Frontiers in Physiology最新文献

{"title":"Circadian system coordination: new perspectives beyond classical models.","authors":"Ovidiu Constantin Baltatu, Luciana Aparecida Campos, José Cipolla-Neto","doi":"10.3389/fphys.2025.1553736","DOIUrl":"10.3389/fphys.2025.1553736","url":null,"abstract":"<p><strong>Background: </strong>This review examines novel interaction mechanisms contributing to the robustness of circadian rhythms, focusing on enhanced communication between the suprachiasmatic nucleus (SCN) and peripheral clocks. While classical models explain biological clocks through molecular interactions and biochemical signaling, they incompletely account for several key features: precision maintenance despite cellular noise, rapid system-wide synchronization, and temperature compensation. We propose that the SCN, acting as a central hub, may utilize non-classical mechanisms to maintain robust synchronization of peripheral clocks, contributing to biological timekeeping stability. The clinical implications of this model are significant, potentially offering new approaches for treating circadian-related disorders through quantum-based interventions. Recent advances in quantum biosensors and diagnostic tools show promise for early detection and monitoring of circadian disruptions, while quantum-based therapeutic strategies may provide novel treatments for conditions ranging from sleep disorders to metabolic syndromes.</p><p><strong>Aim of review: </strong>To evaluate classical models of circadian rhythm robustness and propose a novel synchronization model incorporating quantum mechanical principles, supported by recent advances in quantum biology and chronobiology, with emphasis on potential clinical applications.</p><p><strong>Key scientific concepts: </strong>Recent research in quantum biology suggests potential mechanisms for enhanced circadian system coordination. The proposed model explores how quantum effects, including entanglement and coherence, may facilitate rapid system-wide synchronization and temporal coherence across tissues. These mechanisms could explain features not fully addressed by classical models: precision maintenance in noisy cellular environments, rapid resynchronization following environmental changes, temperature compensation of circadian periods, and sensitivity to weak electromagnetic fields. The framework integrates established chronobiology with quantum biological principles to explain system-wide temporal coordination and suggests new therapeutic approaches for circadian-related disorders.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1553736"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does functional strength training program improve ice speed and agility in young elite ice hockey players? Functional strength training's impact on hockey performance.","authors":"Anna Bieniec, Małgorzata Grabara","doi":"10.3389/fphys.2025.1448495","DOIUrl":"10.3389/fphys.2025.1448495","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the effects of a functional strength training (FST) program on ice speed and agility in young elite male ice hockey players.</p><p><strong>Methods: </strong>Forty-three ice hockey players, aged 15-18 years participated in the study. The athletes were randomly assigned to either a functional strength training group (FSTG), which completed an additional FST program consisting of two 60-min training sessions per week, or a control group (CG), which participated in other team games and swimming sessions, each lasting 60 min. Ice skating speed was assessed using the professional Smart Speed measurement system in forward and backward skating tests over 5, 15, and 30 m, as well as in an agility test.</p><p><strong>Results: </strong>The intervention elicited significant performance improvements in ice skating speed and agility in the FSTG compared to the CG. Significant time × group interactions were observed in the 5-m (p = 0.041, <i>η</i> _<i>p</i> ² = 0.098), 15-m (p = 0.047, <i>η</i> _<i>p</i> ² = 0.093), and 30-m (p = 0.011, <i>η</i> _<i>p</i> ² = 0.149) forward skating tests, highlighting differential responses between groups. Post hoc analysis confirmed significant improvements in the FSTG, particularly in the 15-m and 30-m tests, where post-test results were superior to those of the CG. No significant effects were found for the backward skating tests. Regarding agility, a significant main effect of time (p = 0.023, <i>η</i> _<i>p</i> ² = 0.12) and group (p = 0.001, <i>η</i> _<i>p</i> ² = 0.226) was detected. In the full speed test, only a group effect (p = 0.026, <i>η</i> _<i>p</i> ² = 0.116) was observed, with no significant time × group interaction or time effects.</p><p><strong>Conclusion: </strong>These results underscore the effectiveness of FST in enhancing forward skating speed and agility.