Frontiers in Cardiovascular Medicine最新文献

{"title":"Effects of exercise training on left ventricular systolic and diastolic function after myocardial infarction: systematic review and meta-analysis.","authors":"XiaoMing Zhang, Yao Mi, Mingwang Ding, Xin Gao","doi":"10.3389/fcvm.2025.1526326","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1526326","url":null,"abstract":"<p><strong>Objectives: </strong>Exercise training is a rehabilitative approach to improve cardiac function in patients with myocardial infarction. However, evidence on the effectiveness of exercise training in these patients remains limited. In this meta-analysis, we aim to evaluate the extent to which exercise training improves cardiac function in patients with myocardial infarction.</p><p><strong>Methods: </strong>We conducted a systematic search of the PubMed, Embase, Cochrane Library, and Web of Science databases to compare cardiac function in myocardial infarction patients who received exercise training combined with standard pharmacological therapy. The cardiac function indicators evaluated included: LVEF, E, E/A, LVIDd, LVIDs, NT-proBNP, E' septal, GLS, and LVMI.</p><p><strong>Results: </strong>The final analysis included 12 studies with a total of 922 patients. Compared with the standard treatment group, exercise training significantly improved LVEF (MD = 3.99, 95% CI: 1.30-6.68) and <i>E</i> (MD = 3.86, 95% CI: 1.33-6.39) in myocardial infarction patients, while showing no significant improvement in the remaining indicators.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024571194, PROSPERO (CRD42024571194).</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1526326"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge domains and hotspots of the association between hypertension and noise: a bibliometric analysis and visualization study from 2003 to 2023.","authors":"Tianqi Wu, Siming Zhang, Zhou Zhang, Jun Pu, Ruizi Liu, Tianyi Yuan, Xu Chen, Songnian He, Qingyu Hao, Jue Gu","doi":"10.3389/fcvm.2025.1492051","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1492051","url":null,"abstract":"<p><strong>Objectives: </strong>Noise pollution has become an increasingly severe environmental issue in modern society and has been recognized for its adverse effects on cardiovascular diseases. Hypertension induced by noise exposure has garnered significant research interest and a large quantity of studies have been conducted. This study aims to employ bibliometric methods to comprehensively review the literature on the relationship between noise exposure and hypertension and to analyze the current state of research by identifying key areas of focus while also exploring future trends in this field.</p><p><strong>Methods: </strong>The bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database. The search query included terms related to noise pollution and hypertension. The timeframe for the search was from 2003 to 2023. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Rtools, focusing on publication trends, citation metrics, explosive intensity, and collaborative networks. Pajek was used to adjust pictures.</p><p><strong>Results: </strong>The bibliometric analysis showed a notable rise in research output on the relationship between noise pollution and hypertension. The United States led in the number of publications, with China and Germany coming next. The study identified several key contributors, with Muenzel Thomas being the most prolific author, followed by Daiber Andreas and Pershagen Goran. Institutionally, Johannes Gutenberg University Mainz emerged as the leading institution in terms of publications, followed by Karolinska Institute. Collaborative networks among institutions highlighted significant international cooperation, with extensive collaborations observed, particularly between European and North American institutions. The study also pinpointed research hotspots and emerging trends through keyword analysis. Key areas of focus included the mechanisms linking noise exposure to hypertension, the impact of noise on cardiovascular health, and the role of environmental stressors.</p><p><strong>Conclusions: </strong>This study advances our understanding of noise-induced hypertension's physiological and biological mechanisms, emphasizing the need for continued research. The research underscores the necessity of addressing noise pollution as a significant public health concern.