Frontiers in Cardiovascular Medicine最新文献

{"title":"Case Report: Right-atrial reverse remodeling causing resolution of new-onset torrential tricuspid regurgitation after successful rhythm control.","authors":"Grigorios Korosoglou, Wolfgang Fehske, Patrick Lugenbiel, Norbert Frey","doi":"10.3389/fcvm.2026.1762249","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1762249","url":null,"abstract":"<p><p>In patients with persistent atrial fibrillation, adverse atrial remodeling may induce annular enlargement causing severe mitral- or tricuspid valve regurgitation and heart failure symptoms. Herein, we describe a case of rapidly progressive right atrial (RA) adverse remodeling due to new onset persistent AF, causing tricuspid annular dilatation and torrential tricuspid regurgitation (TR) in a 79-year-old female patient. This condition could be diagnosed by echocardiography, which helped guiding further patient management. After successful electric cardioversion, reverse RA remodeling took place, resulting in resolution of RA enlargement, TR and clinical symptoms within a few weeks. To maintain sinus rhythm, the patient underwent cryoablation and her further clinical course was uneventful.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1762249"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood socioeconomic measures and disparities in hospitalization for atrial fibrillation among medicare beneficiaries: a national county-level analysis.","authors":"Reuben Odai, Chukwuemeka Aghasili, Smith Frimpong, Laiba Sajjad, Anthony Alchaer, Wan-Chi Chan, Ibrahim Touffaha, Andy Le, Freidy Eid","doi":"10.3389/fcvm.2026.1779097","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1779097","url":null,"abstract":"<p><strong>Objectives: </strong>To examine associations between Social Vulnerability Index (SVI), Social Deprivation Index (SDI), and median household income, and rates of hospitalizations for atrial fibrillation (AF) among Medicare beneficiaries.</p><p><strong>Methods: </strong>We analyzed hospitalizations with AF as the principal diagnosis among Medicare beneficiaries (aged ≥65) across 3,116 US counties (2019-2021)<b>.</b> Age-standardized hospitalization rates were obtained from the CDC's Atlas of Heart Disease and Stroke. We examined associations between social determinants and hospitalization rates overall and stratified by sex and race/ethnicity using correlation and linear regression analyses.</p><p><strong>Results: </strong>The overall rate of hospitalization among patients with AF was 575 per 100,000 beneficiaries. Each 0.01-point increase in SVI and 1-point increase in SDI was associated with 1.6 and 1.7 additional hospitalizations per 100,000, respectively (<i>p</i> < 0.001). Each $1,000 increase in median household income was associated with 1.8 fewer hospitalizations (<i>p</i> < 0.001). Income effects were strongest among women (-2.3 per $1,000) and persisted across all racial/ethnic groups. SDI demonstrated superior model fit (AIC: 12,967) compared to SVI (AIC: 13,000) and income (AIC: 13,069), explaining 6.2% of variance in hospitalization rates.</p><p><strong>Conclusions: </strong>Neighborhood social determinants are strongly associated with AF hospitalization rates among Medicare beneficiaries despite near-universal coverage, with pronounced sex disparities. These findings support the use of county-level socioeconomic indices for geographic surveillance, while underscoring that patient-level longitudinal studies are needed to identify the specific drivers of these associations before clinical or policy interventions can be recommended.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1779097"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable venous access port placement in the upper arm of breast cancer patients with persistent left superior vena cava: a case series and literature review.","authors":"Wei Gao, Xiaochen Zhang, Songying Zhu, Huayu Bai, Ran Tan, Ning Zhang","doi":"10.3389/fcvm.2026.1792914","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1792914","url":null,"abstract":"<p><p>Persistent left superior vena cava (PLSVC) is a rare congenital venous anomaly. Although implantable venous access port placement in PLSVC has been reported, the optimal technique, catheter positioning, and safety considerations remain uncertain. This study describes our experience in managing three breast cancer patients with PLSVC and proposes a safe and efficient approach for port placement. All three cases of PLSVC were identified among breast cancer patients undergoing implantable venous access port placement guided by intracavitary electrocardiogram (IC-ECG). A negative P wave appeared on IC-ECG, and persisted as it advanced toward the predicted insertion length. These findings were reproducible on repeated catheterizations. To avoid excessive tip depth, the catheter was withdrawn by approximately 3 cm from the predetermined length. Postoperative X-ray and CT confirmed the final tip position