Frontiers in Physiology最新文献

{"title":"Sleep behaviors modify the association between hemoglobin concentration and respiratory infection: a prospective cohort analysis.","authors":"Yongkui Zhu, Qian Chen, Mengying Wang, Huan Qian, Qiying Song, Bofei Liu","doi":"10.3389/fphys.2025.1638819","DOIUrl":"10.3389/fphys.2025.1638819","url":null,"abstract":"<p><strong>Interpretation: </strong>Hb and respiratory infection showed a nonlinear U-shaped association; such a relation is modified by the chronotype sleep behavior.</p><p><strong>Objective: </strong>To examine the association between Hb and the incidence of hospitalized respiratory infection, and to explore potential modification effects of sleep behaviors.</p><p><strong>Methods: </strong>Included were 292,568 individuals without respiratory disease, cancer, or anemia diagnosis in the United Kingdom Biobank . Hb (g/dL) was measured at baseline. The interaction between Hb and sleep behaviors, including sleep duration, insomnia, chronotype, and daytime sleepiness with respiratory infection, was tested.</p><p><strong>Results: </strong>The cohort was followed up at a median 12.6 years, and 16,669 incident respiratory infections (9,334 in men, 7,335 in women) were identified. There was a nonlinear U-shaped association between Hb and respiratory infection in both men and women, where the risk increased markedly with Hb above 15.0 g/dL for men and 13.5 g/dL for women. In men, compared with the third quintile group, the hazard ratio (HR; 95% confidence interval [CI]) of respiratory infection in the Q1, Q2, Q4, and Q5 quintile groups was 1.28 (1.21-1.37), 1.07 (1.00-1.14), 1.06 (0.99-1.13), and 1.09 (1.02-1.17), respectively. In women, the HR (95% CI) was 1.20 (1.12-1.29), 1.09 (1.01-1.17), 1.01 (0.94-1.09), and 1.05 (0.98-1.13) in the Q1, Q2, Q4, and Q5 quintile groups of Hb, respectively, compared with the third quintile group. There was a significant interaction between Hb concentration and chronotype on the risk of respiratory infection (<i>P</i> for interaction = 0.005). The elevated risk of respiratory infection associated with Hb was more pronounced among participants with late chronotype.</p><p><strong>Conclusion: </strong>The study suggests that Hb and respiratory infection have a nonlinear U-shaped association and that such a relation is modified by chronotype.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1638819"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of an protocol of the stomatognathic and postural system evaluation for patients with obstructive sleep apnea: a cross-sectional study.","authors":"Marta Guijarro-Herraiz, Natalia M Arias Palencia, Maria Figueroa Mayordomo, Rocío Palomo Carrión, Blanca Notario Pacheco","doi":"10.3389/fphys.2025.1649593","DOIUrl":"10.3389/fphys.2025.1649593","url":null,"abstract":"<p><strong>Introduction: </strong>Myofunctional therapy has been used for years as an intervention with high effectiveness in cases of Obstructive Sleep Apnea (OSA). Until now, little importance has been given to postural attitude or morphotype), even though these can modify the state in which we find the musculature and fascial system of the entire stomatognathic system. The objective if this cross-sectional study is to analyse the validity and reliability of a stomatognathic and postural systems assessment protocol for patients with OSA.</p><p><strong>Methods: </strong>This is a cross-sectional study that uses new observational and measurement parameters (the postural attitude or morphotype, the position of the hyoid bone, potential temporomandibular joint disorders and mobility of the spheno-basilar joint), were assessed in 105 adult subjects presenting with symptoms associated with obstructive sleep apnea (OSA). All subjects were evaluated using the same guidelines and standardized tests. Participants ranged in age from 23 to 83 years and volunteered to take part in the study. The assessment followed a specific protocol encompassing two main components (A) postural analysis and (B) specific evaluation of the stomatognathic system. All measurements were conducted by the same examiner (MMGH), thereby minimizing interobserver bias.</p><p><strong>Results: </strong>Criterion validity was assessed using two Spearman correlation tests. The first examined the correlation between the final protocol score and the apnea-hypopnea index (AHI), yielding a value of 0.082. The second analysis assessed the correlation between the diagnostic results from sections A and B of the protocol, with correlation coefficients of 0.824 and 0.907 respectively. Concurrent validity was evaluated using Spearman correlation between the final protocol score and several variables: apnoea-hypopnoea index, Epworth Sleepiness Scale, physical activity, waist circumference, and neck circumference. All correlations were statistically significant (p < 0.01; p < 0.05). An ANCOVA was conducted to examine mean differences in variables across categories of the final protocol score, controlling for age and sex. Internal consistency of the scale was assessed using Cronbach's alpha, which yielded a coefficient of 0.926. Reproducibility of the protocol was evaluated using the standardised intraclass correlation coefficient (ICC).