Frontiers in Physiology最新文献

{"title":"Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m.","authors":"Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C Roach, Beth A Beidleman","doi":"10.3389/fphys.2024.1477070","DOIUrl":"https://doi.org/10.3389/fphys.2024.1477070","url":null,"abstract":"<p><strong>Introduction: </strong>Acute mountain sickness (AMS) is a common altitude illness that occurs when individuals rapidly ascend to altitudes ≥2,500 m without proper acclimatization. Genetic and genomic factors can contribute to the development of AMS or predispose individuals to susceptibility. This study aimed to investigate differential gene regulation and biological pathways to diagnose AMS from high-altitude (HA; 4,300 m) blood samples and predict AMS-susceptible (AMS+) and AMS-resistant (AMS─) individuals from sea-level (SL; 50 m) blood samples.</p><p><strong>Methods: </strong>Two independent cohorts were used to ensure the robustness of the findings. Blood samples were collected from participants at SL and HA. RNA sequencing was employed to profile gene expression. Differential expression analysis and pathway enrichment were performed to uncover transcriptomic signatures associated with AMS. Biomarker panels were developed for diagnostic and predictive purposes.</p><p><strong>Results: </strong>At HA, hemoglobin-related genes (HBA1, HBA2, and HBB) and phosphodiesterase 5A (PDE5A) emerged as key differentiators between AMS+ and AMS- individuals. The cAMP response element-binding protein (CREB) pathway exhibited contrasting regulatory patterns at SL and HA, reflecting potential adaptation mechanisms to hypoxic conditions. Diagnostic and predictive biomarker panels were proposed based on the identified transcriptomic signatures, demonstrating strong potential for distinguishing AMS+ from AMS- individuals.</p><p><strong>Discussion: </strong>The findings highlight the importance of hemoglobin-related genes and the CREB pathway in AMS susceptibility and adaptation to hypoxia. The differential regulation of these pathways provides novel insights into the biological mechanisms underlying AMS. The proposed biomarker panels offer promising avenues for the early diagnosis and prediction of AMS risk, which could enhance preventive and therapeutic strategies.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1477070"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats.","authors":"Jessica M L Grittner, Rebecca Barok, Edgar Juarez Lopez, Misha Shah, Brendan J Dougherty","doi":"10.3389/fphys.2024.1511960","DOIUrl":"10.3389/fphys.2024.1511960","url":null,"abstract":"<p><p>Respiratory function is modulated by circulating steroid hormones. In female rats, steroid hormones fluctuate across the normal estrous cycle and decline with age, similar to human menopause. To determine the influence of steroid hormones, and mimic aspects of age-related reductions in hormones, the ovariectomy model is often employed. Ovariectomy (OVX) induces an immediate and persistent decrease in steroid hormones. The current study aimed to interrogate whether the OVX model of hormone reduction impacted specific aspects of respiratory function [chemosensitivity and the hypoxic ventilatory response (HVR)] in a manner consistent with natural age-related declines in hormones. Using barometric plethysmography, three experimental groups of female rats were assessed for HVR, chemosensitivity, and respiratory neural drive during progressive hypoxic challenges (FIO₂: 0.15, 0.12, and 0.09): young (3-5 mos. old; in proestrus; n = 10), young OVX (3-5 mos. old; n = 10), and aged (>20 mos. old; n = 10). Our findings indicted that sex hormone loss did not appear to impact chemosensitivity or neural drive. Natural aging, but not OVX, resulted in decreased HVR as well as reduced magnitude in ventilatory output during stepwise hypoxia. Differences in metabolism were important to the interpretation of these results. Collectively, these data support the concept that aging impacts female respiratory function in complex and unique ways that differ from OVX.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1511960"},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of 8 weeks of multi-directional movement training combined with balance training on the change of direction of young table tennis players.","authors":"Qianqian Chen, Yanfei Li, Xinchen Heng, Lei Zhao, Bin Wu","doi":"10.3389/fphys.2025.1541639","DOIUrl":"10.3389/fphys.2025.1541639","url":null,"abstract":"<p><strong>Background: </strong>Change of direction (COD) skills are crucial for athletic performance in sports such as table tennis. Improving COD can enhance overall agility and responsiveness during competition.