Frontiers in Cardiovascular Medicine最新文献

{"title":"Imaging manifestations of hereditary hemorrhagic telangiectasia with pulmonary arterial hypertension: a case report.","authors":"Guangmei Qin, Siqi Chen, Fuling Huang, Liupei Mo, Kai Li","doi":"10.3389/fcvm.2025.1548130","DOIUrl":"10.3389/fcvm.2025.1548130","url":null,"abstract":"<p><p>Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disorder. Pulmonary arterial hypertension (PAH) is an uncommon complication (affecting <1% of HHT patients). Here, we report the clinical and imaging findings of a rare case of HHT complicated by PAH in a 41-year-old woman. The patient experienced recurrent exertional dyspnea for over 1 year, accompanied by chest tightness and pain, coughing, and production of white mucus. Her medical history included recurrent epistaxis and bilateral lower extremity edema. Due to persistent symptoms, she was hospitalized for further evaluation. Imaging revealed multiple dilated, tortuous vessels and arteriovenous fistulas in both lower lung lobes and the liver. Additionally, myocardial edema and fibrosis were observed in the ventricular insertion points, interventricular septum, right ventricular inferior wall and left ventricular free wall. Reduced pulmonary artery peak flow velocity, maximal flow, and mean wall shear stress (mWSS) were noted. Right heart catheterization confirmed pre-capillary PAH, and genetic testing identified an <i>ACVRL1</i> mutation. Symptomatic supportive care was provided during hospitalization. We discussed the relationship between PAH and HHT as well as the characteristics of both conditions.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1548130"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of enhanced external counterpulsation on anxiety and depression in patients with paroxysmal atrial fibrillation: a randomized controlled trial.","authors":"Fengqin Yang, Yan Zhang, Yu Jiang, Qinfei Wei, Xiao Cheng, Jingwen Xiao, Geng Chen","doi":"10.3389/fcvm.2025.1548839","DOIUrl":"10.3389/fcvm.2025.1548839","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of Enhanced External Counterpulsation (EECP) on anxiety and depression in patients with Paroxysmal Atrial Fibrillation (PAF).</p><p><strong>Methods: </strong>A cohort of 100 patients diagnosed with PAF at the Fuzhou First Hospital between January 2023 and June 2024 were enrolled in this study. Patients were randomly assigned to either the control group (<i>n</i> = 50) or the EECP group (<i>n</i> = 50) in this randomized controlled trial. The control group received conventional antiarrhythmic therapy with β-blockers or propafenone, and the EECP group underwent EECP therapy in conjunction with pharmacological treatment. The EECP therapy protocol consisted of 60-min sessions, conducted five times per week over a four-week period. Blood pressure, heart rate, cardiac ultrasound-related indexes, Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) scores were compared between the two groups before and after treatment.</p><p><strong>Results: </strong>After the intervention, the systolic blood pressure, diastolic blood pressure, LVEDD and LAD of the two groups decreased significantly compared to the pre-intervention period, the LVEF was higher than before intervention, and the systolic blood pressure, LVEF, LVEDD, and LAD of the EECP group were significantly better than those of the control group. Anxiety and depression indicators were lower in both groups than before the intervention, and scores in the EECP group were significantly lower than those in the control group, suggesting that EECP significantly improved anxiety and depression levels.</p><p><strong>Conclusion: </strong>EECP, as a non-invasive treatment, is effective in improving anxiety and depression in patients with PAF.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1548839"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early experience with a novel transapical transcatheter aortic valve system in patients with severe aortic stenosis: a prospective, multicenter study.","authors":"Lulu Liu, Jian Yang, Haibo Zhang, Jian Liu, Yucheng Zhong, Lai Wei, Xianbao Liu, Zhao Jian, Yuan Zhao, Yingqiang Guo","doi":"10.3389/fcvm.2025.1457180","DOIUrl":"10.3389/fcvm.2025.1457180","url":null,"abstract":"<p><strong>Objectives: </strong>Registered, prospective, multicenter study of the short-term clinical outcomes of a novel transcatheter aortic valve system (Xcor system, Saint Medical Technology, Inc., Nanjing) to evaluate its safety and efficacy.</p><p><strong>Methods: </strong>130 high risk patients with symptomatic severe AS from 11 institutions were treated with the novel Xcor system. All patients were pre-TAVR assessed by transthoracic echocardiography and computed tomography of the aortic valve (AV) and relevant left cardiac and vascular anatomy. Procedural, in-hospital, and follow-up clinical outcomes were evaluated after procedures.