Frontiers in Neuroinformatics最新文献

{"title":"The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint.","authors":"Hakim Baazaoui, Stefan T Engelter, Henrik Gensicke, Lukas S Enz, Marios Psychogios, Matthias Mutke, Patrik Michel, Davide Strambo, Alexander Salerno, Henk A Marquering, Paul J Nederkoorn, Nabila Wali, Stephanie Tanadini-Lang, Björn Menze, Ezequiel de la Rosa, Kaiyuan Yang, Gian Marco De Marchis, Tolga D Dittrich, Francesco Valletta, Manon Germann, Carlo W Cereda, João Pedro Marto, Lisa Herzog, Patrick Hirschi, Zsolt Kulcsar, Susanne Wegener","doi":"10.3389/fninf.2024.1508161","DOIUrl":"https://doi.org/10.3389/fninf.2024.1508161","url":null,"abstract":"<p><strong>Purpose: </strong>The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven stroke centres in Europe. MAGIC consolidates clinical and radiological data from acute ischemic stroke (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, a combination of both, or conservative management.</p><p><strong>Participants: </strong>All centres ensure accuracy and completeness of the data. Only patients who did not refuse use of their routine data collected during or after their hospital stay are included in the repository. Approvals or waivers are obtained from the responsible ethics committees before data exchange. A formal data transfer agreement (DTA) is signed by all contributing centres. The centres then share their data, and files are stored centrally on a safe server at the University Hospital Zurich. There, patient identifiers are removed and images are algorithmically de-faced. De-identified structured clinical data are connected to the imaging data by a new identifier. Data are made available to participating centres which have entered into a DTA for stroke research projects.</p><p><strong>Repository setup: </strong>Initially, MAGIC is set to comprise initial and first follow-up imaging of 2,500 AIS patients. Clinical data consist of a comprehensive set of patient characteristics and routine prehospital metrics, treatment and laboratory variables.</p><p><strong>Outlook: </strong>Our repository will support research by leveraging the entire range of routinely collected imaging and clinical data. This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. We aim to reach approximately 10,000 cases by 2026.</p>","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1508161"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Protecting privacy in neuroimaging analysis: balancing data sharing and privacy preservation.","authors":"Rashid Mehmood, Mariana Lazar, Xiaohui Liang, Juan M Corchado, Simon See","doi":"10.3389/fninf.2024.1543121","DOIUrl":"https://doi.org/10.3389/fninf.2024.1543121","url":null,"abstract":"","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1543121"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging deep learning for robust EEG analysis in mental health monitoring.","authors":"Zixiang Liu, Juan Zhao","doi":"10.3389/fninf.2024.1494970","DOIUrl":"https://doi.org/10.3389/fninf.2024.1494970","url":null,"abstract":"<p><strong>Introduction: </strong>Mental health monitoring utilizing EEG analysis has garnered notable interest due to the non-invasive characteristics and rich temporal information encoded in EEG signals, which are indicative of cognitive and emotional conditions. Conventional methods for EEG-based mental health evaluation often depend on manually crafted features or basic machine learning approaches, like support vector classifiers or superficial neural networks. Despite the potential of these approaches, they often fall short in capturing the intricate spatiotemporal relationships within EEG data, leading to lower classification accuracy and poor adaptability across various populations and mental health scenarios.</p><p><strong>Methods: </strong>To overcome these limitations, we introduce the EEG Mind-Transformer, an innovative deep learning architecture composed of a Dynamic Temporal Graph Attention Mechanism (DT-GAM), a Hierarchical Graph Representation and Analysis (HGRA) module, and a Spatial-Temporal Fusion Module (STFM). The DT-GAM is designed to dynamically extract temporal dependencies within EEG data, while the HGRA models the brain's hierarchical structure to capture both localized and global interactions among different brain regions. The STFM synthesizes spatial and temporal elements, generating a comprehensive representation of EEG signals.