Frontiers in Physiology最新文献

{"title":"Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease.","authors":"Jun-Jie Wang, Xiao-Yuan Chen, Yi-Rong Zhang, Yan Shen, Meng-Lin Zhu, Jun Zhang, Jun-Jie Zhang","doi":"10.3389/fphys.2025.1562848","DOIUrl":"https://doi.org/10.3389/fphys.2025.1562848","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD), is one of the most common chronic liver diseases, which encompasses a spectrum of diseases, from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH), and may ultimately progress to MASH-related cirrhosis and hepatocellular carcinoma (HCC). MASLD is a complex disease that is influenced by genetic and environmental factors. Dysregulation of hepatic lipid metabolism plays a crucial role in the development and progression of MASLD. Therefore, the focus of this review is to discuss the links between the genetic variants and DNA methylation of lipid metabolism-related genes and MASLD pathogenesis. We first summarize the interplay between MASLD and the disturbance of hepatic lipid metabolism. Next, we focus on reviewing the role of hepatic lipid related gene loci in the onset and progression of MASLD. We summarize the existing literature around the single nucleotide polymorphisms (SNPs) associated with MASLD identified by genome-wide association studies (GWAS) and candidate gene analyses. Moreover, based on recent evidence from human and animal studies, we further discussed the regulatory function and associated mechanisms of changes in DNA methylation levels in the occurrence and progression of MASLD, with a particular emphasis on its regulatory role of lipid metabolism-related genes in MASLD and MASH. Furthermore, we review the alterations of hepatic DNA and blood DNA methylation levels associated with lipid metabolism-related genes in MASLD and MASH patients. Finally, we introduce potential value of the genetic variants and DNA methylation profiles of lipid metabolism-related genes in developing novel prognostic biomarkers and therapeutic targets for MASLD, intending to provide references for the future studies of MASLD.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1562848"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise interventions on depressive symptoms in stroke patients: a systematic review and meta-analysis.","authors":"Zhi-Yuan Wang, Ya-Lu Deng, Ting-Yuan Zhou, Zi-Yang Jiang, Yi Liu, Bo-Fu Liu, Yu Cao","doi":"10.3389/fphys.2025.1492221","DOIUrl":"https://doi.org/10.3389/fphys.2025.1492221","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to evaluate the effects of exercise interventions on depressive symptoms in stroke patients.</p><p><strong>Methods: </strong>Following PRISMA guidelines, We conducted searches in PubMed, Embase, CENTRAL, and Web of Science. The topic was the effect of exercise on depression levels in stroke patients. Patient's performance on depression scales after exercise was assessed using standardized mean difference (SMD) and 95% confidence intervals (95% CI). A random effects model (RE) was used to conduct a meta-analysis and compare the results between subgroups conducted based on adherence to ACSM guidelines and the length of exercise interventions.</p><p><strong>Results: </strong>The analysis included 24 randomized controlled trials (RCTs) involving 1,757 participants. The meta-analysis revealed that exercise interventions had a significant positive effect on reducing depressive symptoms in stroke patients, with a standardized mean difference (SMD) of -0.43 (95% CI: 0.65, -0.21). Subgroup analysis indicated that high compliance with ACSM guidelines resulted in a more substantial reduction in depressive symptoms (SMD = -0.79, 95% CI: 1.10, -0.49), compared with low or uncertain compliance (SMD = -0.03, 95% CI: 0.16, 0.10). Longer exercise intervention was associated with greater mitigation of depressive symptoms. The differences between intervention groups of different lengths were statistically significant (p < 0.05).</p><p><strong>Conclusion: </strong>These findings support the integration of tailored exercise programs into post-stroke care to optimize mental health outcomes. Compliance to ACSM-recommended exercise dosages significantly ameliorate depression levels in stroke patients. Further research is warranted to explore standardized exercise regimens in larger, multicenter trials.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#recordDetails, identifier PROSPERO(CRD42024579095).