Frontiers in Physiology最新文献

{"title":"The effects of eccentric cycling on vascular reactivity.","authors":"Manuel Gomez, Samuel Montalvo, Daniel Conde, Gabriel Ibarra-Mejia, Alvaro N Gurovich","doi":"10.3389/fphys.2025.1554054","DOIUrl":"https://doi.org/10.3389/fphys.2025.1554054","url":null,"abstract":"<p><strong>Purpose: </strong>Eccentric cycling has gained attention as a novel exercise modality that increases muscle performance at lower metabolic demand, which could enhance cardiovascular rehabilitation. However, endothelial function response to eccentric cycling (ECC) has yielded contradictory results. Therefore, the purpose of this study was to determine the effect of 30 min of moderate-intensity cycling ECC on endothelial function.</p><p><strong>Methods: </strong>A total of 15 (9 females, 6 males) young, apparently healthy participants were recruited for two laboratory visits. First, a maximum oxygen consumption (VO₂max) and blood lactate (BLa) threshold were measured to determine moderate workload intensity, followed by a familiarization stage on an ECC ergometer. During the second visit, a 30-min of moderate ECC was performed 72 h after the first visit. Endothelial function was measured via Flow-Mediated Dilation (FMD) pre- and post-exercise bout. FMD was calculated following traditional recommendations and adjusting for exercise-induced endothelial shear stress (ESS), utilizing the same pre-exercise baseline artery diameter for post-exercise FMD calculations.</p><p><strong>Results: </strong>There was a significant increase in endothelial function (p = 0.037) when adjusting pre-exercise baseline diameter to adjust for ESS, but when utilizing the traditional method no change in endothelial function was observed.</p><p><strong>Conclusion: </strong>30-min of moderate ECC showed a significant improvement in endothelial function when accounting for exercise-induced ESS. These results support the use of the pre-exercise baseline diameter when calculating post-exercise FMD to avoid the exercise-induced ESS or muscle metabolites effects on post-exercise artery diameter.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1554054"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between cardiometabolic index and psoriasis: a cross-sectional analysis using NHANES data.","authors":"Mengxue Li, Yixiao Gan, Hong Cheng, Zhicheng Wang","doi":"10.3389/fphys.2025.1552269","DOIUrl":"10.3389/fphys.2025.1552269","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is closely associated with metabolic health. The Cardiometabolic Index (CMI) is an innovative and easily obtainable metric employed to assess cardiometabolic health. This study aims to examine the possible relationship between CMI and psoriasis.</p><p><strong>Methods: </strong>Data from four successive cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 2003-2004 and 2009-2014 were employed. This encompassed adults with self-reported psoriasis diagnoses and comprehensive information necessary for calculating the CMI. The calculation formula for CMI is Triglycerides (TG)/High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference/height). A multivariable logistic regression model was utilized to examine the linear relationship between CMI and psoriasis. Subgroup analyses were conducted to investigate potential contributing factors. The linear relationship was further established using smooth curve fitting.</p><p><strong>Results: </strong>This study, utilizing NHANES data, comprised a cohort of 7,327 American adults. The multivariable logistic regression analysis indicated that in the fully adjusted model, people with the greatest CMI had a 71% increased probability of psoriasis relative to those with the lowest CMI (OR = 1.71; 95% CI, 1.11-2.61, P < 0.05). Smooth curve fitting demonstrated a linear connection between CMI and psoriasis (P < 0.05). The subgroup analysis revealed no significant interactions between CMI and specific subgroups (all interactions P > 0.05).</p><p><strong>Conclusion: </strong>Our research indicates a substantial linear correlation between CMI and psoriasis in American adults. This method facilitates the identification of groups at increased risk for psoriasis, therefore guiding therapeutic solutions and public health activities to improve metabolic and dermatological health outcomes.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1552269"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel kinetic model estimating the urea concentration in plasma during non-invasive sweat-based monitoring in hemodialysis.","authors":"Xiaoyu Yin, Sophie Adelaars, Elisabetta Peri, Eduard Pelssers, Jaap Den Toonder, Arthur Bouwman, Daan Van de Kerkhof, Massimo Mischi","doi":"10.3389/fphys.2025.1547117","DOIUrl":"10.3389/fphys.2025.1547117","url":null,"abstract":"<p><strong>Introduction: </strong>The adequacy of hemodialysis (HD) in patients with end-stage renal disease is evaluated frequently by monitoring changes in blood urea concentrations multiple times between treatments. As monitoring of urea concentrations typically requires blood sampling, the development of sweat-sensing technology offers a possible less-invasive alternative to repeated venipuncture. Moreover, this innovative technology could enable personalized treatment in a home-based setting. However, the clinical interpretation of sweat monitoring is hampered by the limited literature on the correlation between urea concentrations in sweat and blood. This study introduces a pioneering approach to estimate blood urea concentrations using sweat urea concentration values as input.