Frontiers in Physiology最新文献

{"title":"Embryonic thermal conditioning and post-hatch heat challenge alter hypothalamic expression of genes related to appetite, thermoregulation, and stress modulation in broiler chicks.","authors":"Reagan Vaughan, Usman Sulaiman, Annalise Flynn, Fernando Biase, Noam Meiri, Dongmin Liu, Paul Siegel, Mark Cline, Elizabeth Gilbert","doi":"10.3389/fphys.2025.1583958","DOIUrl":"https://doi.org/10.3389/fphys.2025.1583958","url":null,"abstract":"<p><p>The objective of this study was to determine the effects of an acute heat challenge on day 4 post-hatch on the transcriptome of several brain nuclei associated with thermal regulation, stress, and appetite. These included the paraventricular nucleus (PVN) of the hypothalamus, the pre-optic anterior/hypothalamic area (POAH), and the nucleus of the hippocampal commissure (nCPa), in broilers that were subjected to either control incubation conditions or embryonic heat conditioning (EHC). Nuclei were collected at three timepoints relative to the start of heat challenge (0, 2, and 12 h). Total RNA was isolated, and RNA-sequencing was performed. Transcript abundance was quantified, differentially expressed genes (DEGs) were identified, and Gene Ontology analyses were performed. In the nCPa, 469 DEGs were identified across the three timepoints. There were 0 DEGs at hour 0, 2 at hour 2, and 467 at hour 12. Gene Ontology analysis of nCPa samples at hour 12 revealed enrichment in five biological processes, namely, mitochondrial electron transport, mitochondrial respiratory chain complex 1 assembly, synaptic vesicle lumen acidification, protein export from the nucleus, and aerobic respiration. Most of these genes were downregulated, suggesting reduced activity in these processes in EHC chicks. In the POAH, a total of 18 DEGs were identified, with 0, 18, and 0 at hour 0, 2, and 12, respectively. Fewer differences were observed in the PVN, with only four DEGs identified. All four were upregulated in the EHC group, with two involved in hypothalamic thermal responses: vasoactive intestinal peptide transporter 1 (VIPR1) and caprin family member 2 (CAPRIN2). In the nCPa, no differences were detected between hour 2 and hour 0; however, the comparison between hour 12 and hour 2 yielded 9 DEGs. All except one were downregulated at hour 12. The hour 12 vs. hour 0 comparison revealed 49 DEGs, of which 24 were downregulated at hour 12. The results revealed pathways associated with energy metabolism were altered in response to EHC, with most differences in the nCPa. Surprisingly, the fewest differences were observed in the PVN. The findings highlight potential target regions, such as the nCPa, and metabolic pathways that may help better understand how EHC affects stress responses and energy homeostasis later in life.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1583958"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of individual components of the Life's Essential 8 on the relationship between atherogenic index of plasma and adverse cardiovascular events: a population-based cohort study in China.","authors":"Fei Wu, Jiantong Yang, Yipei Zhang, Lisha Peng","doi":"10.3389/fphys.2025.1538938","DOIUrl":"https://doi.org/10.3389/fphys.2025.1538938","url":null,"abstract":"<p><strong>Background: </strong>The American Heart Association (AHA) recently emphasized the significance of the \"Life's Essential 8\" in promoting cardiovascular health. The Atherogenic Index of Plasma (AIP) is increasingly recognized as a valuable alternative biomarker for cardiovascular diseases (CVD) and insulin resistance-related metabolic diseases. However, the impact of the individual components of the \"Life's Essential 8\" on the association between AIP and CVD has not been adequately investigated.</p><p><strong>Methods: </strong>We conducted an analysis of data from 8,246 participants enrolled in the China Health and Retirement Longitudinal Study. Lifestyle behaviors and health factors were classified into binary or tertiary categories according to risk levels. We employed multivariate logistic regression and smooth curve fitting techniques to investigate the association between AIP and CVD across varying groups of health behaviors and factors. Additionally, Receiver Operating Characteristic (ROC) curve analysis was utilized to assess the predictive value of combining healthy behaviors, factors, and AIP in forecasting the incidence of CVD.</p><p><strong>Results: </strong>Upon adjusting for established cardiovascular risk factors, elevated AIP levels correlated with a heightened CVD risk (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.29-1.43). Significant interactions between AIP and CVD risk were observed across subgroups differentiated by blood glucose levels, low-density lipoprotein cholesterol (LDL-C), and sleep duration (P for interaction <0.05). Notably, individuals with blood glucose levels ≥6.1 mmol/L (OR, 1.44; 95% CI, 1.33-1.56) or LDL-C ≥3.12 mmol/L (OR, 1.50; 95% CI, 1.37-1.65) exhibited a more pronounced association between AIP and CVD. Furthermore, the inclusion of AIP in the model alongside traditional risk factors notably enhanced the predictive accuracy for CVD events, as evidenced by an increase in the area under the curve (AUC) from 0.651 to 0.671.