Frontiers in Physiology最新文献

{"title":"The effects of an 8-week complex training program on lower limb explosive power and movement agility in adolescent female badminton players.","authors":"Rui Hu, Minchen Zhao, Xiang Shen, Zhiming Wang","doi":"10.3389/fphys.2025.1678866","DOIUrl":"10.3389/fphys.2025.1678866","url":null,"abstract":"<p><strong>Background: </strong>Badminton requires high-intensity lower limb explosive power and agility for executing rapid lunges, jumps, and directional changes. Complex training (CT) combines heavy resistance exercises with plyometric activities to enhance maximal strength and explosive performance through post-activation performance enhancement (PAPE). However, limited research exists on CT effects in adolescent female badminton players.</p><p><strong>Objective: </strong>To investigate the effects of an 8-week complex training program on lower limb explosive power and movement agility in adolescent female badminton players.</p><p><strong>Methods: </strong>Thirty-two adolescent female badminton players were randomly allocated into complex training group (CT group, n = 16, age: 15.69 ± 0.95 years) and resistance training group (RT group, n = 16, age: 15.63 ± 1.15 years). The CT group performed resistance exercises (75%-85% 1RM) paired with plyometric exercises twice weekly for 8 weeks, while the RT group completed traditional resistance training with the same frequency. Pre- and post-intervention assessments included squat jump (SJ), countermovement jump (CMJ), bilateral and unilateral jumps, sprint tests (5 m, 10 m, 15 m, 20 m), hexagon test, modified 505 change of direction (COD) test, on-court COD test, and isometric mid-thigh pull (IMTP). Two-way repeated measures ANOVA was used for statistical analysis (p < 0.05).</p><p><strong>Results: </strong>Significant group × time interactions were observed for SJ, CMJ, unilateral jumps, sprint performance (5 m, 10 m, 20 m), and agility tests (all p < 0.05). The CT group showed greater improvements compared to RT group: SJ (1.83 cm vs. 0.95 cm, Cohen's d = 1.196 vs. 0.642), CMJ (3.64 cm vs. 1.27 cm, Cohen's d = 1.949 vs. 0.681), 5 m sprint (0.18s vs. 0.06s improvement, Cohen's d = 1.889 vs. 0.667), hexagon test (1.29s vs. 0.03s improvement), and COD performance. Both groups significantly improved IMTP with no between-group differences (p > 0.05).</p><p><strong>Conclusion: </strong>An 8-week complex training program elicited significantly greater improvements in lower limb explosive power, sprint acceleration, and multidirectional agility compared to traditional resistance training in adolescent female badminton players. These findings suggest CT is an effective, sport-specific training intervention that capitalizes on the heightened neuromuscular plasticity of adolescent athletes.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1678866"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of a multi-strain probiotic and zinc-glycine chelate, administered <i>in ovo</i>, on immune response in newly hatched chicks.","authors":"Artur Ciszewski, Łukasz S Jarosz, Zbigniew Grądzki, Agnieszka Marek, Beata Kaczmarek, Marcin Hejdysz, Anna Rysiak","doi":"10.3389/fphys.2025.1646143","DOIUrl":"10.3389/fphys.2025.1646143","url":null,"abstract":"<p><strong>Introduction: </strong>The supplementation of chicken embryos with bioactive compounds may elicit a beneficial effect on the development of their gut microbiome and enhance protection against infectious agents after hatching. Therefore, this study aimed to evaluate the effect of <i>in ovo</i> co-supplementation with a multi-strain probiotic and zinc-glycine chelate on the levels of pro- and anti-inflammatory cytokines, acute-phase proteins, and immunoglobulins in the peripheral blood and tissues of broiler chickens on the day of hatching and 7 days post hatching. The effect of supplementation on the growth parameters of chickens was assessed as well.</p><p><strong>Methods: </strong>The study was conducted on 1,500 hatching eggs from a broiler breeding flock (Ross × Ross 308) at 36 weeks. ELISA kits were used to determine levels of acute-phase proteins and immunoglobulins. Expression of immunoglobulins was determined by means of qRT-PCR.