</p><p><strong>Conclusion: </strong>The specific protocol for the evaluation of the stomatognathic and postural system for OSA (SPOSAP) is a valid and reliable instrument for the screening of the pathology. We believe that the validation of this protocol may facilitate the identification of undiagnosed patients presenting with compatible symptomatology, and broaden the range of treatment options currently available.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1649593"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle activity relationships during isometric shoulder internal and external rotation using the ForceFrame dynamometer and athletic shoulder tests in baseball athletes.","authors":"Ben Ashworth, Mikulas Hank, Omid Khaiyat, Ginny Coyles, Petr Miratsky, Ferdia Falon Verbruggen, Frantisek Zahalka, Tomas Maly","doi":"10.3389/fphys.2025.1632248","DOIUrl":"10.3389/fphys.2025.1632248","url":null,"abstract":"<p><strong>Background: </strong>Optimal shoulder and trunk neuromuscular coordination significantly contributes to performance and injury prevention in overhead athletes. Although isolated shoulder rotation tests are often discussed in research, they may not fully evaluate the complex muscle synergies necessary for functional thrower positions or force deficiencies. Despite the increasing use of the athletic shoulder (ASH) test in elite sports, evidence regarding the relationship between muscle activation patterns in this multi-joint test and traditional isolated assessments is lacking. This study aimed to examine the muscle activity relationships during shoulder strength assessment of isometric rotation and the ASH test in overhead throwing athletes.</p><p><strong>Methods: </strong>Surface electromyography was used to analyze the muscle activation of nine shoulder and trunk muscles during maximal voluntary contractions in 17 male national team baseball athletes. Normalized values were used in muscle activation relationship analysis between internal/external rotation and ASH test's three shoulder positions in the dominant arm (ASH I, ASH Y, and ASH T).</p><p><strong>Results: </strong>Analysis between internal rotation, external rotation, and the ASH I, ASH Y, and ASH T test positions showed significant differences in muscle activity (p < 0.05). The infraspinatus, anterior and posterior deltoid, and upper trapezius demonstrated higher activity in the shoulder rotation tests, while the external obliques and pectoralis major indicated higher activity during ASH tests. Moderate (ρ = 0.40-0.69) correlations were found between muscles during the tests, while strong (ρ = 0.70-0.89)-to-very strong (ρ = 0.90-1.00) correlations were found between individual muscles.</p><p><strong>Conclusion: </strong>The ASH and shoulder rotational tests' results showed different shoulder and trunk neuromuscular activation levels, demonstrating a low relationship between the prime movers for ASH positions and muscles activated during shoulder rotation. This implies that muscle synergies vary significantly depending on joint positioning and test mechanics. It also emphasizes the importance of using multiple test batteries to capture force production deficits and abnormalities that are relevant to overhead athletes. The results support rehabilitation progression starting with infraspinatus strengthening in neutral shoulder abduction, followed by scapular stabilizer training at wider abduction angles to restore functional overhead capacity. Acute or chronic performance may be monitored weekly for further training optimization, return-to-sport decisions, and injury prevention in elite overhead throwing athletes.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1632248"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plyometric jump training micro- and high-dose effects on amateur basketball players athletic performance: a randomized controlled trial.","authors":"Bitai Wu, Baiming Zhang, Mingyue Yin, Kai Xu, Rodrigo Ramirez-Campillo, Sen Huang, Limingfei Zhou, Leijiao Yue, Jianxiong Li, Zhifeng Liu, Zhiquan Song, Boyi Zhang, Hengxian Liu, Long Li, Ken Zhang","doi":"10.3389/fphys.2025.1684022","DOIUrl":"10.3389/fphys.2025.1684022","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of a 4-week plyometric training program involving microdosing (MPT; four sessions per week, 400 total jumps) and highdosing (HPT; 2 sessions per week, 800 total jumps) on athletic performance in male amateur basketball players.</p><p><strong>Methods: </strong>Participants were randomly assigned to the MPT (n = 24), HPT (n = 23), or control (CTR; n = 22). The intervention training protocol involved 4 weeks, while the control group received no additional training. Twelve performance metrics were assessed pre- and post-intervention, including countermovement jump (CMJ), countermovement jump with arms (CMJA), 40 cm-drop jump (DJ), reactive strength index (RSI) and modified reactive strength index (RSImod), maximal isometric squat strength, isometric mid-thigh pull (IMTP) rate of force development (RFD), 10 m and 20 m sprint, T-test agility, 5-0-5 test agility, and endurance capacity (yo-yo intermittent recovery test-level 2 - YYIR2). Paired and independent sample t-tests were used to assess within- and between-group (with Bonferroni correction) differences. Effect sizes were calculated using Hedges' g (<i>g</i>) to quantify the magnitude of training effects.