Frontiers in Cardiovascular Medicine最新文献

{"title":"Association between albumin-corrected calcium and all-cause mortality in patients with heart failure: a retrospective study.","authors":"Xiongda Yao, Yurong Leng, Junda Cao","doi":"10.3389/fcvm.2025.1552807","DOIUrl":"10.3389/fcvm.2025.1552807","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF), a global health challenge, is a leading cause of mortality in hospitalized patients. Early and accurate prognostic evaluation in these patients is vital for guiding clinical management. Our aim was to explore the association between albumin-corrected calcium (ACC) and mortality in hospitalized patients.</p><p><strong>Methods: </strong>This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were stratified into three groups based on ACC levels. The association between ACC and clinical outcomes in HF patients was analyzed using Cox proportional hazards regression and restricted cubic spline models.</p><p><strong>Results: </strong>A total of 4,737 heart failure patients were included. Multifactorial Cox regression revealed that elevated ACC levels were significantly associated with increased 30-day and 180-day mortality. Restricted cubic spline analysis demonstrated a U-shaped relationship between ACC levels and mortality, with an inflection point at 9.18. Patients with ACC levels above 9.18 exhibited an 20.4% higher risk of 30-day mortality [Hazard ratio (HR): 1.204, 95% (Confidence interval) CI: 1.009-1.437] and a 20.8% higher risk of 180-day mortality (HR: 1.208, 95% CI: 1.019-1.431) compared to those with ACC below 9.18.</p><p><strong>Conclusions: </strong>The observed U-shaped association between ACC levels and 30- and 180-day mortality in HF patients highlights the potential utility of ACC as a prognostic marker.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1552807"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longer-term and landmark analysis of transcatheter vs. surgical aortic-valve implantation in severe aortic stenosis: a meta-analysis.","authors":"Yu Wang, Xiaowen Zhang, Xinlin Zhang, Wei Xu","doi":"10.3389/fcvm.2025.1479200","DOIUrl":"10.3389/fcvm.2025.1479200","url":null,"abstract":"<p><strong>Background: </strong>Previous reports of longer-term outcomes of transcatheter aortic valve implantation (TAVI) focus on higher risk patients and suggest potential temporal changes.</p><p><strong>Aims: </strong>To evaluate the longer-term and temporal performances of TAVI compared to surgical aortic valve replacement (SAVR).</p><p><strong>Methods: </strong>Randomized controlled trials reporting outcomes with at least 1-year follow-up. The primary outcome was the composite of all-cause death or disabling stroke.</p><p><strong>Results: </strong>We included 8 trials with 8,749 patients. TAVI was associated with a higher risk of longer-term (5-year) primary outcome compared to SAVR among higher-risk [odds ratio (OR), 1.25; 95% CI, 1.07-1.47] but not lower-risk participants [1.0 (0.77-1.29)]. However, a significant temporal interaction was detected in both risk profiles. TAVI with balloon-expandable valves was associated with a higher risk of longer-term primary outcome compared to SAVR [1.38 (1.2-1.6)], whereas no statistical difference was found with self-expanding valves [1.03 (0.89-1.19)]. There was a significant interaction between the two valve systems, and a temporal interaction was detected in both systems. Overall landmark analysis revealed a lower risk in TAVI within the initial 30 days [0.76 (0.6, 0.96)], comparable between 30 days to 2 years [1.04 (0.85, 1.28)], and higher beyond 2 years [1.36 (1.15-1.61)]. Analysis for all-cause death generated largely similar results.</p><p><strong>Conclusions: </strong>TAVI was associated with a higher longer-term risk of primary outcome compared to SAVR in higher-risk patients and with balloon-expandable valves. However, a characteristic temporal interaction was documented in all subgroups. Future studies are warranted to test these findings.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1479200"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal left ventricular ejection fraction variations and outcomes in wide population of cardiovascular patients with and without heart failure.","authors":"Radosław Szczerba, Wiktoria Żelazna, Jakub Sokołowski, Natalia Wyroba, Zuzanna Wydrych, Michał Wita, Małgorzata Cichoń, Michał Orszulak, Katarzyna Mizia-Stec, Krystian Wita, Maciej T Wybraniec","doi":"10.3389/fcvm.2025.1559258","DOIUrl":"10.3389/fcvm.2025.1559258","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure (HF) with improved ejection fraction (HFimpEF) was shown to be related with improved outcome but increase of left ventricular ejection fraction (LVEF) in patients without HF is of less known clinical significance. The aim of the study was to evaluate long-term prognosis in patients with different cardiovascular disorders, with and without HF, depending on temporal variations of LVEF.</p><p><strong>Methods: </strong>The study covered 31 920 patients (median age 71 years, 37.7% females) with different cardiovascular disorders and at least two measurements of LVEF separated by ≥1 month. Clinical parameters were acquired from database of Academic Repository of Clinical Cases of Medical University of Silesia. HFimpEF was defined by LVEF increase ≥10% in HF patients in relation to baseline value. The endpoints were all-cause mortality and Major Adverse Cardiac and Cerebrovascular Event (MACCE).