Frontiers in Physiology最新文献

{"title":"Retraction: Effects of mandibular extension on pial arteriolar diameter changes in glucocorticoid-induced hypertensive rats.","authors":"","doi":"10.3389/fphys.2026.2026350","DOIUrl":"https://doi.org/10.3389/fphys.2026.2026350","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fphys.2019.00003.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"2026350"},"PeriodicalIF":4.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of brain endurance training on cognitive function, physical performance and perceived exertion in healthy adults: a systematic review and three-level meta-analysis.","authors":"Xin Zheng, Yu'an Sun, Ziren Zhao, Chao Wang, Zhangyuting Shang, Yixun Xie, Kai Xu, Kaixiang Zhou, Olivier Girard","doi":"10.3389/fphys.2026.1923855","DOIUrl":"10.3389/fphys.2026.1923855","url":null,"abstract":"<p><strong>Background: </strong>Mental fatigue impairs cognitive function and physical performance in healthy adults. Brain endurance training (BET) has emerged as a strategy to enhance resistance to mental fatigue and improve both cognitive and physical outcomes; however, its effects have not been comprehensively synthesized.</p><p><strong>Objective: </strong>To systematically assess the effects of BET on cognitive function, physical performance, and perceived exertion in healthy adults.</p><p><strong>Methods: </strong>Searches were conducted in PubMed, Web of Science, Embase, Cochrane Library, and SPORTDiscus on September 9, 2025. Data (mean ± standard deviation and sample size) were extracted, and pooled effects were calculated as Hedges'g using random-effects meta-analysis models. Subgroup and meta-regression analyses were performed to explore potential moderators.</p><p><strong>Results: </strong>Eleven studies (13 trials; n=441 participants) were included. BET significantly improved cognitive function (g = 0.64, 95% CI [0.24, 1.04], P = 0.006) and physical performance (g = 0.48, 95% CI [0.33, 0.62], p<0.001), whereas no statistically significant effect was observed for perceived exertion (g = -0.01, 95% CI [-0.25, 0.23]). Effects on cognitive function and physical performance appeared larger under mental-fatigue than non-fatigued testing conditions. Evidence for other potential moderators was inconclusive, and intervention duration was not significantly associated with any outcome. The certainty of evidence was low for cognitive function and physical performance and moderate for perceived exertion.</p><p><strong>Conclusion: </strong>BET was associated with improvements in cognitive function and physical performance in healthy adults, with effects appearing larger under mental-fatigue testing conditions. BET had no statistically significant effect on perceived exertion. Given the limited number of studies and low certainty of evidence for the primary performance outcomes, these findings should be interpreted cautiously.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1923855"},"PeriodicalIF":4.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterologous contralateral repeated bout effect: eccentric knee extensor conditioning enhances neuromuscular fatigue resistance and attenuates muscle stiffness in contralateral elbow flexors in young women.","authors":"Chung-Chan Hsieh, Szu-Kai Fu, Yu-Lin Ning, Chin-Fang Wang, Che-Ming Liu, Chia-Hsien Yu","doi":"10.3389/fphys.2026.1823848","DOIUrl":"https://doi.org/10.3389/fphys.2026.1823848","url":null,"abstract":"<p><strong>Background: </strong>The repeated bout effect (RBE) protects skeletal muscles from exercise-induced muscle damage (EIMD). While homologous contralateral RBE is well-documented, the existence of heterologous RBE-specifically whether lower limb conditioning can protect upper limb muscles-remains debated.</p><p><strong>Purpose: </strong>This study investigated whether high-intensity eccentric exercise of the knee extensors attenuates eccentric exercise-induced neuromuscular fatigue and muscle stiffness and preserves neuromuscular control in the contralateral elbow flexors.