</p><p><strong>Methods: </strong>To simulate the complex transport mechanisms of urea from blood to sweat, a novel pharmacokinetic transport model is proposed. Such a transport model, together with a double-loop optimization strategy from our previous work, was employed for patient-specific estimation of blood urea concentration. 32 patient samples of paired sweat and blood urea concentrations, collected both before and after HD, were used to validate the model.</p><p><strong>Results: </strong>This resulted in an excellent Pearson correlation coefficient (0.98, 95%CI: 0.95-0.99) and a clinically irrelevant bias (-0.181 mmol/L before and -0.005 mmol/L after HD).</p><p><strong>Discussion: </strong>This model enabled the accurate estimation of blood urea concentrations from sweat measurements. By accurately estimating blood urea concentrations from sweat measurements, our model enables non-invasive and more frequent assessments of dialysis adequacy in ESRD patients. This approach could facilitate home-based and patient-friendly dialysis management, enhancing patient comfort while enabling more personalized treatment across diverse clinical settings.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1547117"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Physiological adaptations of insects exposed to different stress conditions, volume II.","authors":"Bimalendu B Nath","doi":"10.3389/fphys.2025.1582575","DOIUrl":"10.3389/fphys.2025.1582575","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1582575"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cnidaria herd optimized fuzzy C-means clustering enabled deep learning model for lung nodule detection.","authors":"R Hari Prasada Rao, Agam Das Goswami","doi":"10.3389/fphys.2025.1511716","DOIUrl":"10.3389/fphys.2025.1511716","url":null,"abstract":"<p><strong>Introduction: </strong>Lung nodule detection is a crucial task for diagnosis and lung cancer prevention. However, it can be extremely difficult to identify tiny nodules in medical images since pulmonary nodules vary greatly in shape, size, and location. Further, the implemented methods have certain limitations including scalability, robustness, data availability, and false detection rate.</p><p><strong>Methods: </strong>To overcome the limitations in the existing techniques, this research proposes the Cnidaria Herd Optimization (CHO) algorithm-enabled Bi-directional Long Short-Term Memory (CHSTM) model for effective lung nodule detection. Furthermore, statistical and texture descriptors extract the significant features that aid in improving the detection accuracy. In addition, the FC2R segmentation model combines the optimized fuzzy C-means clustering algorithm and the Resnet -101 deep learning approach that effectively improves the performance of the model. Specifically, the CHO algorithm is modelled using the combination of the induced movement strategy of krill with the time control mechanism of the cnidaria to find the optimal solution and improve the CHSTM model's performance.</p><p><strong>Results: </strong>According to the experimental findings of a performance comparison between other established methods, the FC2R + CHSTM model achieves 98.09% sensitivity, 97.71% accuracy, and 97.03% specificity for TP 80 utilizing the LUNA-16 dataset. Utilizing the LIDC/IDRI dataset, the proposed approach attained a high accuracy of 97.59%, sensitivity of 96.77%, and specificity of 98.41% with k-fold validation outperforming the other existing techniques.</p><p><strong>Conclusion: </strong>The proposed FC2R + CHSTM model effectively detects lung nodules with minimum loss and better accuracy.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1511716"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary cytoskeletal modulation of coronary blood flow in the presence and absence of type 2 diabetes: the role of cofilin.","authors":"Patricia E McCallinhart, Kathlyene R Stone, Pamela A Lucchesi, Aaron J Trask","doi":"10.3389/fphys.2025.1561867","DOIUrl":"10.3389/fphys.2025.1561867","url":null,"abstract":"<p><strong>Background: </strong>Coronary resistance microvessels (CRMs) from type 2 diabetic (T2DM) mice and pigs are less stiff compared to normal, a finding that is dictated by less stiff coronary vascular smooth muscle cells (VSMCs). Cofilin is an endogenous actin regulatory protein that depolymerizes filamentous (F)-actin, and portions of F-actin bound to cofilin are less stiff compared to their unbound F-actin counterparts. In this study, we hypothesized that altering the actin cytoskeleton modifies VSMC stiffness, which contributes to changes in coronary blood flow in normal and T2DM conditions.</p><p><strong>Methods and results: </strong>Utilizing phalloidin staining, we found that F-actin was significantly reduced in T2DM CRM VSMCs, and we showed cofilin expression was increased in T2DM by proteomics and Western blot analysis. Cofilin knockdown in both human and mouse coronary VSMCs using siRNA significantly increased F/G actin ratio. Cofilin knockdown also caused a significant increase in elastic modulus by atomic force microscopy of coronary VSMCs. Treatment with Latrunculin B, an actin disruptor, significantly decreased VSMC elastic modulus. Acute Latrunculin B infusion into the coronary circulation of <i>ex vivo</i> isolated Langendorff mouse hearts increased peak coronary blood flow.