Frontiers in Cardiovascular Medicine最新文献

{"title":"Characteristics of myocardial work during exercise stress echocardiography in healthy adults.","authors":"Liwei Huang, Luwei Ye, Hongmei Zhang, Qingfeng Zhang, Geqi Ding, Chunmei Li, Yan Deng, Lixue Yin, Yi Wang","doi":"10.3389/fcvm.2025.1511464","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1511464","url":null,"abstract":"<p><strong>Background: </strong>Non-invasive myocardial work (MW) is a more precise parameter for evaluating left ventricular (LV) systolic function. However, studies examining sex-based differences in MW during exercise stress echocardiography (SE) in healthy individuals are scarce. Previous research has shown that global work efficiency (GWE) decreases following exercise.</p><p><strong>Objectives: </strong>To characterize sex-based differences in MW during exercise SE in healthy adults and to explore the factors influencing the decline in GWE post-exercise.</p><p><strong>Methods: </strong>The study enrolled 200 healthy adults, all of whom underwent echocardiographic assessments both at rest and immediately after completing a symptom-limited treadmill stress test. We measured LV volume, ejection fraction (EF), force, peak positive strain (PPS), global work index (GWI), global constructive work (GCW), global wasted work (GWW), and GWE at rest and post-exercise.</p><p><strong>Results: </strong>GWI, GCW, and GWW increased, while GWE decreased after exercise. There were no significant differences in any of the global MW parameters between sexes at rest (all <i>p</i> > 0.05). The change in △GWE was greater in women (<i>p</i> < 0.05), but no significant differences were found in other MW reserve parameters between sexes. The multivariable linear regression analysis revealed that GWW was independently associated with PPS (<i>β</i> = 0.842, <i>p</i> < 0.0001) and force (<i>β</i> = 0.306, <i>p</i> = 0.023). Furthermore, the multivariable linear regression analysis showed that GWE was independently associated with PPS (<i>β</i> = -0.395, <i>p</i> = 0.018) and EF (<i>β</i> = -0.236, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Sex had a minimal effect on MW-based LV systolic function in healthy adults. GWE decreased post-exercise, and both PPS and force were independently associated with GWW. These findings suggest that higher contractility is achieved at the cost of increased wasted work, which subsequently leads to a decrease in mechanical efficiency.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1511464"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and risk factors of type I or II endoleaks after thoracic endovascular aortic repair and open surgery.","authors":"Fan Zhu, Jia Chen, Yuanyuan Guo, Chang Shu","doi":"10.3389/fcvm.2025.1489023","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1489023","url":null,"abstract":"<p><strong>Background: </strong>Type I endoleaks (T1ELs) and type II endoleaks (T2ELs) are among the most severe complications that occur after thoracic endovascular aortic repair (TEVAR) and open surgery. This investigation aimed to analyze the predictors and multiple risk factors of T1ELs and T2ELs, with a particular focus on the diameter of the false lumen and the pathology of the left subclavian artery (LSA).</p><p><strong>Methods: </strong>A total of 245 patients (mean age 57 ± 13 years) who had undergone open surgery or TEVAR were recruited and followed for a mean of 18 ± 10 months. Seven patients (2.8%) were classified into the T1EL group, and another seven (2.8%) were classified into the T2EL group. Contrast-enhanced computed tomography angiography of the entire aorta confirmed the diagnosis of aortic disease (e.g., thoracic aortic dissection, thoracic aortic aneurysm, and/or type B intramural hematoma) as well as the presence of T1ELs or T2ELs.</p><p><strong>Results: </strong>Reoperation was more common in the T1EL group (<i>n</i> = 4; 57%) than in the T2EL group (<i>n</i> = 2; 29%); also, reintervention for stenting of the thoracic endovascular graft was more frequent in the T1EL group (4 vs. 1). In T1EL group, four patients (57%) accepted reoperation due to progressive enlargement of the false lumen's diameter (aneurysm size > 55 mm) (<i>n</i> = 4; 100%) and sharp, persistent chest and back pain (<i>n</i> = 4; 100%). In the T2EL group, two patients (29%) required reintervention due to the false lumen's growth rate (>5 mm in diameter per half year) and symptoms of pulmonary vascular compression such as hemoptysis and dyspnea (<i>n</i> = 2; 100%). The median survival rate of patients in the T1EL and T2EL groups was 31 months [95% confidence interval (CI) 0.0937-11.4] and 30 months (95% CI: 0.08775-10.67), respectively. The proximal opening angle of the LSA (OR 3.141, 95% CI: 2.615-3.773) was significantly associated with the incidence of T1EL. Both the proximal opening angle of the LSA and its diameter were significantly associated with the occurrence of T2ELs.