</p><p><strong>Results: </strong>The median follow-up time was 51.5 months and LVEF was measured median 2 times. HF was diagnosed in 12 152 patients (38.1%), of which 2 843 (23.4%) experienced HFimpEF. MACCE occurrence was greater in HF than non-HF patients (12.78%/year vs. 6.07%/year, <i>p</i> < 0.001). In patients with HF, Kaplan-Meier survival curves showed significantly lower MACCE occurrence in HFimpEF and stable LVEF than in decreased LVEF (11.46%/year vs. 12.5%/year vs. 21.6%/year; log-rank <i>p</i> = 0.199 and <i>p</i> < 0.001) and HFimpEF constituted one of independent predictors of MACCE (HR = 0.84, 95% CI: 0.76-0.93). Conversely, in non-HF population patients with LVEF improvement had higher MACCE occurrence than patients with stable LVEF and lower than deteriorating LVEF (6.97%/year vs. 5.72%/year vs. 14.55%/year respectively; log-rank <i>p</i> = 0.001 and <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Temporal increase of LVEF corresponds with improved survival in patients with HF but not among non-HF patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1559258"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Dual-lumen microcatheter-facilitated wiring technique to correctly access a protruded aorto-ostial stent: a case series.","authors":"Seok Hyun Kim, Kook Jin Chun","doi":"10.3389/fcvm.2025.1467926","DOIUrl":"10.3389/fcvm.2025.1467926","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) through the aorto-ostial coronary stent that is protruding into the aorta remains a technical challenge because of the poor coaxial alignment of the guiding catheter and the inability to advance the guidewire into the distal vessel through the stent's central lumen. In this article, we introduce a dual-lumen microcatheter-facilitated wiring technique performed on two patients to overcome this difficulty.</p><p><strong>Case summary: </strong>The first case was a 75-year-old man who presented with chest pain. He was diagnosed with an unstable angina, and coronary angiography showed near-total in-stent occlusion of the previously placed stent protruding into the aorta. Despite several attempts, the guidewire passed through the side strut of the stent instead of the central stent lumen. Thus, we placed the tip of the microcatheter proximally to the side strut, outside the stent. Then, a second wire was passed through the central lumen successfully. After confirming the wire's position via intravascular ultrasound, we inflated a drug-eluting balloon, subsequently obtaining a successful angiographic result. The second case was a 78-year-old woman diagnosed with non-ST segment elevation myocardial infarction. Coronary angiography revealed tight stenosis at the ostial left anterior descending artery with a previous stent deployed from the left main to the circumflex artery. Owing to the excessive overhanging stent into the aorta, the wire could not be advanced into the stent's central lumen. However, with the facilitation of a dual-lumen microcatheter, a second wire successfully passed through the stent's central lumen. Finally, the patient received a successful PCI with a stent.</p><p><strong>Conclusion: </strong>A dual-lumen microcatheter-facilitated wiring technique may be useful in overcoming wiring difficulty caused by the excessive protrusion of an aorto-ostial stent into the aorta.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1467926"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: The second valve drag technique for managing acute total obstruction of the right coronary artery during transcatheter aortic valve replacement.","authors":"Yanbin Song, Xiaochun Zhang, Daxin Zhou, Wenzhi Pan","doi":"10.3389/fcvm.2025.1535890","DOIUrl":"10.3389/fcvm.2025.1535890","url":null,"abstract":"<p><strong>Introduction: </strong>Despite technological advancements and new generation devices availability, transcatheter aortic valve replacement (TAVR) for bicuspid aortic valve (BAV) stenosis still presents unique technical challenges.</p><p><strong>Methods and results: </strong>We report an uncommon but critical complication of acute right coronary artery occlusion resulting from valve dislocation during TAVR. For the first time, we employed novel approach, namely second valve dragging, to address mispositioned self-expanding valve. This implementation of novel and successful interventional treatment led to the rapid relief of coronary obstruction.</p><p><strong>Discussion: </strong>This innovative approach offers a promising avenue for further management of these patients in critical conditions.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1535890"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of 24-h electrocardiogram recordings for the prediction of a sufficient number of premature ventricular complexes and mapping strategy during catheter ablation.","authors":"Stine Aagaard-Nilsen, Lars Andreas Dejgaard, Ole-Gunnar Anfinsen, Erik Lyseggen, Torbjørn Holm, Trine S Fink, Hans Henrik Odland, Knut Sevre, Erik Kongsgård, Finn Hegbom, Mathis Korseberg Stokke","doi":"10.3389/fcvm.2025.1558130","DOIUrl":"10.3389/fcvm.2025.1558130","url":null,"abstract":"<p><strong>Background and aims: </strong>An insufficient number of premature ventricular complexes (PVCs) during catheter ablation (CA) may prohibit adequate mapping of the site of origin. Parameters to predict this situation have not been established. Our objective was to quantify the association between preprocedural information and the probability of a sufficient number of PVCs for adequate mapping and successful CA.