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1448495"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the mechanism of Dexmedetomidine's effect on postoperative cognitive dysfunction in elderly people.","authors":"Yuanbin Cai, Fan Yu, Wei Wu, Wurong Chen","doi":"10.3389/fphys.2025.1508661","DOIUrl":"10.3389/fphys.2025.1508661","url":null,"abstract":"<p><p>Postoperative cognitive dysfunction (POCD) is a common complication among elderly patients following surgical procedures, significantly impairing postoperative recovery and quality of life. The selection and dosage of intraoperative anaesthetic drugs are frequently implicated as contributing factors in the development of POCD. In recent years, dexmedetomidine (DEX), a novel α2-adrenoceptor agonist, has been increasingly utilized in surgical anaesthesia for elderly patients, showing potential as both a preventive and therapeutic agent for POCD. This paper provides a comprehensive review of current research on the mechanisms by which DEX affects POCD in the elderly. Additionally, it explores DEX's mechanisms of action in the context of neuroprotection, anti-inflammation, antioxidative stress, and the regulation of apoptosis, autophagy, and analgesia. The objective is to provide reliable theoretical support and a reference point for the clinical application of DEX in POCD among the elderly, thereby promoting its broader use in clinical practice to improve outcomes and enhance quality of life.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1508661"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-modal deep learning solution for precise pneumonia diagnosis: the PneumoFusion-Net model.","authors":"Yujie Wang, Can Liu, Yinghan Fan, Chenyue Niu, Wanyun Huang, Yixuan Pan, Jingze Li, Yilin Wang, Jun Li","doi":"10.3389/fphys.2025.1512835","DOIUrl":"10.3389/fphys.2025.1512835","url":null,"abstract":"<p><strong>Background: </strong>Pneumonia is considered one of the most important causes of morbidity and mortality in the world. Bacterial and viral pneumonia share many similar clinical features, thus making diagnosis a challenging task. Traditional diagnostic method developments mainly rely on radiological imaging and require a certain degree of consulting clinical experience, which can be inefficient and inconsistent. Deep learning for the classification of pneumonia in multiple modalities, especially integrating multiple data, has not been well explored.</p><p><strong>Methods: </strong>The study introduce the PneumoFusion-Net, a deep learning-based multimodal framework that incorporates CT images, clinical text, numerical lab test results, and radiology reports for improved diagnosis. In the experiments, a dataset of 10,095 pneumonia CT images was used-including associated clinical data-most of which was used for training and validation while keeping part of it for validation on a held-out test set. Five-fold cross-validation was considered in order to evaluate this model, calculating different metrics including accuracy and F1-Score.</p><p><strong>Results: </strong>PneumoFusion-Net, which achieved 98.96% classification accuracy with a 98% F1-score on the held-out test set, is highly effective in distinguishing bacterial from viral types of pneumonia. This has been highly beneficial for diagnosis, reducing misdiagnosis and further improving homogeneity across various data sets from multiple patients.</p><p><strong>Conclusion: </strong>PneumoFusion-Net offers an effective and efficient approach to pneumonia classification by integrating diverse data sources, resulting in high diagnostic accuracy. Its potential for clinical integration could significantly reduce the burden of pneumonia diagnosis by providing radiologists and clinicians with a robust, automated diagnostic tool.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1512835"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms by which SNX-BAR subfamily controls the fate of SNXs' cargo.","authors":"Yaolin Long, Yang Li, Jin Xue, Wanqing Geng, Mingxia Ma, Xiaohui Wang, Li Wang","doi":"10.3389/fphys.2025.1559313","DOIUrl":"10.3389/fphys.2025.1559313","url":null,"abstract":"<p><p>The SNX-BAR subfamily is a component of the sorting nexins (SNXs) superfamily. Distinct from other SNXs, which feature a PX domain for phosphoinositide binding, the SNX-BAR subfamily includes a BAR domain that induces membrane curvature. Members of the SNX-BAR subfamily work together to recognize and select specific cargo, regulate receptor signaling, and manage cargo sorting both with and without the involvement of sorting complexes. They play a crucial role in maintaining cellular homeostasis by directing intracellular cargo to appropriate locations through endo-lysosomal, autophagolysosomal, and ubiquitin-proteasome pathways. This subfamily thus links various protein homeostasis pathways. This review examines the established and hypothesized functions of the SNX-BAR subfamily, its role in intracellular protein sorting and stability, and explores the potential involvement of subfamily dysfunction in the pathophysiology of cardiovascular and neurodegenerative diseases.