</p><p><strong>Results: </strong>The average age of the 130 patients was 71.2 ± 4.4 years old, 55.4% were male, and the STS score was 8.0 ± 3.9%. Device and procedural success were achieved in 98.5% and 97.7% of the patients, respectively. At 30-day follow-up, all-cause mortality, the incidence of major adverse cardiovascular events, major vascular complications, and new permanent pacemaker implantation were 3.8%, 4.6%, 0.8%, and 0.8%, respectively. 7.7% of patients showed ≥ mild paravalvular leakage, and all 125 (100%) patients were in New York Heart Association Class ≤ II. The procedural and clinical outcomes of bicuspid AV patients were similar to those of tricuspid AV patients.</p><p><strong>Conclusions: </strong>Overall, the 30-day follow-up shows that the procedural outcomes with the novel Xcor system with self-centering support arms are comparable or superior to other contemporary TAVI devices, with a low all-cause mortality, low major adverse cardiovascular events, low PVL and similar clinical outcomes for BAV and TAV patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1457180"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neutrophil to lymphocyte ratio and all-cause mortality in critical patients with coronary artery disease - a study based on the MIMIC-IV database.","authors":"Yao Li, Dongbo Chen, Yifei Fan, Qing Zhu, Han Deng, Xin Chai","doi":"10.3389/fcvm.2025.1502964","DOIUrl":"10.3389/fcvm.2025.1502964","url":null,"abstract":"<p><strong>Background: </strong>Neutrophil-to-lymphocyte ratio (NLR) has been presented as a possible indicator associated with the outcomes of growing patients and an available predictor of inflammation. Nevertheless, just a handful of researches shed light on the association between NLR and the consequences of critical patients with coronary artery disease (CAD). The study aimed to investigate the correlation between NLR and all-cause mortality of short-term and long-term in patients with CAD.</p><p><strong>Methods: </strong>We obtained objective data from the Medical Information Mart for Intensive Care (MIMIC)-IV version 2.2, a comprehensive and large-scale single-center database. NLR was calculated separately. Patients were categorized by quartiles of NLR: Q1 group (NLR < 3.56), Q2 (NLR 3.56-5.54), Q3 group (NLR 5.54-9.05), Q4 group (NLR > 9.05). Kaplan-Meier survival curves based on NLR quartiles were created to compare all-cause mortality rates, and the log-rank test evaluated the differences between groups. The hazard ratio (HR) of NLR as a risk factor for outcome events was assessed using the Cox proportional risk model with the Q1 group serving as the reference group and restricted cubic spline (RCS) with the infection points of 5.54.</p><p><strong>Results: </strong>A total of 3,692 patients were included in this study. The 30-day mortality rate among the patients was 8.85%, while the 365-day mortality rate was 16.98%. High NLR (NLR > 5.54) was significantly associated with 30-day mortality [HR, 3.99,95% confident interval (CI), (3.03-5.24); <i>P</i> < 0.001] and 365-day mortality [HR, 5.72, 95% CI (3.83-8.54); <i>P</i> < 0.001] in patients with critical CAD in the completely adjusted Cox proportional risk model. RCS analysis revealed a U-shaped relationship between NLR and outcome events.</p><p><strong>Conclusion: </strong>In patients diagnosed with critical CAD, a significant correlation was observed between NLR and all-cause mortality, particularly among individuals exhibiting elevated NLR levels. These findings suggest that NLR may serve as a valuable prognostic marker for evaluating both short-term and long-term mortality risk in this patient population.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1502964"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Atrial baffles of pulmonary and systemic veins for the anatomic and physiologic repair of left atrial isomerism heterotaxy-pre- and post-operative three-dimensional reconstructions of two mirror-image pediatric hearts.","authors":"Gregory Perens, Michael Silberbach, Jeffrey Frazer","doi":"10.3389/fcvm.2025.1529485","DOIUrl":"10.3389/fcvm.2025.1529485","url":null,"abstract":"<p><p>Intra-atrial baffles of pulmonary and systemic venous flows are relatively rarely used but are important surgical procedures for late-presenting d-transposition of the great arteries (D-TGA) or heterotaxy with anomalous venous connections. Atrial baffle surgery is employed less frequently today due to the advent of the arterial switch procedure. Two children presented with mirror-image venous connections in polysplenic heterotaxy and underwent intra-atrial baffle biventricular repairs. Both cases had ipsilateral pulmonary venous connections, interrupted inferior vena cava with azygous continuation, and concordant ventriculo-arterial connections. Furthermore, a single superior vena cava receiving the azygous and hepatic veins connected to the atrium contralateral to the sub-pulmonary right ventricle was present in both cases. Volumetric cardiac imaging using computed tomography and magnetic resonance imaging allowed for the creation of three-dimensional (3D) model reconstructions for pre-operative surgical planning and postoperative assessment of the atrial baffle pathways. The 3D model reconstructions presented here provide improved visualization and understanding of complex surgical atrial baffles.