将心肌收缩性概念化为心肌收缩的一种紧急特性。

IF 3.2 3区 医学 Q2 PHYSIOLOGY
Frontiers in Physiology Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1499536
Serena Y Kuang, Gorune Geloian
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引用次数: 0

摘要

心肌收缩力是广泛用于描述心肌力学功能的一个基本概念,但其在教科书和文献中的定义是模糊的、不一致的,甚至经常是相互矛盾的。在本文中,我们将这些问题分为五类,并进行概念分析,从更广泛、更全面的角度重新定义MC。我们提出了一个功能性的、由能力/资源、适应性和能力(肌肉收缩时产生的力(F)和/或速度(V))组成的MC三域框架,强调了三个域之间动态的、非线性的相互作用及其临床意义。具体来说,我们强调了针对MC的干预如何产生非线性效应,建议转向优化资源利用,而不是最大化输出(即,心肌收缩的F和/或V,能力域的输出),这可能会减少正性肌力干预的并发症。我们还讨论了作为三域MC框架副产品的几个新概念发展的含义。此外,我们还简要地确定了MC的系统级突发性特性,包括收缩效率、昼夜节律依赖性、温度依赖性和历史依赖性,这对心肌研究、运动训练和临床决策具有重要意义。MC的三域功能框架解决了定义上的不一致,将MC与心脏表现区分开来,并为促进实验研究和治疗策略提供了一个结构化的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Conceptualizing myocardial contractility as an emergent property that characterizes myocardial contraction.

Myocardial contractility (MC) is a fundamental concept that is widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, and often contradictory. In this article, we categorize these many issues into five groups and conducts a conceptual analysis to redefine MC from a broader, more comprehensive perspective. We propose a functional, three-domain framework of MC consisting of capacity/resource, adaptability, and ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing the dynamic, non-linear interactions among the three domains and their clinical significance. Specifically, we highlight how interventions targeting MC may produce non-linear effects, suggesting a shift toward optimizing resource use rather than maximizing outputs (i.e., F and/or V of myocardial contraction, the outputs of the ability domain), which could potentially reduce the complications of positive inotropic interventions. We also discuss the implications of several new conceptual developments as the byproducts of the three-domain MC framework. Additionally, we identify system-level emergent properties of MC briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, and history-dependence, with implications for cardiac muscle research, exercise training, and clinical decision-making. The three-domain functional framework of MC resolves the inconsistencies in definitions, differentiates MC from cardiac performance, and offers a structured perspective for facilitating both experimental studies and therapeutic strategies.

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来源期刊
CiteScore
6.50
自引率
5.00%
发文量
2608
审稿时长
14 weeks
期刊介绍: Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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