</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1492221"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors and construction of a predictive model for severe acute pancreatitis complicated by sinistral portal hypertension.","authors":"Mengbo Xiao, Yu An, Ying Di, Yunfeng Cui","doi":"10.3389/fphys.2025.1512144","DOIUrl":"https://doi.org/10.3389/fphys.2025.1512144","url":null,"abstract":"<p><strong>Objective: </strong>Sinistral portal hypertension (SPH) is a common complication of severe acute pancreatitis (SAP). Patients with SPH often present asymptomatic, but are at risk of gastrointestinal bleeding and abdominal bleeding due to the presence of varices of the corresponding vessels, which are often fatal. However, there is no prediction model for SAP combined with SPH. This study aimed to identify the risk factors of SAP combined with SPH and to construct a relevant predictive model using independent risk factors.</p><p><strong>Materials and methods: </strong>The clinical data of 431 SAP patients were collected in this study. According to the presence or absence of SPH, the patients were divided into SPH group (n = 126) and non-SPH group (n = 305), and 431 patients were randomly assigned to the training set and validation set. Univariate logistics regression analysis was used to screen out the variables with significant differences, and then backward stepwise regression method was used for multivariate logistic regression analysis to determine the independent risk factors of SAP combined with SPH. Then a prediction model was constructed and represented by a nomogram, and the model was verified by internal validation. Receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the predictive ability and accuracy of the model, and decision curve analysis (DCA) was used to evaluate the clinical value of the model.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that male, MCTSI score, white blood cell count (WBC), and portal venous system vascular lesions (PVPSL) were independent risk factors for SAP complicated with SPH. The area under the working curve (AUC) of the clinical nomogram in the training set was 0.95 (95% CI: 0.92-0.97),and the P value of the Hosmer-Lemeshow test of the calibration curve was 0.969. The AUC in the validation set was 0.98 (95%CI: 0.96-1.00), and the P value of the Hosmer-Lemeshow test of the calibration curve was 0.963. The DCA in the training set and the validation set showed good clinical applicability of the model.</p><p><strong>Conclusion: </strong>Male, MCTSI score, WBC and PVPSL are independent risk factors for SAP complicated with SPH. The establishment of prediction model for SAP complicated with SPH is of great significance for the prevention and treatment of SPH in clinical practice.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1512144"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials.","authors":"Qiuxiang Lin, Debiao Yu, Yuping Zhang, Xiaoting Chen, Jiawei Qin, Fuchun Wu","doi":"10.3389/fphys.2025.1524480","DOIUrl":"https://doi.org/10.3389/fphys.2025.1524480","url":null,"abstract":"<p><strong>Objectives: </strong>The effectiveness of low-load blood flow restriction training (LL-BFRT) in alleviating symptoms in patients with knee osteoarthritis (KOA) remains inconclusive. This systematic review and meta-analysis aim to comprehensively assess the effects of LL-BFRT compared to conventional resistance training on pain, muscle strength, and functional capacity in individuals with KOA.</p><p><strong>Data sources: </strong>PubMed, Embase, Web of Science, EBSCO, Scopus, and Cochrane trails were searched.</p><p><strong>Study selection: </strong>We included randomized controlled trials involving patients with KOA, in which the intervention group underwent LL-BFRT.</p><p><strong>Data extraction: </strong>Literature quality and risk of bias were assessed using the Physiotherapy Evidence Database (PEDro) scale and the Cochrane Risk-of-Bias Tool (ROB 2). Data were extracted using a predefined table, including outcomes such as pain, quadriceps muscle strength, 30-s sit-to-stand test (30STS) and Timed Up and Go test (TUG).</p><p><strong>Result: </strong>Ten studies were included in the meta-analysis. The pooled results indicated that, compared to conventional resistance training, LL-BFRT significantly improved knee joint pain [SMD = 0.25, 95%CI (0.02, 0.48), P = 0.03], increased quadriceps muscle strength [SMD = 0.46, 95%CI (0.04, 0.88), P = 0.03], and enhanced performance on the 30s sit-to-stand test (30STS) [WMD = 1.71, 95%CI (0.30, 3.11), P = 0.02]. However, no significant difference was observed in the improvement of the Timed Up and Go test (TUG) [WMD = -0.13, 95%CI (-0.51, 0.24), P = 0.49]. Subgroup analysis revealed that interventions with an occlusion pressure >100 mmHg and a duration ≤6 weeks had a significant impact on pain relief, quadriceps muscle strength, and the 30STS performance. For patients with KOA aged >65 years, LL-BFRT was more effective in alleviating pain, while for patients aged ≤65 years, it demonstrated more significant improvements in quadriceps strength and 30STS performance.</p><p><strong>Conclusion: </strong>Limited evidence suggests that LL-BFRT may be more effective than conventional resistance training in improving pain, quadriceps muscle strength, and 30STS performance in patients with KOA, while exhibiting a comparable effect on TUG test.