Frontiers in Physiology最新文献

{"title":"Development of the MetFlex Index™: associations between cardiometabolic risk factors and fitness using a novel approach with blood lactate.","authors":"Bryan Jasker, Daniel Dodd, Clara B Peek, Garett J Griffith","doi":"10.3389/fphys.2025.1546458","DOIUrl":"https://doi.org/10.3389/fphys.2025.1546458","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiometabolic health is declining in the U.S. and anticipated to worsen over the next 30 years. Measurements of cardiometabolic health include blood metabolite profiles. One such metabolite is blood lactate. Lactate assessment is common in critical care and performance settings but less frequently used for the general population. The delayed onset of lactate accumulation during exercise may be an indicator of cardiometabolic health. Assessing lactate during a submaximal exercise test may assist in describing cardiometabolic health status in terms of metabolic fitness and metabolic flexibility.</p><p><strong>Objectives: </strong>To introduce the MetFlex Index™ (MFI), a novel, scalable exercise-based and marker of cardiometabolic health, and to characterize its associations with routinely assessed cardiometabolic health risk factors.</p><p><strong>Methods: </strong>Participants completed a submaximal test on a commercial stationary cycle following assessments of body composition, anthropometrics, vital signs, and a blood draw. Lactate was collected at each stage and the 1^st and 2^nd lactate thresholds were described. The MFI was calculated by using the power, in Watts, attained at the 1^st lactate threshold relative to the participant's Body Mass Index (BMI).</p><p><strong>Results: </strong>Data were collected on 827 participants (43 ± 13 years, 67% male, 72% overweight or obese). MFI peaked in the 30-39 year old cohort and decreased in subsequent decades. MFI was negatively associated with most markers of anthropometry, body composition, blood pressure, and was not associated with most blood metabolites.</p><p><strong>Discussion: </strong>The MetFlex Index™ is a novel exercise-based approach using blood lactate to characterize skeletal muscle metabolism and is associated with several cardiometabolic health indices.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1546458"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability with circadian rhythm removed achieved high accuracy for stress assessment across all times throughout the day.","authors":"Yafei Shen, Zihan Fang, Tao Zhang, Feng Yu, Ying Xu, Ling Yang","doi":"10.3389/fphys.2025.1535331","DOIUrl":"https://doi.org/10.3389/fphys.2025.1535331","url":null,"abstract":"<p><strong>Background: </strong>Assessing real-time stress in individuals to prevent the accumulation of stress is necessary due to the adverse effects of excessive psychological stress on health. Since both stress and circadian rhythms affect the excitability of the nervous system, the influence of circadian rhythms needs to be considered during stress assessment. Most studies train classifiers using physiological data collected during fixed short time periods, overlooking the assessment of stress levels at other times.</p><p><strong>Methods: </strong>In this work, we propose a method for training a classifier capable of identifying stress and resting states throughout the day, based on 10 short-term heart rate variability (HRV) feature data obtained from morning, noon, and evening. To characterize the circadian rhythms of HRV features, heartbeat interval data were collected and analyzed from 50 volunteers over three consecutive days. The circadian rhythm trends in the HRV features were then removed using the Smoothness Priors Approach (SPA), and XGBoost models were trained to assess stress.</p><p><strong>Results: </strong>The results show that all HRV features exhibit 12-h and 24-h circadian rhythms, and the circadian rhythm differences across different days for individuals are relatively small. Furthermore, training classifiers on detrended data can improve the overall accuracy of stress assessment across all time periods. Specifically, when combining data from different time periods as the training dataset, the accuracy of the classifier trained on detrended data increases by 13.67%.</p><p><strong>Discussion: </strong>These findings indicate that using HRV features with circadian rhythm trends removed is an effective method for assessing stress at all times throughout the day.