at the T6 level. No functional impairment or catheter-related complications occurred during the entire course of treatment. Therefore, when placing a port from the left side, the presence of a negative P wave upon reaching the predetermined length may indicate PLSVC. Persistence of the negative P wave during further advancement, or the emergence of bidirectional P waves, should heighten suspicion for this anomaly. Postoperative X-ray and CT can confirm both the presence of PLSVC and the final tip position. Based on observed left-right predetermined length discrepancies in the normal population, withdrawing the catheter by approximately 3 cm from the predicted insertion length provides a useful reference. However, final confirmation of tip location should always rely on imaging.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1792914"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes for acute myocardial infarction with supranormal left ventricular ejection fraction.","authors":"Seok Oh, Ju Han Kim, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong","doi":"10.3389/fcvm.2026.1777247","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1777247","url":null,"abstract":"<p><strong>Background/aims: </strong>Despite cumulative evidence of superior outcomes for acute myocardial infarction (AMI) with normal left ventricular ejection fraction (LVEF) compared to those for AMI with reduced LVEF, real-world evidence on outcomes of patients with AMI and supranormal LVEF (snLVEF) is lacking. Therefore, this study aimed to evaluate the clinical outcomes of patients with AMI and snLVEF.</p><p><strong>Methods: </strong>A total of 27,903 patients with AMI were included from the Korean nationwide AMI cohort between November 2011 and June 2020 after excluding those with unmeasurable LVEF. Patients were classified into four groups according to LVEF: supranormal (≥65%), normal (50%-64%), mid-range (40%-49%), and reduced (<40%). The primary outcome was 3-year all-cause mortality.</p><p><strong>Results: </strong>Across four hierarchical Cox models, snLVEF was consistently associated with lower 3-year all-cause mortality compared with normal LVEF (a crude model HR 0.71; 95% CI 0.58-0.87; a fully-adjusted model HR 0.77; 95% CI 0.60-0.98), with similar estimates observed in intermediate models.</p><p><strong>Conclusions: </strong>Patients with AMI and snLVEF experienced the best clinical outcomes with the lowest mortality across the four groups.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1777247"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Bilateral coronary ostial spasm triggered by iatrogenic thyrotoxicosis mimicking left main coronary artery disease.","authors":"Han Ra Choi, Jae Seok Bae, Yun-Ho Cho, Jeong Yoon Jang, Jeong Rang Park, Min Gyu Kang, Kye-Hwan Kim, Jin-Yong Hwang, Jong-Hwa Ahn","doi":"10.3389/fcvm.2026.1814778","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1814778","url":null,"abstract":"<p><strong>Background: </strong>Thyrotoxicosis is associated with enhanced sympathetic activity and increased coronary vasomotor reactivity. However, bilateral coronary ostial spasm mimicking critical left main coronary artery disease is rare.</p><p><strong>Case summary: </strong>A 61-year-old woman presented with a 3-day history of exertional chest pain. She had undergone total thyroidectomy 18 years earlier and was receiving levothyroxine 75 μg daily. One month prior, carvedilol 6.25 mg twice daily had been initiated for palpitations. Treadmill testing demonstrated ST-segment elevation in aVR and anterior leads with reciprocal ST depression in inferior leads. Emergent coronary angiography revealed severe ostial narrowing of both the left main (LM) and right coronary artery (RCA), raising suspicion of critical multivessel disease. However, complete resolution of both lesions following intracoronary nitrate administration confirmed bilateral coronary vasospasm. Laboratory evaluation showed suppressed TSH (0.07 mIU/L) with markedly elevated free T4 and free T3 levels, consistent with iatrogenic thyrotoxicosis. Levothyroxine dose reduction, discontinuation of carvedilol, and initiation of calcium channel blocker therapy resulted in complete symptom resolution.</p><p><strong>Conclusion: </strong>Iatrogenic thyrotoxicosis may precipitate severe bilateral coronary ostial spasm that mimics obstructive coronary artery disease. Recognition of nitrate responsiveness and careful <i>β</i>-blocker selection are critical to avoid unnecessary revascularization.