</p><p><strong>Results: </strong>Compared to the control group, MPT improved CMJ (g = 0.66), RSI (g = 0.96), RSImod (g = 0.71), IMTP (g = 0.64), and 20 m sprint (g = 0.58), and HPT improved RSI (g = 1.08), RSImod (g = 0.88), IMTP (g = 0.64), 20 m sprint (g = 0.79). No differences were observed between MPT and HPT.</p><p><strong>Conclusion: </strong>Both MPT and HPT similarly enhance basketball players' athletic performance. However, microdosing required reduced training volume to attain a similar magnitude of improvement, representing a time-efficient training alternative.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1684022"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of low-load blood flow restriction training and high-load resistance training on physical performance in college 800-m runners: a randomized control trial.","authors":"Jianhua Yu, Jingyan Yu, Lei Zhao, Yi Yang","doi":"10.3389/fphys.2025.1678604","DOIUrl":"10.3389/fphys.2025.1678604","url":null,"abstract":"<p><strong>Background: </strong>High-load resistance training (HLRT) is commonly used to enhance performance in 800-m runners but may not always be suitable. Low-load blood flow restriction (BFR) training offers similar benefits to HLRT while reducing these issues. This study aimed to compare the effects of traditional HL-RT and low-load BFR training on muscular strength, power, endurance, and running performance of collegiate 800-m runners over an 8-week training program.</p><p><strong>Methods: </strong>A total of 22 participants were randomly divided into HL-RT group (n = 11) and BFR group (n = 11). Physical performance was assessed at three time points: baseline, mid-intervention, and post-intervention. The tests included the 20-m sprint test (T20m), countermovement jump test (CMJ), smith machine full-squat test (to assess V1 load), plantar flexion rate of force development test (PF-RFD), 200-m test (T200m), and 800-m test (T800m).</p><p><strong>Results: </strong>Significant time effects were observed for T20m, CMJ, V1 load, PF-RFD, T200m, and T800m (all P < 0.05), and significant interaction effects between time and group was found for V1load (P < 0.05). Post-training comparisons between the HL-RT and BFR groups revealed a significant improvement in V1 load in the HL-RT group (P < 0.05), while no significant differences were found between the groups for the other performance measures. The present results indicate that both HL-RT and BFR training demonstrate positive effects on the muscular strength, power, endurance, and running performance, while HL-RT demonstrate greater gains in muscular power.</p><p><strong>Conclusion: </strong>Low-load BFR training offers an effective alternative to traditional HL-RT for enhancing competitive performance and key physical attributes in collegiate 800-m runners.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1678604"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact load is associated with both contact and non-contact injuries in rugby union.","authors":"Yusuke Iwasaki, Yuki Someya, Masashi Nagao, Masashi Aoyagi, Yuki Shiota, Yuji Takazawa","doi":"10.3389/fphys.2025.1672824","DOIUrl":"10.3389/fphys.2025.1672824","url":null,"abstract":"<p><strong>Objective: </strong>Managing matches and training loads is crucial for injury prevention. Contact load is a defining feature of rugby union, and World Rugby has proposed its management as a key strategy for the prevention of injuries. In fact, increased contact load has been associated with a higher incidence of injuries. However, the specific relationship between contact load and the occurrence of both contact and non-contact injuries remains unclear. In this study, we aimed to clarify the association between contact load and the occurrence of contact and non-contact injuries in elite rugby union players.</p><p><strong>Methods: </strong>Sixty-six elite male rugby union players (age: 26.5 ± 3.5 years) in Japan were monitored over three seasons. Contact load, an indicator of training load, was evaluated based on collision count and collision load, measured using a global positioning system device. For each player, cumulative contact loads were calculated using time windows of 1, 2, 3, 4, 5, 6, 7, 14, 21, and 28 days. The association between contact load and injury incidence (contact and non-contact) was analyzed using generalized estimating equations.