</p><p><strong>Conclusion: </strong>Health behaviors (sleep duration), and health factors, including glucose and LDL-cholesterol levels, may modulate the posstive relationship between the AIP and CVD events in middle-aged and elderly individuals. AIP may offer enhanced predictive value for CVD in patients suffering from diabetes or dyslipidemia.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1538938"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HRV and blood parameters for assessing the physiological functioning of cyclists during long-distance rides across different altitudes.","authors":"Weiping Du, Ming Zhang, Xiaodan Niu, Hao Li, Yimin Wan","doi":"10.3389/fphys.2025.1559417","DOIUrl":"https://doi.org/10.3389/fphys.2025.1559417","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to systematically investigate the changes and interrelationships between heart rate variability (HRV) and hematological parameters in cyclists during prolonged exposure to varying altitudes, in order to reveal the dynamic interplay between autonomic nervous system regulation and hematological adaptation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Seventeen cycling enthusiasts aged 16-25 years participated in an 8-day altitude cycling challenge. HRV and hematological parameters were measured at three altitudes: 485 m, 1,627 m, and 4,182 m.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Hematological parameters, including white blood cell count (WBC), hemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), and plateletcrit (PCT), significantly increased at both 1,627 m and 4,182 m (P &lt; 0.05). Physiological measures such as heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) showed significant elevations at 4,182 m (P &lt; 0.05), while vital capacity (VC) significantly decreased (P &lt; 0.05). HRV time-domain indices, including the standard deviation of R-R intervals (SDNN) and the root mean square of successive R-R interval differences (RMSSD), significantly increased at 1,627 m (P &lt; 0.05) but decreased at 4,182 m (P &lt; 0.05). Frequency-domain indices, including very low-frequency power (VLF), low-frequency power (LF), and high-frequency power (HF), significantly decreased at 4,182 m (P &lt; 0.01). Among nonlinear HRV metrics, the short-term standard deviation of the Poincaré plot (SD1) and long-term standard deviation (SD2) significantly decreased at 4,182 m (P &lt; 0.01), while approximate entropy (ApEn), sample entropy (SampEn), and alpha2 significantly increased (P &lt; 0.05). Correlation analysis revealed that at 485 m, SDNN was negatively correlated with HCT (r = -0.55, P &lt; 0.05) and PLT (r = -0.50, P &lt; 0.05), while LF and HF were negatively correlated with HCT (r = -0.55 and -0.54, P &lt; 0.05). At 1,627 m, SDNN was positively correlated with MCV (r = 0.53, P &lt; 0.05), LF with MCV (r = 0.23, P &lt; 0.05), and LF/HF was negatively correlated with MCHC (r = -0.52, P &lt; 0.05). At 4,182 m, SDNN was positively correlated with MCHC (r = 0.51, P &lt; 0.05), VLF was negatively correlated with WBC (r = -0.63, P &lt; 0.05), ApEn was positively correlated with both WBC (r = 0.76, P &lt; 0.05) and HCT (r = 0.62, P &lt; 0.05), and SampEn was positively correlated with WBC (r = 0.74, P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study systematically evaluated the dynamic changes in HRV and hematological parameters in cyclists during prolonged exposure to different altitudes. The results showed that at moderate altitude, athletes exhibited a coordinated response of enhanced short-term autonomic adaptation and increased red blood cell volume. At very high altitude, HRV decreased overall while its complexity increased, indicating a stress-compensatory mechanism dominated ","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1559417"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: State-of-the-art muscle physiology research: from single molecules and cells to living organisms.","authors":"Norio Fukuda, Madoka Suzuki, Kotaro Oyama, Norika Liu","doi":"10.3389/fphys.2025.1636988","DOIUrl":"https://doi.org/10.3389/fphys.2025.1636988","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1636988"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on cardiopulmonary function, body composition, and physical function in cancer survivors: a meta-analysis of randomized controlled trials.","authors":"Chenggen Peng, Ming Hu, Linlin Yang, Zhichao Yuan","doi":"10.3389/fphys.2025.1594574","DOIUrl":"10.3389/fphys.2025.1594574","url":null,"abstract":"<p><strong>Background: </strong>Advances in cancer treatment have led to a significant increase in the global number of cancer survivors. However, long-term health management challenges-such as reduced cardiopulmonary function, cancer-related fatigue, and metabolic dysregulation-remain formidable. The purpose of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) to comprehensively compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on Cardiopulmonary function, body composition, and physical function in cancer survivors. Thereby providing evidence-based guidance for individualized exercise prescriptions.