</p><p><strong>Results: </strong>The results indicate enhanced synthesis of acute-phase proteins in the liver and increased levels of serum amyloid A in the small intestine tissue, as well as IgA and IgM mRNA and suppressed synthesis of pro-inflammatory cytokines IFN-γ and TNF-α. During the cumulative experimental period (days 0-42), the mean body weight gain (BWG) and feed intake (FI) in the group supplemented with a multi-strain probiotic were statistically significantly lower than the control group.</p><p><strong>Discussion: </strong>It may be concluded that the combined in ovo use of a multi-strain probiotic and Zn-Gly chelate modulates the immune response, helps maintain the balance between the synthesis of Th1 and Th2 cytokines, inhibits inflammatory processes, and stimulates immune system development.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1646143"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.","authors":"Elric Y Allison, Anjali M Bedi, Aedan J Rourke, Vanessa Mizzi, Jeremy J Walsh, Jennifer J Heisz, Baraa K Al-Khazraji","doi":"10.3389/fphys.2025.1606267","DOIUrl":"10.3389/fphys.2025.1606267","url":null,"abstract":"<p><p>Reduced cerebral blood flow (CBF) and cerebrovascular function are critical early-stage biomarkers preceding changes in brain function and structure observed in normal aging and during the onset and progression of Alzheimer's Disease and related dementias (ADRD). Though several interventions attempt to curb the effects of aging and brain neurodegeneration, exercise and lifestyle habits remain one of the most impactful and easily modifiable factors for preserving brain health. Although the effects of aerobic exercise on cerebrovascular function and brain health are well established, resistance training (RT) is rapidly increasing in popularity across all age demographics due to its numerous health benefits. Despite the clear physiological benefits of resistance exercise, its potential efficacy for preserving or improving cerebrovascular and overall brain health remains understudied to date. The aim of this review is to examine the literature pertaining to ways in which resistance exercise may reduce the risk of ADRD and slow age-related decline of brain structures and functions. Additionally, this review seeks to highlight key considerations and challenges regarding the feasibility, adoption, and adherence to resistance exercise in the context of normal aging, mild cognitive impairment, and ADRD.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1606267"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating arm swing via haptic cueing alters interlimb neural coupling in older adults.","authors":"Ines Khiyara, Ben Sidaway, Babak Hejrati","doi":"10.3389/fphys.2025.1657092","DOIUrl":"10.3389/fphys.2025.1657092","url":null,"abstract":"<p><strong>Purpose: </strong>Age-related gait impairments are strongly associated with increased fall risk, disability, and mortality. While traditional rehabilitation focuses on the lower limbs, arm movements play a key role in stabilizing gait through interlimb neural coupling. This study investigates whether rhythmic haptic cueing of arm swing, which enhances gait, affects interlimb neuromuscular coordination in older adults.</p><p><strong>Methods: </strong>Seventeen older adults (mean age = 73.2 <math><mrow><mo>±</mo></mrow> </math> 6.0 years) completed three walking conditions: Baseline walking, self-selected Fast walking, and walking while rhythmically receiving haptic cues (Cueing) to increase arm swing frequency and walking speed. Gait speed, arm range of motion (ROM), and intermuscular coherence were analyzed using inertial measurement units (IMUs) and surface Electromyography (sEMG). Coherence and directionality analyses were performed in the alpha (8-15 Hz), beta (15-30 Hz), and gamma (30-60 Hz) frequency bands to quantify neural coupling and intermuscular directionality.</p><p><strong>Results: </strong>Rhythmic Cueing significantly increased arm ROM and gait speed compared to Baseline walking, with improvements comparable to Fast walking. Overall upper-lower limb coherence increased in the alpha and beta bands during Cueing compared to Baseline, with Cueing also exceeding Fast in the alpha band. In specific muscle pairings, significant alpha-band effects were observed in contralateral shoulder-leg pairs, specifically between the left anterior deltoid and right rectus femoris, and between the left posterior deltoid and right biceps femoris. Directionality analysis revealed dominant zero-lag coherence, reflecting shared subcortical and cortical drive in the alpha and beta/gamma bands, respectively, and greater forward-lag coherence during Cueing compared to Baseline, indicating enhanced cortical arm-to-leg influence.