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1529485"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8.","authors":"Zhong-He Zhang, Hector Barajas-Martinez, Hong-Yi Duan, Guo-Hua Fan, Hong Jiang, Charles Antzelevitch, Hao Xia, Dan Hu","doi":"10.3389/fcvm.2025.1546803","DOIUrl":"10.3389/fcvm.2025.1546803","url":null,"abstract":"<p><strong>Background: </strong>Previous studies suggested that <i>SCN10A</i>/Nav1.8 may influence cardiac electrophysiology and the susceptibility to cardiac arrhythmias. Notably, the expression of <i>SCN10A</i> is not uniform, showing variable expression in each cardiac chamber. The present study aims to explore the functional significance of Nav1.8 expression among different cell types present in the ventricular myocardium.</p><p><strong>Methods: </strong>The effect of the specific Nav1.8 blocker, A-803467, on action potential was recorded from epicardial, mid-myocardial (M cells) and Purkinje tissue slices isolated from the canine left ventricle using standard microelectrode techniques and on late sodium current from Purkinje cells using patch-clamp techniques.</p><p><strong>Results: </strong>A-803467 treatment did not significantly affect maximum diastolic potential, action potential amplitude or maximum rate of rise of the action potential upstroke in epicardial cells, M cells or Purkinje fibers. Action potential duration (APD) was also unaffected by A-803467 in epicardial cells. However, administration of 1,000 nmol/L A-803467 reduced APD₃₀, APD₅₀, and APD₉₀ during relatively slow pacing rates of 0.2 and 0.5 Hz in M cells. In Purkinje fibers, A-803467 (100 and 1,000 nmol/L) substantially abbreviated APD₅₀ and APD₉₀ at slow pacing rates (0.2 and 0.5 Hz). Moreover, 100 nmol/L A-803467 significantly inhibited the development of early afterdepolarizations induced by 10 nmol/L ATX-II (7/8 vs. 2/8, <i>p</i> < 0.05) as well as the amplitude of late sodium current at 0.2 Hz in Purkinje cells.</p><p><strong>Conclusions: </strong>The functional significance of Nav1.8 varies among different types of ventricular and conduction system cardiomyocytes. The reduction in I_Na,L and APD, as well as suppression of early afterdepolarizations by Nav1.8 block in Purkinje fibers suggests Nav1.8 as a potential therapeutic target for bradycardia-dependent arrhythmias.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1546803"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management.","authors":"Wang Dui, Zhao Xiaobin, Zhang Haifeng, Dang Lijuan, Huang Wenhui, Zhang Zhengfeng, Song Jinling","doi":"10.3389/fcvm.2025.1546515","DOIUrl":"10.3389/fcvm.2025.1546515","url":null,"abstract":"<p><p>RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted a lot of research on the application of RNA therapeutics technology in the treatment of CVDs. Despite hurdles in off-target effects and immune responses, the clinical trial outcomes are encouraging. This review synthesizes the current progress in RNA therapeutics for CVDs, examining their mechanisms, advantages, and challenges in delivery and safety. We highlight the potential of personalized medicine, combination artificial intelligence (AI) and bioinformatics in advancing RNA therapeutics. The future of RNA therapeutics in CVDs is poised for significant impact, necessitating continued research and interdisciplinary collaboration to optimize these treatments and ensure patient safety and efficacy.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1546515"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric and visual analysis of miRNAs in heart diseases from 2004 to 2023.","authors":"Ying Jin, Jingqi Duan, Qiaoxiang Yin, Yanmin Ma, Jingli Lou, Wei Zhang","doi":"10.3389/fcvm.2025.1465646","DOIUrl":"10.3389/fcvm.2025.1465646","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNAs) add a new dimension to HD forecast, diagnosis, and therapy based on the potential applications. The miRNA-related research in the heart disease (HD) field has received close attention in the past two decades. However, there is a lack of studies that comprehensively and objectively analyze the current situation of miRNA application in the HD field using the bibliometrics method.</p><p><strong>Objective: </strong>To comprehensively analyze the global scientific outputs of miRNAs in HD research from 2004 to 2023.</p><p><strong>Methods: </strong>All the articles and reviews of miRNA-related research in the HD field were retrieved using the Web of Science core collection (WOSCC) title search, and bibliometric analysis was performed in Microsoft Excel 2019, CiteSpace, VOSviewer, and Bibliometrics (R-Tool of R-Studio).