Frontiers in Physiology最新文献

{"title":"Feasibility and physiological effects of a combined exercise and nutritional intervention in older adults with cancer under catabolic stress.","authors":"Song Ee Park, Jin Hwa Choi, Du Hwan Kim, Don-Kyu Kim, Yongsoon Park, Yong Chan Ha, In Gyu Hwang","doi":"10.3389/fphys.2026.1779559","DOIUrl":"https://doi.org/10.3389/fphys.2026.1779559","url":null,"abstract":"<p><strong>Background: </strong>Ageing and cancer are associated with accelerated skeletal muscle catabolism, leading to sarcopenia, adverse body composition changes, and functional decline. Exercise and nutritional support are established physiological countermeasures against muscle loss; however, their feasibility and physiological effects in older adults exposed to profound catabolic stress remain insufficiently characterized.</p><p><strong>Methods: </strong>Between 2021 and 2023, adults aged ≥65 years with advanced cancer undergoing systemic therapy participated in a 12-week combined exercise and nutritional intervention program. Participants were assigned to an intervention group (exercise plus nutrition, n=20) or a usual-care control group (n=40). The primary endpoint was feasibility, defined as ≥50% adherence to both exercise and nutritional components during the first 6 weeks. Secondary endpoints included changes in skeletal muscle index (SMI), subcutaneous and visceral fat compartments, safety, and patient-reported quality of life.</p><p><strong>Results: </strong>The median age was 72 years, 65% were men, and 41.7% had baseline sarcopenia. Adherence rates were 65% for exercise and 75% for nutritional support, with an overall attrition rate of 5% and no intervention-related adverse events. At 6 weeks, SMI declined significantly in the control group, whereas no statistically significant change in SMI was observed in the intervention group. Subcutaneous fat decreased significantly in the intervention group, with a reduction in visceral fat observed among men. At 12 weeks, body composition parameters remained relatively stable in both groups. Modest improvements were noted in fatigue, appetite loss, and nausea.</p><p><strong>Conclusions: </strong>A combined exercise and nutritional intervention was feasible, safe, and well tolerated in older adults exposed to severe catabolic stress. The preservation of skeletal muscle mass and favorable body composition changes observed suggest meaningful physiological adaptation, supporting exercise and nutritional support as viable physiological countermeasures in vulnerable ageing populations.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1779559"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Lifetime achievements in avian physiology.","authors":"Colin G Scanes, Sandra G Velleman","doi":"10.3389/fphys.2026.1816782","DOIUrl":"https://doi.org/10.3389/fphys.2026.1816782","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1816782"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis.","authors":"Ci Wang, Xiangyuan Huang, Zeyu Zhang, Dongming Lin, Shuwei Huang","doi":"10.3389/fphys.2026.1772535","DOIUrl":"https://doi.org/10.3389/fphys.2026.1772535","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) are the leading global cause of mortality, with potassium homeostasis playing a fundamental role in their pathophysiology. Tightly regulated potassium ions (K⁺) are essential for cardiac electrophysiological stability, and their dysregulation is a critical driver of disorders, particularly cardiac arrhythmias. Systemic potassium homeostasis is maintained by a complex network involving dietary intake, renal and intestinal handling, neuromodulatory control, skeletal muscle buffering and membrane ion channel activity, et al, which together determine extracellular and intracellular potassium homeostasis. This review summarizes the physiological mechanisms underlying potassium homeostasis and critically examines how potassium imbalance contributes to CVDs, with a primary focus on arrhythmia-related pathophysiology. By integrating experimental and clinical evidence, we highlight clinically relevant mechanisms and potential therapeutic strategies aimed at optimizing potassium homeostasis, thereby providing a conceptual framework to improve CVDs prevention and management.