</p><p><strong>Significance: </strong>These findings demonstrate that externally cued arm swing can modulate gait performance and potentially interlimb neural coupling, activating both subcortical and cortical pathways. Rhythmic haptic cueing shows promise as an intervention for older adults, supporting its potential integration into home-based gait rehabilitation programs.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1657092"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key lipid metabolism-related genes in kidney fibrosis: implications for chronic kidney disease management.","authors":"Qiuyu Cao, Longhui Liu, Sai Zhou, Yang Fei, Yi Guo, Yin Li, Shengyun Sun, Aicheng Yang","doi":"10.3389/fphys.2025.1652513","DOIUrl":"10.3389/fphys.2025.1652513","url":null,"abstract":"<p><strong>Background: </strong>Kidney fibrosis (KF) represents a critical pathological alteration in the end stage of chronic kidney disease (CKD) and is the ultimate cause of mortality. Lipid metabolism plays a significant role in the pathogenesis of KF. Therefore, biomarkers associated with lipid metabolism will be identified to guide the treatment and management of CKD.</p><p><strong>Methods: </strong>Three datasets obtained from the GEO database, along with 760 lipid metabolism-related genes sourced from two databases, were utilized to identify lipid metabolism-associated differentially expressed genes (LMDEGs) in KF. Subsequently, we performed GO, KEGG and ssGSEA enrichment analysis to elucidate the characteristics of LMDEGs. Then, machine learning was applied to identify core LMDEGs, Least Absolute Shrinkage and Selection Operator (LASSO) was utilized to construct a diagnostic model, and Receiver Operation Curve (ROC) was operated to evaluate the diagnostic performance. We used unsupervised hierarchical clustering to identify subtypes of KF associated with lipid metabolism and employed Gene Set Variation Analysis (GSVA) to examine differences among clusters. Finally, transcription factor and miRNA regulatory networks upstream of core LMDEGs were constructed using Cytoscape software.</p><p><strong>Results: </strong>We identified 54 LMDEGs and constructed a six core LMDEGs (UGCG, SFRP1A6, OSBPL6, INPP5J, PNPLA3, and GK) predictive model by LASSO regression, achieving area under the curve (AUC) values ranging from 0.723 to 0.774. ssGSEA confirmed that these six core LMDEGs exhibited significant positive or negative correlations with immune cell infiltration. Based on the expression profiles of these core LMDEGs, KF samples were categorized into three distinct subtypes. One subtype is predominantly characterized by enhanced lipid and energy metabolism, another exhibits features of inflammation and immune response activation, while the third displays an intermediate pattern between the two extremes. Moreover, the regulatory network of these core LMDEGs shared several common transcription factors, suggesting a potential interplay between lipid metabolism and immune responses in the pathogenesis of KF.</p><p><strong>Conclusion: </strong>We have identified six core LMDEGs that are significantly associated with KF. Based on this, we have established three distinct clusters related to lipid metabolism in KF, which may provide valuable insights into the treatment and management of CKD.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1652513"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A kinematic analysis of the hammer throw technique in elite female athletes: a comparative study between Chinese and international competitors.","authors":"Weijie Liu, Yiling Ding, Ruihua He, Jianchen Li","doi":"10.3389/fphys.2025.1590350","DOIUrl":"10.3389/fphys.2025.1590350","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the kinematic features of the hammer throw technique among elite female athletes worldwide, which is essential for advancing the development of women's hammer throw in China. By examining the technical differences between Chinese female hammer throwers and their international counterparts, this research offers data support to help Chinese athletes further refine and optimise their throwing techniques, thereby strengthening the scientific basis of training in this discipline.