</p><p><strong>Conclusion: </strong>Together, we demonstrated that the CRM VSMC actin cytoskeleton is altered in T2DM to favor less stiff cells, and pharmacological manipulation of the actin cytoskeleton alters VSMC biomechanics. This study is also the first to demonstrate that coronary cellular modulation of mechanics can acutely modulate coronary blood flow.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1561867"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease.","authors":"Jun-Jie Wang, Xiao-Yuan Chen, Yi-Rong Zhang, Yan Shen, Meng-Lin Zhu, Jun Zhang, Jun-Jie Zhang","doi":"10.3389/fphys.2025.1562848","DOIUrl":"10.3389/fphys.2025.1562848","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD), is one of the most common chronic liver diseases, which encompasses a spectrum of diseases, from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH), and may ultimately progress to MASH-related cirrhosis and hepatocellular carcinoma (HCC). MASLD is a complex disease that is influenced by genetic and environmental factors. Dysregulation of hepatic lipid metabolism plays a crucial role in the development and progression of MASLD. Therefore, the focus of this review is to discuss the links between the genetic variants and DNA methylation of lipid metabolism-related genes and MASLD pathogenesis. We first summarize the interplay between MASLD and the disturbance of hepatic lipid metabolism. Next, we focus on reviewing the role of hepatic lipid related gene loci in the onset and progression of MASLD. We summarize the existing literature around the single nucleotide polymorphisms (SNPs) associated with MASLD identified by genome-wide association studies (GWAS) and candidate gene analyses. Moreover, based on recent evidence from human and animal studies, we further discussed the regulatory function and associated mechanisms of changes in DNA methylation levels in the occurrence and progression of MASLD, with a particular emphasis on its regulatory role of lipid metabolism-related genes in MASLD and MASH. Furthermore, we review the alterations of hepatic DNA and blood DNA methylation levels associated with lipid metabolism-related genes in MASLD and MASH patients. Finally, we introduce potential value of the genetic variants and DNA methylation profiles of lipid metabolism-related genes in developing novel prognostic biomarkers and therapeutic targets for MASLD, intending to provide references for the future studies of MASLD.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1562848"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise interventions on depressive symptoms in stroke patients: a systematic review and meta-analysis.","authors":"Zhi-Yuan Wang, Ya-Lu Deng, Ting-Yuan Zhou, Zi-Yang Jiang, Yi Liu, Bo-Fu Liu, Yu Cao","doi":"10.3389/fphys.2025.1492221","DOIUrl":"10.3389/fphys.2025.1492221","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to evaluate the effects of exercise interventions on depressive symptoms in stroke patients.</p><p><strong>Methods: </strong>Following PRISMA guidelines, We conducted searches in PubMed, Embase, CENTRAL, and Web of Science. The topic was the effect of exercise on depression levels in stroke patients. Patient's performance on depression scales after exercise was assessed using standardized mean difference (SMD) and 95% confidence intervals (95% CI). A random effects model (RE) was used to conduct a meta-analysis and compare the results between subgroups conducted based on adherence to ACSM guidelines and the length of exercise interventions.</p><p><strong>Results: </strong>The analysis included 24 randomized controlled trials (RCTs) involving 1,757 participants. The meta-analysis revealed that exercise interventions had a significant positive effect on reducing depressive symptoms in stroke patients, with a standardized mean difference (SMD) of -0.43 (95% CI: 0.65, -0.21). Subgroup analysis indicated that high compliance with ACSM guidelines resulted in a more substantial reduction in depressive symptoms (SMD = -0.79, 95% CI: 1.10, -0.49), compared with low or uncertain compliance (SMD = -0.03, 95% CI: 0.16, 0.10). Longer exercise intervention was associated with greater mitigation of depressive symptoms. The differences between intervention groups of different lengths were statistically significant (p < 0.05).</p><p><strong>Conclusion: </strong>These findings support the integration of tailored exercise programs into post-stroke care to optimize mental health outcomes. Compliance to ACSM-recommended exercise dosages significantly ameliorate depression levels in stroke patients. Further research is warranted to explore standardized exercise regimens in larger, multicenter trials.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#recordDetails, identifier PROSPERO(CRD42024579095).