{"title":"将心肌收缩性概念化为心肌收缩的一种紧急特性。","authors":"Serena Y Kuang, Gorune Geloian","doi":"10.3389/fphys.2025.1499536","DOIUrl":null,"url":null,"abstract":"<p><p>Myocardial contractility (MC) is a fundamental concept that is widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, and often contradictory. In this article, we categorize these many issues into five groups and conducts a conceptual analysis to redefine MC from a broader, more comprehensive perspective. We propose a functional, three-domain framework of MC consisting of capacity/resource, adaptability, and ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing the dynamic, non-linear interactions among the three domains and their clinical significance. Specifically, we highlight how interventions targeting MC may produce non-linear effects, suggesting a shift toward optimizing resource use rather than maximizing outputs (i.e., F and/or V of myocardial contraction, the outputs of the ability domain), which could potentially reduce the complications of positive inotropic interventions. We also discuss the implications of several new conceptual developments as the byproducts of the three-domain MC framework. Additionally, we identify system-level emergent properties of MC briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, and history-dependence, with implications for cardiac muscle research, exercise training, and clinical decision-making. The three-domain functional framework of MC resolves the inconsistencies in definitions, differentiates MC from cardiac performance, and offers a structured perspective for facilitating both experimental studies and therapeutic strategies.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1499536"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040998/pdf/","citationCount":"0","resultStr":"{\"title\":\"Conceptualizing myocardial contractility as an emergent property that characterizes myocardial contraction.\",\"authors\":\"Serena Y Kuang, Gorune Geloian\",\"doi\":\"10.3389/fphys.2025.1499536\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Myocardial contractility (MC) is a fundamental concept that is widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, and often contradictory. In this article, we categorize these many issues into five groups and conducts a conceptual analysis to redefine MC from a broader, more comprehensive perspective. We propose a functional, three-domain framework of MC consisting of capacity/resource, adaptability, and ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing the dynamic, non-linear interactions among the three domains and their clinical significance. Specifically, we highlight how interventions targeting MC may produce non-linear effects, suggesting a shift toward optimizing resource use rather than maximizing outputs (i.e., F and/or V of myocardial contraction, the outputs of the ability domain), which could potentially reduce the complications of positive inotropic interventions. We also discuss the implications of several new conceptual developments as the byproducts of the three-domain MC framework. Additionally, we identify system-level emergent properties of MC briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, and history-dependence, with implications for cardiac muscle research, exercise training, and clinical decision-making. The three-domain functional framework of MC resolves the inconsistencies in definitions, differentiates MC from cardiac performance, and offers a structured perspective for facilitating both experimental studies and therapeutic strategies.</p>\",\"PeriodicalId\":12477,\"journal\":{\"name\":\"Frontiers in Physiology\",\"volume\":\"16 \",\"pages\":\"1499536\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040998/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fphys.2025.1499536\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fphys.2025.1499536","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Conceptualizing myocardial contractility as an emergent property that characterizes myocardial contraction.
Myocardial contractility (MC) is a fundamental concept that is widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, and often contradictory. In this article, we categorize these many issues into five groups and conducts a conceptual analysis to redefine MC from a broader, more comprehensive perspective. We propose a functional, three-domain framework of MC consisting of capacity/resource, adaptability, and ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing the dynamic, non-linear interactions among the three domains and their clinical significance. Specifically, we highlight how interventions targeting MC may produce non-linear effects, suggesting a shift toward optimizing resource use rather than maximizing outputs (i.e., F and/or V of myocardial contraction, the outputs of the ability domain), which could potentially reduce the complications of positive inotropic interventions. We also discuss the implications of several new conceptual developments as the byproducts of the three-domain MC framework. Additionally, we identify system-level emergent properties of MC briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, and history-dependence, with implications for cardiac muscle research, exercise training, and clinical decision-making. The three-domain functional framework of MC resolves the inconsistencies in definitions, differentiates MC from cardiac performance, and offers a structured perspective for facilitating both experimental studies and therapeutic strategies.
期刊介绍:
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.