</p><p><strong>Objective: </strong>To investigate the effects of an 8-week multi-directional movement training combined with balance training on the COD performance of young table tennis players.</p><p><strong>Methods: </strong>Thirty young table tennis players from the same team were randomly assigned to two groups: the multi-directional movement training combined with the balance training group (MB, n = 15) and the control group (CON, n = 15). The MB group underwent balance training on unstable surfaces, while the CON group performed the same balance exercises on stable ground. Both groups participated in the same multi-directional movement training program, which was conducted three times a week with 24-48 h of recovery between sessions for a duration of 8 weeks.</p><p><strong>Results: </strong>Significant group effects were observed in the modified agility test, non-dominant leg, dominant leg, and push block side lunge right test (p < 0.05). No significant group effects were found for the hexagon agility test, 3 m side slide test, A-movement test, or the whole table variable speed pendulum test (p > 0.05). Significant time-by-group interactions were noted for all variables (p < 0.05), indicating that improvements over time differed between the MB and CON groups. In the MB group, significant improvements were observed across all tests post-intervention, with high effect sizes (Partial η² values ranging from 0.361 to 0.815). In contrast, the CON group showed significant time effects in only a few tests, including the 3 m side slide test, A-movement test, modified agility test, and push block side lunge right test (p < 0.05), with no significant time effects for other variables.</p><p><strong>Conclusion: </strong>This study aimed to explore whether multi-directional movement training, when combined with balance exercises, could improve COD skills in young table tennis players. The results will inform future training strategies for enhancing agility and movement efficiency in table tennis athletes.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1541639"},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluctuation in body composition and urine specific gravity of Turkish wrestlers in a top-level official wrestling competition.","authors":"Ersel Donmez, Ozkan Isik, Mario Baic","doi":"10.3389/fphys.2024.1516149","DOIUrl":"10.3389/fphys.2024.1516149","url":null,"abstract":"<p><strong>Purpose: </strong>This research aimed to examine the fluctuations in body composition and Urine-Specific Gravity (U_SG) of elite wrestlers in a high-level official wrestling competition.</p><p><strong>Method: </strong>Thirty-one wrestlers in the Türkiye Senior Greco-Romen Wrestling national team participated in this research. Wrestlers were divided into weight loss and non-weight loss groups, and changes in their body composition and U_SG were measured at three different times (beginning of the camp, weigh-in, and before the competition). The duration between the beginning of the camp and the competition weigh-in time was considered as a dehydration process and the duration between the competition weigh-in time and before the competition was regarded as a rehydration process. In the data analysis, 3 × 2 repeated measures ANOVA was used.</p><p><strong>Results: </strong>It was determined that during the dehydration process of wrestlers who lost weight, there was a decrease of 4.02%, 2.50%, 14.62%, and 2.66% in body weight, FFM, FM, and TBW, whereas, during the rehydration process, there was a gain of 1.85%, 1.77%, 2.63%, and 1.87%, respectively. In addition, it was determined that wrestlers who lost weight had a 0.87% increase in U_SG during the dehydration process and a 0.41% decrease in the rehydration process. The results show that wrestlers cannot regain body weight and FM lost in the hydration fluctuation during a competition, but they can regain FFM, TBW, and U_SG. However, although it was determined that the wrestlers were statistically able to regain FFM, TBW, and U_SG, they could not return to the levels at the beginning of the camp.</p><p><strong>Conclusion: </strong>It was determined that before a high-level official wrestling competition, wrestlers still preferred weight loss practices and it was determined that they were exposed to fluctuations in their body composition and U_SG. It is thought that this result may negatively affect the wrestlers' health and competition performance during a high-level competition.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1516149"},"PeriodicalIF":3.