</p><p><strong>Conclusions: </strong>To prevent the occurrence of T1ELs and T2ELs, appropriate stent grafts and the pathology of the LSA should be carefully considered.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1489023"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive association between serum lactate dehydrogenase levels and blood pressure: evidence from NHANES 2015-2016.","authors":"Tao Hu, Linfeng Li, Qiqiang Cao, Weiling Tu, XianTao Huang, Tan Yuan","doi":"10.3389/fcvm.2025.1554702","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1554702","url":null,"abstract":"<p><strong>Background: </strong>Serum lactate dehydrogenase (sLDH) is an enzyme implicated in tissue injury and inflammatory responses. Despite its established role in these pathophysiological processes, the association between sLDH and blood pressure remains underexplored. The present findings suggest that sLDH could emerge as a valuable biomarker for blood pressure regulation and may hold significant promise in the management of hypertension.</p><p><strong>Methods: </strong>Our investigation utilized data from the National Health and Nutrition Examination Survey (NHANES) 2015-2016, comprising 3,469 participants after excluding those under the age of 20, individuals on antihypertensive therapies, and cases with incomplete data. sLDH levels were categorized into tertiles, while blood pressure measurements were conducted under standardized protocols. To elucidate the relationship between sLDH levels and blood pressure, multivariate regression analyses and smooth curve fitting techniques were employed, adjusting for 17 covariates, including age, sex, and body mass index.</p><p><strong>Results: </strong>sLDH corresponds with both systolic blood pressure (SBP) and diastolic blood pressure (DBP). The adjusted smooth curve fitting diagram demonstrates a linear positive connection between sLDH and SBP, with an increment of 0.053 mmHg (95% CI: 0.032, 0.074; <i>p</i> < 0.001) in SBP for every 1 U/L increment in LDH concentrations. The connection between sLDH and DBP is non-linear. sLDH concentrations below 123 U/L have a linear positive connection with DBP, increasing 0.079 mmHg (95% CI: 0.042, 0.115, <i>p</i> < 0.001). When sLDH concentrations exceed 123 U/L, there is not a substantial connection with DBP (<i>P</i> = 0.574).</p><p><strong>Conclusion: </strong>Our study demonstrates a linear positive correlation between sLDH and SBP. A non-linear association was observed between sLDH and DBP, with a positive relationship for sLDH levels below 123 U/L. These findings underscore the potential of sLDH as a biomarker for blood pressure regulation.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1554702"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of exercise interventions on arterial stiffness in individuals at risk for cardiovascular disease: a systematic review and network meta-analysis.","authors":"Ruo-Shan Wu, Yan Zhang, Xin-Wang Yuan, Xin Yan, Xiao-Lei Fu","doi":"10.3389/fcvm.2025.1489382","DOIUrl":"10.3389/fcvm.2025.1489382","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that exercise can improve arterial stiffness (AS). However, it remains unclear which type of exercise is most effective for managing AS, particularly in individuals at high risk for cardiovascular diseases (CVD). This review aims to evaluate the effects of various exercises on AS and related variables in individuals at high risk for CVD.</p><p><strong>Methods: </strong>A comprehensive search strategy was employed to systematically explore MEDLINE (PubMed), Embase, Cochrane Library, EBSCOhost, and Web of Science to identify relevant studies. Inclusion criteria were: (1) randomized controlled trials; (2) participants with known CVD risk factors as per the American College of Sports Medicine guidelines; (3) interventions including interval training (INT), aerobic exercise (AE), resistance exercise, and combined exercise (CT); (4) control groups engaging in no intervention, routine care, or health education; (5) outcome measures of pulse wave velocity (PWV), systolic blood pressure (SBP), and diastolic blood pressure; and (6) studies published in English. Studies were assessed using the Cochrane risk of bias tool and analyzed with a random-effects network meta-analysis.</p><p><strong>Results: </strong>The review included 2,034 participants from 43 studies. Both CT [standardized mean difference (SMD) = -0.98, <i>p</i> < 0.001, <i>I</i> ² = 84%] and INT (SMD = -0.77, <i>p</i> < 0.001, <i>I</i> ² = 61%) significantly reduced PWV, but both showed considerable heterogeneity. INT (SMD = -0.382, <i>p</i> < 0.001, <i>I</i> ² = 45%) and AE (SMD = -0.369, <i>p</i> < 0.001, <i>I</i> ² = 43%) significantly reduced SBP. Surface under the cumulative ranking curve (SUCRA) showed that CT (SUCRA = 87.2) was the most effective for lowering PWV, while INT (SUCRA = 81.3) was the most effective for lowering SBP.