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1559313"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pathophysiological intersection between metabolic biomarkers and memory: a longitudinal study in the STZ-induced diabetic mouse model.","authors":"Maria Teresa Venuti, Elisa Roda, Federico Brandalise, Meghma Sarkar, Mattia Cappelletti, Attilio F Speciani, Irene Soffientini, Erica Cecilia Priori, Francesca Giammello, Daniela Ratto, Carlo A Locatelli, Paola Rossi","doi":"10.3389/fphys.2025.1455434","DOIUrl":"10.3389/fphys.2025.1455434","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a metabolic disorder characterized by high blood sugar levels due to insufficient insulin production or insulin resistance. Recently, metabolic biomarkers, such as glycated albumin (GA) and methylglyoxal (MGO), have been successfully employed for the management of diabetes and its complications. The main goal of this study was to investigate the relationship between metabolic parameters, related to diabetic conditions, and the recognition memory, a declarative episodic long-term memory, in a streptozotocin (STZ)-induced diabetes mouse model. The longitudinal experimental plan scheduled five experimental timepoints, starting from 9 months and lasting until 19 months of age, and included different evaluations: i) fasting serum glucose, GA, and MGO, ii) recognition memory performance; iii) histological examinations of pancreas and hippocampus. At 13 months of age, mice were randomly divided into two groups, and STZ (50 mg/kg i.p.) or vehicle was administered for 5 consecutive days. Mice were fed with a normal diet but, starting from 14 months, half of them were given water with a high sugar (HS) to explore the potential detrimental effects of HS intake to hyperglycemia. Our main outcomes are as follows: i) HS intake alone does not contribute to worsened diabetic condition/hyperglycemia; ii) GA emerges as a reliable biomarker for monitoring diabetic conditions, consistently increasing with hyperglycemia; iii) diabetic conditions correlate with a worsening of recognition memory; iv) diabetic mice display mild-to-severe insulitis and injured hippocampal cytoarchitecture, detectable in Ammon's horns regions CA1 and CA3; v) correlation among recovered normal fasting glycemic level and recognition memory, partial regaining of physiological pancreatic morphology, and hippocampal cytoarchitecture.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1455434"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable cerebral blood flow responsiveness to acute hypoxic hypoxia.","authors":"Hannah R Johnson, Max C Wang, Rachael C Stickland, Yufen Chen, Todd B Parrish, Farzaneh A Sorond, Molly G Bright","doi":"10.3389/fphys.2025.1562582","DOIUrl":"10.3389/fphys.2025.1562582","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebrovascular reactivity (CVR) to changes in blood carbon dioxide and oxygen levels is a robust indicator of vascular health. Although CVR is typically assessed with hypercapnia, the interplay between carbon dioxide and oxygen, and their ultimate roles in dictating vascular tone, can vary with pathology. Methods to characterize vasoreactivity to oxygen changes, particularly hypoxia, would provide important complementary information to established hypercapnia techniques. However, existing methods to study hypoxic CVR, typically with arterial spin labeling (ASL) MRI, demonstrate high variability and paradoxical responses.</p><p><strong>Methods: </strong>To understand whether these responses are real or due to methodological confounds of ASL, we used phase-contrast MRI to quantify whole-brain blood flow in 21 participants during baseline, hypoxic, and hypercapnic respiratory states in three scan sessions.</p><p><strong>Results: </strong>Hypoxic CVRreliability was poor-to-moderate (ICC = 0.42 for CVR relative to P_ETO₂ changes, ICC = 0.56 relative to SpO₂ changes) and was less reliable than hypercapnic CVR (ICC = 0.67).</p><p><strong>Discussion: </strong>Without the uncertainty from ASL-related confounds, we still observed paradoxical responses at each timepoint. Concurrent changes in blood carbon dioxide levels did not account for paradoxical responses. Hypoxic CVR and hypercapnic CVR shared approximately 40% of variance across the dataset, indicating that the two effects may indeed reflect distinct, complementary elements of vascular regulation. The data included in this article were collected as part of a randomized cross-over clinical trial, but do not assess the outcomes of this trial: Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia (NCT05164705), https://clinicaltrials.gov/study/NCT05164705.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1562582"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral vasoconstriction is not elevated during hyperreactive responses to the cold pressor test: a cross-sectional study.","authors":"Jon Stavres, Anabelle Vallecillo-Bustos, Sarah Parnell, Ryan S Aultman, Ta'Quoris A Newsome, Sydney H Swafford, Abby T Compton, Rhett C Schimpf, Sophia N Schmidt, Carstell Lee, Austin J Graybeal","doi":"10.3389/fphys.2025.1532992","DOIUrl":"10.3389/fphys.2025.1532992","url":null,"abstract":"<p><strong>Background: </strong>Individuals demonstrating increases in systolic systolic blood pressure or diastolic diastolic blood pressure blood pressure of at least 15 mmHg are considered hyperreactors to the cold pressor test (CPT). However, it remains unclear if peripheral vasoconstriction is similarly exaggerated during the CPT in these individuals.