Frontiers in Physiology最新文献

{"title":"Mechanistic insights into effects of the cardiac myosin activator omecamtiv mecarbil from mechanokinetic modelling.","authors":"Alf Månsson","doi":"10.3389/fphys.2025.1576245","DOIUrl":"https://doi.org/10.3389/fphys.2025.1576245","url":null,"abstract":"<p><strong>Introduction: </strong>Small molecular compounds that affect the force, and motion-generating actin-myosin interaction in the heart have emerged as alternatives to treat or alleviate symptoms in severe debilitating conditions, such as cardiomyopathies and heart failure. Omecamtiv mecarbil (OM) is such a compound developed to enhance cardiac contraction. In addition to potential therapeutic use, its effects may help to elucidate myosin energy transduction mechanisms in health and disease and add insights into how the molecular properties govern contraction of large myosin ensembles in cardiac cells. Despite intense studies, the effects of OM are still incompletely understood.</p><p><strong>Methods: </strong>Here we take an <i>in silico</i> approach to elucidate the issue. First, we modify a model, previously used in studies of skeletal muscle, with molecular parameter values for human ventricular β-myosin to make it useful for studies of both myosin mutations and drugs. Repeated tests lead to at a set of parameter values that allow faithful reproduction of range of functional variables of cardiac myocytes. We then apply the model to studies of OM.</p><p><strong>Results and discussion: </strong>The results suggest that major effects of OM such as large reduction of the maximum velocity with more limited effects on maximum isometric force and slowed actin-activated ATPase can be accounted for by two key molecular effects. These encompass a reduced difference in binding free energy between the pre- and post-power-stroke states and greatly increased activation energy for the lever arm swing during the power-stroke. Better quantitative agreement, e.g., isometric force minimally changed from the control value by OM is achieved by additional changes in model parameter values previously suggested by studies of isolated proteins.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1576245"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin in the modulation of bone and cartilage homeostasis: a review on osteoarthritis relief potential.","authors":"Mengtong Zhang, Wengieng Xiong, Ruohan Qiao, Minhan Li, Chuhan Zhang, Chi Yang, Yan Zhu, Jiaying He, Zhigui Ma","doi":"10.3389/fphys.2025.1570157","DOIUrl":"https://doi.org/10.3389/fphys.2025.1570157","url":null,"abstract":"<p><p>Osteoarthritis, a progressive and degenerative joint disease, disrupts the integrity of the entire joint structure, underscoring the urgency of identifying more effective therapeutic strategies and innovative targets. Among these, exercise therapy is considered a key component in the early management of osteoarthritis, functioning by stimulating the secretion of myokines from the skeletal muscle system. Irisin, a myokine predominantly secreted by skeletal muscle during exercise and encoded by the FNDC5 gene, has garnered attention for its regulatory effects on bone health. Emerging evidence suggests that irisin may play a protective role in osteoarthritis by promoting tissue homeostasis, enhancing subchondral bone density and microstructure, and inhibiting chondrocyte apoptosis. By improving chondrocyte viability, preserving extracellular matrix integrity, and maintaining homeostasis in osteoblasts, osteoclasts, and osteocytes, irisin emerges as a promising therapeutic target for osteoarthritis. This review delves into the role of irisin in osteoarthritis pathogenesis, highlighting its influence on cartilage and bone metabolism as well as its dynamic relationship with exercise. Additionally, this review suggests that further exploration on its specific molecular mechanisms, optimization of drug delivery systems, and strategic utilization of exercise-induced benefits will be pivotal in unlocking the full potential of irisin as a novel intervention for osteoarthritis.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1570157"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the <i>in silico</i> adaptation of the Nephroblastoma Oncosimulator to MRI scans, treatment data, and histological profiles of patients from different risk groups.","authors":"Marcel Meyerheim, Foteini Panagiotidou, Eleni Georgiadi, Dimitrios Soudris, Georgios Stamatakos, Norbert Graf","doi":"10.3389/fphys.2025.1465631","DOIUrl":"https://doi.org/10.3389/fphys.2025.1465631","url":null,"abstract":"<p><strong>Introduction: </strong>Nephroblastoma or Wilms' tumor is the most prevalent type of renal tumor in pediatric oncology. Although the overall survival rate for this condition is excellent today (∼90%), there have been no significant improvements over the past two decades. In silico models aim to simulate tumor progression and treatment responses over time; they hold immense potential for enhancing the predictive accuracy and optimizing treatment protocols as they are inspired by the digital twin paradigm.</p><p><strong>Methods: </strong>The present study uses T2-weighted magnetic resonance images, chemotherapy treatment plans, and post-surgical histological profiles from three patients enrolled in the SIOP 2001/GPOH clinical trial, where each patient represents a distinct clinically assessed risk group. We investigated the clinical adaptation of the Nephroblastoma Oncosimulator to the datasets from these patients with the goal of deriving appropriate value distributions of the model input parameters that enable accurate prediction of tumor volume reduction in response to preoperative chemotherapy.