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1492051"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-cerebral infarction: a narrative review of pathophysiology, treatment challenges, and prognostic implications.","authors":"Weiwei Gao, Lingfeng Yu, Jingjing She, Junxuan Sun, Shouyue Jin, Jingjing Fang, Xingyu Chen, Renjing Zhu","doi":"10.3389/fcvm.2025.1507665","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1507665","url":null,"abstract":"<p><p>Cardio-cerebral infarction (CCI) is a rare clinical syndrome characterized by the simultaneous or sequential occurrence of acute myocardial infarction (AMI) and acute ischemic stroke (AIS). Despite its complex pathogenesis and more severe prognosis compared to isolated AMI or AIS, no consensus has been established regarding its definition, classification, epidemiology, treatment protocols, or prognostic management. Current research is largely confined to case reports or small case series, and there are no unified diagnostic or treatment guidelines, nor any expert consensus. Consequently, clinicians often rely on single-disease guidelines for AMI or AIS, or personal experience, when managing CCI cases. This approach complicates treatment decisions and may result in missed opportunities for optimal interventions, thereby adversely affecting long-term patient outcomes. This narrative review aimed to systematically summarize the definition, classification, epidemiological features, pathogenesis and therapeutic strategies, and prognostic aspects of CCI while thoroughly examining the progress and limitations of existing studies to guide future research and clinical practice. By offering a detailed analysis of reperfusion strategies, antiplatelet therapy, and anticoagulation in CCI patients, this review highlights the safety and efficacy differences among current treatments and explores methods for optimizing individualized management to improve clinical outcomes. Furthermore, this article aimed to enhance clinicians' understanding of CCI, provide evidence-based recommendations for patient care, and outline directions for future research. Ultimately, by refining diagnostic and therapeutic strategies, we aimed to reduce CCI-related mortality and improve long-term prognoses for affected patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1507665"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation.","authors":"Prabhash Kumar Jha, Toshiaki Nakano, Lucas Yuji Umesaki Itto, Miguel Cantadori Barbeiro, Adrien Lupieri, Elena Aikawa, Masanori Aikawa","doi":"10.3389/fcvm.2025.1574489","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1574489","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream. These toxins play a pivotal role in mediating vascular inflammation, a key contributor to the high cardiovascular morbidity and mortality observed in CKD patients. This review article explores the intricate mechanisms by which uremic toxins accelerate vascular inflammation. Macrophages, as versatile immune cells, are central to the inflammatory response. Evidence suggests that the uremic milieu influences macrophage biology. In this review article, we focus on the signaling through which uremic toxins, particularly indoxyl sulfate-an independent risk factor for cardiovascular complications in CKD patients, modulate macrophage activation and function, and how these changes contribute to vascular inflammation, leading to the increased cardiovascular risk. Investigation of such mechanisms provide molecular bases for the development of new therapies that retard the development of cardiovascular disorders in CKD patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1574489"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of plasma aldosterone concentration with peripheral artery disease in hypertensive patients: insights from a large cross-sectional analysis.","authors":"Yingying Zhang, Xintian Cai, Shuaiwei Song, Junli Hu, Pan Zhou, Kangxin Cai, Rui Ma, Huimin Ma, Di Shen, Wenbo Yang, Delian Zhang, Qin Luo, Jing Hong, Nanfang Li","doi":"10.3389/fcvm.2025.1549878","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1549878","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between plasma aldosterone concentration (PAC) and the prevalence of peripheral artery disease (PAD) in hypertensive patients and to determine any potential threshold effects.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 13,157 hypertensive individuals from the People's Hospital of Xinjiang Uygur Autonomous Region, China. PAD was diagnosed based on an ankle-brachial index (ABI) of ≤0.90. A multivariate logistic regression model was utilized to evaluate the association between PAC and PAD, and a generalized additive model (GAM) was employed to explore non-linear relationships.</p><p><strong>Results: </strong>The fully adjusted logistic regression model revealed a significant positive association between PAC and PAD, with an odds ratio (OR) [95% confidence interval (CI)] of 1.06 (1.04, 1.08) per unit increase in PAC. The GAM identified a critical threshold at 17.00 ng/dl for PAC, above which the prevalence of PAD increased by 9% for each unit increase in PAC, with an OR (95% CI) of 1.09 (1.06, 1.11). Sensitivity and subgroup analyses confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>This study establishes a non-linear relationship between PAC and the prevalence of PAD in hypertensive patients, with a critical threshold at 17.00 ng/dl. These findings underscore the importance of aldosterone homeostasis in vascular health and the need for further large-scale, prospective studies to validate these results and explore their clinical implications.