HTLV-1携带者昼夜节律信号通路中CLOCK和CSNK1D功能的评估

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-08-16 DOI:10.2217/fvl-2023-0050

Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani

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引用次数: 0

摘要

目的：内部昼夜节律途径的破坏可能导致一系列疾病。在这项研究中，我们的目的是通过评估HTLV-1携带者中CLOCK和CSNK1D基因与健康个体之间的相互作用来评估昼夜节律途径。材料与方法：采用RT-qPCR技术检测CLOCK和CSNK1D基因的表达。利用获得的结果设计并分析了与发病机制相关的信号网络。结果：两组患者的年龄差异无统计学意义。携带者的CLOCK和CSNK1D基因表达水平显著高于健康个体（分别为p=0.04和p=0.03）。结论：除了引入潜在的生物标志物外，所获得的结果可能是未来进一步研究该信号通路的好主意。

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Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers

Aim: Disruption of the internal circadian rhythm pathway could lead to a range of diseases. In this study, we aim to evaluate the circadian rhythm pathway by assessing the interaction between CLOCK and CSNK1D genes in HTLV-1 carriers in comparison with healthy individuals. Materials & methods: CLOCK and CSNK1D gene expression was assessed using the RT-qPCR. Pathogenesis-related signaling networks were designed and analyzed using the obtained results. Results: There was no significant difference in age between the groups. CLOCK and CSNK1D gene expression levels were significantly higher in carriers than in healthy individuals (p = 0.04, p = 0.03, respectively). Conclusion: In addition to introducing potential biological markers, obtained results could be a good idea to further investigate this signaling pathway in the future.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.