</p><p><strong>Results: </strong>Our primary focus was on the total cell kill ratio as a parameter reflecting treatment effectiveness. We derived the distribution of this parameter for one patient from each risk group: low (<i>Mdn</i> = 0.875, <i>IQR</i> [0.750, 0.875], <i>n</i> = 178), intermediate (<i>Mdn</i> = 0.875, <i>IQR</i> [0.750, 0.875], <i>n</i> = 175), and high (<i>Mdn</i> = 0.485, <i>IQR</i> [0.438, 0.532], <i>n</i> = 103). Statistically significant differences were observed between the high-risk group and both the low- and intermediate-risk groups (<i>p</i> < 0.001).</p><p><strong>Discussion: </strong>The present work establishes a foundation for further studies using available retrospective datasets and additional patients per risk group. These efforts are expected to help validate the findings, advance model development, and extend this mechanistic multiscale discretized cancer model. However, clinical validation is ultimately required to assess the potential uses of the model in clinical decision-support systems.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1465631"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders.","authors":"Hong Sun, Chao Xu, Zhilin Xiong, Miao Liu, Xu Ning, Yong Zhuang","doi":"10.3389/fphys.2025.1524100","DOIUrl":"https://doi.org/10.3389/fphys.2025.1524100","url":null,"abstract":"<p><p>With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well as a substantial economic burden on society. The advancements in conservative and surgical interventions for MSDs have been remarkable in recent years; however, the current treatment modalities still fall short of meeting the optimal requirements of patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its remarkable antioxidative, anti-inflammatory, and anti-apoptotic properties. It has been found that Prdx6 is involved in multiple system diseases, including MSDs; however, the exact role of Prdx6 in MSDs is still lacking. This study aimed to summarize the structure, regulatory mechanism, and potential function of Prdx6. These findings may demonstrate Prdx6 as a novel target for inhibiting the advancement of MSDs.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1524100"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?","authors":"Ivan Curovic","doi":"10.3389/fphys.2025.1549609","DOIUrl":"https://doi.org/10.3389/fphys.2025.1549609","url":null,"abstract":"<p><p>The majority of \"specialised\" exercise configurations (e.g., supersets, drop sets, blood flow restriction) are being assessed as \"shortcuts\" to hypertrophy and strength improvements. However, these advanced training techniques may also offer significant benefits for systemic health and functional outcomes across recreational and clinical populations via locally induced metabolic responses. Stress-regulating mechanisms are known to enhance the body's resilience by facilitating allostasis, the process of coordinating adaptive processes in reaction to stressors such as physical training. Yet, the role of the local metabolic stress provoked by resistance exercise has not gained much research attention despite its wide potential. Positive effects are not only linked to improved muscular endurance, hypertrophy and strength via primary and secondary mechanisms, but also to the release of myokines, hormones, microRNAs, immune factors, inflammatory substances and other endocrine molecules that initiate numerous health-promoting modifications on a systemic level. Resistance exercise strategies that maximise the local accumulation of metabolites are not well defined, although high volume, close proximity to failure and shorter rests seem to be a necessity. Additionally, blood flow restriction training provides a potent alternative for inducing local acidosis, thereby triggering several pathways associated with improved immunity and physical function even in remote muscle tissues. Future research is warranted to further explore advanced resistance training techniques, as these approaches may offer comparable benefits for physical and mental health to those seen with other forms of exercise such as high-intensity interval training and heavy resistance training.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1549609"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle.","authors":"Yuqing Li, Wanjun Zhao, Qi Yang","doi":"10.3389/fphys.2025.1554222","DOIUrl":"https://doi.org/10.3389/fphys.2025.1554222","url":null,"abstract":"<p><p>Exercise and physical activity confer health advantages, in part, by enhancing skeletal muscle mitochondrial respiratory function. The objective of this study is to analyze the impacts of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the dynamics and functionality of the mitochondrial network within skeletal muscle. 20 young male participants were assigned to either HIIT or MICT group. Initial assessments of exercise-related indicators were conducted, followed by skeletal muscle biopsies from the vastus lateralis before, 1 day after, and 6 weeks post-experiment. We utilized multi-dimensional myofiber imaging to analyze mitochondrial morphology and arrangement, and assessed citrate synthase activity, complex I activity, and dynamics-related mRNA. Both training modalities increased VO_2max, W_max, citrate synthase and complex I activities, mitochondrial content, and volume density, though the changes differed between the two groups. 