Frontiers in Physiology最新文献

{"title":"Current state of research on acupuncture for acne: a scoping review.","authors":"Huiyuan Huang, Ying Liu, Shuhui Wu, Dan Zhao, Huie Zheng, Mingfang Zhu","doi":"10.3389/fphys.2025.1661850","DOIUrl":"10.3389/fphys.2025.1661850","url":null,"abstract":"<p><strong>Objective: </strong>Acne vulgaris is recognized as one of the top eight most disabling dermatological diseases globally. Acupuncture has emerged as a clinically valuable and widely practiced intervention for acne, with the World Health Organization endorsing it as an effective non-pharmacological treatment. While existing evidence demonstrates acupuncture's ability to significantly improve acne symptoms, the research remains scattered and lacks comprehensive synthesis. This scoping review systematically maps the current clinical research on acupuncture for acne treatment to identify knowledge gaps and inform future research directions.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, EMBASE, the Cochrane Library, Web of Science, AMED, SinoMed, CNKI, WanFang, and VIP databases to identify relevant studies published between January 2014 and October 2024. Data extraction and synthesis were performed using descriptive statistics and visual analytics. The review followed the PRISMA-ScR guidelines and was prospectively registered with the OSF.</p><p><strong>Results: </strong>This study included 114 eligible studies, comprising 48 randomized controlled trials, 63 non-randomized interventional studies, and 3 systematic reviews, with the vast majority conducted in China. After 2019, the publication output of acupuncture studies for acne treatment showed a declining trend, which was generally consistent with changes in research funding. Cochrane risk-of-bias assessment revealed that the overall methodological quality of RCTs was moderate, with a low proportion of high-quality studies. The main acupuncture interventions for acne included filiform needle acupuncture, pricking-cupping, fire needling, autohemotherapy, bloodletting therapy, and catgut embedding at acupoints, with Ashi point (local lesion area) being the most frequently selected acupoint. Among the 16 outcome measures evaluated, the effective rate was the most commonly used indicator. Overall, acupuncture demonstrated good safety in treating acne, although fire needling showed a significantly higher frequency of adverse events compared to other therapies.</p><p><strong>Conclusion: </strong>As a globally prevalent complementary therapy, acupuncture has established a substantial research base for acne treatment; however, methodological limitations persist in existing studies. Future research should conduct multicenter, large-sample randomized controlled trials adhering to standardized reporting guidelines, develop comprehensive efficacy evaluation systems incorporating objective indicators, and investigate connections between clinical outcomes and mechanistic pathways. These efforts will elevate the evidence level for acupuncture in acne management.</p><p><strong>Systematic review registration: </strong>https://doi.org/10.17605/OSF.IO/S2QT6.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1661850"},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral strength balance of knee extensor and flexor muscles in female soccer players.","authors":"Oscar Andrades-Ramírez, David Ulloa-Díaz, Luis Romero-Vera, Bryan Alfaro-Castillo, Gustavo Muñoz-Bustos, Carlos Jorquera-Aguilera, Claudio Carvajal-Parodi, Luis-Javier Chirosa-Ríos","doi":"10.3389/fphys.2025.1681804","DOIUrl":"10.3389/fphys.2025.1681804","url":null,"abstract":"<p><strong>Background: </strong>The aim of our study was analyze the bilateral strength balance of the knee extensor and flexor muscles in female soccer players.</p><p><strong>Methodology: </strong>Participated in this study twenty-three professional female soccer players. The volunteer participants of the study were eligibly if: (a) signing of informed consent, (b) 5 years of sporting experience as a soccer player and have experience with training and evaluation of muscle strength in the lower limb, (c) participate in five weekly training sessions (d) no musculoskeletal pathology in the lower limbs 6 months prior to the evaluation date. The assessment was performed unilaterally, with peak muscle strength values recorded using the FEMD device software at a constant velocity of 0.4 m s^-1. The range of motion (ROM) was 90°-0° of joint extension in the sitting position and 150°-90° of flexion in the prone position. Each participant was required to perform their maximum effort for all repetitions.