Frontiers in Physiology最新文献

{"title":"Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats.","authors":"Jacob Raber, Mitali Chaudhari, Alexis De la Torre, Sarah Holden, Kat Kessler, Breanna Glaeser, Marek Lenarczyk, Scott Willem Leonard, Alexander Borg, Andy Kwok, Chirayu Patel, Amy Kronenberg, Christopher M Olsen, Jeffrey S Willey, Jeffrey Morré, Jaewoo Choi, Jan Frederik Stevens, Gerd Bobe, Jessica Minnier, John Baker","doi":"10.3389/fphys.2024.1486767","DOIUrl":"10.3389/fphys.2024.1486767","url":null,"abstract":"<p><strong>Introduction: </strong>Effects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic rays (GCRs). One of the limitations of previous studies on simulated weightlessness using hindlimb unloading (HU) is that a control HU condition was not included.</p><p><strong>Methods: </strong>We characterized the behavioral performance of male Fischer rats 2 months after sham or total body irradiation with a simplified 5-ion 6-mixed-beam exposure representative of GCRs in the absence or presence of HU. Six months later, the plasma, hippocampus, and cortex were processed to determine whether the behavioral effects were associated with long-term alterations in the metabolic pathways.</p><p><strong>Results: </strong>In the open field without and with objects, interactions were observed for radiation × HU. In the plasma of animals that were not under the HU or control HU condition, the riboflavin metabolic pathway was affected most for sham irradiation vs. 0.75 Gy exposure. Analysis of the effects of control HU on plasma in the sham-irradiated animals showed that the alanine, aspartate, glutamate, riboflavin, and glutamine metabolisms as well as arginine biosynthesis were affected. The effects of control HU on the hippocampus in the sham-irradiated animals showed that the phenylalanine, tyrosine, and tryptophan pathway was affected the most. Analysis of effects of 0.75 Gy irradiation on the cortex of control HU animals showed that the glutamine and glutamate metabolic pathway was affected similar to the hippocampus, while the riboflavin pathway was affected in animals that were not under the control HU condition. The effects of control HU on the cortex in sham-irradiated animals showed that the riboflavin metabolic pathway was affected. Animals receiving 0.75 Gy of irradiation showed impaired glutamine and glutamate metabolic pathway, whereas animals receiving 1.5 Gy of irradiation showed impaired riboflavin metabolic pathways. A total of 21 plasma metabolites were correlated with the behavioral measures, indicating that plasma and brain biomarkers associated with behavioral performance are dependent on the environmental conditions experienced.</p><p><strong>Discussion: </strong>Phenylalanine, tyrosine, and tryptophan metabolism as well as phenylalanine and tryptophan as plasma metabolites are biomarkers that can be considered for spaceflight as they were revealed in both Fischer and WAG/Rij rats exposed to simGCRsim and/or HU.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1486767"},"PeriodicalIF":3.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cerebral perfusion heterogeneity by the electrical impedance tomography.","authors":"Mingxu Zhu, Yu Wang, Junyao Li, Weice Wang, Guobin Gao, Zhenyu Ji, Benyuan Liu, Lei Wang, Weichen Li, Xuetao Shi","doi":"10.3389/fphys.2024.1476040","DOIUrl":"10.3389/fphys.2024.1476040","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate the ability of global inhomogeneity index (GI) and left-right asymmetry index (AI) based on electrical impedance tomography (EIT) to be used in assessing cerebral perfusion heterogeneity. The diagnostic value of these two indices in identifying abnormalities in the degree of cerebral perfusion heterogeneity was also explored.</p><p><strong>Methods: </strong>In this study, Transcranial Doppler (TCD) was used as a control, and unilateral carotid artery was compressed to change the degree of heterogeneity of cerebral perfusion in 15 healthy volunteers. The control group consisted of an additional 15 volunteers without any intervention. EIT perfusion images were obtained by calculating the impedance difference between at the beginning and end of cerebral vasodilation. Subsequently, GI and AI were calculated based on the pixel values of intracranial regions.</p><p><strong>Results: </strong>The GI and AI values in the non-carotid artery compression (NCAC) group were significantly lower than those in the unilateral carotid artery compression (UCAC) group (P < 0.001), whereas there was no significant difference between the left carotid artery compression (LCAC) and right carotid artery compression (RCAC) groups. ROC analysis showed that the area under the curve (AUC), specificity and sensitivity of GI in distinguishing between NCAC and UCAC were 0.94, 0.90 and 0.87, respectively. The AUC, specificity and sensitivity of AI in distinguishing between NCAC and UCAC were 0.86, 0.87 and 0.73, respectively.