Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-09-01 DOI:10.2217/fvl-2023-0142

Vitor Won-Held Rabelo, Verônica Diniz da Silva, Maria Leonisa Sanchez Nuñez, Leonardo dos Santos Corrêa Amorim, Camilla Djenne Buarque, Richard J Kuhn, Paula Alvarez Abreu, Izabel Christina Nunes de Palmer Paixão

引用次数: 0

Abstract

Aim: This work aimed to investigate the antiviral activity of two 1,4-disubstituted-1,2,3-triazole derivatives (1 and 2) against Chikungunya virus (CHIKV) replication. Materials & methods: Cytotoxicity was analyzed using colorimetric assays and the antiviral potential was evaluated using plaque assays and computational tools. Results: Compound 2 showed antiviral activity against CHIKV 181-25 in BHK-21 and Vero cells. Also, this compound presented a higher activity against CHIKV BRA/RJ/18 in Vero cells, like compound 1. Compound 2 exhibited virucidal activity and inhibited virus entry while compound 1 inhibited virus release. Molecular docking suggested that these derivatives inhibit nsP1 protein while compound 1 may also target capsid protein. Conclusion: Both compounds exhibit promising antiviral activity against CHIKV by blocking different steps of virus replication.

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1,4-二取代-1,2,3-三唑衍生物对基孔肯雅病毒的抗病毒评价

目的:研究两种1,4-二取代-1,2,3-三唑衍生物(1和2)对基孔肯雅病毒(CHIKV)复制的抗病毒活性。材料,方法:用比色法分析细胞毒性，用斑块法和计算工具评估抗病毒潜力。结果:化合物2对BHK-21和Vero细胞具有抗病毒活性。该化合物与化合物1一样，在Vero细胞中对CHIKV BRA/RJ/18具有较高的抑制活性。化合物2具有杀病毒活性，抑制病毒进入，化合物1抑制病毒释放。分子对接表明，这些衍生物抑制nsP1蛋白，而化合物1也可能靶向衣壳蛋白。结论:两种化合物通过阻断病毒复制的不同步骤，显示出良好的抗病毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.