Frontiers in Physiology最新文献

{"title":"Corrigendum: Effect of a honey-sweetened beverage on muscle soreness and recovery of performance after exercise-induced muscle damage in strength-trained females.","authors":"Hadis Hemmati, Walaa Jumah Alkasasbeh, Mohammad Hemmatinafar, Mohsen Salesi, Sepideh Pirmohammadi, Babak Imanian, Rasoul Rezaei","doi":"10.3389/fphys.2024.1523903","DOIUrl":"https://doi.org/10.3389/fphys.2024.1523903","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2024.1426872.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1523903"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia.","authors":"Wirongrong Wongkitikamjorn, Eiji Wada, Jun Hosomichi, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Ken-Ichi Yoshida, Takashi Ono, Yukiko K Hayashi","doi":"10.3389/fphys.2024.1518152","DOIUrl":"https://doi.org/10.3389/fphys.2024.1518152","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fphys.2023.1067683.].</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1518152"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function.","authors":"Diego A Bonilla, Jeffrey R Stout, Darren G Candow, José Daniel Jiménez-García, Luis M Gómez-Miranda, Melinna Ortiz-Ortiz, Scott C Forbes, Sergej M Ostojic, Salvador Vargas-Molina, Richard B Kreider","doi":"10.3389/fphys.2024.1496544","DOIUrl":"https://doi.org/10.3389/fphys.2024.1496544","url":null,"abstract":"","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1496544"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema.","authors":"Adana-Christine Campbell, Kevin G Kuonqui, Gopika Ashokan, Jonathan Rubin, Jinyeon Shin, Bracha L Pollack, Arielle Roberts, Ananta Sarker, Hyeung Ju Park, Raghu P Kataru, Andrea V Barrio, Babak J Mehrara","doi":"10.3389/fphys.2024.1510389","DOIUrl":"https://doi.org/10.3389/fphys.2024.1510389","url":null,"abstract":"<p><p>Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with more severe manifestations. Despite these differences in clinical presentation, the cellular mechanisms underlying sex differences are poorly understood. Previous studies have shown that inducible nitric oxide synthase (iNOS) expression by inflammatory cells is an important regulator of lymphatic pumping and leakiness in lymphedema and that lymphatic endothelial cells are highly sensitive to nitrosative stress. Based on this rationale, we used a mouse tail model of lymphedema to study the role of nitric oxide in sex-related differences in disease severity. Consistent with clinical findings, we found that male mice have significantly worse tail edema and higher rates of tail necrosis compared with female mice following tail skin/lymphatic excision (p = 0.001). Our findings correlated with increased tissue infiltration of iNOS + inflammatory cells, increased iNOS protein expression, and increased nitrosative stress in male mouse lymphedematous skin tissues (p < 0.05). Importantly, transgenic male mice lacking the iNOS gene (iNOS-KO) displayed markedly reduced swelling, inflammation, and tissue necrosis rates, whereas no differences were observed between wild-type and iNOS-KO female mice. Overall, our results indicate that iNOS-mediated nitric oxide production contributes to sex-based differences in secondary lymphedema severity, emphasizing the need to consider sex as a biological variable in lymphedema research.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1510389"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the diabetic foot in the population of type 2 diabetes mellitus from tongue images and clinical information using multi-modal deep learning.","authors":"Zhikui Tian, Dongjun Wang, Xuan Sun, Chuan Cui, Hongwu Wang","doi":"10.3389/fphys.2024.1473659","DOIUrl":"https://doi.org/10.3389/fphys.2024.1473659","url":null,"abstract":"<p><strong>Aims: </strong>Based on the quantitative and qualitative fusion data of traditional Chinese medicine (TCM) and Western medicine, a diabetic foot (DF) prediction model was established through combining the objectified parameters of TCM and Western medicine.</p><p><strong>Methods: </strong>The ResNet-50 deep neural network (DNN) was used to extract depth features of tongue demonstration, and then a fully connected layer (FCL) was used for feature extraction to obtain aggregate features. Finally, a non-invasive DF prediction model based on tongue features was realized.