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia.","authors":"Yuetong Wu, Li Zhang, Jing Li, Boyang Xue, Wenyuan Shang, Yingli Lu","doi":"10.3389/fphys.2025.1510949","DOIUrl":"10.3389/fphys.2025.1510949","url":null,"abstract":"<p><strong>Background/objectives: </strong>To evaluate the impact of maximal fat oxidation intensity exercise combined with calorie restriction intervention on lipid-related parameters in a hypercholesterolemic population, and to determine if an optimal range of calorie restriction exists for effectively enhancing blood lipid profiles.</p><p><strong>Methods: </strong>A 4-week intervention study combined exercise and calorie restriction for 64 patients aged 18-60 with secondary hypercholesterolemia. Ultimately, 43 participants completed the study. The dietary intervention adhered to the principles of a balanced diet, with meal plans designed to provide three meals per day for the duration of the study. Each subject's daily calorie intake was set to match their individual resting energy expenditure (REE) plus varying proportions of physical activity (PA) calories. Participants were divided into four groups based on these proportions: REE only, REE + PA33%, REE + PA67%, and REE + PA100%. FATmax exercises were conducted 5 times per week, lasting 1 h each.</p><p><strong>Results: </strong>1) Compared with baseline, subjects' body weight, fat mass and body fat rate decreased significantly; fat-free mass also decreased significantly in the REE, REE + PA33%, and REE + PA67% groups. 2) Subjects' serum TC decreased significantly; serum LDL-C and ApoB decreased significantly in the REE, REE + PA33%, and REE + PA67% groups; there were no significant changes in serum HDL-C and ApoA1. 3) Serum PCSK9 was significantly decreased in the REE and the REE + PA 67% groups; serum LDLR was significantly decreased in all groups of subjects. 4) Between the groups, the rate of change in serum LDL-C was significantly different.</p><p><strong>Conclusion: </strong>FATmax exercise combined with proper proportions of calorie restriction can significantly decrease serum cholesterol levels and fat mass in hypercholesterolemic patients. Nevertheless, it is misleading to assume that a drastic reduction in calorie intake invariably results in superior outcomes. Optimal cost-effectiveness may be achieved within a calorie restriction range of REE + PA33-67%.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1510949"},"PeriodicalIF":3.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How effective is the addition of specific exercise therapy for patients after anterior cruciate ligament surgery? A systematic review and meta-analysis.","authors":"Hao Zhou, Jia Qian, Yu-Mei Xing, Long Cui, Yi-Feng Bu","doi":"10.3389/fphys.2025.1501458","DOIUrl":"10.3389/fphys.2025.1501458","url":null,"abstract":"<p><strong>Context: </strong>Anterior cruciate ligament (ACL) injuries are prevalent in sports and often require surgical intervention followed by rehabilitation. Several rehabilitation methods have been used for patients after ACL surgery.</p><p><strong>Objective: </strong>This study aimed to assess the overall efficacy of exercise therapy in improving outcomes for patients following ACL surgery using a systematic review and meta-analysis of randomized controlled trials (RCTs).</p><p><strong>Data sources: </strong>PubMed, Web of Science, Embase, and the Cochrane Library were searched for randomized controlled trials published from 1 January 2000 to 30 August 2024. Study quality was assessed using the Cochrane Risk-of-Bias tool.</p><p><strong>Study selection: </strong>A total of 11 randomized controlled trials (whole-body vibration training = 4, core-stability training = 2, strength training = 3, blood flow restriction training = 1, and aquatic training = 1) involving 552 anterior cruciate ligament surgery patients were included.</p><p><strong>Data extraction: </strong>Two researchers individually screened the key information for each eligible study and evaluated the quality of the studies. Any dispute was discussed by a third researcher.</p><p><strong>Results: </strong>Compared with conventional therapy, exercise therapy significantly reduced pain scores (mean difference: -0.53, 95% CI: -0.82 to -0.24, and <i>p</i> < 0.001) and improved muscle strength (flexion: 13.76 and extension: 12.46) and knee function (effect size: 2.06 and <i>p</i> = 0.001). Secondary outcomes, although less pronounced, also demonstrated improvement.</p><p><strong>Limitation: </strong>The sources of heterogeneity among the included studies were not fully identified, particularly concerning variations in exercise protocols or patient characteristics. Additionally, the therapeutic effects of specific exercise modalities (e.g., strength training versus aquatic training) were not directly compared.