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1549878"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender correlation between sleep duration and risk of coronary heart disease: a systematic review and meta-analysis.","authors":"Cun Li, Shun-Xin Luo, Tian-Wei Liang, Dan Song, Jin-Xiao Fu","doi":"10.3389/fcvm.2025.1452006","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1452006","url":null,"abstract":"<p><strong>Objective: </strong>The influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic.</p><p><strong>Methods: </strong>This analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase. A two-stage hierarchical regression model evaluates potential linear dose-response relationships. Data analysis utilizes random-effects restricted cubic spline models with four knots.</p><p><strong>Results: </strong>Involving 17 studies and 906,908 participants, this meta-analysis identifies a pronounced U-shaped nonlinear relationship between sleep duration and CHD risk applicable to both genders (<i>P</i> < 0.01). Notably, shorter sleep durations are linked to higher CHD risks in women, whereas longer durations are more consequential for men. The optimal sleep duration for minimizing CHD risk is between 7.0-8.0 h daily for men and 7.5-8.5 h for women.</p><p><strong>Conclusion: </strong>The influence of sleep duration on CHD risk differs significantly between genders.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier (CRD42023478235).</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1452006"},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Pulmonary hypertension in atrial septal defect.","authors":"K Krishnathasan, I Rafiq, K Dimopoulos","doi":"10.3389/fcvm.2025.1589305","DOIUrl":"10.3389/fcvm.2025.1589305","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1589305"},"PeriodicalIF":2.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.","authors":"Gufeng Gao, Ai Chen, Yan Yan, Mohammad Ismail Hajary Sagor, Weijun Lin, Huakan Lin, Guili Lian, Liangdi Xie, Li Luo","doi":"10.3389/fcvm.2025.1543319","DOIUrl":"10.3389/fcvm.2025.1543319","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension (PAH) is a severe disease marked by the remodeling of arteries due to the abnormal growth of vascular cells, including pulmonary arterial smooth muscle cells (PASMCs). The insulin receptor substrate-1 (IRS-1) plays a crucial role in the insulin signaling pathway; however, its function in PAH is still not fully understood. The objective of this research was to explore the role of the protein kinase C (PKC)/IRS-1/ERK signaling pathway in the progression of PAH and its influence on the proliferation and migration of PASMCs.</p><p><strong>Methods: </strong>To establish the PAH model, low-dose Monocrotaline (MCT) was intraperitoneally administered to male SD rats twice a week. Four weeks following the initial treatment, measurements of mean pulmonary arterial pressure (mPAP) and the right ventricular hypertrophy index (RVHI) were conducted. Additionally, calculations were performed to determine the percentage of wall area (WA%) and wall thickness (WT%). The protein levels of PKC, p-PKC, IRS-1, p-IRS-1 (Ser318), ERK, and p-ERK in lung tissues were assessed. <i>in vitro</i> experiments involved stimulating PASMCs with platelet-derived growth factor-BB (PDGF-BB) to promote proliferation and migration. The impact of the PKC inhibitor Gö 6983 and IRS-1 overexpression via adenoviral vectors (AdIRS-1) on the PKC/IRS-1/ERK signaling pathway and PASMCs behavior was analyzed through Western blotting, EdU incorporation assay, and wound healing assay.</p><p><strong>Results: </strong>In PAH rats, there was a significant rise in mPAP and RVHI (<i>p</i> < 0.05), accompanied by notable pulmonary vascular remodeling. Analysis of lung tissues revealed enhanced levels of p-PKC, p-IRS-1(Ser318), and p-ERK, whereas the expression of total IRS-1 decreased significantly (<i>p</i> < 0.05). In PASMCs stimulated with PDGF-BB, a similar trend of increased p-PKC, p-IRS-1(Ser318), and p-ERK levels was observed, along with a decrease in IRS-1 expression. The administration of Gö 6983 or the overexpression of IRS-1 effectively inhibited the activation of the PKC/IRS-1/ERK signaling pathway, leading to reduced proliferation and migration of PASMCs compared to stimulation with PDGF-BB alone (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The PKC/IRS-1/ERK signaling pathway is implicated in the abnormal proliferation and migration of PASMCs, contributing to pulmonary vascular remodeling in PAH. Targeting this pathway through PKC inhibition or IRS-1 stabilization may offer novel therapeutic strategies for PAH management.