</p><p><strong>Methods: </strong>Clinical characteristics and results from examinations and procedural data were collected retrospectively from health journals for patients admitted for CA of PVCs from 2011 to 2020.</p><p><strong>Results: </strong>In total, 46 of 332 patients (14%) had an insufficient number of PVCs to enable adequate electroanatomical mapping. Patients with a sufficient number of PVCs had nominally more PVCs in the 24-h electrocardiogram (ECG), with a strong statistical trend [16,007 (6,509-26,205) vs. 8,332 (3,066-20,974), <i>p</i> = 0.055]. The receiver operator curve for a sufficient number of PVCs in 24-h ECGs had an area under the curve of 0.610 (95% CI 0.498-0.722, <i>p</i> = 0.055). The best predictive values were found at >10,000 PVCs per 24-h, with a positive predictive value of 67% and a negative predictive value of 57%. Patients for whom activation mapping was used as the sole mapping method had more PVCs in the 24-h ECG than did patients for whom pace mapping was added or used as an alternative [19,769 (10,564-30,526) vs. 15,237 (6,000-25,033), <i>p</i> = 0.022]. Neither acute outcome nor procedure time depended on the mapping strategy.</p><p><strong>Conclusion: </strong>The number of PVCs in a 24-h ECG was moderately associated with the presence of a sufficient number of PVCs to perform electroanatomical mapping during CA. The presence of more PVCs in the preprocedural 24-h ECG was associated with the use of activation mapping as the sole mapping strategy.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1558130"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Sodium-glucose cotransporter-2 inhibitors improve cardiovascular outcomes post-acute coronary syndrome complicated by acute heart failure.","authors":"Alaa Rahhal, Tahseen Hamamyh, Ammar Chapra, Khaled J Zaza, Mostafa Najim, Mohammad Hemadneh, Hazem Faraj, Wael Kanjo, Ahmed Yasin, Haneen Toba, Wafa Mohammed, Mohammad Khair Hamad, Nawras Al-Tikrety, Mhd Baraa Habib, Ahmed Awaisu, Ahmed Mahfouz, Sumaya Alyafei, Abdul Rahman Arabi, Ashfaq Patel, Mohammed Al-Hijji","doi":"10.3389/fcvm.2025.1580343","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1580343","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fcvm.2024.1383669.].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1580343"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based analysis of 12-lead electrocardiograms in school-age children: a proof of concept study.","authors":"Shuhei Toba, Yoshihide Mitani, Yusuke Sugitani, Hiroyuki Ohashi, Hirofumi Sawada, Mami Takeoka, Naoki Tsuboya, Kazunobu Ohya, Noriko Yodoya, Takato Yamasaki, Yuki Nakayama, Hisato Ito, Masahiro Hirayama, Motoshi Takao","doi":"10.3389/fcvm.2025.1471989","DOIUrl":"10.3389/fcvm.2025.1471989","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnostic performance of automated analysis of electrocardiograms for screening children with pediatric heart diseases at risk of sudden cardiac death is unknown. In this study, we aimed to develop and validate a deep learning-based model for automated analysis of ECGs in children.</p><p><strong>Methods: </strong>Wave data of 12-lead electrocardiograms were transformed into a tensor sizing 2 × 12 × 400 using signal processing methods. A deep learning-based model to classify abnormal electrocardiograms based on age, sex, and the transformed wave data was developed using electrocardiograms performed in patients at the age of 6-18 years during 2003-2006 at a tertiary referral hospital in Japan. Eighty-three percent of the patients were assigned to a training group, and 17% to a test group. The diagnostic performance of the model and a conventional algorithm (ECAPS12C, Nihon Kohden, Japan) for classifying abnormal electrocardiograms were evaluated using the cross-tabulation, McNemar's test, and decision curve analysis.</p><p><strong>Results: </strong>We included 1,842 ECGs performed in 1,062 patients in this study, and 310 electrocardiograms performed in 177 patients were included in the test group. The specificity of the deep learning-based model for detecting abnormal electrocardiograms was not significantly different from that of the conventional algorithm. For detecting electrocardiograms with ST-T abnormality, complete right bundle branch block, QRS axis abnormality, left ventricular hypertrophy, incomplete right bundle branch block, WPW syndrome, supraventricular tachyarrhythmia, and Brugada-type electrocardiograms, the specificity of the deep learning-based model was higher than that of the conventional algorithm at the same sensitivity.</p><p><strong>Conclusions: </strong>The present new deep learning-based method of screening for abnormal electrocardiograms in children showed at least a similar diagnostic performance compared to that of a conventional algorithm. Further studies are warranted to develop an automated analysis of electrocardiograms in school-age children.