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1814778"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From signal analysis to clinical practice: the use of peak frequency in mapping and ablation.","authors":"Omnia Kamel, Mohamed Abdelazem, Sherien Awad, Mohamed Sharief, Ahmed Ammar","doi":"10.3389/fcvm.2026.1787169","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1787169","url":null,"abstract":"<p><p>Differentiating near-field (NF) from far-field (FF) electrograms (EGMs) is essential for accurate mapping and ablation of cardiac arrhythmias. With the advent of high density mapping systems, this distinction has traditionally relied on bipolar voltage analysis and activation mapping, while the evaluation of signal frequency has remained largely underexplored. Recently, a novel algorithm called peak frequency (PF) has been introduced as a complementary tool to conventional mapping strategies. By applying Wavelet transformation (WT), PF enables objective quantification of signal frequency, accurate identification of FF electrograms, and visualization of high frequency components on electro-anatomical maps. This review examines the role of peak frequency in mapping and ablation, spanning from fundamental signal analysis to clinical applications.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1787169"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nintedanib combined with anticoagulant therapy in advanced lung cancer complicated with pulmonary fibrosis and pulmonary embolism: two case reports and clinical decision-making analysis.","authors":"Xiuli Zhou, Li Zhao, Wenming Ma, Baosheng Liu","doi":"10.3389/fcvm.2026.1771163","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1771163","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer remains the leading cause of cancer-related deaths worldwide. With the development of targeted therapy and immunotherapy, the prognosis of patients with advanced non-small cell lung cancer has been significantly improved. However, the occurrence of comorbidities such as pulmonary fibrosis (PF) and pulmonary embolism (PE) significantly worsens the prognosis of these patients. Nintedanib is an effective antifibrotic drug, but its inhibition of vascular endothelial growth factor receptor may increase the risk of bleeding. Anticoagulant therapy is the cornerstone of PE treatment, and the combined use of nintedanib and anticoagulants may further increase the bleeding risk, which poses a clinical dilemma. At present, real-world data on the combined use of nintedanib and anticoagulants in patients with lung cancer complicated with PF and PE are scarce.</p><p><strong>Case presentation: </strong>We reported two cases of patients with advanced lung adenocarcinoma complicated with PF and PE. Case 1 was a 67-year-old male patient with left lung adenocarcinoma (cT2N2M1c IVB) complicated with idiopathic pulmonary fibrosis and acute PE. He had a history of hemoptysis after chemotherapy and was treated with nintedanib for antifibrosis before admission. After admission, nintedanib was temporarily discontinued due to the relative contraindication between anticoagulation therapy and bleeding. After the patient's condition stabilized, low-dose nintedanib was reinitiated, and the anticoagulant was switched to rivaroxaban orally after discharge. Follow-up showed no bleeding and the thrombosis disappeared. Case 2 was a 69-year-old male patient with right lung adenocarcinoma (cT4N3M1a IVA) with BRAF V600E and TP53 mutations, complicated with drug-related interstitial pneumonia and acute PE. He was treated with nintedanib combined with enoxaparin sodium. After the occurrence of mild hemoptysis, only the anticoagulant dose was adjusted without discontinuing nintedanib, and the bleeding symptoms were gradually relieved after discharge.</p><p><strong>Conclusion: </strong>The core contradiction in the treatment of advanced lung adenocarcinoma complicated with PF and PE is the balancing of bleeding risk between nintedanib antifibrotic treatment and anticoagulant therapy. Clinical decisions need to be based on individualized risk-benefit assessment. Individualized risk assessment and precise plan adjustment are key to improving the prognosis of these complex patients and providing practical references for similar clinical cases. Further studies are required in the future to confirm the safety of nintedanib when used in combination with anticoagulants.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1771163"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Virtual reality assessment of right ventricle-pulmonary artery conduit dilation and coronary compression risk: a retrospective bi-center feasibility study.","authors":"David Hochstein, Yona Rothé, Avshalom Shaffer, Yisrael Parmet, Oliana Vazhgovsky, Hanita Shai, Alona Raucher, Racheli Sion Sarid, Erica Pollak, Dor Freidin, Lior Sasson, Yishai Salem, Uriel Katz, Sagi Asa, Netanel Nagar, Shai Tejman-Yarden, Sharon Borik Chiger","doi":"10.3389/fcvm.2026.1768043","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1768043","url":null,"abstract":"<p><strong>Background: </strong>Right ventricle-to-pulmonary artery (RV-PA) conduits are crucial to establishing or restoring RV-PA continuity in children with complex congenital heart disease. Progressive conduit obstruction is common, particularly in growing patients, and may necessitate transcatheter dilation and stenting. One of the major procedural concerns in these cases is the risk of coronary artery compression during stent implantation. This study evaluated the technical feasibility and clinical utility of patient-specific three-dimensional (3D) reconstruction and virtual reality (VR) modeling to enhance pre-procedural planning and coronary risk assessment.