</p><p><strong>Methods: </strong>Twenty-four sedentary young women were randomized into a Knee Extensor-Contralateral Elbow Flexor (KE-CEF) group and a Control Elbow Flexor (CEF) group. The KE-CEF group performed 60 maximal eccentric contractions (MaxEc) of the non-dominant knee extensors, followed 14 days later by 30 MaxEc of the dominant elbow flexors. The CEF group performed only the elbow flexor MaxEc. Outcome measures, including maximal voluntary isometric contraction (MVC), Acoustic Radiation Force Impulse (ARFI) imaging, and the Joint Release Angle (JRA) test, were assessed up to 120 h post-exercise.</p><p><strong>Results: </strong>The KE-CEF group demonstrated significantly less MVC loss immediately post-exercise compared to the CEF group (70.00 ± 19.85% vs. 57.67 ± 8.28%; <i>p</i> = 0.029). Furthermore, prior lower limb conditioning significantly attenuated peak muscle stiffness at 48 h (ARFI: 108.25 ± 4.73% vs. 125.63 ± 6.99% in CEF) and entirely preserved JRA proprioceptive stability during peak fatigue (26.58 ± 0.78° vs. 24.75 ± 1.55°; between-group <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>These findings provide novel evidence that a single bout of lower limb eccentric exercise confers a robust heterologous protective effect on upper limb muscles, highlighting the role of global systemic and neural adaptations in cross-limb rehabilitation strategies.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1823848"},"PeriodicalIF":4.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal and neonatal outcomes of pregnancies complicated by maternal sleep-disordered breathing: a systematic review.","authors":"Mayu Niisaka, Jun Hosomichi, Sakina Mitsuishi, Shiho Kino, Takashi Ono","doi":"10.3389/fphys.2026.1775697","DOIUrl":"https://doi.org/10.3389/fphys.2026.1775697","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal obstructive sleep apnea (OSA) and the broader spectrum of sleep-disordered breathing (SDB) during pregnancy may be associated with fetal and neonatal outcomes, but the literature is heterogeneous and uses clinically distinct exposure definitions. This systematic review aimed to evaluate associations between maternal SDB and fetal/neonatal outcomes while preserving differences in exposure ascertainment.</p><p><strong>Methods: </strong>Following PRISMA 2020, the review was re-audited using updated PubMed and Web of Science searches, backward and forward citation searching, and ClinicalTrials.gov and WHO ICTRP registry searches. Exposures were classified as (1) objectively confirmed OSA/SDB, (2) administrative-code-defined OSA, and (3) symptom-, snoring-, or questionnaire-defined SDB risk. No meta-analysis was conducted because clinically comparable subsets were insufficient for quantitative pooling.</p><p><strong>Results: </strong>The completed re-audit identified 64 eligible publications mapped to 53 conservative cohort/dataset families (55 if two probable overlap pairs are treated as separate): 22 objective/physiologic, 11 administrative/clinical, and 31 symptom/questionnaire publications. Objective studies showed mixed findings, with fetal-growth or neonatal signals in selected cohorts but null findings in several other objectively assessed populations. Administrative-code OSA was repeatedly associated with preterm birth and selected neonatal outcomes, although exposure misclassification and residual confounding remain important. Symptom/questionnaire studies were heterogeneous, with associations varying by symptom definition, timing, and outcome.</p><p><strong>Conclusion: </strong>Current evidence does not establish a consistent fetal or neonatal risk pattern for objectively confirmed maternal OSA/SDB. Administrative-code and symptom/questionnaire evidence suggests associations for selected outcomes, particularly preterm birth, but should not be interpreted as a single homogeneous OSA effect.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251110706.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1775697"},"PeriodicalIF":4.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of artificial intelligence in traditional Chinese medicine tongue diagnosis: a bibliometric review of research trends and hotspots, 2015-2026.","authors":"Yilin Li, Yang Yang, Shaoqin Lin, Hengxu Wang, Liyuan Yan, Mingxiang Zheng, Lei Xiang, Xiangjiang Tang","doi":"10.3389/fphys.2026.1895902","DOIUrl":"https://doi.org/10.3389/fphys.2026.1895902","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to characterize the development landscape of artificial intelligence (AI)-assisted tongue diagnosis in Traditional Chinese Medicine (TCM) by comparing publication trends, collaboration patterns, research hotspots, and emerging topics between CNKI-indexed and WoSCC-indexed literature.