Kaushik","doi":"10.2217/fvl-2023-0091","DOIUrl":"https://doi.org/10.2217/fvl-2023-0091","url":null,"abstract":"","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44346692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers HTLV-1携带者昼夜节律信号通路中CLOCK和CSNK1D功能的评估
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-16 DOI: 10.2217/fvl-2023-0050
Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani
{"title":"Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers","authors":"Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani","doi":"10.2217/fvl-2023-0050","DOIUrl":"https://doi.org/10.2217/fvl-2023-0050","url":null,"abstract":"Aim: Disruption of the internal circadian rhythm pathway could lead to a range of diseases. In this study, we aim to evaluate the circadian rhythm pathway by assessing the interaction between CLOCK and CSNK1D genes in HTLV-1 carriers in comparison with healthy individuals. Materials & methods: CLOCK and CSNK1D gene expression was assessed using the RT-qPCR. Pathogenesis-related signaling networks were designed and analyzed using the obtained results. Results: There was no significant difference in age between the groups. CLOCK and CSNK1D gene expression levels were significantly higher in carriers than in healthy individuals (p = 0.04, p = 0.03, respectively). Conclusion: In addition to introducing potential biological markers, obtained results could be a good idea to further investigate this signaling pathway in the future.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43477198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LMP1 encoded by Epstein–Barr virus may activate AHR through the ERK pathway in nasopharyngeal carcinoma cells EB病毒编码的LMP1可能通过ERK途径激活鼻咽癌细胞的AHR
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-08 DOI: 10.2217/fvl-2023-0093
Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, B. Luo
{"title":"LMP1 encoded by Epstein–Barr virus may activate AHR through the ERK pathway in nasopharyngeal carcinoma cells","authors":"Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, B. Luo","doi":"10.2217/fvl-2023-0093","DOIUrl":"https://doi.org/10.2217/fvl-2023-0093","url":null,"abstract":"Aim: To investigate the role of AHR in nasopharyngeal carcinoma (NPC) and explore the relationship between Epstein–Barr virus (EBV) infection and the AHR pathway. Methods: The effect of LMP1 on the expression of AHR was analyzed using real-time PCR and western blot. Proliferation and migration of cells were assessed using CCK8 and Transwell analysis. Results: EBV infection downregulated the expression of AHR in NPC cells, possibly through activation of the ERK pathway by LMP1 thereby accelerating AHR proteasomal degradation following translocation to the nucleus. Cell proliferation, migration and autophagy are promoted by activating the AHR pathway. Conclusion: In NPC cells, LMP1 increases the phosphorylation of ERK, which may activate the AHR pathway.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42362963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and identification of dominant B-cell epitopes of human cytomegalovirus UL138 and its clinical applications 人巨细胞病毒UL138显性b细胞表位的筛选鉴定及其临床应用
4区 医学
Future Virology Pub Date : 2023-08-01 DOI: 10.2217/fvl-2023-0052
Hua Zhu, Xuanlu Xu, Jing Jiang, Xiangyang Xue, Wenmiao Zhang, Ruanmin Zou
{"title":"Screening and identification of dominant B-cell epitopes of human cytomegalovirus <i>UL138</i> and its clinical applications","authors":"Hua Zhu, Xuanlu Xu, Jing Jiang, Xiangyang Xue, Wenmiao Zhang, Ruanmin Zou","doi":"10.2217/fvl-2023-0052","DOIUrl":"https://doi.org/10.2217/fvl-2023-0052","url":null,"abstract":"Aim: To predict the dominant B-cell epitope of the human cytomegalovirus UL138 gene and to provide a new assay for its latent infection. Methods: Recombinant plasmids were constructed with the predicted dominant epitopes, induced to be expressed and immunized in mice as a way to identify peptide antigenicity, immunogenicity and human serum. Results: Five potentially dominant B-cell epitopes were obtained. The positive rate of detection was found to be significantly higher in neonatal, adult and mouse serum specimens than in human cytomegalovirus (HCMV) (IgG, IgM) and UL138 gene DNA and cDNA assays (p < 0.05). Conclusion: The predicted dominant B-cell epitope is highly sensitive for the detection of human serum HCMV latent infection and can replace the traditional HCMV IgG assay.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135053252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical transmission and maternal passive immunity post-SARS-CoV-2. 严重急性呼吸系统综合征冠状病毒2型后的垂直传播和母体被动免疫。
IF 3.1 4区 医学
Future Virology Pub Date : 2023-08-01 Epub Date: 2023-10-04 DOI: 10.2217/fvl-2023-0089
Hanie Karimi, Vahid Mansouri, Nima Rezaei
{"title":"Vertical transmission and maternal passive immunity post-SARS-CoV-2.","authors":"Hanie Karimi,&nbsp;Vahid Mansouri,&nbsp;Nima Rezaei","doi":"10.2217/fvl-2023-0089","DOIUrl":"10.2217/fvl-2023-0089","url":null,"abstract":"<p><p>Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2 have rendered the pandemic interminable. Vertical transmission (VT) through the placenta and breast milk, which is frequent for certain virus types, is thought to exist for SARS-CoV-2 and is hypothesized by many researchers. Conversely, antibodies are produced to counteract the effect of viruses. Since newborns' immunologic system cannot produce proper antibodies, maternal antibodies are usually transferred from mother to infant/fetus to meet the need. This theory leads to the hypothesis of transmission of antibodies through the placenta and breast milk following SARS-CoV-2 infection or vaccination. This paper further discusses these hypotheses, considering consequences of fetus/infant harm versus benefit.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564388/pdf/fvl-2023-0089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41197546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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