Functional training improves cognitive function, functional fitness, and BDNF levels in older women with mild cognitive impairment: a randomized controlled trial.
Salviano Resende-Silva, Antônio Gomes de Resende-Neto, Alan Bruno Silva Vasconcelos, Marcos Raphael Pereira-Monteiro, Alan Pantoja-Cardoso, Laíza Ellen Santana Santos, Newton Benites Carvalho Lima, José Lucas de Jesus Santos, José Carlos Aragão-Santos, Dulce Marta Schimieguel, José Ronaldo Dos Santos, Marzo Edir Da Silva-Grigoletto
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引用次数: 0
Abstract
Introduction: To oppose the aging-related cognitive and functional decline, the efficacy of different training methods has been tested, aiming body multisystemic adaptations. In this sense, Functional Training (FT) has shown relevant results in the physical fitness of older adults. However, little is known about its impact on older women with mild cognitive impairment (MCI).
Objective: To compare the effects of functional and aerobic training on cognitive function and functional fitness in older women with mild cognitive impairment.
Methods: Sixty-eight older women completed a 16-week intervention through three groups: 1) Functional Training (FT: n = 28; mean age = 67.5 ± 4.8 years), 2) Aerobic Training (AT: n = 22; mean age = 66.3 ± 4.6 years), and 3) Control Group (CG: n = 18; mean age = 67.5 ± 4.6 years). The training sessions did occur three times per week, with a duration of 50 min per session for both exercised groups. The training load was quantified daily in the FT group. Cognitive function, serum levels of Brain-Derived Neurotrophic Factor (BDNF), and functional fitness were assessed pre- and post-intervention.
Results: FT and AT groups showed improvements in cognitive status (FT: d = 0.99, p ≤ 0.001; AT: d = 0.97, p ≤ 0.001) and semantic memory (FT: d = 0.95, p < 0.001; AT: d = 0.97, p < 0.001); however, only FT led to improvements in executive function (d = 0.63, p = 0.043) and increased serum BDNF levels (d = 0.95, p = 0.011). Regarding functional fitness, both groups showed improvements in gait and stand up ability, as well as cardiorespiratory fitness. However, only FT improved dexterity and upper limb strength. No statistically significant differences were observed between the FT and AT groups in the measured outcomes.
Conclusion: Both FT and AT improve cognitive function and functional fitness in older women with mild cognitive impairment. However, in addition to eliciting a greater magnitude of effects on some outcomes, FT was the only intervention to modulate peripheral BDNF concentration.
为了对抗与衰老相关的认知和功能衰退，我们测试了不同训练方法的效果，以身体多系统适应为目标。从这个意义上说，功能训练（FT）在老年人的身体健康中显示出相关的结果。然而，它对患有轻度认知障碍（MCI）的老年妇女的影响知之甚少。目的：比较功能性和有氧训练对老年轻度认知障碍妇女认知功能和功能适应度的影响。方法：68名老年妇女通过三组完成了为期16周的干预：1)功能训练组（FT: n = 28，平均年龄= 67.5±4.8岁），2)有氧训练组（AT: n = 22，平均年龄= 66.3±4.6岁），3)对照组（CG: n = 18，平均年龄= 67.5±4.6岁）。训练每周进行三次，每次持续时间为50分钟。FT组每日量化训练负荷。在干预前后分别评估认知功能、脑源性神经营养因子（BDNF）血清水平和功能适应度。结果：FT组和AT组在认知状态（FT: d = 0.99, p≤0.001;AT: d = 0.97, p≤0.001）和语义记忆（FT: d = 0.95, p < 0.001; AT: d = 0.97, p < 0.001）方面均有改善；然而，只有FT能改善执行功能（d = 0.63, p = 0.043）和提高血清BDNF水平（d = 0.95, p = 0.011）。在功能适应性方面，两组患者的步态和站立能力以及心肺功能均有所改善。然而，只有FT能提高灵活性和上肢力量。FT组和AT组的测量结果没有统计学上的显著差异。结论：FT和AT均可改善老年轻度认知障碍妇女的认知功能和功能健康。然而，除了对某些结果产生更大程度的影响外，FT是唯一调节外周BDNF浓度的干预措施。
期刊介绍：
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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