</p><p><strong>Methods: </strong>Literature published between January 2015 and August 2026 was retrieved from the Web of Science Core Collection (WoSCC) and China National Knowledge Infrastructure (CNKI). Publication trends were summarized descriptively, and CiteSpace and VOSviewer were used for collaboration-network, keyword co-occurrence, clustering, timeline, burst-detection, and journal citation analyses. CNKI-indexed and WoSCC-indexed records were analysed separately because of differences in database coverage, indexing characteristics, metadata structures, and publication practices.</p><p><strong>Results: </strong>A total of 482 studies were included, comprising 295 WoSCC-indexed and 187 CNKI-indexed records. Publication output showed an overall upward trend in both datasets over the study period. The CNKI keyword clustering network showed high clustering quality (modularity Q = 0.7929; weighted mean silhouette S = 0.9413), as did the WoSCC network (Q = 0.8000; S = 0.9239). In CNKI, the strongest keyword bursts included \"deep learning\" (strength = 2.95), \"image segmentation\" (2.69), and \"transfer learning\" (2.61); in WoSCC, prominent bursts included \"artificial intelligence\" (2.13), \"image colour analysis\" (2.10), and \"machine learning\" (1.86). CNKI-indexed literature showed prominent themes involving tongue-image objectification, segmentation, and TCM-oriented diagnostic concepts, whereas WoSCC-indexed literature showed more differentiated themes involving AI architectures, tongue-feature analysis, computational modelling, and disease-related applications. Highly cited publications in both datasets further reflected the importance of tongue-image extraction and segmentation and the subsequent expansion toward disease-oriented modelling. Across both datasets, the temporal patterns suggested a shift in research attention from conventional image processing and feature extraction toward machine learning, deep learning, and more integrated AI-based approaches.</p><p><strong>Conclusions: </strong>The two datasets showed complementary but database-specific thematic structures in AI-assisted tongue diagnosis. Although the literature indicates a shift toward more advanced and disease-oriented AI applications, these bibliometric patterns do not establish the scientific or medical validity, diagnostic accuracy, or clinical readiness of AI-assisted tongue analysis. Further standardization, multicentre external validation, and clinically interpretable and reproducible research are needed before broader clinical application.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1895902"},"PeriodicalIF":4.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of bioenergetic pathways in Medusozoa based on integrated genomic, transcriptomic and proteomic data.","authors":"Edgar Gamero-Mora, Legna Gabriela Pasos-Ramirez, Julio Cesar Barcelo-Navarro, Adriana Muhlia-Almazan","doi":"10.3389/fphys.2026.1932200","DOIUrl":"https://doi.org/10.3389/fphys.2026.1932200","url":null,"abstract":"<p><strong>Introduction: </strong>Jellyfish possess the biochemical and physiological capabilities that enable them to survive from the beginning of the animal era to the impacts of global warming (ocean warming and deoxygenation) on the seas today. Despite their confirmed ability to bloom, significant gaps remain about the molecular basis of specific physiological responses, and limited data allow us to understand the metabolic pathways that enable medusozoans to transform energy and successfully cope with the challenges the marine environment imposes.</p><p><strong>Methods: </strong>This research integrates and describes prior knowledge (genomic and transcriptomic information) and experimental data (a mitochondrial proteome) to compare, analyze, and reconstruct the major bioenergetic pathways of Medusozoa.</p><p><strong>Results: </strong>From the conserved glycolytic enzymes to the novel and distinctive molecules enabling jellyfish to build large energy reserves, this manuscript describes the presence of alternative enzymes composing the mitochondrial branched respiratory chain, anaerobic metabolism, and the phosphagen systems in the four classes of true jellyfish.