</p><p><strong>Results: </strong>The study found that the average release velocity of Chinese athletes was lower than that of world-class athletes, with Zheng Wang recording the highest release velocity among the Chinese throwers. There was minimal difference in the average release angle between Chinese and international athletes. Apart from Zheng Wang, most Chinese athletes showed irregular timing in their average rotational phases, which negatively impacted the release phase. Notably, the average preliminary swing speed of Chinese athletes was markedly higher than that of international athletes, indicating a technical tendency towards active acceleration during the initial rotation phase. Additionally, the average trajectory length per turn among top Chinese athletes was generally longer than that of elite international athletes.</p><p><strong>Conclusion: </strong>The international elite female hammer throwers exhibit superior release-related indices and more effective double-support mechanics compared with their Chinese counterparts. These results highlight the central role of double-support coordination, trunk-pelvis coupling, and phase-specific timing in optimizing release velocity and overall performance. Targeted technical interventions focusing on these elements may help close the performance gap and advance elite-level outcomes.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1590350"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational modeling of cough-induced droplets and mucosal film dynamics in the upper airway for pulmonary disease classification.","authors":"Olusegun J Ilegbusi, Rafid Jahangir Khan, Bari Hoffman","doi":"10.3389/fphys.2025.1666826","DOIUrl":"10.3389/fphys.2025.1666826","url":null,"abstract":"<p><strong>Introduction: </strong>Cough-generated droplets are critical in the transmission and progression of respiratory diseases. This study investigates droplet formation and transport in the upper airway during a cough to improve understanding of their biomechanical behavior and explore their potential for non-invasive classification of airway diseases.</p><p><strong>Methods: </strong>A computational fluid dynamics model is employed to simulate a transient, droplet-laden cough in a CT-derived human upper airway, using an experimentally acquired cough profile. The method incorporates mucus film dynamics using the Eulerian Wall Film (EWF) model and droplet transport using the Discrete Phase Model (DPM). Three mucus thicknesses-healthy baseline (Type I), intermediate pathological thickening (Type II), and advanced pathological thickening (Type III)-and three viscosity levels for Type II: baseline viscosity (Type II-A), intermediate viscosity (Type II-B), and high viscosity (Type II-C) are considered. These cases represent a progressive increase in both mucus thickness and viscosity, encompassing a spectrum of respiratory conditions.</p><p><strong>Results: </strong>The results show that a 50% increase in mucus thickness (from 20 μm to 30 μm) results in 4.3-fold increase in exhaled droplet count and a 20% increase in mean droplet size. Conversely, a 50% increase in mucus viscosity reduces exhaled droplet count by 2.7-fold while increasing mean droplet size by 9%. Absorbed droplets, which remain within the airway, exhibit similar trends; however, as they are not measurable non-invasively, their diagnostic utility is limited.</p><p><strong>Discussion: </strong>These findings highlight the role of mucus in droplet dynamics, with increased thickness and viscosity driving larger droplet sizes, with increased thickness and viscosity driving larger droplet sizes, and support the potential of exhaled droplet size distribution as a diagnostic biomarker for airway disease.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1666826"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Molecular mechanisms of ion channel activation and modulation.","authors":"Meng Cui, Miao Zhang","doi":"10.3389/fphys.2025.1695777","DOIUrl":"https://doi.org/10.3389/fphys.2025.1695777","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1695777"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal challenge significantly alters gene expression in breast muscle of commercial turkey poults.","authors":"Kent M Reed, Sandra G Velleman, Gale M Strasburg","doi":"10.3389/fphys.2025.1651079","DOIUrl":"10.3389/fphys.2025.1651079","url":null,"abstract":"<p><p>Temperature extremes can compromise livestock welfare and pose serious threats to both economic stability and global food security. In commercial poultry production, newly hatched