Frontiers in Chemistry最新文献

{"title":"Editorial: Supramolecular cancer therapeutic biomaterials-volume II.","authors":"Yong Yao, Guifei Huo, Ruibo Zhao","doi":"10.3389/fchem.2025.1574334","DOIUrl":"10.3389/fchem.2025.1574334","url":null,"abstract":"","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1574334"},"PeriodicalIF":3.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer.","authors":"Afzal B Shaik, Richie R Bhandare, M Mukhlesur Rahman, Kamal Dua","doi":"10.3389/fchem.2025.1578852","DOIUrl":"10.3389/fchem.2025.1578852","url":null,"abstract":"","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1578852"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring tannin structures to enhance enzymatic polymerization.","authors":"Romina Romero, Tihare Gonzalez, Bruno F Urbano, Cristina Segura, Alessandro Pellis, Myleidi Vera","doi":"10.3389/fchem.2025.1555202","DOIUrl":"10.3389/fchem.2025.1555202","url":null,"abstract":"<p><p>The enzymatic polymerization of biomass-derived polyphenols presents a sustainable approach to producing advanced materials. However, the structural diversity and incomplete characterization of tannins pose challenges to optimizing the process. This study investigates how tannin composition and the presence of phenolic and non-phenolic compounds in aqueous <i>Pinus radiata</i> bark extracts influence laccase-catalyzed polymerization and the resulting material's thermal and structural properties. The extracts were characterized using proximate and ultimate analysis, Py-GC/MS, FT-IR, TGA, and phenol content analysis before polymerization with <i>Myceliophthora thermophila</i> laccase (MtL). Structural and thermal analysis of the polymers revealed significant transformations driven by enzymatic oxidation. Tannin extracts rich in resorcinol and low in carbohydrates and less polar compounds produced highly cross-linked polymers with exceptional thermal stability, retaining 86% residual mass at 550°C. These findings demonstrate that tannin composition plays a key role in polymerization efficiency and material performance. The resulting thermally stable polymers offer potential applications in flame retardancy and sustainable material development, providing a promising pathway for biomass valorization.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1555202"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced oxidation using modified enteromorpha algae-derived biochar for marine sediment dehydration.","authors":"Lun Tan, Jian Zhang, Jiaoyang Du, Lianjie Guo, Hong Deng, Ying-Ying Gu","doi":"10.3389/fchem.2025.1546240","DOIUrl":"10.3389/fchem.2025.1546240","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to enhance the dewatering performance of marine sediment using modified Enteromorpha algae-derived biochar to activate persulfate through an advanced oxidation process. Dehydration of marine dredged sediment is a challenging issue in the field of environmental remediation. Traditional dewatering methods are often inefficient due to the high water content, high Cl⁻ levels, and large volume of marine sediment.</p><p><strong>Methods: </strong>To address this, we developed an effective and environmentally friendly dewatering approach using biochar as a conditioning agent in combination with the strong oxidizing properties of persulfate. The biochar was prepared by pyrolyzing Enteromorpha algae at high temperatures and modified with FeSO₄ solution to enhance its dewatering performance.</p><p><strong>Results: </strong>The results showed that under the optimal conditions of adding 4% of modified biochar and 1% of persulfate, the specific resistance to filtration (SRF) of sediment decreased by 73.4%, the yield of net solid (Y_N) increased by 105%, and the dehydration amount increased by 118%.</p><p><strong>Discussion: </strong>The mechanism underlying the improved dehydration performance of marine sediment was revealed through the analysis of extracellular polymeric substances (EPS), zeta potential, compression coefficient changes, and microstructure analysis. It was found that Fe²⁺ compressed the double electric layer of sediment, while the activation of persulfate generated ·OH and SO₄ ^-· that effectively degraded EPS, thereby enhancing the dewatering performance. This research not only provides a new strategy for the sustainable treatment of marine sediment but also offers a theoretical basis for the resourceful utilization of algal biomass.