</p><p><strong>Results: </strong>Among the 391 patients included, there were 267 DF patients, with their BMI (25.2 vs. 24.2) and waist-to-hip ratio (0.953 vs. 0.941) higher than those of type 2 diabetes mellitus (T2DM) group. The diabetes (15 years vs. 8 years) and hypertension durations (10 years vs. 7.5 years) in DF patients were significantly higher than those in T2DM group. Moreover, the plantar hardness in DF patients was higher than that in T2DM patients. The accuracy and sensitivity of the multi-mode DF prediction model reached 0.95 and 0.9286, respectively.</p><p><strong>Conclusion: </strong>We established a DF prediction model based on clinical features and objectified tongue color, which showed the unique advantages and important role of objectified tongue demonstration in the DF risk prediction, thus further proving the scientific nature of TCM tongue diagnosis. Based on the qualitative and quantitative fusion data, we combined tongue images with DF indicators to establish a multi-mode DF prediction model, in which tongue demonstration and objectified foot data can correct the subjectivity of prior knowledge. The successful establishment of the feature fusion diagnosis model can demonstrate the clinical practical value of objectified tongue demonstration. According to the results, the model had better performance to distinguish between T2DM and DF, and by comparing the performance of the model with and without tongue images, it was found that the model with tongue images performed better.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1473659"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromuscular and balance adaptations following acute stretching exercise: a randomized control trial.","authors":"Bin Wang, Bin Wu, Yi Yang, Mengbiao Cai, Shewang Li, Hui Peng","doi":"10.3389/fphys.2024.1486901","DOIUrl":"https://doi.org/10.3389/fphys.2024.1486901","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the acute effects of static stretching (SS) and dynamic stretching (DS) on neuromuscular function and balance in recreationally active men.</p><p><strong>Method: </strong>Sixty participants were randomly assigned to SS, DS, or no stretching (NS) groups. Before and after their respective stretching protocols, participants were assessed using the stork balance test (SBT), Y-balance test (YBT), T-change of direction test (CoD T-test), countermovement jump test (CMJT), squat jump test (SJT), and five-time jump test (FJT).</p><p><strong>Results: </strong>Significant main effects of time were observed for the SBT, YBT, and CoD T-test. Significant interactions between time and group were found for the SBT, YBT, CoD T-test, and CMJT (P < 0.05). Compared to the NS group, the SS group showed significant improvement in the SBT (P < 0.05), while the DS group demonstrated significant improvements in the SBT, YBT (all directions), CoD T-test, CMJT, and SJT (P < 0.05). Post-training, the DS group showed greater improvements than the SS group in the YBT, CoD T-test, CMJT, and SJT (P < 0.05), with no significant differences in the SBT.</p><p><strong>Conclusion: </strong>SS acutely improves static balance, while DS has a broader impact, enhancing both neuromuscular function and balance.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1486901"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of exhaustive exercise on autonomic nervous system activity: insights from HRV analysis.","authors":"Weichao Wang, Mingrui Shao, Weiping Du, Yanjun Xu","doi":"10.3389/fphys.2024.1462082","DOIUrl":"https://doi.org/10.3389/fphys.2024.1462082","url":null,"abstract":"<p><strong>Introduction: </strong>Exhaustive exercise is a common training method in sports, but its impact on the autonomic nervous system of the human body remains unclear. Understanding the effects of exhaustive exercise on the body and its connection with the autonomic nervous system and central nervous system is crucial for guiding healthy training methods.</p><p><strong>Methods: </strong>Twenty-three participants were selected, and exhaustive exercise intervention was performed using the Bruce Protocol. By measuring heart rate variability (HRV), the effects of exhaustive exercise on the autonomic nervous system function were analyzed.