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1543319"},"PeriodicalIF":2.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Maintaining a balance between vascular access patency and stable dissection status in a hemodialysis patient with unrepaired type A aortic dissection.","authors":"Qiquan Lai, Ling Chen, Xuejing Gao, Hongtao Tie, Ziming Wan","doi":"10.3389/fcvm.2025.1561645","DOIUrl":"10.3389/fcvm.2025.1561645","url":null,"abstract":"<p><strong>Introduction: </strong>Type A aortic dissection (AD) is a lethal situation with high mortality within short time after onset. We present here a rare hemodialysis patient whose condition was comorbid with unrepaired type A AD. The challenge we face is whether low-molecular-weight heparin (LMWH) should be used during dialysis.</p><p><strong>Case presentation: </strong>A 72-year-old man with a history of hemodialysis for 2 years and 7 months sought medical attention due to thrombosis of the dialysis catheter. He had been diagnosed with an unrepaired type A aortic dissection (involving the aortic root, the ascending aorta, the aortic arch, the descending aorta, the abdominal aorta, the left common iliac artery, and the femoral artery) for more than 5 years. LMWH was not given during the previous dialysis process because of concerns about the rupture of the dissection. The lesion was salvaged via urokinase thrombolysis. However, the anticoagulant-free dialysis pattern occasionally caused dialyzer clotting and further increased the risk of catheter dysfunction. The patient repeatedly experienced dysfunction of the catheter in the following 8 months, with 2 episodes resolved via thrombolysis and 2 episodes replaced with new catheters. Finally, LMWH was used for each dialysis session to prevent thrombosis, with the dosage gradually increasing from 1,000 units to 2,000 units. The dosage of 2,000 units could support sufficient 4-hour dialysis for each session. Twenty-five months have passed since then, the patient has not experienced any further occlusion of the catheter, and the aortic dissection has not shown obvious changes (neither obvious expansion nor rupture).</p><p><strong>Conclusion: </strong>Reducing the dosage of LMWH during hemodialysis is a feasible solution to maintain a balance between hemodialysis access patency and stable dissection status in this particular patient.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1561645"},"PeriodicalIF":2.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current exercise-based rehabilitation impacts on poststroke exercise capacity, blood pressure, and lipid control: a meta-analysis.","authors":"Md Moneruzzaman, Zhiqing Tang, Xiaohe Li, Weizhen Sun, Kellina Maduray, Meiling Luo, Manzur Kader, Yonghui Wang, Hao Zhang","doi":"10.3389/fcvm.2025.1457899","DOIUrl":"10.3389/fcvm.2025.1457899","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review aimed to evaluate the impact of post-stroke exercise-based rehabilitation programs on blood pressure, lipid profile, and exercise capacity.</p><p><strong>Methods: </strong>Through a systemic search of literature from inception to 2024 using five databases, we analyzed data on the mean difference (MD) using a meta-analysis method to estimate effectiveness.</p><p><strong>Results: </strong>Thirty-seven randomized control trials were included encompassing various exercises such as aerobic, resistance, stretching, exergaming, robot-assisted training, and community-based training. Significant improvement was illustrated at discharge in systolic [MD 2.76 mmHg; 95% confidence interval (CI) -1.58 to 3.92, <i>P</i> < 0.05] and diastolic (MD 1.28 mmHg; 95% CI 0.54-2.12, <i>P</i> < 0.05) blood pressure and peak oxygen volume (MD -0.29 ml/kg/min; 95% CI -0.53 to 0.05, <i>P</i> < 0.05). We also observed significant improvement at discharge in high-density lipoprotein only after resistance exercise from two articles and low-density lipoprotein only in the intervention groups compared to the control groups from ten articles.</p><p><strong>Conclusion: </strong>Overall, current exercise-based rehabilitation programs significantly improve blood pressure and exercise capacity in patients with stroke at discharge. However, lipoprotein changes remained inconclusive. Although ameliorative changes were noted in most variables, more research is needed to determine optimum exercise intensity, type combination, and health education to reduce post-stroke complications and mortality.</p><p><strong>Systematic review registration: </strong>https://doi.org/10.17605/OSF.IO/X89FW.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1457899"},"PeriodicalIF":2.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}