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1772535"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of shoulder extension angle on elbow flexor hypertrophy in the cable curl exercise.","authors":"Stian Larsen, Benjamin Sandvik Kristiansen, Nordis Østerås Sandberg, Andrea Bao Fredriksen, Roland van den Tillaar, Milo Wolf, Paul Alan Swinton, Hallvard Nygaard Falch","doi":"10.3389/fphys.2026.1750722","DOIUrl":"https://doi.org/10.3389/fphys.2026.1750722","url":null,"abstract":"<p><p>This within-participant randomized study compared elbow flexor hypertrophy following cable curls performed in a neutral <i>versus</i> maximally extended shoulder position, with resistance profiles and elbow extension range of motion (ROM) matched between conditions. Thirty untrained men participated, with one arm assigned to train at the individualized peak shoulder extension angle and the contralateral arm at a neutral position. Twenty-four participants completed the intervention, which consisted of six to eight weekly sets of unilateral cable curls to momentary failure over 10 weeks under supervised conditions. Elbow flexor muscle thickness was assessed with ultrasonography at 50% and 70% of humerus length before and after the intervention. A Bayesian framework was used to estimate the average treatment effect (ATE) and quantify the strength of evidence with Bayes factors (BF). Both conditions produced increases in muscle thickness of approximately 7%-9%. Posterior distributions of the ATE were centered close to zero (Proximal/ATE_Neutral:Peak = -0.40 [95% CrI: -1.06 to 0.26 mm]; Distal/ATE_Neutral:Peak = 0.21 [95% CrI: -0.25-0.65 mm]), with BFs indicating anecdotal to moderate evidence in favor of the null hypothesis. These findings suggest that when resistance profiles, elbow ROM, and effort are matched, altering shoulder extension angle in isolation does not appear to produce meaningful differences in elbow flexor hypertrophy in untrained men over 10 weeks.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1750722"},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females.","authors":"S A Sanduni Samudika De Alwis, Xueying Zhang, Huihui Mei, Xinyi Bi, Xinyue Ma, Ying Liu, Li Xue, Dehuang Kong, Lu Wang, Hongbo Wang, John R Speakman","doi":"10.3389/fphys.2026.1716140","DOIUrl":"https://doi.org/10.3389/fphys.2026.1716140","url":null,"abstract":"<p><strong>Introduction: </strong>Physical activity (PA) costs energy. However, recent theory suggests the relationship of increasing PA to total energy expenditure (TEE) is non-linear because high levels of activity suppress resting metabolism mediated via changes in thyroid hormones (THs; T3- triiodothyronine, T4- thyroxine, fT3- free triiodothyronine, fT4 - free thyroxine, TSH - thyroid stimulating hormone).</p><p><strong>Method: </strong>We conducted a cross-sectional study on 38 euthyroid females (NCT06377943) to examine the relationship between PA, resting metabolic rate (RMR), and TEE. Multiple linear regression and Bootstrapped structural equation model were used to assessed whether THs statistically accounted for the association between PA and RMR.</p><p><strong>Results: </strong>Bootstrapped structural equation models indicated that PA was significantly associated with lower TH levels (β = -4.33, 95% CI [-8.51, -1.70], p = 0.011), while the association between THs and RMR was small and non-significant (β = 0.043, 95% CI [-0.02, 0.10], p = 0.16), resulting in a non-significant indirect effect (β = -0.19, 95% CI [-0.67, 0.08], p = 0.31). In multiple regression plots, physical activity energy expenditure (PAEE) and PA showed a trend toward significance (p = 0.07) when THs were added.</p><p><strong>Conclusion: </strong>Overall, although PA was associated with modest changes in THs, these changes did not correspond to any detectable decrease in RMR.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1716140"},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of high-intensity interval training and small-sided games on physical fitness among players: a systematic review with meta-analysis.","authors":"Yu Zeng, Xinzhi Wang, Kim Geok Soh, Shuzhen Ma, Yue Zhao, Wenchao Rong, Xinrui Zhang, Ningfei Wei","doi":"10.3389/fphys.2026.1754825","DOIUrl":"https://doi.org/10.3389/fphys.2026.1754825","url":null,"abstract":"<p><strong>Background: </strong>With the continuous advancement of sports training methodologies, high-intensity interval training (HIIT) and small-sided games (SSG) have emerged as crucial strategies for enhancing players' physical fitness. However, the comparative effects of these training modalities on various fitness components and their underlying physiological adaptation mechanisms remain insufficiently explored.</p><p><strong>Objectives: </strong>This systematic review and meta-analysis aim to compare the overall impact of HIIT and SSG on players' physical fitness and examine the moderating effects of different training parameters, including training frequency, intervention duration, players' training experience, age, and gender. The findings seek to provide theoretical insights for optimising training protocols.