Frontiers in Cardiovascular Medicine最新文献

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Rethinking mechanical heart valves in the aortic position: new paradigms in design and testing.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-30 eCollection Date: 2024-01-01 DOI: 10.3389/fcvm.2024.1458809
Sreyashi Chakraborty, Melinda G Simon, Alessandro Bellofiore
{"title":"Rethinking mechanical heart valves in the aortic position: new paradigms in design and testing.","authors":"Sreyashi Chakraborty, Melinda G Simon, Alessandro Bellofiore","doi":"10.3389/fcvm.2024.1458809","DOIUrl":"10.3389/fcvm.2024.1458809","url":null,"abstract":"<p><p>Bileaflet mechanical heart valves (MHV) remain a viable option for aortic valve replacement, particularly for younger patients and patients from low- and middle-income countries and underserved communities. Despite their exceptional durability, MHV recipients are at increased risk of thromboembolic complications. As such, the development of the next generation of MHVs must prioritize improved thromboresistance and aim for independence from anticoagulant therapy. However, innovation in MHV design faces several challenges: strict performance and biocompatibility requirements, limited understanding of the mechanisms underlying MHV thrombosis, and a lack of effective testing methodologies to assess how design variations impact both hemodynamic performance and thrombogenicity of MHVs. This paper reviews the emerging paradigms in MHV design, materials and surface modifications that may inspire the development of a new generation of MHVs for aortic valve replacement. We also discuss challenges and opportunities in developing experimental and numerical approaches to achieve a more comprehensive understanding of MHV flow features and the mechanisms of flow-induced blood clotting.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1458809"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiofrequency ablation vs. cryoablation for pediatric atrioventricular nodal reentrant tachycardia in the era of three-dimensional electroanatomical mapping.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-30 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1527768
Yao-Wei Chan, Chieh-Mao Chuang, Pi-Chang Lee, I-Hsin Tai, Ying-Hsuan Peng, Wen-Po Fan, Yu-Shin Lee, Ming-Chih Lin, Sheng-Ling Jan, Yun-Ching Fu, Shih-Ann Chen
{"title":"Radiofrequency ablation vs. cryoablation for pediatric atrioventricular nodal reentrant tachycardia in the era of three-dimensional electroanatomical mapping.","authors":"Yao-Wei Chan, Chieh-Mao Chuang, Pi-Chang Lee, I-Hsin Tai, Ying-Hsuan Peng, Wen-Po Fan, Yu-Shin Lee, Ming-Chih Lin, Sheng-Ling Jan, Yun-Ching Fu, Shih-Ann Chen","doi":"10.3389/fcvm.2025.1527768","DOIUrl":"10.3389/fcvm.2025.1527768","url":null,"abstract":"<p><strong>Background: </strong>Cryoablation for pediatric atrioventricular nodal reentry tachycardia (AVNRT) is favored for reducing conduction system injury compared to radiofrequency (RF) ablation. The safety advantage of cryoablation over RF ablation primarily results from studies conducted without a three-dimensional electroanatomical mapping (3D EAM) system. Currently, 3D EAM systems offer precise and efficient guidance, improving safety and outcomes. This study compares RF ablation and cryoablation using a 3D EAM system for pediatric AVNRT treatment.</p><p><strong>Methods: </strong>A retrospective study enrolled consecutive pediatric patients with AVNRT who underwent RF ablation (RF group) or cryoablation (Cryo group) guided by a 3D EAM system at multiple centers from July 2018 to January 2024.</p><p><strong>Results: </strong>Among 95 patients, 69 received RF ablation and 26 received cryoablation. Recurrence rates were 2.9% in the RF group and 0% in the Cryo group (<i>p</i> > 0.99), with no difference in AVNRT-free survival. No major complications, such as permanent atrioventricular (AV) block, were observed. The minor complication rates, including transient AV block, did not differ significantly (14.5% vs. 11.5%, <i>p</i> > 0.99). The RF group had a significantly shorter procedure time (111 vs. 153.5 min, <i>p</i> = 0.005). Ablation outside the low Koch triangle and cryoablation were independently associated with longer procedure times. The procedure time decreased significantly in the recent 50% of RF ablation cases, but not in cryoablation cases.</p><p><strong>Conclusion: </strong>With 3D EAM guidance, both RF ablation and cryoablation are considered safe and effective for pediatric AVNRT. RF ablation is more efficient with a shorter procedure time after increasing experience.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1527768"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-30 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1501296