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1471989"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framing anticoagulation control according to clinical practice for patients with atrial fibrillation in Spain: a multidisciplinary vision trough AMFA Project.","authors":"Juan Cosín-Sales, Jose Polo-García, Olga Gavín Sebastián, Marta Rubio Cabezas, María Lloret Avellá","doi":"10.3389/fcvm.2025.1426072","DOIUrl":"10.3389/fcvm.2025.1426072","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>The use of vitamin K antagonists (VKA) in patients with atrial fibrillation (AF) in Spain remains high, even though the available data on anticoagulation control (TRT, time in therapeutic range) shows suboptimal results. The objective of the AMFA project, an atlas of the management of anticoagulation in patients with AF, was to describe oral anticoagulation management in Spanish´ patients.</p><p><strong>Materials and methods: </strong>The AMFA Project is a descriptive, multicenter study. It included information from 60 healthcare areas from each of the 17 Spanish regions. Consensus methodologies were used to analyze qualitative information obtained from the physicians' experience and perception and quantitative data collected through a specialized study questionnaire. In this questionnaire, experts were asked to include data of the last 10 consecutive patients attended with AF on anticoagulation treatment.</p><p><strong>Results: </strong>Records from 1,580 patients were obtained from 176 experts. Of them, 34.7% were cardiologists, 32.9% general practitioners (GPs), and 32.4% hematologists. The utilization rates of Direct Oral Anticoagulants (DOACs) and VKAs in clinical practice was 55.8% and 43.3%, respectively, which was not correlated with experts' perception. Clinical practice data revealed that 30.3% of the patients included did not have international normalized ratio (INR) or TTR data available, while only 3.8% of the experts reported that INR/TTR information was not available according to their perception. Considering only patients who had INR and TTR available, clinical practice showed that 59.0% of the patients had their coagulation in range, while the remaining 41.0% were uncontrolled. This result matches with the general perception reported by the experts, 62.6% of patients in range. Additionally, up to 22.2% of patients received DOAC treatment at suboptimal doses.</p><p><strong>Conclusions: </strong>These data highlight the suboptimal control of the INR of patients, as well as the difficulties in DOACs access in Spain. The study uncovers the need to implement actions to improve INR control, facilitate access to DOACs treatment, and standardize AF patients' management. Establishing protocols that facilitate intervention may optimize the management of the patients with AF.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1426072"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cor Triatriatum: an uncommon congenital anomaly - the experience of a tertiary care center in a developing country.","authors":"Jad Abdul Khalek, Christophe El Rassi, Maria Abou Mansour, Bshara Sleem, Issam El Rassi, Fadi Bitar, Mariam Arabi","doi":"10.3389/fcvm.2025.1531754","DOIUrl":"10.3389/fcvm.2025.1531754","url":null,"abstract":"<p><strong>Background: </strong>Cor Triatriatum is a congenital anomaly characterized by the abnormal presence of a fibromuscular junction in one of the atria, as seen on echocardiography. This anomaly can lead to major hemodynamic problems and obstruction of blood flow. This study aims to explore the risk factors, diagnostic modalities, and surgical interventions used to tackle this congenital anomaly at a tertiary care center over an 18-year period.</p><p><strong>Materials and methods: </strong>Medical records of congenital heart disease patients at the Children's Heart Center at the American University of Beirut Medical Center between 2006 and 2024 were retrospectively reviewed. Data collection included demographic characteristics, clinical outcomes, hospitalization details, and surgical treatment. Ethical approval was obtained, and descriptive statistics were employed for data analysis using SAS 9.4.</p><p><strong>Results: </strong>At our center, 7 patients were diagnosed with Cor Triatriatum, with a median age of 5 months. 4 of the patients were female, 3 were males, and the median hospital stay was 7 days. All patients were diagnosed with Cor Triatriatum Sinister, and respiratory symptoms were prevalent. Pulmonary vein abnormalities were observed in 4 ouf of 7 (57.1%) patients and atrial septal defects in 2 out of 7 patients (28.5%). Surgery resulted in successful membrane resection for all operated patients, with significant symptom improvement postoperatively.</p><p><strong>Conclusion: </strong>Cor Triatriatum is a rare congenital anomaly requiring early detection and diagnosis. Surgical intervention remains the mainstay of treatment, with favorable outcomes when performed promptly. Larger studies are recommended to optimize management strategies and improve long-term outcomes for affected patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1531754"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}