6 weeks training induced remodeling of the mitochondrial network within skeletal muscle. Before training, the network appeared sparse and punctate. After MICT, it adopted a grid-like structure with partially robust longitudinal connections. In contrast, HIIT resulted in a less obvious grid structure but showed a stronger longitudinally oriented network. Training also increased mRNA expression of mitochondrial fusion proteins and decreased fission protein expression, with these effects being more pronounced in HIIT. Similarly, peroxisome proliferator-activated receptor γ coactivator 1-alpha mRNA expression showed a comparable trend, though the changes differed between 1 day and 6 weeks of training. In conclusion, HIIT and MICT induce distinct mitochondrial adaptation in skeletal muscle, reflected in different network remodeling and molecular pathways. These findings may be due to HIIT's more pronounced effect on mitochondrial dynamics or respiratory function, but the study has only conducted preliminary observational experiments and further evidence is required for confirmation.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1554222"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of time of day on visual reaction time performance in boxers: evaluation in terms of chronotype.","authors":"Kemal Kurak, İsmail İlbak, Stefan Stojanović, Ramazan Bayer, Yunus Emre İlbak, Krzysztof Kasicki, Tadeusz Ambroży, Łukasz Rydzik, Wojciech Czarny","doi":"10.3389/fphys.2025.1589740","DOIUrl":"https://doi.org/10.3389/fphys.2025.1589740","url":null,"abstract":"<p><strong>Introduction: </strong>Considering the impact of individual differences on athletes' performance, chronotype emerges as a crucial variable in training program design. Chronotype influences an individual's ability to achieve peak physical and cognitive performance at different times of the day based on their biological rhythms. While numerous studies have explored the relationship between chronotype and physical performance, its effect on reaction time performance remains insufficiently investigated. In sports, where reaction time is a key determinant-such as in boxing-understanding this relationship could contribute to the personalization of training programs. Therefore, the aim of this cross-sectional study was to examine how the visual reaction performance of active boxers varies at different times of the day based on their chronotypes.</p><p><strong>Methods: </strong>Twenty-four active boxers participated in the study. Their chronotypes were determined using the Morningness-Eveningness Questionnaire, categorizing them as either morning type (M-type) or evening type (E-type). The participants were divided into two groups: M-type (n = 12) and E-type (n = 12). Each participant completed a visual reaction time (VRT) performance test at three different times of the day: morning (09:00 h), afternoon (13:00 h), and evening (17:00 h).</p><p><strong>Results: </strong>The findings revealed a statistically significant group × time interaction effect on VRT performance (p < 0.01). M-type athletes showed a significant decline in VRT performance during the evening compared to the morning and afternoon. In contrast, E-type athletes demonstrated significantly better performance in the evening compared to the morning.</p><p><strong>Conclusions: </strong>Boxers' visual reaction time performance varies throughout the day depending on their chronotype. These results suggest that coaches and exercise specialists should consider athletes' chronotypes when designing training programs focused on reaction time enhancement. To optimize performance, it is recommended that M-type athletes conduct such training sessions in the morning, while E-type athletes should train in the evening, when their reaction time performance tends to peak.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1589740"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualizing myocardial contractility as an emergent property that characterizes myocardial contraction.","authors":"Serena Y Kuang, Gorune Geloian","doi":"10.3389/fphys.2025.1499536","DOIUrl":"https://doi.org/10.3389/fphys.2025.1499536","url":null,"abstract":"<p><p>Myocardial contractility (MC) is a fundamental concept that is widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, and often contradictory. In this article, we categorize these many issues into five groups and conducts a conceptual analysis to redefine MC from a broader, more comprehensive perspective. We propose a functional, three-domain framework of MC consisting of capacity/resource, adaptability, and ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing the dynamic, non-linear interactions among the three domains and their clinical significance. Specifically, we highlight how interventions targeting MC may produce non-linear effects, suggesting a shift toward optimizing resource use rather than maximizing outputs (i.e., F and/or V of myocardial contraction, the outputs of the ability domain), which could potentially reduce the complications of positive inotropic interventions. We also discuss the implications of several new conceptual developments as the byproducts of the three-domain MC framework. Additionally, we identify system-level emergent properties of MC briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, and history-dependence, with implications for cardiac muscle research, exercise training, and clinical decision-making. The three-domain functional framework of MC resolves the inconsistencies in definitions, differentiates MC from cardiac performance, and offers a structured perspective for facilitating both experimental studies and therapeutic strategies.