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1546240"},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent achievements in synthesis of anthracene scaffolds catalyzed transition metals.","authors":"Fadhil Faez Sead, Vicky Jain, R Roopashree, Aditya Kashyap, Suman Saini, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas","doi":"10.3389/fchem.2025.1545252","DOIUrl":"10.3389/fchem.2025.1545252","url":null,"abstract":"<p><p>In the last 10 years, the synthesis of anthracene scaffolds has attracted considerable interest because of their distinctive electronic characteristics and various uses in organic electronics, photovoltaics, and therapeutics. Anthracene, a polycyclic aromatic hydrocarbon, is valued for its lightweight, stability, and electron transport capabilities, making it a key building block in advanced materials. Traditional synthesis methods often face challenges such as low selectivity and harsh conditions. However, recent advancements in transition metal-catalyzed reactions have transformed the field, offering more efficient and versatile approaches. This review examines methodologies utilizing transition metal catalysts like palladium, zinc, indium, cobalt, gold, iridium, rhodium and ruthenium, which have enabled novel synthetic pathways and selective formation of substituted anthracenes through cross-coupling reactions. The function of ligands, including phosphines and N-heterocyclic carbenes, in improving reaction efficiency and selectivity is also examined. The shift towards greener methodologies is noted, with a focus on minimizing waste and reducing toxic reagents. The shift towards greener methodologies is noted, with a focus on minimizing waste and reducing toxic reagents. Several case studies demonstrate the successful application of these techniques, highlighting the structural diversity and functional potential of anthracene derivatives in various applications.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1545252"},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of extraction technologies for plant extracts and absolutes.","authors":"Shoutao Cao, Jinchang Liang, Mingguang Chen, Chao Xu, Xiaoqiang Wang, Lei Qiu, Xianyan Zhao, Wenxiao Hu","doi":"10.3389/fchem.2025.1536590","DOIUrl":"10.3389/fchem.2025.1536590","url":null,"abstract":"<p><p>Plant extracts and absolutes have high application value in several industries such as medicine, food, and fragrance. Especially in the field of fragrance, while there is expensive, they are prized by perfumers and provide a rich and lasting aroma. Owing to advancements in extraction technology, their yields have increased and their ingredients have become richer. However, no extraction technology is universal and each extraction technology has its own distinct advantages and disadvantages. Therefore, this review systematically characterizes the extraction technologies for plant extracts and absolutes, including traditional extraction technologies, such as maceration, percolation, reflux, and Soxhlet extraction, and green extraction technologies, such as microwave-assisted, ultrasonic-assisted, pressurized liquid, and supercritical fluid extractions. These extraction technologies are analyzed and compared in terms of their principles, advantages and disadvantages, improvement solutions, and applications. In addition, this review summarizes and compares new green extraction solvents and discusses the practical applications of these advanced extraction methods and solvents from different perspectives.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1536590"},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, <i>in silico</i> studies and antiproliferative evaluation of some novel hybrids of pyrimidine-morpholine.","authors":"Elaheh Ataollahi, Leila Emami, Al-Anood Mohammad Al-Dies, Fateme Zare, Alireza Poustforoosh, Mina Emami, Fateme Saadat, Fateme Motamen, Zahra Rezaei, Soghra Khabnadideh","doi":"10.3389/fchem.2025.1537261","DOIUrl":"https://doi.org/10.3389/fchem.2025.1537261","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. These cells can invade nearby tissues and organs, or they may metastasize to other parts of the body through the bloodstream or lymphatic system.</p><p><strong>Methods: </strong>In this study, eight novel pyrimidine-morpholine hybrides (<b>2a-2h</b>) were designed and synthesized based on molecular hybridization approach to identify potent cytotoxic agents. Spectroscopic methods, including infrared spectroscopy (IR), proton and carbon nuclear magnetic resonance (¹HNMR & ¹³CNMR), and mass spectrometry, were employed to confirm the structures of the compounds. The cytotoxic effects of the derivatives were evaluated against cancerous cell lines, including MCF-7 and SW480, using the MTT assay.