</p><p><strong>Results: </strong>A total of 193 injuries were recorded. Of these, 136 were contact injuries and 57 were non-contact injuries. The contact load was significantly associated with both types of injury. For contact injuries, the highest odds ratio for the collision count was observed on day 1 and gradually decreased toward day 7 (day 1: odds ratio, 2.10 [95% confidence interval: 1.67-2.64]; day 7: 1.31 [1.15-1.48]). The odds ratio for collision load also declined from days 1-7 (day 1: 3.27 [2.18-4.90]; day 7: 1.44 [1.17-1.78]). By contrast, non-contact injuries showed a different pattern. For collision count, the highest odds ratio was observed on day 2 and then gradually decreased toward day 4 (day 2: 1.38 [1.04-1.83]; day 4: 1.35 [1.06-1.72]). The odds ratio for collision load was also the highest on day 2 and decreased toward day 4 (day 2: 1.75 [1.16-2.65]; day 4: 1.56 [1.07-2.27]).</p><p><strong>Conclusion: </strong>Contact load was associated with both contact and non-contact injuries in elite rugby union players.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1672824"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on corporate social responsibility of professional football clubs on fans' consumption intentions in China.","authors":"Chengfeng Zhang, Keke Song, Linhua Chen","doi":"10.3389/fphys.2025.1651356","DOIUrl":"10.3389/fphys.2025.1651356","url":null,"abstract":"<p><strong>Purpose: </strong>To examine how Chinese fans' perception of club CSR affects consumption intentions via fan identification and motivational attribution, and to test the moderating role of involvement.</p><p><strong>Methods: </strong>A total of 1,327 valid questionnaires were collected and analyzed using structural equation modeling and cluster analysis.</p><p><strong>Results: </strong>CSR perception had a significant positive effect on consumption intentions; this effect was fully mediated by fan identification and motivational attribution, with the model explaining 40.3% of the variance. Highly involved fans relied primarily on the fan identification path, whereas low-involvement fans relied on the motivational attribution path.</p><p><strong>Conclusion: </strong>Clubs should implement differentiated CSR strategies tailored to fans' levels of involvement to effectively enhance consumption intentions.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1651356"},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centripetal filling and pathological insights: a rare case of sporadic renal hemangioblastoma with literature review.","authors":"Lin Guo, Botao Tang, Sheng Chen, Peng Jiang, Ting Zhang, Taisheng Liang, Jibing Chen, Hongjun Gao","doi":"10.3389/fphys.2025.1604834","DOIUrl":"10.3389/fphys.2025.1604834","url":null,"abstract":"<p><strong>Background: </strong>Renal hemangioblastoma (RH) is an uncommon benign tumor primarily found in the central nervous system (CNS), with an exceptionally rare occurrence in the kidney. Its imaging characteristics closely resemble those of malignant tumors, such as renal cell carcinoma (RCC), and its histological features are similar to other hypervascular tumors, including RCC and angiomyolipoma (AML). Consequently, diagnosing RH presents significant challenges. To date, only approximately 31 cases of RH have been reported worldwide, most of which are not associated with Von Hippel-Lindau (VHL) disease. This article presents a case of sporadic RH, supplemented by a comprehensive literature review, with the aim of enhancing the understanding of this condition. The paper will explore its imaging and pathological characteristics, discuss its clinical significance for diagnosis and management, and provide clinicians with valuable insights for differential diagnosis and treatment strategies.</p><p><strong>Case presentation: </strong>A 48-year-old male patient was admitted after a routine physical examination revealed a mass in his left kidney. Abdominal computed tomography (CT) showed a solid mass in the upper pole of the left kidney, measuring approximately 6.9 × 5.7 × 5.6 cm with well-defined borders. Contrast-enhanced imaging demonstrated peripheral enhancement of the mass in a \"centripetal filling\" pattern. Following consultation, we had ultimately performed a nephron-sparing surgery (NSS). Postoperative pathology confirmed sporadic RH. Immunohistochemistry results showed positivity for S-100, inhibin-α, and Neuron-Specific Enolase (NSE), further supporting the diagnosis. During the 9-month postoperative follow-up period, the patient remained free of clinical recurrence.</p><p><strong>Conclusion: </strong>This case report and literature review summarize the clinical features, imaging manifestations, and pathological characteristics of RH. Immunohistochemical markers, including Inhibin-α, S-100, and NSE, are essential for the diagnosis of RH. These markers assist in differentiating RH from other renal tumors, such as RCC and AML, which may present with similar histological features. For patients with minimal symptoms, NSS is the preferred treatment option, as it optimizes renal function preservation and avoids unnecessary overtreatment. This article provides valuable insights for clinicians on the differential diagnosis and treatment strategies for RH, highlighting the importance of a comprehensive evaluation that integrates imaging, pathology, and immunohistochemical findings.