</p><p><strong>Results: </strong>After exhaustive exercise, time-domain indices SDNN, RMSSD, and PNN50 all significantly decreased, with changes reaching significant levels (<i>p</i> < 0.01). Among them, the decrease in pNN50 was particularly pronounced, with a change rate of -94.55%. Frequency-domain indices VLF, LF, and HF also showed significant decreases (<i>p</i> < 0.01), but the ratio of LF to HF showed an upward trend (<i>p</i> < 0.01), with LF showing a greater decrease. Nonlinear indices SD1 and SD2 showed extremely significant decreases (<i>p</i> < 0.01), and the SD2/SD1 ratio showed a significant increase (<i>p</i> < 0.01), indicating significant changes in HRV nonlinear characteristics after exercise.</p><p><strong>Discussion: </strong>Exhaustive exercise leads to a decrease in autonomic nervous system activity and an increase in sympathetic nervous system activity. These findings underscore the profound impact of exhaustive exercise on the autonomic nervous system, with implications for understanding the physiological responses to intense physical exertion. Further research is warranted to explore the long-term effects of exhaustive exercise on autonomic regulation and its potential implications for training methodologies and athlete health.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1462082"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of exercise in restoring executive function: a comparison of tobacco-exposed college athletes and sedentary students.","authors":"Minjia Wang, Shuya Wu, Qian Ma, Hao Hu, Yanpei Liu, Yaozheng Wang, Shitao Zhan, Dongsen Liu, Olivier Girard","doi":"10.3389/fphys.2024.1499587","DOIUrl":"https://doi.org/10.3389/fphys.2024.1499587","url":null,"abstract":"<p><strong>Introduction: </strong>As adolescent smoking rates rise, its impact on cognitive function has drawn greater attention. This study explores whether exercise can mitigate the negative effects of smoking on executive function in male college students.</p><p><strong>Methods: </strong>Sixty male college students were divided into four groups (n = 15 each): sedentary smokers, sedentary nonsmokers, athletic smokers, and athletic nonsmokers. All participants completed the Eriksen flanker task, with prefrontal cortex activation measured using functional near-infrared spectroscopy. After the baseline test, all sedentary students engaged in 33 min of high-intensity interval training, followed by the same procedures as in the pre-test.</p><p><strong>Results: </strong>In the flanker task, college athletes exhibited superior executive function compared to sedentary students, with higher accuracy (<i>p</i> = 0.042), faster reaction times (<i>p</i> = 0.002), and more pronounced brain activation (<i>p</i> = 0.048). Post-exercise, reaction times improved significantly in sedentary groups (<i>p</i> < 0.05). Smoking impaired executive function both before and after exercise, with smokers showing lower accuracy (<i>p</i> < 0.001), slower reaction times (<i>p</i> < 0.001), and diminished brain activation (<i>p</i> < 0.001) compared to nonsmokers.</p><p><strong>Discussion: </strong>Engaging in acute aerobic exercise may improve executive function in sedentary smokers. Exercise may help mitigate smoking-related declines in executive function among college students.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1499587"},"PeriodicalIF":3.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is conduction system pacing more effective than right ventricular pacing in reducing atrial high-rate episodes in patients with heart failure and preserved ejection fraction?","authors":"Ying Chen, Zhu-Lin Ma, Fei Liu, Nan Wang, Yue-Yang Ma, Zi-An Guan, Zhuang-Chuan Zhe, Yun-Long Xia, Ying-Xue Dong","doi":"10.3389/fphys.2024.1500159","DOIUrl":"https://doi.org/10.3389/fphys.2024.1500159","url":null,"abstract":"<p><strong>Background: </strong>The relationship between conduction system pacing (CSP) and the incidence of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF) remains uncertain. This study aims to investigate the occurrence of atrial high-rate episodes (AHREs) following CSP in patients with HFpEF, in comparison to right ventricular pacing (RVP).</p><p><strong>Methods: </strong>Patients with HFpEF who received dual-chamber pacemakers for atrioventricular block were retrospectively enrolled from January 2018 to January 2023. Both new-onset and progressive AHREs were recorded, along with other clinical data, including cardiac performance and lead outcomes.