</p><p><strong>Conclusion: </strong>The results demonstrated that the GI and AI effectively quantify the distribution of intracranial perfusion, demonstrating excellent validity and interindividual comparability, and the ability to detect abnormal cerebral perfusion heterogeneity.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1476040"},"PeriodicalIF":3.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipin1 as a therapeutic target for respiratory insufficiency of duchenne muscular dystrophy.","authors":"Alexandra Brown, Brooklyn Morris, John Karanja Kamau, Ryan J Rakoczy, Brian N Finck, Christopher N Wyatt, Hongmei Ren","doi":"10.3389/fphys.2024.1477976","DOIUrl":"10.3389/fphys.2024.1477976","url":null,"abstract":"<p><p>In Duchenne muscular dystrophy (DMD), diaphragm muscle dysfunction results in respiratory insufficiency which is a leading cause of death in patients. Mutations to the dystrophin gene result in myocyte membrane instability, contributing to the structural deterioration of the diaphragm muscle tissues. With previous works suggesting the importance of lipin1 for maintaining skeletal muscle membrane integrity, we explored the roles of lipin1 in the dystrophic diaphragm. We found that the protein expression levels of lipin1 were reduced by 60% in the dystrophic diaphragm. While further knockdown of lipin1 in the dystrophic diaphragm leads to increased necroptosis, restoration of lipin1 in the dystrophic diaphragm results in reduced inflammation and fibrosis, decreased myofiber death, and improved respiratory function. Our results demonstrated that lipin1 restoration improved respiratory function by enhancing membrane integrity and suggested that lipin1 could be a potential therapeutic target for preventing respiratory insufficiency and respiratory failure in DMD. Continued investigation is required to better understand the mechanisms behind these findings, and to determine the role of lipin1 in maintaining muscle membrane stability.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1477976"},"PeriodicalIF":3.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Differential effects of clopidogrel and/or aspirin on the healing of tooth extraction wound bone tissue.","authors":"Jiaping Wang, Juan Lin, Xin Song, Mengting Wang, Yan Chen, Ning Luo, Xin Wu","doi":"10.3389/fphys.2024.1522884","DOIUrl":"10.3389/fphys.2024.1522884","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2024.1387633.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1522884"},"PeriodicalIF":3.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the effects of different exercise modes on cardiac function and peak oxygen uptake in patients with type 2 diabetes mellitus.","authors":"He Jianghua, Ma Feier, Zhu Dong, Li Qiuying, Wen Ya, Wang Yan","doi":"10.3389/fphys.2024.1448385","DOIUrl":"10.3389/fphys.2024.1448385","url":null,"abstract":"<p><strong>Background: </strong>The benefits of exercise for primary and secondary prevention of cardiovascular events have been reported in patients with type 2 diabetes mellitus (T2DM). However, the effects of exercise on cardiac structure and function require clarification.</p><p><strong>Methods: </strong>A literature search for clinical studies reporting on the effects of exercise on cardiac structure, cardiac function, and VO₂peak in T2DM patients was conducted. PubMed, Embase, EBSCO, Web of Science, and China National Knowledge Infrastructure were systematically searched for original articles published from January 2000 to July 2023. The effect size was expressed as the mean difference (MD) or standardized mean difference (SMD) and its 95% confidence interval (CI). Subgroup analyses were performed by exercise mode (high-intensity interval training [HIIT] or moderate-intensity continuous training [MICT]) and intervention duration (>6 or ≤6 months).</p><p><strong>Results: </strong>Compared to usual care, both HIIT and MICT significantly affected left ventricular end-diastolic volume (MD: 19.44, 95% CI: 13.72 to 25.17, <i>p</i> < 0.00001; I² = 42%; MD: 13.90, 95% CI: 7.64 to 20.16, <i>p</i> < 0.0001; I² = 0%), but only HIIT significantly affected left ventricular mass (MD: 17.04 g, 95% CI: 5.45 to 28.62, <i>p</i> = 0.004; I² = 0%). HIIT significantly improved left ventricular ejection fraction (MD: 5.52, 95% CI: 2.31 to 8.73, <i>p</i> = 0.0008; I² = 0%), as did MICT in the ≤6 months subgroup (MD: 1.36, 95% CI: 0.61 to 2.10, <i>p</i> = 0.0004; I² = 0%). Neither significantly affected systolic tissue velocity. HIIT significantly improved VO₂peak (MD: 8.04, 95% CI: 6.26 to 9.83, <i>p</i> < 0.00001; I² = 0%), as did MICT in the ≤6 months subgroup (MD: 3.33, 95% CI: 2.39 to 4.27, <i>p</i> < 0.00001; I² = 0%).</p><p><strong>Conclusion: </strong>Exercise significantly improved cardiac structure, systolic function, and VO₂peak, but did not significantly affect diastolic function in T2DM patients. HIIT seemed to be superior to MICT at improving VO₂peak and left ventricular ejection fraction in T2DM patients. <b>Systematic Review Registration:</b> https://www.crd.york.ac.uk/PROSPERO/, PROSPERO registration no.: CRD4242018087376.