Irina Zyubanova, Nadezhda Ryumshina, Victor Mordovin, Musheg Manukyan, Valeriya Lichikaki, Ekaterina Solonskaya, Anna Gusakova, Tatjana Suslova, Stanislav Pekarskiy, Simzhit Khunkhinova, Anastasia Popova, Veronika Rudenko, Alla Falkovskaya
{"title":"Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function.","authors":"Irina Zyubanova, Nadezhda Ryumshina, Victor Mordovin, Musheg Manukyan, Valeriya Lichikaki, Ekaterina Solonskaya, Anna Gusakova, Tatjana Suslova, Stanislav Pekarskiy, Simzhit Khunkhinova, Anastasia Popova, Veronika Rudenko, Alla Falkovskaya","doi":"10.3389/fcvm.2025.1501296","DOIUrl":"10.3389/fcvm.2025.1501296","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the sex differences in the efficacy of renal denervation (RDN) in patients with resistant hypertension (RHT) concerning the size of abdominal fat depots, changes in biomarkers of sympathetic activity, and renal function.</p><p><strong>Materials and methods: </strong>24 men (56.5 ± 7.8 years) and 33 women (59.5 ± 8.4 years) with RHT were enrolled in the study and underwent RDN. 24-h ambulatory blood pressure (BP) [systolic/diastolic (SBP/DBP)], serum creatinine (with eGFR calculation), serum adipocytokines (leptin, adiponectin, resistin), serum metanephrines and normetanephrines were measured baseline and 12 months after RDN. The size of subcutaneous, visceral, and perirenal adipose tissue (SAT, VAT, and PRAT) was assessed using MRI.</p><p><strong>Results: </strong>After RDN, BP decreased, leptin increased, and adiponectin, resistin, and metanephrine levels did not change in both sexes. There was a decrease in normetanephrine levels in women and a similar trend in men. In men, the eGFR did not change. In women, the eGFR remained unchanged only in those with chronic kidney disease (CKD) (<i>n</i> = 10) and decreased in the absence of CKD (<i>n</i> = 23) from 79.7 ± 14.1 to 72.1 ± 12.0 ml/min/1.73 m<sup>2</sup> (<i>p</i> = 0.011). Men had larger visceral fat depots, and women had larger subcutaneous fat depots. After RDN, the size of adipose tissue in men remained unchanged, and in women, the PRAT thickness decreased from 2.36 ± 1.23 to 2.10 ± 1.17 cm (<i>p</i> = 0.002). Lowering BP in women was associated with increased leptin levels after RDN (<i>r</i> = -0.47 for SBP, <i>r</i> = -0.48 for DBP). Dependence of BP reduction on baseline eGFR was observed in men only [<i>r</i> = 0.44 for SBP, <i>r</i> = 0.48 for pulse pressure (PP)]. Additionally, in men, the decrease in SBP and PP depended on VAT areas (<i>r</i> = -0.44 and <i>r</i> = -0.58, respectively). In women, the SBP reduction showed an inverse correlation between baseline weight (<i>r</i> = -0.35) and waist circumference (<i>r</i> = -0.38).</p><p><strong>Conclusions: </strong>The magnitude of the antihypertensive effect of RDN depends on signs of visceral obesity and, in men, also on the presence of CKD. Renoprotective effects of RDN in men are obtained regardless of the initial kidney function, while in women, it was observed only in individuals with CKD. Additional beneficial effects of RDN in women include a decrease in normetanephrine levels and a reduction in PRAT size.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1501296"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic IVC occlusion caused by unopened filter after conversion: case report and literature review.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-30 eCollection Date: 2024-01-01 DOI: 10.3389/fcvm.2024.1520836
Shi Sheng, Yiqing Li