</p><p><strong>Results: </strong>A total of 498 patients were enrolled, comprising 387 patients with RVP and 111 patients with CSP, with a follow-up duration of 44.42 ± 10.41 months. In patients without a prior history of AF, CSP was associated with a significantly lower incidence of new-onset AHREs when the percentage of ventricular pacing was ≥20% (9.52% vs. 29.70%, <i>P</i> = 0.001). After adjusting for confounding factors, CSP exhibited a lower hazard ratio for new-onset AHREs compared to RVP (HR 0.336; [95% CI: 0.142-0.795]; <i>P</i> = 0.013), alongside left atrial diameter (LAD) (HR 1.109; [95% CI: 1.048-1.173]; <i>P</i> < 0.001). In patients with a history of AF, the progression of AHREs in CSP and RVP did not differ significantly (32.35% vs. 34.75%, <i>P</i> = 0.791). Cardiac performance metrics, including left ventricular end-diastolic diameter (LVEDD) (49.09 ± 4.28 mm vs. 48.08 ± 4.72 mm; <i>P</i> = 0.015), LAD (40.68 ± 5.49 mm vs. 39.47 ± 5.24 mm; <i>P</i> = 0.001), and NYHA class (2.31 ± 0.46 vs. 1.59 ± 0.73; <i>P</i> < 0.001), improved obviously following CSP, while LVEDD (48.37 ± 4.57 mm vs. 49.30 ± 5.32 mm; <i>P</i> < 0.001), LAD (39.77 ± 4.58 mm vs. 40.83 ± 4.80 mm; <i>P</i> < 0.001), NYHA class (2.24 ± 0.43 vs. 2.35 ± 0.83; <i>P</i> = 0.018), and left ventricular ejection fraction (LVEF) (57.41 ± 2.42 vs. 54.24 ± 6.65; <i>P</i> < 0.001) deteriorated after RVP.</p><p><strong>Conclusion: </strong>Our findings suggest that CSP may be associated with improvements in cardiac performance and a reduction in new-onset AHREs compared to RVP in patients with HFpEF. However, prospective randomized trials are anticipated to confirm these potential benefits.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1500159"},"PeriodicalIF":3.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-brain crosstalk mediated by exercise-induced myokines - insights from experimental studies.","authors":"Magdalena Kostka, Julia Morys, Andrzej Małecki, Marta Nowacka-Chmielewska","doi":"10.3389/fphys.2024.1488375","DOIUrl":"https://doi.org/10.3389/fphys.2024.1488375","url":null,"abstract":"<p><p>Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result of exercise or physical activity in general. The importance of this phenomenon is currently studied in terms of the impact that exercise- or physical activity -induced signaling factors have, in the interaction of the \"muscle-brain crosstalk.\" So far, skeletal muscle-derived myokines were demonstrated to intercede in the connection between muscles and a plethora of various organs such as adipose tissue, liver, or pancreas. However, the exact mechanism of muscle-brain communication is yet to be determined. It is speculated that, in particular, brain-derived neurotrophic factor (BDNF), irisin, cathepsin B (CTSB), interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) partake in this crosstalk by promoting neuronal proliferation and synaptic plasticity, also resulting in improved cognition and ameliorated behavioral alterations. Researchers suggest that myokines might act directly on the brain parenchyma via crossing the blood-brain barrier (BBB). The following article reviews the information available regarding rodent studies on main myokines determined to cross the BBB, specifically addressing the association between exercise-induced myokine release and central nervous system (CNS) impairments. Although the hypothesis of skeletal muscles being critical sources of myokines seems promising, it should not be forgotten that the origin of these factors might vary, depending on the cell types engaged in their synthesis. Limited amount of research providing information on alterations in myokines expression in various organs at the same time, results in taking them only as circumstantial evidence on the way to determine the actual involvement of skeletal muscles in the overall state of homeostasis. The following article reviews the information available regarding rodent studies on main myokines determined to cross the BBB, specifically addressing the association between exercise-induced myokine release and CNS impairments.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1488375"},"PeriodicalIF":3.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}