</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1492221"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors and construction of a predictive model for severe acute pancreatitis complicated by sinistral portal hypertension.","authors":"Mengbo Xiao, Yu An, Ying Di, Yunfeng Cui","doi":"10.3389/fphys.2025.1512144","DOIUrl":"10.3389/fphys.2025.1512144","url":null,"abstract":"<p><strong>Objective: </strong>Sinistral portal hypertension (SPH) is a common complication of severe acute pancreatitis (SAP). Patients with SPH often present asymptomatic, but are at risk of gastrointestinal bleeding and abdominal bleeding due to the presence of varices of the corresponding vessels, which are often fatal. However, there is no prediction model for SAP combined with SPH. This study aimed to identify the risk factors of SAP combined with SPH and to construct a relevant predictive model using independent risk factors.</p><p><strong>Materials and methods: </strong>The clinical data of 431 SAP patients were collected in this study. According to the presence or absence of SPH, the patients were divided into SPH group (n = 126) and non-SPH group (n = 305), and 431 patients were randomly assigned to the training set and validation set. Univariate logistics regression analysis was used to screen out the variables with significant differences, and then backward stepwise regression method was used for multivariate logistic regression analysis to determine the independent risk factors of SAP combined with SPH. Then a prediction model was constructed and represented by a nomogram, and the model was verified by internal validation. Receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the predictive ability and accuracy of the model, and decision curve analysis (DCA) was used to evaluate the clinical value of the model.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that male, MCTSI score, white blood cell count (WBC), and portal venous system vascular lesions (PVPSL) were independent risk factors for SAP complicated with SPH. The area under the working curve (AUC) of the clinical nomogram in the training set was 0.95 (95% CI: 0.92-0.97),and the P value of the Hosmer-Lemeshow test of the calibration curve was 0.969. The AUC in the validation set was 0.98 (95%CI: 0.96-1.00), and the P value of the Hosmer-Lemeshow test of the calibration curve was 0.963. The DCA in the training set and the validation set showed good clinical applicability of the model.</p><p><strong>Conclusion: </strong>Male, MCTSI score, WBC and PVPSL are independent risk factors for SAP complicated with SPH. The establishment of prediction model for SAP complicated with SPH is of great significance for the prevention and treatment of SPH in clinical practice.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1512144"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials.","authors":"Qiuxiang Lin, Debiao Yu, Yuping Zhang, Xiaoting Chen, Jiawei Qin, Fuchun Wu","doi":"10.3389/fphys.2025.1524480","DOIUrl":"10.3389/fphys.2025.1524480","url":null,"abstract":"<p><strong>Objectives: </strong>The effectiveness of low-load blood flow restriction training (LL-BFRT) in alleviating symptoms in patients with knee osteoarthritis (KOA) remains inconclusive. This systematic review and meta-analysis aim to comprehensively assess the effects of LL-BFRT compared to conventional resistance training on pain, muscle strength, and functional capacity in individuals with KOA.</p><p><strong>Data sources: </strong>PubMed, Embase, Web of Science, EBSCO, Scopus, and Cochrane trails were searched.</p><p><strong>Study selection: </strong>We included randomized controlled trials involving patients with KOA, in which the intervention group underwent LL-BFRT.</p><p><strong>Data extraction: </strong>Literature quality and risk of bias were assessed using the Physiotherapy Evidence Database (PEDro) scale and the Cochrane Risk-of-Bias Tool (ROB 2). Data were extracted using a predefined table, including outcomes such as pain, quadriceps muscle strength, 30-s sit-to-stand test (30STS) and Timed Up and Go test (TUG).</p><p><strong>Result: </strong>Ten studies were included in the meta-analysis. The pooled results indicated that, compared to conventional resistance training, LL-BFRT significantly improved knee joint pain [SMD = 0.25, 95%CI (0.02, 0.48), P = 0.03], increased quadriceps muscle strength [SMD = 0.46, 95%CI (0.04, 0.88), P = 0.03], and enhanced performance on the 30s sit-to-stand test (30STS) [WMD = 1.71, 95%CI (0.30, 3.11), P = 0.02]. However, no significant difference was observed in the improvement of the Timed Up and Go test (TUG) [WMD = -0.13, 95%CI (-0.51, 0.24), P = 0.49]. Subgroup analysis revealed that interventions with an occlusion pressure >100 mmHg and a duration ≤6 weeks had a significant impact on pain relief, quadriceps muscle strength, and the 30STS performance. For patients with KOA aged >65 years, LL-BFRT was more effective in alleviating pain, while for patients aged ≤65 years, it demonstrated more significant improvements in quadriceps strength and 30STS performance.</p><p><strong>Conclusion: </strong>Limited evidence suggests that LL-BFRT may be more effective than conventional resistance training in improving pain, quadriceps muscle strength, and 30STS performance in patients with KOA, while exhibiting a comparable effect on TUG test.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD42024603542.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1524480"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}