{"title":"Chronic IVC occlusion caused by unopened filter after conversion: case report and literature review.","authors":"Shi Sheng, Yiqing Li","doi":"10.3389/fcvm.2024.1520836","DOIUrl":"10.3389/fcvm.2024.1520836","url":null,"abstract":"<p><strong>Background: </strong>The VenaTech Convertible Vena Cava Filter (VTCF) is a device designed for insertion into the inferior vena cava (IVC) to prevent life-threatening pulmonary embolism (PE). Upon removal of its retrieval hook, the filter's legs are intended to expand, forming a stent-like structure that is suitable for long-term residence in the human body. However, in clinical practice, the filtering legs do not always expand fully, and the long-term effects on patients remain insufficiently studied.</p><p><strong>Materials and methods: </strong>This report presents the case of a male patient with thrombophilia, in whom the VTCF failed to expand completely after conversion, resulting in IVC occlusion and the development of acute deep vein thrombosis (DVT) in the lower limbs. A review of the relevant literature is also provided.</p><p><strong>Conclusion: </strong>The inability of the filtering legs to fully expand after retrieval hook removal highlights a design limitation of the VTCF, necessitating proactive management during conversion to ensure complete expansion. For younger or thrombophilic patients, careful evaluation of the filter's suitability and extended follow-up are crucial to optimize outcomes.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1520836"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular management of a spontaneous aorto-caval fistula resulting from abdominal aortic aneurysm: case report and literature review.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-30 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1518025
Dongbo Wu, Cheng Peng, Zhiyong Zhou, Jie Chen, Bin He, Zhidong Ye
{"title":"Endovascular management of a spontaneous aorto-caval fistula resulting from abdominal aortic aneurysm: case report and literature review.","authors":"Dongbo Wu, Cheng Peng, Zhiyong Zhou, Jie Chen, Bin He, Zhidong Ye","doi":"10.3389/fcvm.2025.1518025","DOIUrl":"10.3389/fcvm.2025.1518025","url":null,"abstract":"<p><strong>Background: </strong>Aorto-caval fistula is a rare complication of abdominal aortic aneurysms that can occur spontaneously, iatrogenically, or traumatically, associated with high morbidity and mortality. Endovascular stent graft repair represents a practical approach to managing this fatal condition.</p><p><strong>Case presentation: </strong>A 75-year-old male patient was admitted to the nephrology department of our hospital, complaining of acute back pain, hematuria, and repeated vomiting for one week. The laboratory assessments yielded high creatinine levels, indicating an acute renal impairment. Computed tomography angiography revealed an aorto-caval fistula complicating infrarenal abdominal aortic aneurysm. The patient was successfully treated with the endovascular approach by deploying covered stent grafts that completely excluded the fistula.</p><p><strong>Conclusion: </strong>Utilizing covered stent grafts for endovascular management of aorto-caval fistula is a good alternative to conventional surgery, especially in elderly high-risk patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1518025"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-associated thoracic aorta arterial thrombosis: case report and review of the literature.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1480310
Miguel Borregón, María Valero, Asia Ferrández, Álvaro Muñoz, Carmen Roque, Javier-David Benítez-Fuentes
{"title":"Cancer-associated thoracic aorta arterial thrombosis: case report and review of the literature.","authors":"Miguel Borregón, María Valero, Asia Ferrández, Álvaro Muñoz, Carmen Roque, Javier-David Benítez-Fuentes","doi":"10.3389/fcvm.2025.1480310","DOIUrl":"10.3389/fcvm.2025.1480310","url":null,"abstract":"<p><strong>Background: </strong>Arterial thrombosis is an uncommon complication in cancer patients, often overshadowed by venous thromboembolic events. Its occurrence in patients with solid tumors on active antineoplastic treatment poses a significant clinical challenge.