</p><p><strong>Discussion: </strong>These results may contribute, from an energetic perspective, to explain the physiological ability of jellyfish to cope with environmental changes by increasing their populations and occupying new environments.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1932200"},"PeriodicalIF":4.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Machine learning for enhancing the ablation outcomes using recurrence quantification analysis in human persistent atrial fibrillation.","authors":"Noor N Qaqos, Fernando S Schlindwein, G André Ng, Xin Li","doi":"10.3389/fphys.2026.2009113","DOIUrl":"https://doi.org/10.3389/fphys.2026.2009113","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2026.1831826.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"2009113"},"PeriodicalIF":4.3,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral lower-limb asymmetry and phase-specific trunk acceleration during the Timed Up and Go in older women: an analysis based on muscle morphology and antagonist coactivation.","authors":"Danming Xu, Hongqin Xu, Xin Zhang, Ming Li, Xiangwei Meng","doi":"10.3389/fphys.2026.1915589","DOIUrl":"10.3389/fphys.2026.1915589","url":null,"abstract":"<p><p>The Timed Up and Go (TUG) test is widely used to assess mobility and fall risk in older adults, but total completion time does not capture phase-specific motor control. This study quantified bilateral lower-limb asymmetry in muscle morphology and neuromuscular control and examined its association with phase-specific trunk acceleration during the TUG. Twenty-seven healthy older women (78.96 ± 2.44 years) participated. Bilateral muscle thickness was measured by B-mode ultrasound, and bilateral surface electromyography and L4 trunk acceleration were recorded during a five-phase instrumented TUG. Mean and peak coactivation index (CCI) and asymmetry index (ASI) of the knee (QUAD-BF) and ankle (TA-MG) muscle pairs, together with anteroposterior and mediolateral trunk acceleration RMS (RMS_AP, RMS_ML), were calculated. No significant group-level left-right differences in muscle thickness were detected, although ASI exceeded 15% for all four muscles. After FDR correction, significant bilateral differences were retained for mean CCI_QUAD-BF during sit-to-stand (p< 0.001, q = 0.005), mean CCI_TA-MG during sit-to-stand (p = 0.001, q = 0.013) and peak CCI_QUAD-BF during sit-to-stand (p = 0.002, q = 0.013); the difference for mean CCI_QUAD-BF during return walk (p = 0.016) did not survive correction. Coactivation ASI was generally higher at the knee than the ankle. After Benjamini-Hochberg false discovery rate correction, three peak coactivation asymmetry correlations with RMS_AP survived: peak ASI_TA-MG during outbound walk (r = 0.72, q< 0.001), peak ASI_QUAD-BF during turn (r = 0.53, q = 0.043) and peak ASI_TA-MG during sit-to-sit (r = 0.57, q = 0.044). The negative correlations of ASI_MG with RMS_AP during sit-to-stand and outbound walk (r = -0.52, r = -0.51) did not survive FDR correction. No ASI correlated significantly with RMS_ML. Bilateral asymmetry was heterogeneous in direction, and phase-specific peak coactivation asymmetry was more consistently associated with anteroposterior trunk acceleration than muscle thickness. These measures may provide complementary information beyond muscle morphology or total TUG time, but their reliability and clinical relevance require further investigation.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1915589"},"PeriodicalIF":4.3,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of core training on athletic performance (speed and jumping) in different sports: a meta-analysis.","authors":"İdris Kayantaş","doi":"10.3389/fphys.2026.1946447","DOIUrl":"10.3389/fphys.2026.1946447","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to conduct a comprehensive, holistic examination, using meta-analysis, of the effects of core stabilisation training on speed and jumping-key indicators of athletic performance-in individuals participating in various sports.