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1535331"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The membrane-associated β2e-subunit of voltage-gated calcium channels translocates to the nucleus and regulates gene expression.","authors":"Erick Miranda-Laferte, Katalin Barkovits, Svitlana Rozanova, Nadine Jordan, Katrin Marcus, Patricia Hidalgo","doi":"10.3389/fphys.2025.1555934","DOIUrl":"https://doi.org/10.3389/fphys.2025.1555934","url":null,"abstract":"<p><p>The β-subunit (Cavβ) is a central component of the voltage-gated calcium channel complex. It lacks transmembrane domains and exhibits both channel-related and non-related functions. Previous studies have shown that, in the absence of the Cavα1 pore-forming subunit, electrostatic interactions between the N-terminus of Cavβ2e and the plasma membrane mediate its anchoring to the cell surface. Here, we demonstrate that, upon phospholipase C activation, Cavβ2e dissociates from the plasma membrane and homogeneously distributes between the cytosol and the nucleus. Mutagenesis analysis identified critical residues in the N-terminus of the protein, including a stretch of positively charged amino acids and a dileucine motif, which serve as nuclear import and export signals, respectively. Fusion of the Cavβ2e N-terminus to a trimeric YFP chimeric construct shows that this segment suffices for nuclear shuttling. Thus, the N-terminus of Cavβ2e emerges as a regulatory hotspot region controlling the subcellular localization of the protein. Quantitative mass spectrometry analysis revealed that the heterologous expression of a nuclear-enriched Cavβ2e mutant regulates gene expression. Our findings demonstrate the presence of active nuclear localization signals in Cavβ2e that enables its nuclear targeting and regulation of protein expression. Furthermore, they establish the membrane-associated Cavβ2e as a novel signaling mediator within the phospholipase C cascade.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1555934"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of detection methods of fetomaternal haemorrhage.","authors":"Xinyang Li, Changfei Li, Tiemei Liu","doi":"10.3389/fphys.2025.1445757","DOIUrl":"https://doi.org/10.3389/fphys.2025.1445757","url":null,"abstract":"<p><p>Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother's blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1445757"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemidiaphragm work in large pleural effusion and its insignificant impact on blood gases: a new insight based on <i>in silico</i> study.","authors":"Tomasz Gólczewski, Anna M Stecka, Elżbieta M Grabczak, Marcin Michnikowski, Monika Zielińska-Krawczyk, Rafał Krenke","doi":"10.3389/fphys.2025.1539781","DOIUrl":"https://doi.org/10.3389/fphys.2025.1539781","url":null,"abstract":"<p><strong>Objective: </strong>Computer simulations, enabling observations of variables inaccessible in living patients, provide a powerful approach to studying complex physiological phenomena. This <i>in silico</i> study presents the use of a virtual patient to investigate the impact of large pleural effusion (PE) and therapeutic thoracentesis (TT) on hemidiaphragm function and arterial blood gases.</p><p><strong>Methods: </strong>Inspired by unexpected phenomena observed in living patients undergoing large-volume TT, we formulated four questions regarding this impact. To answer these questions, we simulated right-sided PE in our virtual patient and studied changes in the pleural pressure in the ipsilateral hemithorax (Ppli) and lung volume during the respiratory cycle (exemplified by Ppli-V loops, where V is the volume of both lungs), airflows in the main bronchi, and alveolar O2 (PAO2) and CO2 (PACO2) partial pressures.</p><p><strong>Results: </strong>Simulations highlighted that: (a) mediastinal compliance critically affects hemidiaphragm work; (b) the 8-shaped Ppli-V loops are associated with hemidiaphragm inversion, where exhalation from the ipsilateral lung occurs during a part of both the inspiratory and expiratory phases, and vice versa; (c) pre-TT PAO2 may be elevated due to reduction of the tidal volume to end-expiratory lung volume ratio; and (d) pre-TT Ppli amplitudes during respiration can exceed post-TT values when mediastinal compliance is high.</p><p><strong>Conclusion: </strong>Our findings emphasize the significance of mediastinal compliance in pleural effusion physiology and suggest insignificant influence of the ipsilateral hemidiaphragm inverted due to large PE on arterial gas tensions. This study underscores the utility of virtual patient models for elucidating unexpected physiological behaviors and optimizing clinical interventions.