</p><p><strong>Key clinical question: </strong>Given the lack of consensus on the optimal therapy for arterial thrombosis in cancer patients, the best practices for managing an aortic thrombus, and the benefit of low molecular weight heparin (LMWH) must be reviewed.</p><p><strong>Clinical approach: </strong>We present the case of a 70-year-old female with stage IVA lung adenocarcinoma who developed an aortic thrombus during chemo-immunotherapy. The thrombus was successfully treated with LMWH, avoiding further complications, and allowing for the continuation of her cancer therapy.</p><p><strong>Conclusions: </strong>This case highlights the importance of early detection and management of arterial thrombus in cancer patients. LMWH proved effective in resolving the thrombus, underscoring its role in managing such complications.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1480310"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1534533
Katongo Hope Mutengo, Bruno Bezerra Lima, Wilbroad Mutale, Aggrey Mweemba, Lorrita Kabwe, Clive Banda, Callistus Kaayunga, Mutale Mulenga, Douglas Heimburger, Sepiso K Masenga, John Jeffrey Carr, Annet Kirabo
{"title":"The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies.","authors":"Katongo Hope Mutengo, Bruno Bezerra Lima, Wilbroad Mutale, Aggrey Mweemba, Lorrita Kabwe, Clive Banda, Callistus Kaayunga, Mutale Mulenga, Douglas Heimburger, Sepiso K Masenga, John Jeffrey Carr, Annet Kirabo","doi":"10.3389/fcvm.2025.1534533","DOIUrl":"10.3389/fcvm.2025.1534533","url":null,"abstract":"<p><strong>Introduction: </strong>Human immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize associations between HIV and myocardial fibrosis from CMR-based observational studies in adults.</p><p><strong>Methods: </strong>We identified 12 studies (2013-2024) with 1,769 participants [1,117 people with HIV (PWH)]. Three studies were cohort and nine were cross-sectional. Meta-analysis included seven studies on late gadolinium enhancement (LGE) (1,081 participants: 669 PWH), eight on native T1 mapping (840 participants: 467 PWH), and ten on ECVF (1,603 participants: 992 PWH). We examined myocardial fibrosis prevalence via the prevalence difference in LGE, and severity by mean differences in native T1 mapping values [milliseconds (ms)] and global extracellular volume fraction (ECVF,%) between PWH and HIV-uninfected individuals, using random effects model.</p><p><strong>Results and discussion: </strong>Pooled analyses showed PWH had a 33% higher prevalence of LGE (95% CI: 12.0%-54.0%, I<sup>2</sup> = 94.5%, <i>p</i> < 0.001), a mean native T1 mapping difference of 27.30 ms (95% CI: 11.21-43.39 ms, I<sup>2</sup> = 88.2%, <i>p</i> < 0.001), and a mean ECVF difference of 1.85% (95% CI: 0.63%-3.08%, I<sup>2</sup> = 90.5%, <i>p</i> < 0.001), respectively. Meta-regression showed no significant associations between ECVF and demographic, HIV-related, or cardiac factors. LGE and native T1 mapping analyses lacked sufficient data for meta-regression. In conclusion, PWH exhibit significantly higher prevalence and severity of myocardial fibrosis compared to HIV-uninfected individuals. But standardized methodologies and further research are essential to enhance consistency.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=533379, CRD [42024533379].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1534533"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal ultrasound diagnosis, associated anomalies and pregnancy outcomes of fetal right aortic arch.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1521338
Yuting Xie, Zongjie Weng, Ronghua Wang, Qiumei Wu, Wen Ling, Jinwen Chen, Shan Guo
{"title":"Prenatal ultrasound diagnosis, associated anomalies and pregnancy outcomes of fetal right aortic arch.","authors":"Yuting Xie, Zongjie Weng, Ronghua Wang, Qiumei Wu, Wen Ling, Jinwen Chen, Shan Guo","doi":"10.3389/fcvm.2025.1521338","DOIUrl":"10.3389/fcvm.2025.1521338","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to summarise the prenatal ultrasound characteristics, associated anomalies and pregnancy outcomes of fetal right aortic arch (RAA) and to discuss the value of prenatal ultrasound diagnosis and prognostic analysis.