</p><p><strong>Results: </strong>Bilateral strength balance measurements were obtained in the range of 10.68%-13.80% for maximum muscle strength in knee extension and 13.27%-15.21%. No significant differences (<i>p</i> > 0.05) were found in the comparison of independent means for maximum muscle strength between the knee extension and flexion in the concentric and eccentric phases. Significant differences (<i>p</i> < 0.01) and small ES (ES < 3.32) were found in peak muscle strength measurements of the dominant and non-dominant lower extremity in the unilateral comparison of the extensor muscle and the flexor muscle group in the concentric and eccentric phase.</p><p><strong>Conclusion: </strong>In the analysis of bilateral strength balance, lower indices are presented in the knee extensor compared to the flexor, these bilateral indices would reveal intrinsic and extrinsic risk factors for musculoskeletal injuries in the hamstring muscles and anterior cruciate ligament of professional soccer players.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1681804"},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the lab coat: methodological challenges in space life sciences.","authors":"Martine Van Puyvelde, Nicholas H van den Berg, Lara Stas, Perseverence Savieri, Hortense Corlùy, Jeroen Van Cutsem, Xavier Neyt, Guido Simonelli, Nathalie Pattyn","doi":"10.3389/fphys.2025.1663701","DOIUrl":"10.3389/fphys.2025.1663701","url":null,"abstract":"<p><p>As plans for deep space and long-duration missions advance, research in space and space-analog environments is becoming an urgent scientific priority. However, this type of fieldwork poses a unique set of challenges. The development of research methodologies and designs cannot rely on broad evidence base and thus requires scientific judgment and multidisciplinary psychophysiological expertise. Most studies comprise small samples, often lack control groups, sex differences have seldom been directly tested in this area and inter-individual variability is prevalent in this population. Moreover, this research domain is characterized by several exceptional factors that must be addressed. The target population is highly trained and not representative of the general population, demanding adapted study designs and highly sensitive and operationally relevant research tools. To avoid overburdening the already heavy operational schedules of this population, a careful and feasible balance must be established between scientific data quality and acceptable monitoring load. Furthermore, several issues of location, timing, and type of baseline measures must be explicitly considered, while long-term follow-up designs are necessary to assess both recovery and persistent post-mission effects. Major space agencies have indeed identified methodological issues as a knowledge gap in this area. In this review, we provide an overview of these methodological challenges unique to space life sciences and offer solutions where possible. We argue that space research remains feasible despite these constraints, but only when it is approached with the understanding that such fieldwork often requires fundamentally different methods than traditional laboratory science.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1663701"},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YAP activity protects against ventilator-induced lung injury.","authors":"Huan Liu, Xuepeng Yang, Feng Qi, Xuan Li, Yu Liu, Ge Liu, Xiaojie Lin","doi":"10.3389/fphys.2025.1578901","DOIUrl":"10.3389/fphys.2025.1578901","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanical ventilation (MV) activates inflammatory signaling pathways, leading to ventilator-induced lung injury (VILI), the activation of lung repair processes, persistent inflammatory stimulation and incomplete tissue repair leads to pulmonary fibrosis. The role of Yes-associated protein (YAP) in VILI and related tissue repair mechanisms remains elusive.