</p><p><strong>Methods: </strong>A systematic search was conducted in databases including PubMed, Web of Science, Scopus, and EBSCOhost to identify relevant English-language randomised controlled trials that met predefined eligibility criteria. Hedges' g was used as the effect size metric, and a random-effects model was applied for meta-analyses of power, speed, endurance, and agility. Subgroup analyses were performed to assess the influence of potential moderators.</p><p><strong>Results: </strong>The meta-analysis revealed that, compared to SSG, HIIT produced a small but statistically significant improvement in speed (ES = 0.564) and a moderate and statistically significant improvement in endurance (ES = 0.706). In contrast, gains in power (ES = -0.144) and agility (ES = -0.159) were trivial in magnitude and not statistically significant. Subgroup analyses indicated that lower training frequency (<3 sessions per week) and shorter intervention duration (<6 weeks) yielded significant improvements. Furthermore, players across different age groups benefited from HIIT, while sex did not exhibit a significant moderating effect.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis confirm that both HIIT and SSG effectively enhance players' physical fitness, with HIIT demonstrating a distinct advantage in improving speed and endurance. Although HIIT showed relatively limited improvements in power and agility compared to SSG, both training modalities exert their effects through distinct physiological adaptation mechanisms. Subgroup analysis findings suggest that appropriately balancing training frequency and intervention duration is crucial for achieving optimal training outcomes. Future research should further investigate the long-term effects of these interventions to provide a more robust theoretical foundation for personalised training program design.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024555633.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1754825"},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise regimens on balance ability in older patients with osteoporosis: a systematic review and Bayesian network meta-analysis of randomized controlled trials.","authors":"Xiangyue Liu, Mengjing Chang, Huiyun Yuan, Xuemei Zheng, Wenling Tian, Dongwen Li, Dongfa Liao, Lin Cui","doi":"10.3389/fphys.2026.1793389","DOIUrl":"https://doi.org/10.3389/fphys.2026.1793389","url":null,"abstract":"<p><p>To determine the optimal exercise regimen for improving balance and preventing severe falls in older patients with osteoporosis (OP). Four databases were searched until September 1, 2025. The risk of bias was assessed using Cochrane ROB2. Outcomes included Berg Balance Scale (BBS, primary), timed up and go test (TUG), bone mineral density (BMD), one-leg stand test (OLS), and number of falls. A Bayesian network meta-analysis in R4.4.1/GeMTC synthesized effects, presented as MD (95% CrI) and ranked by SUCRA. Analysis of 22 RCTs (n=1538) versus usual care showed virtual reality (VR) most effective for BBS (MD 9.2, 95% CrI 7.2, 11; SUCRA 99.66%) and TUG (MD -4.6, 95% CrI -5.8, -3.3; SUCRA 98.51%); balance training+resistance training+aerobics (BT + RT + aerobics) best improved BMD (MD 0.016, 95% CrI 0.012, 0.020; SUCRA 72.38%); trampoline best improved OLS (MD 8.8, 95% CrI 1.7, 5.5; SUCRA 72.38%); RT most significantly reduced falls (MD 0.29, 95% CrI 0.100, 0.68; SUCRA 84.86%). For older OP patients, VR is most effective in improving overall balance and mobility, with reliable evidence. Combination training, trampoline, and RT exhibit potential benefits for BMD, OLS, and fall prevention, respectively. Due to the limited amount of evidence and network strength, however, these interventions cannot yet be considered definitive clinical recommendations. More high-quality direct comparisons are required for further validation in the future.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1793389"},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Redox Physiology in Fish.","authors":"Slađan Pavlović, Gisele Cristina Favero, Mustafa Canli","doi":"10.3389/fphys.2026.1829914","DOIUrl":"https://doi.org/10.3389/fphys.2026.1829914","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1829914"},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between visual skills and sport-specific performance in team athletes: a systematic review and meta-analysis.","authors":"Mulin Yang, Yuqiang Guo, Feng Yang, Kewei Zhao","doi":"10.3389/fphys.2026.1797347","DOIUrl":"https://doi.org/10.3389/fphys.2026.1797347","url":null,"abstract":"<p><strong>Background: </strong>Visual skills are increasingly recognized as key contributors to performance in team sports, yet the strength and consistency of their associations with sport-specific outcomes remain uncertain. To address this gap, the present review systematically synthesized empirical evidence examining how different domains of visual skill relate to sport-specific performance among team-sport athletes.