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD42024603542.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1524480"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature.","authors":"María E Santana-Román, Santos Ramírez-Carreto, Paola Maycotte, Victoria Pando-Robles","doi":"10.3389/fphys.2025.1578531","DOIUrl":"https://doi.org/10.3389/fphys.2025.1578531","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2025.1507059.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1578531"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of extracellular metabolic acidosis on the homeostasis of intracellular pH in hippocampal neurons.","authors":"Patrice G Bouyer, Rossana Occhipinti, Sara Taki, Fraser J Moss, Walter F Boron","doi":"10.3389/fphys.2024.1494956","DOIUrl":"https://doi.org/10.3389/fphys.2024.1494956","url":null,"abstract":"<p><p>This <i>Hypothesis</i> & <i>Theory</i> contribution accompanies the research paper by Bouyer et al. (Frontiers in Physiology 2024), the first to employ out-of-equilibrium (OOE) CO₂/HCO₃ ^- solutions to examine systematically the intracellular pH (pH_i) effects of extracellular (o) metabolic acidosis (MAc) and its components: an isolated decrease in pH_o (pure acidosis, pAc) and an isolated decrease in [HCO₃ ^-]_o (pure metabolic/down, pMet↓). In this study, after reviewing various types of acid-base disturbances and the use of OOE solutions, we discuss pH_i \"state\" (ΔpH_i, in response to a single acid-base challenge) and \"behavior\" (the ΔpH_i transition observed between two successive challenges), along with approaches for quantifying state and behavior. We then discuss the molecular basis of how individual extracellular acid-base disturbances influence pH_i via effects on-and interactions among-acid-base transporters, acid-base sensors, and cellular constitution. Next, we examine the determinants of states and behaviors, their impact on the buffering of extracellular acid loads, and how variability in state and behavior might arise. We conclude with a consideration of how mathematical models-despite their inherent limitations-might assist in the interpretation of experiments and qualitative models presented in this study. Among the themes that emerge are (1) hippocampal neurons must have distinct sensors for pH_o and [HCO₃ ^-]_o; (2) these pH_o- and [HCO₃ ^-]_o-driven signal transduction pathways produce additive pH_i effects in naïve neurons (those not previously challenged by an acid-base disturbance); and (3) these pathways produce highly non-additive pH_i effects in neurons previously challenged by MAc.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1494956"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary endurance-training responsiveness of metabolic syndrome patients to individualized and standardized exercise prescriptions: a randomized controlled trial.","authors":"Ruojiang Liu, Jinmei Qin, Xiang Zhang, Feng Wang, Weizhen Xue","doi":"10.3389/fphys.2025.1427629","DOIUrl":"https://doi.org/10.3389/fphys.2025.1427629","url":null,"abstract":"<p><strong>Objective: </strong>This investigation compares the effects of two exercise prescriptions with equal energy consumption but different exercise intensity-determination methods on cardiopulmonary endurance in a population with metabolic syndrome (MetS). This investigation verified the effectiveness of individualized methods in patients with MetS undergoing moderate-intensity exercises.</p><p><strong>Methods: </strong>The participants were randomized into a standardized group or individualized group. Exercise intensity was determined based on the heart rate reserve method in the standardized group and ventilatory threshold model in the individualized group. The two groups completed 12 weeks of an exercise prescription with equal exercise frequency and energy consumption. Using cardiopulmonary exercise testing (CPET), primary and secondary cardiovascular endurance indicators were measured. The percentage change of PeakVO₂ was used to classify participants as responders and non-responders. Other markers were used in auxiliary analysis of individual training responses.</p><p><strong>Results: </strong>A total of 40 MetS participants (75% male; mean age: 43.58 ± 11.73; body mass index: 30.39 ± 4.26) completed all exercise interventions. The PeakVO₂ increased significantly (P < 0.05) in both the standardized and individualized groups. Significant improvements in peak heart rate and maximum voluntary ventilation were observed in the individualized group. Differences in training responsiveness were also observed between the standardized and individualized groups, with 70% and 90%, respectively, being classified as responders, and improvements in PeakVO₂ experienced by 14.6% and 22.1%, respectively. During the training period (weeks 4-12), a significant difference in responsiveness was observed between the groups. Similar adverse changes were present in the CPET markers of adverse responders.