病毒基因的N6-甲基腺苷甲基化

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-09-05 DOI:10.2217/fvl-2022-0201

Jiting Sun, Yan Zhang, Bin Luo

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引用次数: 0

摘要

N6-甲基腺苷（m6A）修饰是真核生物中最普遍的RNA表观遗传学修饰类型，也是最常见的mRNA转录后修饰类型。m6A修饰是一个动态可逆的过程，可以影响基因表达，并在mRNA代谢和多种生物过程中发挥关键作用，从RNA加工、核输出和RNA翻译到衰变。同时，大量证据表明，m6A甲基化调节病毒的生命周期，抑制或促进各种病毒的发展。然而，病毒相关肿瘤中m6A甲基化的机制尚未完全阐明。这篇综述强调了m6A修饰在各种病毒中的作用，以帮助建立治疗相关疾病的新方法。

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N6-methyladenosine methylation of viral genes

N6-methyladenosine (m6A) modification is the most pervasive type of RNA epigenetic modification in eukaryotes and the most common type of posttranscriptional modification of mRNA. m6A modification is a dynamic reversible process that can affect gene expression and play a crucial role in mRNA metabolism and multiple biological processes, ranging from RNA processing, nuclear export and RNA translation to decay. Meanwhile, much evidence has shown that m6A methylation regulates the life cycle of viruses and inhibits or promotes the development of various viruses. However, the mechanism of m6A methylation in virus-associated tumors has not been fully elucidated. This review highlights the role of m6A modification in various viruses to help establish new approaches for treating related diseases.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.