</p><p><strong>Methods: </strong>PubMed, Web of Science™, MEDLINE, and SPORTDiscus databases were systematically searched from inception to October 2025 to identify studies relating visual skills to sport-specific performance in team-sport athletes. Risk of bias was conducted using a modified and validated tool for observational and correlational studies, and certainty of evidence was evaluated using the GRADE approach.</p><p><strong>Results: </strong>Of 4,118 records identified, 22 studies (<i>n</i> = 1,113, male = 954, female = 159) were included, encompassing basketball, soccer, baseball, volleyball, handball, and other team sports. The relationship between multiple object tracking and sport-specific performance was large (<i>r</i> = 0.54; 95% CI: 0.30-0.71; <i>p</i> = 0.00), while visual attention (<i>r</i> = 0.39; 95% CI: 0.16-0.53; <i>p</i> = 0.00), and visual search (<i>r</i> = 0.36; 95% CI: 0.16-0.48; <i>p</i> = 0.00), demonstrated moderate associations. Simple reaction time (<i>r</i> = -0.31; 95% CI: -0.42 to -0.19; <i>p</i> = 0.00) and choice reaction time (<i>r</i> = -0.37; 95% CI: -0.58 to -0.11; <i>p</i> = 0.01) showed moderate negative correlations with performance, indicating faster reaction speeds were associated with better performance. Visual working memory, eye-hand coordination, and inhibitory control exhibited small effect sizes. In contrast, depth perception, the only visual-perceptual skill analyzed, showed trivial and non-significant associations (<i>r</i> = 0.09; 95% CI: -0.20-0.36; <i>p</i> = 0.56).</p><p><strong>Conclusion: </strong>Visual-cognitive skills appear to show stronger links with team-sport performance, whereas basic perceptual skills contribute little. Evidence quality remains limited, and more robust, ecologically valid studies are needed to clarify causality and guide training applications.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD420251171665, identifier CRD420251171665.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1797347"},"PeriodicalIF":3.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral low-load blood flow restriction vs. high-load training in the Bulgarian split squat: a randomized within-subject design on strength, hypertrophy, and asymmetry.","authors":"Yanfei Wang, Xinyuan Zhao, Lingfeng Zhang, Xin Gao, Zhanfei Zheng, Shoudu Wang","doi":"10.3389/fphys.2026.1786733","DOIUrl":"https://doi.org/10.3389/fphys.2026.1786733","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of a 6-week unilateral low-load blood flow restriction (LL-BFR) training protocol versus traditional high-load resistance training (HL-RT) on maximal strength, muscle hypertrophy, and explosive power in resistance-trained men.</p><p><strong>Methods: </strong>Twenty-four resistance-trained males (age: 21.0 ± 2.0 years) completed a randomized within-subject trial. Each participant performed unilateral Bulgarian split squats (BSS) with one leg assigned to LL-BFR (30% 1RM, 30-15-15-15 repetitions at 80% arterial occlusion pressure [AOP]) and the contralateral leg to HL-RT (80% 1RM, 4 sets of 10 repetitions). Training consisted of 18 sessions over 6 weeks. Variable assessments, including BSS 1RM, vastus lateralis (VL) muscle thickness, and single-leg countermovement jump (SLCMJ) height and relative peak power were conducted both before (pretests) and after (posttests) the intervention.</p><p><strong>Results: </strong>Both conditions resulted in significant time-dependent improvements in BSS 1RM (LL-BFR: +10.7%; HL-RT: +13.0%), VL muscle thickness (LL-BFR: +8.1%; HL-RT: +9.3%), and SLCMJ performance (height: +10.7-13.0%; relative peak power: +6.5-8.7%) (all P < 0.05). Crucially, no significant condition × time interactions were detected for any variable, indicating that the magnitude of adaptation was comparable between the LL-BFR and HL protocols. Additionally, training did not exacerbate inter-limb asymmetry.</p><p><strong>Conclusions: </strong>Unilateral LL-BFR and HL-RT produced similar time-dependent improvements in maximal strength, muscle hypertrophy, and explosive performance in resistance-trained men. LL-BFR may be considered as a joint-sparing option when high mechanical loading is not feasible or desirable.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"17 ","pages":"1786733"},"PeriodicalIF":3.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}