</p><p><strong>Conclusion: </strong>The ventilatory threshold model-based individualized method has advantages in the MetS population. However, the responsiveness to the individualized method did not reach 100% in patients with MetS.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1427629"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Cell death programs in the pathogenesis of heart disease.","authors":"Jennifer Q Kwong, Robert N Correll, Qinghang Liu","doi":"10.3389/fphys.2025.1581282","DOIUrl":"https://doi.org/10.3389/fphys.2025.1581282","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1581282"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine and enzymatic shifts during insect diapause: a review of regulatory mechanisms.","authors":"Hamzeh Izadi","doi":"10.3389/fphys.2025.1544198","DOIUrl":"https://doi.org/10.3389/fphys.2025.1544198","url":null,"abstract":"<p><p>Insect diapause is a vital survival strategy that enables insects to enter a state of suspended development, allowing them to withstand unfavorable environmental conditions. During diapause, insects significantly lower their metabolic rate and build up energy reserves, which they gradually utilize throughout this period. The regulation of diapause involves a complex interaction of hormones and enzymes. Juvenile hormones (JHs) affect adults and larvae differently; in adults, the absence of JH typically triggers diapause, while in larvae, the presence of JH encourages this state. Ecdysteroids, which regulate molting and metamorphosis, are carefully controlled to prevent premature development. Reduced signaling of insulin-like peptides enhances stress resistance and promotes energy storage. Several enzymes play crucial roles in the metabolic adjustments necessary for diapause. These adjustments include the degradation of JH, the ecdysteroidogenic pathway, and the metabolism of fatty acids, glycogen, cryoprotectants, and stress responses. Understanding diapause's molecular and biochemical mechanisms is essential for fundamental entomological research and practical applications. Despite recent advances, many aspects of diapause regulation, especially the interactions among hormonal pathways and the role of enzymes, remain poorly understood. This review analyzes approximately 250 papers to consolidate current knowledge on the enzymatic and hormonal regulation of diapause. It offers a comprehensive overview of key processes based on recent studies and suggests future research directions to fill gaps in our understanding of this significant biological phenomenon. The review also lays the groundwork for enhancing pest control strategies and ecological conservation by deepening our understanding of diapause mechanisms.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1544198"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the placental bacterial microbiota: implications for maternal and infant health.","authors":"Zhuojun Xie, Zhongsheng Chen, Yang Chai, Wang Yao, Guangyu Ma","doi":"10.3389/fphys.2025.1544216","DOIUrl":"https://doi.org/10.3389/fphys.2025.1544216","url":null,"abstract":"<p><p>The human placenta is a unique organ that forms under specific physiological conditions and plays a crucial role in nutrient and metabolite exchange between the mother and fetus. Research on the placenta is important for understanding maternal-fetal diseases. Traditionally, the placenta was considered \"sterile,\" but advancements in detection techniques have revealed the presence of a low level of microorganisms. This discovery challenges the traditional notion that the uterine placenta is sterile. The revelation of this truth marks a significant breakthrough in medical research, prompting more researchers to focus on this vital organ, the placenta. Placental microbial communities may originate from the oral, vaginal, and intestinal microbiota of expectant mothers. These microorganisms may reach the maternal-fetal interface, collectively shaping the placental microbiota and contributing to the composition of normal placental microbial communities. Abnormal placental microbial communities may be associated with some pregnancy complications and fetal developmental issues such as preterm birth, gestational hypertension, fetal growth restriction, and gestational diabetes mellitus. Intervention strategies targeting microbial communities, which include modulation of placental microbiota composition or function, such as probiotics, may help prevent or treat complications related to abnormal placental microbiota during pregnancy.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1544216"},"PeriodicalIF":3.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}