Expression of miR-203 and its target genes in condyloma acuminatum and their relationships with clinical recurrence

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-09-01 DOI:10.2217/fvl-2023-0086

Beilei He, Yangfan Wu, Qingyun Yang, Enyi Ye, Tingkai Xiang, Xinyi Wang, Lin Deng, Kune Lu, Jue Liu, Xiaohong Yu, Zhangyu Bu

引用次数: 0

Abstract

Aim: To examine the expression of miR-203 and its target genes survivin and p63 in condyloma acuminatum (CA) and to determine their relationships with clinical recurrence. Methods: Case and control groups were assessed for general data and the expression levels of miR-203, survivin and p63. The case group received carbon dioxide laser treatment, had a 3-month follow-up period, and was then divided into recurrence and non-recurrence groups. The relevant data were analyzed using SPSS v. 25.0 software. Results: miR-203 was identified as an independent protective factor against the recurrence of CA, while wart number, survivin and p63 were independent risk factors for CA recurrence. Conclusion: miR-203 could be a specific clinical bioindicator for the prognosis and recurrence of CA.

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miR-203及其靶基因在尖锐湿疣组织中的表达及其与临床复发的关系

目的:检测miR-203及其靶基因survivin和p63在尖锐湿疣(CA)中的表达，并探讨其与临床复发的关系。方法:比较病例组和对照组的一般数据及miR-203、survivin、p63的表达水平。病例组接受二氧化碳激光治疗，随访3个月，分为复发组和非复发组。采用SPSS v. 25.0软件对相关数据进行分析。结果:miR-203是CA复发的独立保护因素，疣数、survivin和p63是CA复发的独立危险因素。结论:miR-203可作为CA预后及复发的特异性临床生物指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.