</p><p><strong>Conclusion: </strong>Exercise therapy is effective in reducing pain, enhancing muscle strength, and improving knee function in ACL surgery patients. These findings underscore the importance of integrating tailored exercise therapies into rehabilitation programs.</p><p><strong>Systematic review registration number: </strong>https://www.crd.york.ac.uk/PROSPERO/, identifier registration number. CRD42023476653.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1501458"},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy.","authors":"Wen-Ying Yu, Jing Liu, Ze-Hao Lin, Hong Liu, Liang-Zhi Zhang, Xiang-Long Feng, Zhong-Biao Xiu","doi":"10.3389/fphys.2024.1496425","DOIUrl":"10.3389/fphys.2024.1496425","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic injury to the rectus femoris muscle induces and exacerbates the progression of knee osteoarthritis (KOA). However, the lesion characteristics of the rectus femoris muscle in KOA at different stages have not been fully characterized. The aim of this study was to analyze the pattern of lesion characteristics of the rectus femoris muscle at different stages of KOA and to investigate the mechanism by which ultrasound-guided acupotomy operations can prevent and control KOA.</p><p><strong>Methods: </strong>Early, middle, and late-stage rabbit KOA models were constructed using the modified Videman method. Ultrasonography was used to record the elastic modulus and cross-sectional area of the rectus femoris muscle, and morphology was used to observe the ultramicroscopic changes in the rectus femoris muscle and assess the degree of fibrosis. Additionally, ultrasound-guided acupotomy operations were performed on the rabbit model of late-stage KOA, and alterations in the key molecular markers of rectus femoris fibrosis were determined using Western Blot and qPCR methods.</p><p><strong>Results: </strong>As the disease progressed, the elastic modulus of the rectus femoris muscle in KOA rabbits gradually increased, the cross-sectional area gradually decreased, and the degree of fibrosis increased. In contrast, the degree of fibrosis in the rectus femoris muscle improved after ultrasound-guided acupotomy intervention.</p><p><strong>Conclusion: </strong>These findings highlight the gradual increase in the modulus of elasticity, the gradual decrease in cross-sectional area, and the increased fibrosis of the rectus femoris muscle in KOA rabbits as the disease progressed. Ultrasoundguided acupotomy operations have been shown to have a protective effect on KOA cartilage and to delay the progression of KOA by ameliorating pathological changes in the rectus femoris muscle. The mechanism may involve reducing chronic injury to the rectus femoris muscle and protecting joint homeostasis by attenuating the degree of rectus femoris fibrosis.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1496425"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of previous injury on subsequent training loads, physical fitness, and injuries in youth female basketball players.","authors":"Yuanqi Huang, Shaonan Wang, Changfei Li, Yukun Wang, Zhanshuang Bai, Binghao Lv, Yuheng Gui, Zhongjian Wei","doi":"10.3389/fphys.2025.1506611","DOIUrl":"10.3389/fphys.2025.1506611","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that athletes accustomed to higher chronic workloads are less susceptible to injury than those exposed to lower chronic workloads. However, few studies have evaluated whether previous injury influences them. Therefore, this study investigated the impact of previous injuries on subsequent training loads, physical fitness, and injury rates in female youth basketball players.</p><p><strong>Methods: </strong>Training load, physical fitness, and injuries of 18 young female basketball players (age 16.8 ± 1.4 years) were monitored. Previous injury status was clustered using the K-means clustering algorithm to separate players into high-risk and low-risk groups. Linear mixed models were used to analyze the effects of previous injury status on subsequent training load and physical fitness. Meanwhile, the differences between the players' injury groups were analyzed.</p><p><strong>Results: </strong>Previous injury status can significantly impact a player's subsequent training loads, including acute loads, chronic loads, skill-based training loads, training monotony, and training strain (all <i>p</i> < 0.05). The two groups had no significant differences in physical fitness (all <i>p</i> > 0.05). Furthermore, the incidence of non-contact injuries was significantly higher in the high-risk group than low-risk group, which would result in more training time lost (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study identified the impact of previous injury status on subsequent training load, physical fitness, and injuries in youth female basketball players. These findings provide valuable insight for coaches to optimize training loads according to previous injury status, aiming to minimize the likelihood of subsequent injuries.