</p><p><strong>Methods: </strong>We examined the effects of inhibiting or stimulating YAP activity on VILI, lung repair and fibrosis in a mouse model of MV-induced lung injury. Mice were subjected to either low tidal volume ventilation (LVT) or high tidal volume ventilation (HVT), and HVT was used in subsequent experiments. Additional mice were treated with or without the YAP inhibitor verteporfin (VP) and with or without the YAP stimulator XMU-MP-1 (X) and then subjected to HVT. The severity of lung injury and fibrosis was evaluated via histological analysis; the extent of lung repair was tested by measuring the levels of alveolar epithelial cell (AEC) marker proteins; YAP activity was assessed via Western blotting, immunoprecipitation and immunofluorescence.</p><p><strong>Results: </strong>MV caused lung injury and fibrosis, decreased the protein expression of AEC markers and β-catenin, increased YAP expression, and the effect of HVT was greater than that of LVT. After inhibition of YAP activity, HVT decreased β-catenin expression, further inhibiting regeneration of AECs and worsening lung injury and fibrosis. In contrast, after stimulation of YAP activity, the reduction in β-catenin was mitigated, the impairment of AEC regeneration was ameliorated, lung injury and fibrosis were alleviated.</p><p><strong>Discussion: </strong>The results indicate stimulation of YAP activity alleviates VILI by promoting lung repair and inhibiting fibrosis development.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1578901"},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of velocity-based resistance training (VBT) on lower-limb strength performance in male collegiate boxers: a randomized controlled trial.","authors":"Yemin Han, Yiqing Xie, Zhen Zhang, Amador García-Ramos","doi":"10.3389/fphys.2025.1701045","DOIUrl":"10.3389/fphys.2025.1701045","url":null,"abstract":"<p><strong>Background: </strong>Boxing performance heavily relies on lower-limb strength and power. Velocity-based resistance training (VBT), which adjusts load and repetition volume using real-time velocity feedback, may provide a more individualized and effective approach compared to traditional percentage-based training (PBT). However, its long-term effect on boxing-specific performance outcomes remains underexplored.</p><p><strong>Methods: </strong>Twenty-eight male collegiate boxers were randomly assigned to a VBT group (n = 14) or a PBT group (n = 14) for an 8-week training program. Both groups performed four sets of each exercise (back squat, Bulgarian split-squat, and deadlift) at 70% of their one-repetition maximum (1RM). The VBT group performed a flexible number of repetitions until their velocity dropped below a 10% threshold, whereas the PBT group consistently performed sets of 5 repetition. Pre- and post-intervention assessments included 1RM strength, countermovement jump (CMJ) height, standing long jump (SLJ) distance, and 30 m sprint run time.</p><p><strong>Results: </strong>All dependent variables demonstrated significant main effects of \"time\" (<i>p</i> < 0.001; averaged Hedges' g = 0.44 for VBT group and 0.23 for PBT group). Notably, significant \"time\" × \"group\" interactions were observed for the CMJ, SLJ, and 30 m sprint run (<i>p</i> ≤ 0.038), whereas no significant interactions were found for 1RM strength measures across exercises (<i>p</i> ≥ 0.163). Furthermore, when comparing the magnitude of changes between groups, the VBT group exhibited small effect size improvements in CMJ height (Hedges' g = 0.41), SLJ distance (Hedges' g = 0.56), and 30 m sprint time (Hedges' g = 0.51). In contrast, all other variables only showed trivial (Hedges' g < 0.20) differences between groups.</p><p><strong>Conclusion: </strong>Both training programs led to comparable improvements in maximal strength (1RM) across exercises. However, VBT was more effective than PBT in enhancing performance in high-velocity tasks such as vertical and horizontal jumps and sprinting. These findings support the use of VBT to optimize neuromuscular adaptations relevant to explosive actions in male collegiate boxers.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1701045"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction for gastrointestinal bleeding in pediatric Henoch-Schönlein purpura using an interpretable transformer model.","authors":"Gahao Chen, Ziwei Yang","doi":"10.3389/fphys.2025.1630807","DOIUrl":"10.3389/fphys.2025.1630807","url":null,"abstract":"<p><strong>Objective: </strong>Henoch-Schönlein purpura (HSP), clinically recognized as IgA vasculitis (IgAV), a prevalent systemic vasculitis in pediatric populations, frequently involves gastrointestinal (GI) tract manifestations that may lead to serious complications including hemorrhage and tissue necrosis. Timely identification of GI bleeding risk enables prompt clinical intervention and improves therapeutic outcomes. This study aims to develop and clinically validate an interpretable Transformer-based predictive model for assessing GI bleeding risk in pediatric patients with IgAV.