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1499536"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis.","authors":"Dongchen Li, Zhilong Huang, Teng Ma, Yu Su, Zhao Li, Liang Sun, Ming Li, Zhong Li, Yao Li, Qian Wang, Yao Lu","doi":"10.3389/fphys.2025.1373721","DOIUrl":"https://doi.org/10.3389/fphys.2025.1373721","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Necrosis of the Femoral Head (NFH) represents a challenging orthopedic condition, characterized by elusive early detection and rapid progression, predominantly in the middle-aged demographic. Current research on the pathophysiological and immunoregulatory mechanisms underpinning immune cell infiltration in NFH is sparse. This study employs bioinformatics analysis of publicly available RNA sequencing databases to elucidate the pivotal molecules and pathways implicated in NFH progression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The NFH-related dataset GSE123568 was obtained from the Gene Expression Omnibus (GEO). Subsequently, CIBERSORT was utilized to assess the proportion and distribution of immune cell types, followed by the identification of critical Hub immune cells using LASSO and RFE algorithms. The dataset GSE123568 was then explored to identify significantly differentially expressed genes (DEGs). These genes were further refined by intersecting with death-associated genes reported in existing literature. GO and KEGG pathway enrichment analyses were conducted to elucidate their underlying molecular mechanism. A protein-protein interaction (PPI) network was constructed using the STRING database and visualized via Cytoscape. Hub genes were identified using the CytoHubba plugin, followed by enrichment analysis, and their expression levels were evaluated using the ROC curve. In addition, we performed expression data visualization and ROC curve analysis on the external dataset GSE74089 to further evaluate the discriminative power of the hub genes. Moreover, the study analyzed the correlation between the identified hub genes and Hub immune cells. Finally, we verified the hub genes utilizing real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Four types of immune cells (Neutrophil, Mast cell resting, Myeloid dendritic cell activated, Macrophage M0) were identified. Fourteen pivotal genes (BCL2L1, BIRC2, NFKBIA, XIAP, CFLAR, AKT1, BIRC3, IKBKB, RIPK1, CASP8, TNFRSF1A, IL1B, CASP1, STAT3) were identified, and the findings were validated using the external dataset GSE74089. Among these, STAT3 exhibited the most pronounced positive correlation with neutrophils (r = 0.6804, p = 3.525e-05). Conversely, XIAP displayed the most significant negative correlation with Myeloid dendritic cell activated (r = -0.3610, p = 0.04003). In experiments, the experimental outcomes for five hub genes (CASP8, TNFRSF1A, AKT1, XIAP and STAT3) were congruent with the results obtained from bioinformatics analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study identified CASP8, TNFRSF1A, AKT1, XIAP, STAT3 and BCL2L1 as potential biomarkers for NFH patients and elucidated the immune cell types with the strongest association to these markers. These insights may be crucial for the early diagnosis, understanding of the pathophysiological mechanisms, and the development of treatment","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1373721"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customizing individual heat mitigation strategies to optimize performance in elite athletes.","authors":"Yasuki Sekiguchi, William M Adams, Yuri Hosokawa, Courteney L Benjamin, Rebecca L Stearns, Robert A Huggins, Douglas J Casa","doi":"10.3389/fphys.2025.1380645","DOIUrl":"https://doi.org/10.3389/fphys.2025.1380645","url":null,"abstract":"<p><p>The aim of this review is twofold: 1) provide a brief discussion surrounding the interindividual variability that has been observed within the context of heat acclimation/acclimatization, body cooling, and hydration strategies, and 2) provide the reader with a practitioner-focused approach for creating individualized heat mitigation strategies. Considering individual variability for heat acclimation and heat acclimatization, various body cooling strategies, and hydration assessment/fluid replacement is important to maximize effects of these strategies, which lead to better performance and health outcomes. There are many factors to consider, and comprehensive approaches are required. The evidenced-informed decision is critical when making an individual approach, and data will help to make decisions effectively. It is important to keep adjusting the approach based on observed data as data is useful information to check if the approach is effective. Specific considerations to individualize the plan are discussed in this review.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1380645"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}