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1539781"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Clinical uses and alternative approaches of frailty determination.","authors":"Kenneth L Seldeen, John A Batsis","doi":"10.3389/fphys.2025.1575742","DOIUrl":"https://doi.org/10.3389/fphys.2025.1575742","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1575742"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms underlying targeted mitochondrial therapy for programmed cardiac cell death.","authors":"Fengting Jing, Min Zhao, Hemin Xiong, Xin Zeng, Jun Jiang, Tao Li","doi":"10.3389/fphys.2025.1548194","DOIUrl":"https://doi.org/10.3389/fphys.2025.1548194","url":null,"abstract":"<p><p>Heart diseases are common clinical diseases, such as cardiac fibrosis, heart failure, hypertension and arrhythmia. Globally, the incidence rate and mortality of heart diseases are increasing by years. The main mechanism of heart disease is related to the cellular state. Mitochondrion is the organ of cellular energy supply, participating in various signal transduction pathways and playing a vital role in the occurrence and development of heart disease. This review summarizes the cell death patterns and molecular mechanisms associated with heart disease and mitochondrial dysfunction.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1548194"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of contrast compression therapy and water immersion contrast therapy on biomechanical parameters of the forearm muscles in martial arts athletes.","authors":"Robert Trybulski, Jarosław Muracki, Robert Roczniok, Wacław Kuczmik, Nicola Lovecchio, Adrian Kużdżał","doi":"10.3389/fphys.2025.1494762","DOIUrl":"https://doi.org/10.3389/fphys.2025.1494762","url":null,"abstract":"<p><strong>Objective: </strong>This study compared the immediate effects of game-ready contrast therapy (GRT) and contrast water immersion therapy (CWT) on stiffness, muscle tone, flexibility, pressure pain threshold, and isometric muscle strength.</p><p><strong>Design: </strong>Experimental, single-blind, randomized controlled trial. Thirty volunteers training MMA (age: 28.20 ± 7.57 years, BMI: 26.35 ± 4.06, training experience: 10.37 ± 7.34) were randomized to two groups: experimental (n = 15) and control (n = 15). In the first phase, the experimental group underwent GRT and the control-game-ready sham therapy (GRS). After a 2-week break, the experimental group underwent CWT and the control-contrast water sham therapy (CWS). The main outcome measures were muscle tone (T) stiffness (S) elasticity (E), pressure pain threshold (PPT), and maximum isometric strength (Fmax) assessed before therapy (Rest) and 5-min and 1-h after treatment (PostTh5min and PostTh1h).</p><p><strong>Results: </strong>Analysis of variance results for T, S, E, PPT, and Fmax showed statistically significant differences (p < 0.0001) for main effects and interactions. For both therapies GRT and CWT: T, S, and E were lower 5 min after therapy and 1 h after therapy compared to Rest (interaction effect, p < 0.00001). For both therapies GRT and CWT the PPT and Fmax were higher 5min and 1 h after therapy compared to Rest (interaction effect, p < 0.0001). The <i>post hoc</i> test showed statistically significant differences (p < 0.0001) for T, S, E, PPT, and Fmax in the experimental groups (GRT and CWT) for Rest-PostTh5min and Rest-Post1h. No statistically significant differences were found for Post5mi-Post1h. The effect size of Cohen's d for S, E, PPT, and Fmax showed similar values, with only T being significantly more pronounced in the GRT group (large, d > 0.8). There were no statistically significant differences (p > 0.05) in the control groups (GRT for GRS and CWT for CWS) in the Rest-PostTh5min-PostTh1h range.</p><p><strong>Conclusion: </strong>The positive impact of both contrast therapy strategies as a stimulus influencing important aspects of biomechanics was confirmed. The results showed similar effects of CWT and GRT (both similarly lowering S and E and increasing Fmax and PPT) except for the analysis of muscle tone, where the lowering effect of GRT had larger effect. These findings can be directly applied by researchers, sports medicine specialists, and martial arts trainers interested in the biomechanical effects of therapy on athletes, improving their understanding and practice.