</p><p><strong>Results and discussion: </strong>It was demonstrated that all derivatives had appropriate cytotoxic potential with IC₅₀ in range of 5.12-117.04 μM. Compound <b>2g</b> was identified as the most potent compound, exhibiting IC₅₀ values of 5.10 ± 2.12 μM and 19.60 ± 1.13 μM toward the SW480 and MCF-7 cell lines, respectively. Cell cycle analysis showed that <b>2g</b> could induces phase arrest in MCF-7 breast cancer cells. The apoptosis assay demonstrated the induction of apoptosis in the SW480 cell line. The biological activity of the compounds was confirmed by the docking studies. DFT analysis for compounds <b>2g</b> and <b>2h</b> was conducted at the B3LYP/6-31+G** level of theory. It was concluded that <b>2g</b> is both thermodynamically and kinetically more stable than <b>2h</b>. Moreover, the interpretation of ADME (Absorption, Distribution, Metabolism, and Excretion) indicates that these new series of compounds possess acceptable prognostic physicochemical properties. These synthesized compounds may serve as promising candidates for further investigation as anticancer agents.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1537261"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical porous 1D/2D hybrid aerogels with highly matched charge storage performance for aqueous asymmetric supercapacitors.","authors":"Panji Xu, Kunhua Quan, Xiyuan Wei, Yubing Li, Shuaikai Xu","doi":"10.3389/fchem.2025.1550285","DOIUrl":"https://doi.org/10.3389/fchem.2025.1550285","url":null,"abstract":"<p><p>Asymmetric supercapacitors (ASCs) have attracted widespread attention because of their high energy density, high power density and long cycle life. Nevertheless, the development of anodes and cathodes with complementary potential windows and synchronous energy storage kinetics represents a pivotal challenge. We propose to construct nanochannel-coupled vertically porous CNF/Ti₃CNT_x and CNF/rGO hybrid aerogel electrodes via a unidirectional bottom-up cryoprocess. The vertically porous structure will greatly shorten the ion diffusion path and enhance the charge/ion transfer/diffusion kinetics, and the inserted cellulose nanofibers (CNFs) will impede the re-stacking of the nanosheets and enlarge the interlayer nano-channels, thus improving the accessibility of electrolyte ions. Ultimately, all-solid-state ASCs assembled based on nanochannel-coupled vertically porous MXene and graphene aerogel can achieve an excellent energy density of 20.8 Wh kg^-1 at 2.3 kW·kg^-1, a high multiplicity performance, and retains 95.1% of energy density after 10,000 cycles. This work not only demonstrates the great superiority of nanochannel-coupled vertically porous hybrid aerogels, but also provides an effective strategy for designing asymmetric supercapacitor electrodes with matched structural and electrochemical properties.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1550285"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Bioactive containing plant based waste for (nano)-biocomposites: applications in biomedicine, health, and bioremediation.","authors":"Ram Prasad, Juan Bueno","doi":"10.3389/fchem.2025.1575200","DOIUrl":"https://doi.org/10.3389/fchem.2025.1575200","url":null,"abstract":"","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1575200"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of salidroside promoting testosterone secretion induced by H₂O₂ in TM3 Leydig cells based on metabolomics and network pharmacology.","authors":"Zixu Wang, Yunlong Xu, Huazhong Xiong","doi":"10.3389/fchem.2025.1544876","DOIUrl":"10.3389/fchem.2025.1544876","url":null,"abstract":"<p><p>Oxidative stress-induced damage is a significant contributor to the impairment of Leydig cells in the testes, potentially diminishing the secretion of testosterone and other androgens, thereby resulting in testosterone deficiency. Salidroside, the principal bioactive constituent derived from Rhodiola, exhibits potent antioxidant properties. This study aims to investigate the underlying mechanisms by which salidroside enhances testosterone secretion. The study investigated the oxidative damage in TM3 cells induced by H₂O₂ and demonstrated that salidroside significantly decreased the levels of ROS and MDA, while increasing the levels of testosterone, SOD, GSH. These changes effectively ameliorated oxidative stress, mitigated oxidative damage, protected TM3 cells, and enhanced testosterone secretion. Additionally, UPLC-QE-Orbitrap-MS was employed to analyze the metabolomics of TM3 cells, identifying 28 distinct metabolites and associated metabolic pathways. Key metabolic pathways identified include Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Citrate cycle (TCA cycle), Phenylalanine metabolism, Pyruvate metabolism. Utilizing network pharmacology, the core targets of salidroside in enhancing testosterone secretion were further investigated, revealing the involvement of AMACR, CYP3A4, ECHS1, HSD17B10, MPO, and TYR. This discovery was confirmed by dry-wet analysis. To sum up, salidroside can reduce the level of oxidative stress and promote testosterone secretion through multiple metabolic pathways and multiple targets. In a word, salidroside may provide a new strategy for preventing and treating testosterone deficiency.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1544876"},"PeriodicalIF":3.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}