</p><p><strong>Methods: </strong>We retrospectively analysed 157 cases of fetal RAA diagnosed via prenatal ultrasound in our hospital from October 2017 to October 2022. RAA features were characterised by comparing prenatal ultrasound data with anatomical casting results after pregnancy termination or postnatal imaging and surgical intervention to analyse the prognosis and misdiagnoses of fetal RAA.</p><p><strong>Results: </strong>Of the 157 fetal RAA cases, 50 (31.8%) cases were isolated RAA and 107 (68.2%) cases were nonisolated RAA. In terms of typing, 78 cases (49.7%) of right aortic arch-aberrant left subclavian artery (RAA-ALSA) and 75 cases (47.8%) of right aortic arch-mirror branch (RAA-MB), 3 cases (1.9%) of right aortic arch-isolated left subclavian artery (RAA-ILSA) and 1 case (0.6%) of right aortic arch-isolated left innominate artery (RAA-ILINA) were identified, and the incidence of combined cardiac anomalies and chromosomal anomalies was significantly greater in the RAA-MB group than the RAA-ALSA group. The live birth rate was significantly lower in the nonisolated RAA group than the isolated RAA group, and the prognosis of RAA-MB was significantly worse than that of RAA-ALSA. Among the 76 surviving patients, 72 (94.7%) cases were correctly diagnosed via prenatal ultrasound, and 4 (5.3%) cases had missed diagnoses and misdiagnoses. Of the 81 terminated pregnancies, 19 cases received pathological anatomy or vascular casting, including 18 cases with results consistent with the prenatal ultrasound and 1 case with inconsistent results.</p><p><strong>Conclusions: </strong>Prenatal echocardiography is useful for diagnosing fetal RAA. It is also necessary to classify RAA types as accurately as possible and detect the presence of potential cardiac and extracardiac anomalies and genetic abnormalities, which facilitates prenatal counselling and prognostic assessment of fetuses with RAA.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1521338"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-29 eCollection Date: 2024-01-01 DOI: 10.3389/fcvm.2024.1505298
R Mohamad Javier, Stephanie Angela Prijanto, Vallexa Septina Yora, Desak Gede Yuliana Eka Pratiwi, Errini Sabilla Lilhawa Ditsi, Bella Adelia, Verika Christabela Tansuri, Hendry Wijaya, Georaldhy Yussufy Caecarma, Intan Trikumala Damayanti, Anisa Ramadhanti, Atika Rahmaputri, Chabib Fachry Albab, Afif Ferdian, Fatih Farabi, Fadila Risang Ayu, Ni Putu Ika Regina Maharani, Andika Prasetyo Arifin, Eko Setyo Herwanto, Saidah Rahmat A, Safira Dita Arviana, Syifa Nur Lathifah, Nanda Rizki Yulinar, Laksmitha Saktiono Safitri, Basyar Adnani, M Rizki Fazrian Danu, Natasya Naomi, Dayu Dwi Deria, Aulia Syifa, Panca Andana, Adrian Prasetya, Fachira Rachel Agfata, Magistra Cylvia Margaretha, Subandono Bambang Indrasto, Sukirman, Rachmanto, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch Aleq Sander
{"title":"Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults.","authors":"R Mohamad Javier, Stephanie Angela Prijanto, Vallexa Septina Yora, Desak Gede Yuliana Eka Pratiwi, Errini Sabilla Lilhawa Ditsi, Bella Adelia, Verika Christabela Tansuri, Hendry Wijaya, Georaldhy Yussufy Caecarma, Intan Trikumala Damayanti, Anisa Ramadhanti, Atika Rahmaputri, Chabib Fachry Albab, Afif Ferdian, Fatih Farabi, Fadila Risang Ayu, Ni Putu Ika Regina Maharani, Andika Prasetyo Arifin, Eko Setyo Herwanto, Saidah Rahmat A, Safira Dita Arviana, Syifa Nur Lathifah, Nanda Rizki Yulinar, Laksmitha Saktiono Safitri, Basyar Adnani, M Rizki Fazrian Danu, Natasya Naomi, Dayu Dwi Deria, Aulia Syifa, Panca Andana, Adrian Prasetya, Fachira Rachel Agfata, Magistra Cylvia Margaretha, Subandono Bambang Indrasto, Sukirman, Rachmanto, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch Aleq Sander","doi":"10.3389/fcvm.2024.1505298","DOIUrl":"10.3389/fcvm.2024.1505298","url":null,"abstract":"<p><strong>Background: </strong>The Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients.</p><p><strong>Methods: </strong>This review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications.</p><p><strong>Result: </strong>The study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases.</p><p><strong>Conclusion: </strong>MPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1505298"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis.