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1604834"},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based radiomics approach assessing preoperative non-contrast CT for microsatellite instability prediction in colon cancer.","authors":"Dongming Ren, Yingjuan Wang, Luda Chen, Jianfeng He, Tao Shen","doi":"10.3389/fphys.2025.1672636","DOIUrl":"10.3389/fphys.2025.1672636","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the feasibility of non-contrast CT-based radiomics model for predicting microsatellite instability (MSI) status in colon cancer.</p><p><strong>Methods: </strong>Leveraging non-contrast abdominal CT imaging data from 57 retrospectively enrolled patients with balanced class distribution (training cohort: n = 38, 19 non-MSI-H and 19 MSI-H; test cohort: n = 19, 9 non-MSI-H and 10 MSI-H), we implemented a voxel volume-based tumor feature selection method. Feature selection integrated four feature selection filters-correlation analysis, univariate logistic regression, least absolute shrinkage and selection operator (LASSO), and recursive feature elimination (RFE). We comparatively evaluated multiple classifiers using cross-validation combined with accuracy for choosing the best classifier.</p><p><strong>Results: </strong>A multilayer perceptron-based classification model was developed, achieving average multifold accuracy of 0.871 in cross-validation on the training cohort. In the test cohort, the model achieved an AUC of 0.944 (95% CI 0.841-1.000) with accuracy of 0.842, while maintaining sensitivity of 0.889 and specificity of 0.800, demonstrating excellent and comparable performance to previous contrast-enhanced CT-based radiomics models.</p><p><strong>Conclusion: </strong>We validated the feasibility of non-contrast CT for MSI prediction in colon cancer with radiomics analysis, highlighting its potential as a flexible and cost-effective preliminary screening tool. This approach, which does not require supplementary medical examination, may enhance clinical decision-making by providing a valuable tool for identifying MSI-H molecular subtypes in colon cancer patients.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1672636"},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-augmented prenatal care: a dual-modal fetal health assessment system integrating cardiotocography and uterine contraction synergy.","authors":"Tianxin Qiu, Xinghe Zhou, Jun Zhou, Chunxia Lin, Shiling Jiang, Hui Cheng, Xinhao Wang, Qingshan You","doi":"10.3389/fphys.2025.1638788","DOIUrl":"10.3389/fphys.2025.1638788","url":null,"abstract":"<p><strong>Introduction: </strong>Fetal heart monitoring (FHR) is a critical tool for assessing fetal health, but traditional methods rely on subjective physician interpretation, exhibiting significant variability that can lead to misdiagnosis and overtreatment. Artificial intelligence (AI) technology offers a novel approach to address this issue, yet existing research predominantly utilizes unimodal (FHR-only) data, failing to align with clinical guidelines emphasizing \"bimodality analysis of fetal heart rate and uterine contractions (UC).\" This study aims to develop a deep learning-based bimodal intelligent monitoring system to enhance the accuracy and clinical utility of fetal health assessment.</p><p><strong>Methods: </strong>The research team constructed the first fetal heart-contraction bimodal clinical dataset for Chinese pregnant women (n = 326). Based on the DenseNet121 architecture, a selective attention mechanism (SK module) was introduced, proposing the DenseNet121-SK model. Standardized FHR and UC signals were extracted using image processing techniques. Dense connections and the SK module dynamically fused multi-scale features (e.g., transient fluctuations and contraction cycle associations). The model employed lightweight design during training to enhance physician usability.</p><p><strong>Results: </strong>(1) Dual-modality input significantly outperformed single-modality input, achieving a classification AUC of 0.944 (vs. 0.812 for single-modality), validating the clinical value of multi-parameter collaborative interpretation; (2) The SK module simulated obstetricians' multi-scale cognition, achieving 95.88% accuracy with 100% recall for abnormal cases; (3) The system effectively reduced subjective interpretation variability, providing technical support for minimizing overtreatment.</p><p><strong>Discussion: </strong>This study achieves a balance between clinical interpretability and high performance through lightweight AI design (only 8.3 million parameters) and dual-modality data fusion, making it particularly suitable for resource-constrained primary care settings. Future work should further optimize generalization capabilities through multicenter validation and explore integration with large language models to generate standardized reports. These findings provide important references for optimizing perinatal healthcare resources and AI-assisted decision-making.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1638788"},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}