</p><p><strong>Results and discussion: </strong>Our empirical results confirm that the EEG Mind-Transformer significantly surpasses conventional approaches, achieving an accuracy of 92.5%, a recall of 91.3%, an F1-score of 90.8%, and an AUC of 94.2% across several datasets. These findings underline the model's robustness and its generalizability to diverse mental health conditions. Moreover, the EEG Mind-Transformer not only pushes the boundaries of state-of-the-art EEG-based mental health monitoring but also offers meaningful insights into the underlying brain functions associated with mental disorders, solidifying its value for both research and clinical settings.</p>","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1494970"},"PeriodicalIF":2.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Emerging trends in large-scale data analysis for neuroscience research.","authors":"Farouk S Nathoo, Olave E Krigolson, Fang Wang","doi":"10.3389/fninf.2024.1538787","DOIUrl":"https://doi.org/10.3389/fninf.2024.1538787","url":null,"abstract":"","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1538787"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of ROI-based fMRI data in short-term memory tasks using discriminant analysis and neural networks.","authors":"Magdalena Fafrowicz, Marcin Tutajewski, Igor Sieradzki, Jeremi K Ochab, Anna Ceglarek-Sroka, Koryna Lewandowska, Tadeusz Marek, Barbara Sikora-Wachowicz, Igor T Podolak, Paweł Oświęcimka","doi":"10.3389/fninf.2024.1480366","DOIUrl":"https://doi.org/10.3389/fninf.2024.1480366","url":null,"abstract":"<p><p>Understanding brain function relies on identifying spatiotemporal patterns in brain activity. In recent years, machine learning methods have been widely used to detect connections between regions of interest (ROIs) involved in cognitive functions, as measured by the fMRI technique. However, it's essential to match the type of learning method to the problem type, and extracting the information about the most important ROI connections might be challenging. In this contribution, we used machine learning techniques to classify tasks in a working memory experiment and identify the brain areas involved in processing information. We employed classical discriminators and neural networks (convolutional and residual) to differentiate between brain responses to distinct types of visual stimuli (visuospatial and verbal) and different phases of the experiment (information encoding and retrieval). The best performance was achieved by the LGBM classifier with 1-time point input data during memory retrieval and a convolutional neural network during the encoding phase. Additionally, we developed an algorithm that took into account feature correlations to estimate the most important brain regions for the model's accuracy. Our findings suggest that from the perspective of considered models, brain signals related to the resting state have a similar degree of complexity to those related to the encoding phase, which does not improve the model's accuracy. However, during the retrieval phase, the signals were easily distinguished from the resting state, indicating their different structure. The study identified brain regions that are crucial for processing information in working memory, as well as the differences in the dynamics of encoding and retrieval processes. Furthermore, our findings indicate spatiotemporal distinctions related to these processes. The analysis confirmed the importance of the basal ganglia in processing information during the retrieval phase. The presented results reveal the benefits of applying machine learning algorithms to investigate working memory dynamics.</p>","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1480366"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"hvEEGNet: a novel deep learning model for high-fidelity EEG reconstruction.","authors":"Giulia Cisotto, Alberto Zancanaro, Italo F Zoppis, Sara L Manzoni","doi":"10.3389/fninf.2024.1459970","DOIUrl":"https://doi.org/10.3389/fninf.2024.1459970","url":null,"abstract":"<p><strong>Introduction: </strong>Modeling multi-channel electroencephalographic (EEG) time-series is a challenging tasks, even for the most recent deep learning approaches. Particularly, in this work, we targeted our efforts to the high-fidelity reconstruction of this type of data, as this is of key relevance for several applications such as classification, anomaly detection, automatic labeling, and brain-computer interfaces.</p><p><strong>Methods: </strong>We analyzed the most recent works finding that high-fidelity reconstruction is seriously challenged by the complex dynamics of the EEG signals and the large inter-subject variability. So far, previous works provided good results in either high-fidelity reconstruction of single-channel signals, or poor-quality reconstruction of multi-channel datasets. Therefore, in this paper, we present a novel deep learning model, called hvEEGNet, designed as a hierarchical variational autoencoder and trained with a new loss function. We tested it on the benchmark Dataset 2a (including 22-channel EEG data from 9 subjects).