An update on long-acting agents in HIV therapy

Since the advent of highly active antiretroviral therapy, many efforts have been made to broaden the spectrum of possible regimens. Long-acting antiretrovirals, are particularly attractive, since they allow for less frequent dosing and can potentially overcome difficulties associated with daily tablet consumption, including the need for flexibility and privacy. In this article, we present a summary and update on currently available long-acting antiretrovirals and those under development and discuss issues related to their effective implementation.