</p><p><strong>Methods: </strong>Studies published in Web of Science, PubMed and Google Scholar between 2020 and June 2026 examining speed and jumping performance were screened. Studies involving pre-test-post-test designs with experimental and control groups were recorded for analysis. A total of 49 studies meeting the inclusion criteria were included. This meta-analysis followed the PRISMA statement reporting guidelines. The CMA Ver. 2.0 statistical package was used to assess publication bias, calculate means and standard deviations, determine effect sizes and perform moderator analyses. The I² statistic assessed heterogeneity between studies; 25 per cent, 50 per cent and 75 per cent cut-off values represent low, moderate and high levels, respectively. Due to anticipated clinical and methodological diversity across sports disciplines, participant competitive levels, and test protocols, a random-effects model was applied <i>a priori</i> for all pooled analyses across speed and jumping outcomes. All estimates are reported with corresponding 95 per cent confidence intervals (CI). The α level was set at 0.05 for statistical significance.</p><p><strong>Results: </strong>The findings of this meta-analysis, which included a total of 49 studies, indicate that core training has a positive effect on the speed and jumping performance of individuals participating in various sports. The overall effect size calculated for speed performance was 0.601, whilst the overall effect size for jumping performance was determined to be 0.489. These findings indicate that core training has a positive effect on both speed and jumping performance.</p><p><strong>Conclusions: </strong>Core training is a useful complementary method for improving speed and jumping performance. Its effectiveness depends not only on training duration and sample size but also on exercise selection, intensity, frequency, athlete characteristics, and sport specificity. Therefore, combining core training with sport-specific sprint, strength, and plyometric exercises may enhance athletic performance.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1946447"},"PeriodicalIF":4.3,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlation of hemodynamic parameters using blood flow prediction model in cerebrovascular arteries.","authors":"Jun Yup Kim, Wheesung Lee, Young-Lin Yoo, Da Hyun Lee, Si Un Lee, Beom Joon Kim, Jihoon Kang, Chae-Yong Kim, Tae-Rin Lee, Kihwan Hwang","doi":"10.3389/fphys.2026.1874450","DOIUrl":"10.3389/fphys.2026.1874450","url":null,"abstract":"<p><strong>Introduction: </strong>Patient-specific hemodynamic assessment is pivotal for optimizing treatment strategies in cerebrovascular interventions; however, conventional modalities are often limited by restricted clinical accessibility or prolonged acquisition times.</p><p><strong>Methods: </strong>This study evaluates the previously developed Dr. NEAR flow (DNF), a streamlined computational framework designed for rapid and clinically feasible blood flow prediction, validated against Non-invasive Optimal Vessel Analysis (NOVA), a quantitative magnetic resonance angiography technique. The DNF methodology reconstructs a one-dimensional vascular topology from standard time-of-flight magnetic resonance angiography (MRA-TOF) sequences, and flow rate, velocity, and relative pressure are computed throughout the reconstructed vascular network using a Poiseuille-based fluid model. For validation, patient-specific boundary conditions were parameterized using proximal inflow measurements obtained from NOVA, and quantitative comparisons were performed at arterial locations with corresponding NOVA measurements.</p><p><strong>Results: </strong>Across 230 arterial segments in 35 subjects, NOVA-measured and DNF-predicted flow rates were strongly correlated (<i>r</i> = 0.77), and the association remained significant after accounting for within-patient clustering (<i>β</i> = 0.863, 95% CI 0.769-0.957). Repeated-measures Bland-Altman analysis showed a mean bias (-58.04 mm³/s). After conversion of flow rates to velocities, vessel-averaged distributions across the major cerebral arteries showed generally similar patterns between the two modalities, although artery-specific correlations were variable.</p><p><strong>Discussion: </strong>These findings indicate that DNF is a feasible approach for cerebrovascular hemodynamic assessment.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1874450"},"PeriodicalIF":4.3,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}