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 758 pediatric IgAV cases (ages 0-14 years) admitted to the Department of Pediatrics at the Affiliated Hospital of North Sichuan Medical College between 1 May 2020, and 31 January 2024. Comprehensive clinical data including symptoms and laboratory parameters were systematically collected. GI complications were stratified into three severity tiers: 1) no complications, 2) abdominal pain without bleeding), and 3) documented rectal bleeding or hemorrhage, based on standardized diagnostic criteria. Five machine learning algorithms (Random Forest, XGBoost, LightGBM, CatBoost, and TabPFN-V2) were optimized through nested cross-validation. Model performance was evaluated using multiple metrics: accuracy, precision, recall, <i>F1</i>-score, the <i>Kappa</i> coefficient, and ROC-AUC. The optimal model was subsequently interpreted using Shapley Additive Explanations (SHAP) values to elucidate feature importance.</p><p><strong>Results: </strong>Among the evaluated models, the Transformer-based TabPFN-V2 demonstrated superior predictive performance, achieving a validation accuracy of 0.88, precision of 0.88, recall of 0.87, <i>F1</i>-score of 0.88, <i>Kappa</i> coefficient of 0.82, and AUC-ROC of 0.98. SHAP analysis revealed the five most influential biomarkers for global interpretability: D-dimer, total cholesterol, platelet count, apolipoprotein, and C-reactive protein.</p><p><strong>Conclusion: </strong>The interpretable Transformer-based TabPFN-V2 model demonstrated robust predictive performance for GI bleeding risk in pediatric IgAV patients. Clinically accessible laboratory parameters identified by this model not only offer practical guidance for clinical decision-making but also establish a foundation for advancing medical artificial intelligence integration in pediatric care.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1630807"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unbiased kinome profiling identifies key and novel mediators of chronic kidney disease in hyperlipidemic mice.","authors":"Andrea Bonnin-Marquez, Sanne L Maas, Melissa Corcini-Berndt, Emiel P C Van der Vorst","doi":"10.3389/fphys.2025.1684982","DOIUrl":"10.3389/fphys.2025.1684982","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is a progressive condition associated with increased mortality and morbidity, placing a substantial burden on healthcare systems globally. CKD often coexists with cardiovascular disease (CVD), further complicating patient outcomes. This study investigates the kinomic profile of hyperlipidemic mice to understand the signaling mechanisms underlying CKD progression and its cardiovascular consequences.</p><p><strong>Methods: </strong><i>Apoe</i> ^<i>-/-</i> mice were subjected to a Western-type diet, with or without adenine supplementation to induce CKD. Kinase activity was profiled using PamGene® assays on renal cortex samples collected at early (4 weeks) and late (12 weeks) stages of CKD.</p><p><strong>Results: </strong>It could be demonstrated that CKD led to significant increases in peptide phosphorylation related to both tyrosine and serine-threonine kinases, which were particularly pronounced in the late-stage model. Therefore, the kinase activity in the kidney increased upon CKD development in a CKD-stage-dependent manner. Notably, the activity of cyclin-dependent kinases (CDKs) was reduced at early disease stages but remained unaffected in late stages. Pathway analysis revealed stage-specific alterations in cell cycle regulation, inflammation, oxidative stress, lipid metabolism, and fibrosis pathways associated with kinase activity changes throughout disease progression.</p><p><strong>Discussion: </strong>These findings highlight critical kinases involved in CKD development and suggest their potential roles in mediating pathological processes such as inflammation and fibrosis. Targeting specific kinases may offer novel therapeutic strategies for mitigating CKD progression and its cardiovascular complications. Future research should explore the causal relationships between newly identified kinases and CKD development.