</p><p><strong>Results: </strong>We show that it is able to reconstruct all EEG channels with high-fidelity, fastly (in a few tens of epochs), and with high consistency across different subjects. We also investigated the relationship between reconstruction fidelity and the training duration and, using hvEEGNet as an anomaly detector, we spotted some data in the benchmark dataset that are corrupted and never highlighted before.</p><p><strong>Discussion: </strong>Thus, hvEEGNet could be very useful in several applications where automatic labeling of large EEG dataset is needed and time-consuming. At the same time, this work opens new fundamental research questions about (1) the effectiveness of deep learning models training (for EEG data) and (2) the need for a systematic characterization of the input EEG data to ensure robust modeling.</p>","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1459970"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonizing AI governance regulations and neuroinformatics: perspectives on privacy and data sharing.","authors":"Roba Alsaigh, Rashid Mehmood, Iyad Katib, Xiaohui Liang, Abdullah Alshanqiti, Juan M Corchado, Simon See","doi":"10.3389/fninf.2024.1472653","DOIUrl":"10.3389/fninf.2024.1472653","url":null,"abstract":"","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1472653"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Addressing large scale computing challenges in neuroscience: current advances and future directions.","authors":"Tam V Nguyen, Min Wang, Domenico Maisto","doi":"10.3389/fninf.2024.1534396","DOIUrl":"10.3389/fninf.2024.1534396","url":null,"abstract":"","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1534396"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Improving autism spectrum disorder diagnosis using machine learning techniques.","authors":"Mahmoud Elbattah, Osman Ali Sadek Ibrahim, Gilles Dequen","doi":"10.3389/fninf.2024.1529839","DOIUrl":"10.3389/fninf.2024.1529839","url":null,"abstract":"","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1529839"},"PeriodicalIF":2.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised method for representation transfer from one brain to another.","authors":"Daiki Nakamura, Shizuo Kaji, Ryota Kanai, Ryusuke Hayashi","doi":"10.3389/fninf.2024.1470845","DOIUrl":"10.3389/fninf.2024.1470845","url":null,"abstract":"<p><p>Although the anatomical arrangement of brain regions and the functional structures within them are similar across individuals, the representation of neural information, such as recorded brain activity, varies among individuals owing to various factors. Therefore, appropriate conversion and translation of brain information is essential when decoding neural information using a model trained using another person's data or to achieving brain-to-brain communication. We propose a brain representation transfer method that involves transforming a data representation obtained from one person's brain into that obtained from another person's brain, without relying on corresponding label information between the transferred datasets. We defined the requirements to enable such brain representation transfer and developed an algorithm that distills the assumption of common similarity structure across the brain datasets into a rotational and reflectional transformation across low-dimensional hyperspheres using encoders for non-linear dimensional reduction. We first validated our proposed method using data from artificial neural networks as substitute neural activity and examining various experimental factors. We then evaluated the applicability of our method to real brain activity using functional magnetic resonance imaging response data acquired from human participants. The results of these validation experiments showed that our method successfully performed representation transfer and achieved transformations in some cases that were similar to those obtained when using corresponding label information. Additionally, we reconstructed images from individuals' data without training personalized decoders by performing brain representation transfer. The results suggest that our unsupervised transfer method is useful for the reapplication of existing models personalized to specific participants and datasets to decode brain information from other individuals. Our findings also serve as a proof of concept for the methodology, enabling the exchange of the latent properties of neural information representing individuals' sensations.</p>","PeriodicalId":12462,"journal":{"name":"Frontiers in Neuroinformatics","volume":"18 ","pages":"1470845"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}