birds are particularly vulnerable to thermal stress, with growth-selected species such as turkeys being at heightened risk. To cope with temperature challenges, poultry undergo metabolic, physiological, and behavioral adaptations-responses that may have lasting effects on muscle development and, ultimately, meat quality. This study examined transcriptional changes in the breast muscle of young commercial turkey poults exposed to acute thermal stress. Hatchlings were brooded for 3 days at one of three temperatures: control (35 °C), cold (31 °C), or heat (39 °C). <i>Pectoralis major</i> muscle samples were collected, RNA extracted, and transcriptomes were analyzed via deep sequencing. Both cold and heat exposure resulted in reduced body weight compared to control poults. Both thermal stress conditions produced significant differential gene expression. In commercial birds, affected genes were involved in muscle differentiation and development, stress adaptation and apoptosis/protein turnover, energy metabolism and nutrient processing, as well as mitochondrial function and oxidative stress response. Notably, cold stress altered genes related to lipid and glucose metabolism (<i>PDK4</i>, <i>ANGPTL4</i> and <i>DGAT2</i>), while heat stress affected genes (<i>C/EBPβ</i> and <i>MUSTN1</i>) were associated with differentiation and development and intracellular lipid accumulation. These findings provide a foundation for further studies into the genetic mechanisms driving physiological responses to thermal challenge in poultry.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1651079"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under the background of the new global definition of ARDS: an interpretable machine learning approach for predicting 28-day ICU mortality in patients with sepsis complicated by ARDS.","authors":"Peijie Zhang, Shuo Yuan, Shuzhan Zhang, Zhiheng Yuan, Zi Ye, Lanxin Lv, Hongning Yang, Hui Peng, Haiquan Li, Ningjun Zhao","doi":"10.3389/fphys.2025.1617196","DOIUrl":"10.3389/fphys.2025.1617196","url":null,"abstract":"<p><strong>Background: </strong>Acute respiratory distress syndrome (ARDS) is a prevalent clinical complication among patients with sepsis, characterized by high incidence and mortality rates. The definition of ARDS has evolved over time, with the new global definition introducing significant updates to its diagnosis and treatment. Our objective is to develop and validate an interpretable prediction model for the prognosis of sepsis patients complicated by ARDS, utilizing machine learning techniques in accordance with the new global definition.</p><p><strong>Methods: </strong>This study extracted data from the MIMIC database (version MIMIC-IV 2.2) to create the training set for our model. For external validation, this study used data from sepsis patients complicated by ARDS who met the new global definition of ARDS, sourced from the Affiliated Hospital of Xuzhou Medical University. Lasso regression with cross-validation was used to identify key predictors of patient prognosis. Subsequently, this study established models to predict the 28-day prognosis following ICU admission using various machine learning algorithms, including logistic regression, random forest, decision tree, support vector machine classifier, LightGBM, XGBoost, AdaBoost, and multi-layer perceptron (MLP). Model performance was assessed using ROC curves, clinical decision curves (DCA), and calibration curves, while SHAP values were utilized to interpret the machine learning models.</p><p><strong>Results: </strong>A total of 905 patients with sepsis complicated by ARDS were included in our analysis, leading to the selection of 15 key variables for model development. Based on the AUC of the ROC curve, as well as DCA and calibration curve results from the training set, the support vector classifier (SVC) model demonstrated strong performance, achieving an average AUC of 0.792 in the internal validation set and 0.816 in the external validation set.</p><p><strong>Conclusion: </strong>The application of machine learning methodologies to construct prognostic prediction models for sepsis patients complicated by ARDS, informed by the new global definition, proves to be reliable. This approach can assist clinicians in developing personalized treatment strategies for affected patients.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1617196"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}