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1448385"},"PeriodicalIF":3.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of the oxyhemoglobin dissociation curve in COVID-19 related ARDS patients.","authors":"Charlotte Dalne, Patrick Biston, Michaël Piagnerelli","doi":"10.3389/fphys.2024.1463775","DOIUrl":"10.3389/fphys.2024.1463775","url":null,"abstract":"<p><strong>Introduction: </strong>Severe hypoxemia is the leading cause of admission in intensive care (ICU) in patients with COVID-19 related acute respiratory distress syndrome (ARDS). In these patients, several studies reported a left shift of the oxyhemoglobin dissociation curve associated with a lower mortality. However, these results are conflicting, as these studies include few patients and often no control groups. Moreover, the calculation of P50, representing the PaO2 value at which 50% of hemoglobin is saturated, is not corrected for factors known to influence it (pH, PaCO2 or temperature). For all of these reasons, we compared the corrected P50 between ICU patients with severe COVID-19 related ARDS on mechanical ventilation or not, and ARDS from other causes. We investigated the evolution of the corrected P50 during the first 3 days of ICU and its relationship with ICU mortality.</p><p><strong>Methods and patients: </strong>We retrospectively calculated the corrected P50 in three groups of patients: intubated and mechanically ventilated COVID-19 related ARDS, non-intubated COVID-19 related ARDS and intubated patients with ARDS due to other infectious causes. The corrected P50 was calculated, on the worst blood gas analysis on days 1 and 3 of ICU admission, by the formula of Hill but modified by Dash et al., controlled for pH, PaCO2 and temperature. We collected ICU mortality.</p><p><strong>Results: </strong>463 blood gas analysis at days 1 and 3 from 214 ICU COVID-19 related ARDS patients (114 with intubation and 100 without) and 35 ICU patients with ARDS from other causes were analyzed. All patients were severely hypoxemic: PaO2/FiO2 of 76 [58-108] mmHg for intubated COVID-19, 79 [60-108] mmHg for non-intubated COVID-19 and 142 [78-197] mmHg for the third group (<i>p</i> < 0.001). The mortality rate was higher in intubated COVID-19 related ARDS patients (44.7 versus 14 versus 37% in ARDS from other causes; <i>p</i> < 0.001). The corrected P50 was significantly lower in COVID-19 patients, especially in non- intubated patients (21.2 [18.8-25.2] mmHg vs. 25.5 [19.2-30.3] mmHg in intubated patients; compared to ARDS from other causes: 27.2 [23.3-35.4] mmHg; <i>p</i> < 0.001. The corrected P50 does not change over the first 3 days, except for the non intubated COVID-19 related ARDS and is not correlated with ICU mortality (odds ratio = 0.98 [0.95-1.03]; <i>p</i> = 0.51), in contrast of PaO2/FiO2 and ICU gravity scores.</p><p><strong>Conclusion: </strong>The oxyhemoglobin dissociation curve at ICU admission was left shifting in severe COVID-19 related ARDS patients regardless of the type of ventilation. This deviation increases the third day only in non-intubated COVID-19 related ARDS and was not related to the outcome.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1463775"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and functional disparities in perivascular adipose tissue.","authors":"Erling Guo, Dan Liu, Ziming Zhu","doi":"10.3389/fphys.2024.1499340","DOIUrl":"10.3389/fphys.2024.1499340","url":null,"abstract":"<p><p>The adipose tissue surrounding blood vessels is known as perivascular adipose tissue (PVAT), which represents a distinct ectopic fat depot that adheres to the majority of the vasculature. In recent years, owing to its unique location and function, PVAT has been regarded as a new type of adipose tissue distinct from traditional visceral fat. It releases adipokines with vasoconstrictive functions, which regulate vascular function through paracrine and endocrine mechanisms. Interestingly, PVAT can be categorized as white, brown or a mixture of both depending on its anatomical location. Brown adipose tissue (BAT) is located adjacent to the thoracic aorta in rodents, while a mix of brown and white tissue surrounds the abdominal aorta. PVAT exhibits regional phenotypic differences in different parts of the vasculature bed, which may lead to heterogeneity in the secretion profiles and norepinephrine (NE) content in regional PVAT and subsequently affect the regulation of specific adipokine signaling pathways in regional PVAT, resulting in differences in the regulation of vascular function. The aim of this review was to explore the potential factors that influence the anticontractile function of regional PVAT in the vasculature, including the heterogeneity of regional PVAT, the anticontractile function mediated by endothelial nitric oxide synthase (eNOS) in regional PVAT, the activity of the adiponectin-eNOS pathway in regional PVAT adipocytes, and the concentration of the sympathetic neurotransmitter NE in regional PVAT.