IF 2.8 3区 医学
Frontiers in Cardiovascular Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.3389/fcvm.2025.1450470
Ting Zhang, Zhimao Li, Qimin Mei, Joseph Harold Walline, Zhaocai Zhang, Yecheng Liu, Huadong Zhu, Bin Du
{"title":"Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis.","authors":"Ting Zhang, Zhimao Li, Qimin Mei, Joseph Harold Walline, Zhaocai Zhang, Yecheng Liu, Huadong Zhu, Bin Du","doi":"10.3389/fcvm.2025.1450470","DOIUrl":"10.3389/fcvm.2025.1450470","url":null,"abstract":"<p><strong>Introduction: </strong>There is growing evidence that patients with SARS-CoV-2 (The severe acute respiratory syndrome coronavirus 2) may have a variety of cardiovascular complications in the post-acute phase of COVID-19, but these manifestations have not yet been comprehensively characterized.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis of primary research papers which evaluated individuals at least four weeks after confirmed COVID-19 diagnosis and reported on cardiovascular disease prevalence. Systematic search conducted without language restrictions from December 1, 2019 to June 31, 2022 on PubMed, EMBASE, Web of Science, Cochrane library, ProQuest Coronavirus Research Database, COVID-19 Living Overview of the Evidence (L-OVE) subset of Episteminokos and the World Health Organization (WHO) Covid-19 databases. Study was reported according to MOOSE-lists and the PRISMA guidelines. The risk of bias was identified using the Newcastle-Ottawa Scale (NOS) for observational studies. Random-effects meta-analyses examined the pooled risk difference in the prevalence of each symptom or symptom combination in cases with confirmed SARS-coV-2 infection compared with controls.</p><p><strong>Results: </strong>Eight cohort studies were eligible, including nearly 10 million people. Long COVID-19 was associated with a higher risk of thromboembolic disorders [HR 3.12 (1.60, 6.08)], coronary heart disease [HR 1.61 (1.13, 2.31)], stroke [HR 1.71 (1.07,2.72)], arrhythmia [HR 1.60 (1.13, 2.26)], cardiomyopathy [HR 1.71 (1.12, 2.61)], myocarditis [HR 6.11 (4.17,8.94)], hypertension [HR 1.70 (1.56, 1.85)], heart failure [HR 1.72 (1.15,2.59)] and cardiogenic shock [HR 2.09 (1.53,2.86)] compared to non-COVID-19 controls. Pooled risk differences in long COVID cases compared to controls were significantly higher for cardiomyopathy [0.15% (0.06, 0.23)], deep vein thrombosis [0.45% (0.06, 0.83)] and hypertension (0.32%, (0.06, 0.58) but not for thromboembolic disorders, coronary disease, stroke, arrhythmia, cardiomyopathy, myocarditis, hypertension, heart failure or cardiogenic shock.</p><p><strong>Conclusion: </strong>The risk of cardiovascular disease increased significantly four weeks or more after recovering from acute COVID-19. Care for survivors after an acute attack of COVID-19 should include paying close attention to cardiovascular health and disease.</p><p><strong>Systematic review registration: </strong>PROSPERO [CRD42022353965].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1450470"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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