</p><p><strong>Methods: </strong>By the PRISMA guidelines, we systematically searched databases including PubMed, Web of Science, Scopus, Embase, the Cochrane Library, and EBSCOhost up to February 2025. A total of 12 eligible RCTs were included, breast cancer (n = 7), colorectal cancer (n = 3), and mixed cancer types (n = 2). Meta-analysis was performed using Cochrane Collaboration's Review Manager 5.4, while sensitivity analyses were conducted with Stata MP 14.0 to assess the stability and reliability of the results. Egger's test was utilized to evaluate the presence of publication bias.</p><p><strong>Results: </strong>The meta-analysis revealed that, compared with MICT, HIIT was significantly more effective in improving VO₂ peak (Peak Oxygen Uptake) in cancer survivors [SMD = 0.53, 95% CI (0.21, 0.84), Z = 3.30, P = 0.001]. However, no statistically significant differences were found between HIIT and MICT in terms of body composition (including Body Mass, Total Fat Mass, Lean Body Mass, Fat Percentage, Body Mass Index, Waist Circumference, and Hip Circumference) or physical function (including Sit-to-Stand Test and 6-Minute Walk Test).</p><p><strong>Conclusion: </strong>HIIT appears superior to MICT in enhancing VO₂ peak and, consequently, cardiopulmonary function in cancer survivors. Nonetheless, both training modalities yield comparable outcomes in body composition and physical function. Given the variability in the quantity and quality of the included studies, further well-designed and objective RCTs are warranted to validate these findings.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier CRD420250654968.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1594574"},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation.","authors":"Mostafa Abdollahpur, Chiara Celotto, Carlos Sánchez, Felix Plappert, Sten Östenson, Pyotr G Platonov, Pablo Laguna, Esther Pueyo, Frida Sandberg","doi":"10.3389/fphys.2025.1498426","DOIUrl":"10.3389/fphys.2025.1498426","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study explores transient and stationary effects of sympathetic and parasympathetic stimulation on f-wave characteristics in atrial fibrillation (AF) patients undergoing a tilt test. Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 minutes post-change until phase end) representing a stable autonomic state.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Our primary aim is to investigate how the two branches of the autonomic nervous system (ANS) influence the f-wave frequency time series ( &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt; &lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;/math&gt; ). An analysis of &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt; &lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;/math&gt; in terms of the mean over time ( &lt;math&gt; &lt;mrow&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;/math&gt; ) and the magnitude of respiration-modulated &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt; &lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;/math&gt; variations ( &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;/math&gt; ) is conducted during baseline supine rest (B), head-down tilt (HDT) and head-up tilt (HUT). We analyzed data from a previous study in which 24 patients with persistent AF underwent a tilt test protocol, during which electrocardiograms (ECGs) were recorded. A model-based method was used to extract &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt; &lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;/math&gt; series from the ECG. Subsequently, an orthogonal subspace projection method was employed to quantify &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;/math&gt; , considering an ECG-derived respiratory signal. Electrophysiological computational simulations were conducted on 2D and 3D human atrial persistent AF models to aid the interpretation of clinical findings. Various levels of cholinergic stimulation by acetylcholine and &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;/mrow&gt; &lt;/math&gt; -adrenergic stimulation by isoproterenol were tested in the models. The temporal modulation of acetylcholine, representing changes associated with respiration, was cyclically modeled using sinusoidal waveforms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Analysis of the clinical data showed a decrease in &lt;math&gt; &lt;mrow&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;/math&gt; from B to HDT and an increase from HDT to HUT. During HDT, &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;/math&gt; initially increased in the transient phase before decreasing in the steady phase, then rose again during HUT. Analysis of the simulated data showed that increasing the concentration of Isoproterenol and/or acetylcholine resulted in a rise in &lt;math&gt; &lt;mrow&gt; &lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;F&lt;/mi&gt;&lt;/mrow&gt; &lt;","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1498426"},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Investigating ethylene oxide exposure and its associations with kidney indicators and lipid profiles: the mediating effect of HDL in NHANES 2013-2020.","authors":"Yiheng Luo, Duo Xu, Weiyong Zhang, Kai Wang, Mingqin Kuang, Yueyang Liu","doi":"10.3389/fphys.2025.1633971","DOIUrl":"https://doi.org/10.3389/fphys.2025.1633971","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2025.1523940.