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1506611"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of nitric oxide production: mechanisms, strategies, and possibilities.","authors":"Marcos Gonzalez, Sarah Clayton, Eric Wauson, Daniel Christian, Quang-Kim Tran","doi":"10.3389/fphys.2025.1545044","DOIUrl":"10.3389/fphys.2025.1545044","url":null,"abstract":"<p><p>The discovery of nitric oxide (NO) and the role of endothelial cells (ECs) in its production has revolutionized medicine. NO can be produced by isoforms of NO synthases (NOS), including the neuronal (nNOS), inducible (iNOS), and endothelial isoforms (eNOS), and via the non-classical nitrate-nitrite-NO pathway. In particular, endothelium-derived NO, produced by eNOS, is essential for cardiovascular health. Endothelium-derived NO activates soluble guanylate cyclase (sGC) in vascular smooth muscle cells (VSMCs), elevating cyclic GMP (cGMP), causing vasodilation. Over the past four decades, the importance of this pathway in cardiovascular health has fueled the search for strategies to enhance NO bioavailability and/or preserve the outcomes of NO's actions. Currently approved approaches operate in three directions: 1) providing exogenous NO, 2) promoting sGC activity, and 3) preventing degradation of cGMP by inhibiting phosphodiesterase 5 activity. Despite clear benefits, these approaches face challenges such as the development of nitrate tolerance and endothelial dysfunction. This highlights the need for sustainable options that promote endogenous NO production. This review will focus on strategies to promote endogenous NO production. A detailed review of the mechanisms regulating eNOS activity will be first provided, followed by a review of strategies to promote endogenous NO production based on the levels of available preclinical and clinical evidence, and perspectives on future possibilities.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1545044"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison and verification of detection accuracy for late deceleration with and without uterine contractions signals using convolutional neural networks.","authors":"Ikumi Sato, Yuta Hirono, Eiri Shima, Hiroto Yamamoto, Kousuke Yoshihara, Chiharu Kai, Akifumi Yoshida, Fumikage Uchida, Naoki Kodama, Satoshi Kasai","doi":"10.3389/fphys.2025.1525266","DOIUrl":"10.3389/fphys.2025.1525266","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiotocography (CTG) is used to monitor and evaluate fetal health by recording the fetal heart rate (FHR) and uterine contractions (UC) over time. Among these, the detection of late deceleration (LD), the early marker of fetal mild hypoxemia, is important, and the temporal relationship between FHR and UC is an essential factor in deciphering it. However, there is a problem with UC signals generally tending to have poor signal quality due to defects in installation or obesity in pregnant women. Since obstetricians evaluate potential LD signals only from the FHR signal when the UC signal quality is poor, we hypothesized that LD could be detected by capturing the morphological features of the FHR signal using Artificial Intelligence (AI). Therefore, this study compares models using FHR only (FHR-only model) and FHR with UC (FHR + UC model) constructed using a Convolutional Neural Network (CNN) to examine whether LD could be detected using only the FHR signal.</p><p><strong>Methods: </strong>The data used to construct the CNN model were obtained from the publicly available CTU-UHB database. We used 86 cases with LDs and 440 cases without LDs from the database, confirmed by expert obstetricians.</p><p><strong>Results: </strong>The results showed high accuracy with an area under the curve (AUC) of 0.896 for the FHR-only model and 0.928 for the FHR + UC model. Furthermore, in a validation using 23 cases in which obstetricians judged that the UC signals were poor and the FHR signal had an LD-like morphology, the FHR-only model achieved an AUC of 0.867.</p><p><strong>Conclusion: </strong>This indicates that using only the FHR signal as input to the CNN could detect LDs and potential LDs with high accuracy. These results are expected to improve fetal outcomes by promptly alerting obstetric healthcare providers to signs of nonreassuring fetal status, even when the UC signal quality is poor, and encouraging them to monitor closely and prepare for emergency delivery.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1525266"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}