</p><p><strong>Methods: </strong>This retrospective bi-center feasibility analysis of pediatric patients who underwent evaluation for RV-PA conduit dilation and stenting was conducted at the Sheba and Wolfson Medical Centers, Israel, between January 2018 and September 2022. For 19 eligible patients, cardiac CT datasets were processed to generate high-fidelity 3D VR models. Two independent cardiologists assessed the models, quantified the distances between the conduit and the major coronary arteries before and after simulated balloon expansion, and provided structured qualitative feedback on VR usability.</p><p><strong>Results: </strong>VR-based anatomical measurements demonstrated strong inter-operator agreement (intraclass correlation coefficient >0.7 across most parameters). Both cardiologists rated VR significantly superior to CT alone for delineating coronary trajectories and assessing compression risk (mean score 4.58 vs. 3.78, <i>p</i> < 0.0001). VR model generation was technically successful in all cases, with intuitive user interface performance and rapid rendering times.</p><p><strong>Conclusions: </strong>Patient-specific 3D VR modeling is technically feasible and provides clinically meaningful advantages for planning RV-PA conduit interventions. VR enhances visualization of complex coronary anatomy beyond what is achievable with standard CT imaging and may support more accurate risk stratification, improved procedural planning, and potentially reduce catheterization-associated complications. These preliminary findings support further prospective evaluation for the integration of VR tools into routine congenital cardiac practice.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1768043"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Exploring the role of exercise in hypertension and blood pressure variability.","authors":"Giuseppe Caminiti, Marco Alfonso Perrone","doi":"10.3389/fcvm.2026.1836245","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1836245","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1836245"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of three risk prediction models for deep vein thrombosis in patients with acute stroke: a single-center cohort study.","authors":"Lina Fu, Kairu Feng, Chunyan Cui, Lanjun Li, Bing Zou, Nan Liu","doi":"10.3389/fcvm.2026.1753784","DOIUrl":"https://doi.org/10.3389/fcvm.2026.1753784","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the predictive performance of three previously established risk models for deep vein thrombosis (DVT) in patients with acute stroke and to support model selection in clinical practice.</p><p><strong>Methods: </strong>In this single-center spatial validation cohort study, patients diagnosed with acute stroke and admitted to the Stroke Center of South China Hospital of Shenzhen University between January 2023 and January 2025 were consecutively enrolled. Three DVT prediction models, previously identified by a systematic review conducted by our research team, were selected for external validation. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), Brier score, bootstrap calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>A total of 1,270 patients with acute stroke were included, among whom 217 developed DVT, yielding an incidence of 17.08%. The AUCs were 0.699, 0.804, and 0.753 for the Shen Xiaofang, Lu Qiufang, and Xi Pan models, respectively. The Lu Qiufang model achieved the highest positive predictive value (48.4%), specificity (84.9%), accuracy (82.1%), and Youden index (0.536). All three models had negative predictive values exceeding 90%. The Brier scores were 0.182, 0.154, and 0.245. Calibration curves indicated that the Lu Qiufang model demonstrated the best goodness-of-fit, whereas the Shen Xiaofang and Xi Pan models exhibited systematic bias in certain risk intervals. DCA curves showed that the Lu Qiufang model provided greater net benefit within the threshold probability range of approximately 0.20-0.70, indicating superior clinical decision value.</p><p><strong>Conclusion: </strong>All three DVT risk prediction models demonstrated acceptable predictive performance in patients with acute stroke. Among them, the Lu Qiufang model showed comparatively superior discrimination, calibration, and clinical net benefit. However, given the single-center design of this study, further multicenter and cross-regional validation studies are warranted to confirm model transportability and generalizability across diverse healthcare settings.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"13 ","pages":"1753784"},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}