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1499340"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single and consecutive 10-day remote ischemic preconditioning modify physical performance, post-exercise exerkine levels, and inflammation.","authors":"Magdalena Kochanowicz, Paulina Brzezinska, Jan Mieszkowski, Andrzej Kochanowicz, Bartlomiej Niespodzinski, Marcin Surmiak, Joanna Reczkowicz, Andzelika Borkowska, Jedrzej Antosiewicz","doi":"10.3389/fphys.2024.1428404","DOIUrl":"10.3389/fphys.2024.1428404","url":null,"abstract":"<p><strong>Purpose: </strong>Remote ischemic preconditioning (RIPC) is a method of protection against induced ischemia reperfusion injury, and an increasing number of studies showed some of its inconclusive ergogenic effects in sports. RIPC involves short cycles of cuff inflation followed by its deflation which may affect many body systems. While most of the studies focus on single RIPC effects, there is insufficient data regarding training-like repeated RIPC interventions. Thus, in this study, we analyzed the effect of a single- and consecutive 10-day RIPC procedure on a single leg, focusing on the exerkine levels and changes in inflammation markers following the Wingate Anaerobic Test (WAnT).</p><p><strong>Methods: </strong>Two single-blinded, sham-controlled protocols were designed to evaluate the 1) single (crossover study) and 2) consecutive 10-day (parallel study) RIPC effects on the WAnT performance and exercise-induced lactate, glucose, exerkine, and inflammation markers (BDNF; IL-6; IL-10; IL-15; LIF; oncostatin M). In each protocol, 37 physically active men (19.98 ± 1.17 years) were randomly assigned into two groups according to a particular study design.</p><p><strong>Results: </strong>An increase in participants' mean (4.81%, p < 0.05) and peak power (6.25%, p < 0.05) during the WAnT was observed only after the consecutive 10-day RIPC. Similarly, a significant 15.5% (p < 0.05) decrease in the IL-6 concentration 120 min after the WAnT was observed only in the consecutive 10-day RIPC protocol, as well as a 12.2% (p < 0.01) increase in oncostatin M 60 min after the WAnT.</p><p><strong>Conclusion: </strong>The results demonstrate the efficacy of the consecutive 10-day RIPC procedure in modulating exercise performance and post-exercise inflammation markers.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1428404"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of lipid droplets-mitochondria coupling in obesity and metabolic syndrome: insights and pharmacological implications.","authors":"Chunmei Zhang, Mingxuan Zheng, Runlin Bai, Jiale Chen, Hong Yang, Gan Luo","doi":"10.3389/fphys.2024.1491815","DOIUrl":"10.3389/fphys.2024.1491815","url":null,"abstract":"<p><p>Abnormal lipid accumulation is a fundamental contributor to obesity and metabolic disorders. Lipid droplets (LDs) and mitochondria (MT) serve as organelle chaperones in lipid metabolism and energy balance. LDs play a crucial role in lipid storage and mobilization, working in conjunction with MT to regulate lipid metabolism within the liver, brown adipose tissue, and skeletal muscle, thereby maintaining metabolic homeostasis. The novelty of our review is the comprehensive description of LD and MT interaction mechanisms. We also focus on the current drugs that target this metabolism, which provide novel approaches for obesity and related metabolism disorder treatment.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1491815"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SRPNet: stroke risk prediction based on two-level feature selection and deep fusion network.","authors":"Daoliang Zhang, Na Yu, Xiaodan Yang, Yang De Marinis, Zhi-Ping Liu, Rui Gao","doi":"10.3389/fphys.2024.1357123","DOIUrl":"10.3389/fphys.2024.1357123","url":null,"abstract":"<p><strong>Background: </strong>Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging.</p><p><strong>Methods: </strong>A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is proposed to solve the problem mentioned above. First, the two-level feature selection method is used to screen comprehensive features related to stroke risk, enabling accurate identification of significant risk factors while eliminating redundant information. Next, the deep fusion network integrating Transformer and fully connected neural network (FCN) is utilized to establish the risk prediction model SRPNet for stroke patients.</p><p><strong>Results: </strong>We evaluate the performance of the SRPNet using screening data from the China Stroke Data Center (CSDC), and further validate its effectiveness with census data on stroke collected in affiliated hospital of Jining Medical University. The experimental results demonstrate that the SRPNet model selects features closely related to stroke and achieves superior risk prediction performance over benchmark methods.</p><p><strong>Conclusions: </strong>SRPNet can rapidly identify high-quality stroke risk factors, improve the accuracy of stroke prediction, and provide a powerful tool for clinical diagnosis.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1357123"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}