</p><p><strong>Results: </strong>3,874 publications were included in the bibliometric analysis. Collaborative network analysis indicates that China with the maximum number of publications (2,063) and the USA with the highest total citations (59,331) are influential countries in this field. Peking Union Medical College is the most prolific university with the maximum publications (134), and the University of California System is the most authoritative institution regarding betweenness centrality (0.27). PLOS ONE tops the journal list of publications, closely followed by the International Journal of Molecular Sciences and Scientific Reports with more than 100 articles. Considering the number of publications, citations, and total link strength overall, Olson. Eric N, Van Rooij Eva, Thum Thomas, Yang Baofeng, Wang Kun; and Lu Yanjie are authoritative authors in this field. The expression changes and regulatory mechanisms of specific miRNAs in various heart biological and pathophysiological processes have been the continuous research hotspots. \"exosomes\", \"extracellular vesicles\", \"autophagy\", and \"management\" have been novel hot research topics since 2018, which focused on the diagnosis and treatment of HD. The current research development trend is how to translate the achievement of miRNA-related diagnosis and therapeutic drugs for HD into the clinic.</p><p><strong>Conclusion: </strong>Our study revealed the intellectual structure of miRNA in HD research, which may help scholars understand this field comprehensively and find partners.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1465646"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Diagnosis and treatment of congenital right atrial dissection associated with atrial aneurysm.","authors":"Yuan-Yuan Zhang, Chi-Heng Zhou, Qun-Shen Shen","doi":"10.3389/fcvm.2025.1463926","DOIUrl":"10.3389/fcvm.2025.1463926","url":null,"abstract":"<p><p>Spontaneous atrial dissection and atrial aneurysm are extremely rare conditions. This may be the first reported case diagnosed in the fetal period and successfully treated with surgery under extracorporeal circulation in infancy. Although the infant in this case underwent surgery successfully, recovered, and was discharged, the optimal timing for surgical intervention in such cases remains unclear. This report aims to provide a treatment reference for similar cases.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1463926"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling patient profiles associated with elevated Lp(a) through an unbiased clustering analysis.","authors":"Miguel Saraiva, Jonatas Garcez, Beatriz Tavares da Silva, Inês Poças Ferreira, José Carlos Oliveira, Isabel Palma","doi":"10.3389/fcvm.2025.1546351","DOIUrl":"10.3389/fcvm.2025.1546351","url":null,"abstract":"<p><strong>Introduction: </strong>Lipoprotein(a) [Lp(a)] has been recognized as key factor in cardiovascular research. This study aimed to identify key patient profiles based on the characteristics of a Portuguese cohort of adults who were referred for Lp(a) measurement.</p><p><strong>Method: </strong>An unsupervised clustering analysis was performed on 661 Portuguese adults to identify patient profiles associated with lipoprotein a [Lp(a)] based on a range of demographic and clinical indicators. Lp(a) levels were deliberately excluded from the algorithm, to ensure an unbiased cluster formation.</p><p><strong>Results: </strong>The analysis revealed two distinct clusters based on Lp(a) levels. Cluster 1 (<i>n</i> = 336) exhibited significantly higher median Lp(a) levels than Cluster 2 (<i>n</i> = 325; <i>p</i> = 0.004), with 46.4% of individuals exceeding the 75 nmol/L (30 mg/dl) risk threshold (<i>p</i> < 0.001). This group was characterized by older age (median 57 vs. 45 years), lower body mass index (27.17 vs. 29.40), and a majority male composition (73.8% vs. 26.5%). Additionally, Cluster 1 displayed a higher prevalence of hypertension (56.5% vs. 31.1%), diabetes <i>mellitus</i> (38.7% vs. 17.2%), and dyslipidemia (88.7% vs. 55.4%). These data suggest that the Cluster 1 profile has a potential increased risk for cardiovascular complications and underscore the importance of considering specific patient profiles for Lp(a) screening and cardiovascular risk assessment.</p><p><strong>Conclusion: </strong>Despite the study limitations, including single-institution data and potential selection bias, this study highlights the utility of cluster analysis in identifying clinically meaningful patient profiles and suggests that proactive screening and management of Lp(a) levels, particularly in patients with characteristics resembling those of Cluster 1, may be beneficial.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1546351"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}