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1494762"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of resistance training on gluteus maximus hypertrophy: a systematic review and meta-analysis.","authors":"Walter Krause Neto, Thaís Lima Vieira Krause, Eliane Florencio Gama","doi":"10.3389/fphys.2025.1542334","DOIUrl":"https://doi.org/10.3389/fphys.2025.1542334","url":null,"abstract":"<p><p>This systematic review aims to examine and synthesize the existing literature regarding gluteus maximus (GMax) hypertrophy as a result of dynamic exercises that incorporate hip extension with external resistance. A comprehensive search was undertaken across the following databases: PubMed/Medline, SportDiscuss, Scopus, Web of Science, CINAHL, Science Direct, Google Scholar, and ResearchGate. Twelve articles met the established inclusion criteria, leading to the subsequent key findings: 1) resistance training exhibits a moderate effect on GMax hypertrophy (11 studies, SMD 0.71, 95% CI [0.50, 0.91], p < 0.00001, I² = 22%); 2) subgroup analyses of single (seven studies, SMD 0.74, 95% CI [0.36, 1.13], p = 0.0001, I² = 52%) and combined (six studies, SMD 0.68, 95% CI [0.44, 0.92], p < 0.00001, I² = 0%) training protocols have demonstrated moderate effects; 3) when emphasizing GMax hypertrophy at the expense of other muscle groups, single exercises, such as the barbell hip thrust, should be prioritized; 4) back squats performed in parallel or full range of motion significantly enhance GMax hypertrophy; 5) leg press machines and kneeling hip extensions can also facilitate increased GMax hypertrophy; 6) training programs that incorporate combined hip extension exercises, whether single-joint or multi-joint, significantly promote an increase in GMax hypertrophy. This study concludes that a variety of exercises-whether focused on a specific joint (single-joint) or encompassing multiple joints (multi-joint)-can effectively stimulate GMax hypertrophy, whether executed individually or in combination.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1542334"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of blood flow restriction training on post activation potentiation and fatigue level: systematic review with meta-analysis.","authors":"Nannan Zeng, Haiyang Liu, Jian Wang, Lizhu Jiang","doi":"10.3389/fphys.2025.1558008","DOIUrl":"https://doi.org/10.3389/fphys.2025.1558008","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to comprehensively explore the effects of blood flow restriction (BFR) training on the post-activation potentiation (PAP) and the rating of perceived exertion (RPE) through meta-analysis, so as to provide a scientific basis for athletes' physical fitness training.</p><p><strong>Methods: </strong>The PubMed, CNKI, Web of Science and EBSCO databases were searched to look for randomized controlled trials (RCTs) on the effects of BFRT on post-activation potentiation (PAP) and the rating of perceived exertion (RPE). The Cochrane risk of bias tool was used to screen the literature. With the help of Revman 5.4 and Stata 17.0 software, the literature quality assessment and statistical analysis were completed. Meanwhile, sensitivity analysis and funnel plots were utilized to examine the stability of the results and the publication bias.</p><p><strong>Results: </strong>A total of 31 related studies were included, among which 22 studies focused on the relationship between BFR training and PAP, covering 347 participants. Meta-analysis showed that BFRT could significantly affect PAP [<i>SMD</i> = 0.49, 95% CI (0.20, 0.77), <i>P</i> = 0.0008]. When the testing method was Squat Jump [<i>SMD</i> = 1.35, 95% CI (0.40, 2.30), <i>P</i> < 0.0005], the exercise intensity was 40%-70% 1RM [<i>SMD</i> = 1.21, 95% CI (0.69, 1.73), <i>P</i> < 0.0001], and the compression intensity was ≤50% AOP [<i>SMD</i> = 0.77, 95% CI (0.24, 1.30), <i>P</i> = 0.05], the effects on PAP reached the maximum, respectively, and were statistically significant. In terms of the impact of BFR training on RPE, 18 studies with 238 subjects were included. BFR training could significantly increase the RPE of the subjects [<i>SMD</i> = 1.21, 95% CI (0.69, 1.73), <i>P</i> < 0.0001]. When the exercise mode was Knee flexion [<i>SMD</i> = 0.65, 95% CI (0.18, 1.11), <i>P</i> = 0.0006], the exercise intensity was Mixed oxygen Training [<i>SMD</i> = 1.03, 95% CI (0.50, 1.56), <i>P</i> = 0.0001], and the compressive strength was ≥60% AOP [<i>SMD</i> = 0.75, 95% CI (0.02, 1.48), <i>P</i> = 0.05], a more significant effect size was presented.</p><p><strong>Conclusion: </strong>Blood flow restriction training can induce the occurrence of post-activation potentiation (PAP). BFR exercises with 40%-70% 1RM and ≤50% AOP are more likely to stimulate PAP. Meanwhile, BFR training will significantly affect the rating of perceived exertion (RPE). BFR training under mixed oxygen training and with a compressive strength of ≥60% AOP has a stronger perception of fatigue. <b>Systematic Review Registration:</b> http://inplasy.com, identifier INPLASY202430008.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1558008"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}