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1684982"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of lower limb muscle fatigue in basketball players based on sEMG signals.","authors":"Xiao Ma, Siwei Chen, Qiwei Li","doi":"10.3389/fphys.2025.1689324","DOIUrl":"10.3389/fphys.2025.1689324","url":null,"abstract":"<p><p>Muscle fatigue is an inevitable physiological phenomenon during exercise, which not only leads to a decline in athletic performance but also increases the risk of sports injuries. Therefore, effectively identifying an athlete's muscle fatigue states is of critical importance. This study used the Transformer model to investigate the identification of lower limb muscle fatigue states in basketball players based on surface electromyography (sEMG) signals. The lower limb sEMG signals of 15 basketball players were collected during the experimental process, and the three muscles with higher contribution were selected by combining the muscle synergy analysis method, and then 8 types of feature signals were extracted and fused. The results showed that the Transformer fatigue recognition model based on fused features outperformed the single-feature model in all evaluation metrics. The classification accuracies of the three muscles were 94.28% ± 3.25%, 93.36% ± 3.87% and 94.11% ± 3.28% under the fusion-feature-based condition, respectively. In this paper, LSTM and XGBoost were selected as the comparison models, and the results showed that Transformer significantly outperforms the comparison models in all evaluation metrics, exhibiting stronger robustness and generalization ability.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1689324"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent hemato-biochemical and genotoxic responses of common carp (<i>Cyprinus carpio</i>) to flupyradifurone.","authors":"Önder Yıldırım, Ümit Acar, Rifat Tezel, Yavuz Erden, Gökçen Bilge, Sercan Yapıcı","doi":"10.3389/fphys.2025.1676992","DOIUrl":"10.3389/fphys.2025.1676992","url":null,"abstract":"<p><p>Flupyradifurone (FPF), a systemic butenolide insecticide introduced in 2014, is increasingly used as an alternative to neonicotinoids, yet its safety for non-target aquatic organisms remains poorly understood. This study evaluated the acute and sub-lethal toxicity of FPF in juvenile common carp (<i>Cyprinus carpio</i>). A 96-h static bioassay determined an LC₅₀ of 140.47 mg/L. Fish were then exposed for 14 days to sub-lethal concentrations (1, 3, 5, 25, 75 and 125 mg/L) to assess hematological, biochemical, and genotoxic responses. Hematological analysis revealed significant, dose-dependent declines in red blood cells (1.71 × 10⁶/μL in control vs. 1.12 × 10⁶/μL at 125 mg/L), hemoglobin (8.34 vs. 3.34 g/dL), and hematocrit (26.08% vs. 13.73%), accompanied by reduced mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration at higher doses, indicating anemia and impaired oxygen transport. Biochemically, glucose increased sharply (102.21 mmol/L in control to 230.29 mmol/L at 125 mg/L), while triglycerides, cholesterol, total protein, and albumin declined significantly, suggesting metabolic disruption. Hepatic enzyme activities (alkaline phosphatase, serum glutamic oxaloacetic transaminase, serum glutamate pyruvate transaminase) increased markedly, with serum glutamic oxaloacetic transaminase rising from 36.47 U/L in controls to 144.02 U/L at 125 mg/L, indicative of hepatocellular damage. Comet assay confirmed pronounced DNA damage at ≥25 mg/L, with significant elevations in tail length, tail moment, and % DNA in tail. Collectively, these results demonstrate that FPF exposure compromises hematological health, disrupts metabolic balance, and induces genotoxicity in common carp, even at sub-lethal concentrations. Incorporating both physiological and genomic endpoints is essential for comprehensive ecological risk assessments of emerging insecticides.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1676992"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Decoding vascular aging: unraveling the enigma of pathological conditions and pre-mature vascular aging.","authors":"Mitra Esfandiarei, Roshanak Rahimian","doi":"10.3389/fphys.2025.1707757","DOIUrl":"https://doi.org/10.3389/fphys.2025.1707757","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1707757"},"PeriodicalIF":3.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}