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1633971"},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combining cold exposure and compression on muscle recovery: a randomized crossover study.","authors":"G Millour, R Lepers, A Coste, C Hausswirth","doi":"10.3389/fphys.2025.1598075","DOIUrl":"10.3389/fphys.2025.1598075","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to evaluate the effects of combining lower-limb cold exposure and intermittent compression on optimizing post-exercise recovery.</p><p><strong>Methods: </strong>Fifteen male recreational athletes were recruited for a randomized crossover study comparing two recovery strategies: cryocompression and passive recovery, both applied in a supine position for 30 min. These interventions followed a high-intensity plyometric exercise and were repeated over the subsequent 2 days. Performance metrics included counter movement jumps and squat jumps, 30-s Wingate cycling test, maximal voluntary contraction (MVC) force of knee extensors, prolonged low-frequency force depression (PLFFD), inflammatory markers, and subjective assessments of muscle soreness and heaviness. Measurements were taken at four time points: pre-exercise, immediately post-recovery, 24 h post, and 48 h post.</p><p><strong>Results: </strong>Cryocompression significantly accelerated muscle recovery by reducing PLFFD and inflammation markers (salivary interleukin-1 beta and thigh circumference), while enhancing performance during MVC. Furthermore, perceived lower-limb heaviness, muscle soreness, and body pain decreased more rapidly with cryocompression at 24- and 48-h post-recovery. However, no significant differences were observed between the recovery strategies in cycling or jumping performance.</p><p><strong>Discussion: </strong>These findings underscore cryocompression as a promising recovery strategy for athletes seeking to mitigate exercise-induced muscle damage and restore performance. Further research is warranted to investigate the applicability of these results across diverse athletic populations.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1598075"},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: USP22 protects against myocardial ischemia-reperfusion injury via the SIRT1-p53/SLC7A11-dependent inhibition of ferroptosis-induced cardiomyocyte death.","authors":"Frontiers Editorial Office","doi":"10.3389/fphys.2025.1641580","DOIUrl":"https://doi.org/10.3389/fphys.2025.1641580","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fphys.2020.551318.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1641580"},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weakly supervised multiple-instance active learning for tooth-marked tongue recognition.","authors":"Feilin Deng, Shangxuan Li, Zizhu Yang, Wu Zhou","doi":"10.3389/fphys.2025.1598850","DOIUrl":"10.3389/fphys.2025.1598850","url":null,"abstract":"<p><strong>Introduction: </strong>Recognizing a tooth-marked tongue has important clinical diagnostic value in traditional Chinese medicine. Current deep learning methods for tooth mark detection require extensive manual labeling and tongue segmentation, which is labor-intensive. Therefore, we propose a weakly supervised multipleinstance active learning model for tooth-marked tongue recognition, aiming to eliminate preprocessing segmentation and reduce the annotation workload while maintaining diagnostic accuracy.</p><p><strong>Method: </strong>We propose a one-stage method tongenerate tooth mark instances that eliminates the need for pre-segmentation of the tongue. To make full use of unlabeled data, we introduce a semisupervised learning paradigm to pseudo-label unlabeled tongue images with high model confidence in active learning and incorporate them into the training set to improve the training efficiency of the active learning model. In addition, we propose an instance-level hybrid query method considering the diversity of tooth marks.</p><p><strong>Result: </strong>Experimental results on clinical tongue images verify the effectiveness of the proposed method, which achieves an accuracy of 93.88% for tooth-marked tongue recognition, outperforming the recently introduced weakly supervised approaches.</p><p><strong>Conclusion: </strong>The proposed method is effective with only a small amount of image-level annotation, and its performance is comparable to that of image-level annotation, instance-level annotation and pixel-level annotation, which require a large number of tooth markers. Our method significantly reduces the annotation cost of the binary classification task of traditional Chinese medicine tooth mark recognition.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1598850"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}