</p><p><strong>Methods: </strong>Fifty-five individuals (54.5% non-White, 67.3% female) performed a single-visit study including a 2-min CPT of the foot, a 2-min bout of rhythmic handgrip exercise ([HG] 25% maximal voluntary contraction), and a 2-min combined trial (CPT + HG). Beat-by-beat heart rate (HR), blood pressure, and forearm blood flow (FBF) were continuously recorded, and vascular conductance (FVC) was calculated as FBF/mean arterial pressure (MAP).</p><p><strong>Results: </strong>Hyperreactors (<i>n</i> = 21) demonstrated exaggerated increases in blood pressure and rate pressure product during the CPT compared to normoreactors (<i>n</i> = 34; all <i>p</i> < 0.001), while no significant differences were observed for ΔFBF (<i>f</i> = 1.33, <i>p</i> = 0.259) or ΔFVC responses (<i>f</i> = 2.10, <i>p</i> = 0.083). Results also indicated a blunted increase in ΔMAP during the CPT + HG trial compared to the CPT only trial in hyperreactors (<i>f</i> = 6.95, <i>p</i> < 0.001), which was not observed in normoreactors (<i>f</i> = 0.982, <i>p</i> = 0.420), and a blunted ΔFVC response during the CPT + HG trial in hyperreactors compared to normoreactors (<i>f</i> = 2.57, <i>p</i> = 0.039). When analyzed separately, the blood pressure responses to HG exercise were also significantly exaggerated in hyperreactors compared to normoreactors (all <i>p</i> < 0.001), while ΔFBF and ΔFVC responses were not (both <i>p</i> ≥ 0.701).</p><p><strong>Conclusion: </strong>These findings indicate that hyperreactive blood pressure responses to the CPT are not accompanied by increased peripheral vasoconstriction. Moreover, handgrip exercise attenuates hyperreactive blood pressure responses to the CPT.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1532992"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The effect of muscle pathogenesis on avian physiology, animal welfare, and quality of muscle as a food.","authors":"Sandra G Velleman, Wei Guo, Gale M Strasburg","doi":"10.3389/fphys.2025.1577465","DOIUrl":"https://doi.org/10.3389/fphys.2025.1577465","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1577465"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of exercise training in a hypobaric/normobaric hypoxic environment on body composition and glycolipid metabolism in individuals with overweight or obesity: a systematic review and meta-analysis.","authors":"Peng Liu, Hao Chen, Xin Jiang, Jorge Diaz-Cidoncha Garcia","doi":"10.3389/fphys.2025.1571730","DOIUrl":"10.3389/fphys.2025.1571730","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the impact of hypoxia training on body composition and glycolipid metabolism in excess body weight or living with obese people through meta-analysis.</p><p><strong>Methods: </strong>Randomized controlled trials investigating the effects of hypoxia training on body composition, glucose, and lipid metabolism in excess body weight or living with obese people were systematically searched from databases including CNKI, PubMed, and Web of Science. The meta-analysis was performed by using Stata 18 and RevMan 5.4 analytic tools. The risk of bias was assessed using the Cochrane evaluation tool, and the level of certainty of evidence was determined by the GRADE framework. Between-study heterogeneity was examined using the <i>I</i> ² test, and the publication bias was evaluated via the Egger test or funnel plot.</p><p><strong>Results: </strong>A total of 32 RCTs with 1,011 participants were included. A meta-analysis of 25 RCTs was performed (499 men and 480 women, Age: 40.25 ± 15.69, BMI: 30.96 ± 3.65). In terms of body composition, the outcome indexes of body fat ratio (MD is -1.16, 95% CI -1.76 to -0.56, <i>P</i> = 0.00) in the hypoxia group were better than the normal oxygen group. There was no significant difference in body mass and BMI between the hypoxia group and the normal-oxygen group (<i>P ></i> 0.05). In terms of lipid and glucose metabolism, no significant changes were found between the hypoxia group and the normoxia group (<i>P ></i> 0.05). Subgroup analysis showed that training in hypoxic environment at altitude 2001-2,500 m could effectively improve body mass, TG and LDL-C (<i>P</i> < 0.05). The effective program to reduce body mass is to carry out moderate intensity training of 45-60 min for ≤8 weeks, ≥4 times a week (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Hypoxic training is essential for reducing body fat ratio in excess body weight or obese people. It is recommended to carry out 45-60 min of moderate-intensity aerobic exercise for ≤8 weeks, ≥4 times a week, in a hypoxia environment of 2,001-2,500 m to lose body mass. The effects of hypoxia training and normoxia training on lipid and glucose metabolism in excess body weight or obese people are the same.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024628550.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1571730"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}