</p><p><strong>Conclusion: </strong>In high-risk populations for CVD, CT was most effective in improving AS, while INT demonstrated the greatest reduction in SBP. AE showed greater benefits at moderate to low intensities. Due to significant heterogeneity in CT, its results should be interpreted with caution. Further research with larger sample sizes is needed to confirm these findings.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1489382"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort.","authors":"Chang Liu, Yao Ma, Shiyuan Qiao, Kexin Li, Mengyao Qi, Chunyu Gu, Lanxin Zhang, Jia Wei, Dengfeng Gao","doi":"10.3389/fcvm.2025.1462263","DOIUrl":"10.3389/fcvm.2025.1462263","url":null,"abstract":"<p><strong>Background: </strong>SARS-CoV-2 antibody positivity, whether due to natural infection or vaccination, is known to be associated with specific cardiac and vascular damage, yet its impact on cardiac structure and function in prospective cohorts remains incompletely understood.</p><p><strong>Objective: </strong>We aimed to assess cardiac changes in the UK Biobank cohort among individuals with self-reported seropositive results for SARS-CoV-2 antibodies.</p><p><strong>Methods: </strong>UK Biobank participants with self-reported serological results for SARS-CoV-2 antibodies, who underwent their first cardiac magnetic resonance (CMR) scan after 2019 were included. Cardiac changes potentially associated with SARS-CoV-2 antibody positivity were assessed, with measurements of left ventricular (LV) parameters, including volume, dimensions, wall thickness, myocardial mass, cardiac output (CO), and cardiac index (CI), manually extracted from the CMR images. Propensity score matching (PSM) was used to pair seropositive and seronegative individuals. Native T1 was used to assess the within-subject changes in seropositive individuals. Logistic regression was performed to assess the association between SARS-CoV-2 antibody status and the incidence of LV hypertrophy.</p><p><strong>Results: </strong>A total of 720 participants were included, with 453 individuals self-reporting as SARS-CoV-2 antibody positive. After PSM, 261 participants remained in each group. Over an average follow-up period of 110 days, significant decreases in CO and CI were observed in the paired participants. Additionally, native T1 values appeared to be elevated in seropositive participants (852.77 ± 53.55 ms vs. 860.01 ± 47.81 ms, <i>P</i> = 0.012). Logistic regression analysis in the overall cohort indicated an association between SARS-CoV-2 antibody positivity and an increased risk of LV hypertrophy, with an adjusted odds ratio of 3.257 [95% CI (1.036-10.239), <i>P</i> = 0.043].</p><p><strong>Conclusions: </strong>Our findings suggest subtle cardiac changes associated with SARS-CoV-2 antibody positivity within approximately hundred days. SARS-CoV-2 antibody positivity appeared to be associated with an increased risk of LV hypertrophy. However, these results are exploratory, and further longitudinal studies with extended follow-up are needed to better understand the long-term cardiac impact of SARS-CoV-2 antibody positivity.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1462263"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of postoperative prognosis in patients with acute ST-segment elevation myocardial infarction after PCI using LRP1.","authors":"Jingwen Guan, Yikang Xu, Limin Liu, Mengran Su, Jingru Ma","doi":"10.3389/fcvm.2025.1520696","DOIUrl":"10.3389/fcvm.2025.1520696","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prognostic value of Low-density lipoprotein receptor-related protein 1 (LRP1) in patients with acute ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI).</p><p><strong>Method: </strong>This prospective study included 96 STEMI patients who underwent PCI and 19 control subjects with normal coronary arteries. Coronary blood was taken from both groups, and LRP1 expression levels were quantified using real-time quantitative PCR (qPCR). The STEMI patients were stratified into low, middle, and high LRP1 groups based on tertiles of LRP1 expression. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE) during a six-month follow-up period post-PCI.</p><p><strong>Results: </strong>LRP1 expression in arterial blood was significantly lower in the STEMI group [0.63(0.23,1.1)] compared to the control group [1.5(0.84,1.85)] (<i>P</i> < 0.05). The incidence of MACE showed an increasing trend across the LRP1 tertiles: 6.7% (95% CI: 1.9-21.3%) in the low LRP1 group, 22.6% (95% CI: 11.4-39.8%) in the middle LRP1 group, and 41.9% (95% CI: 26.4-59.2%) in the high LRP1 group. The high LRP1 group exhibited a significantly higher MACE rate compared to the low LRP1 group (<i>P</i> < 0.05). Spearman's rank correlation analysis revealed positive correlations between LRP1 and both NT-proBNP and cTnT (<i>r</i> = 0.349, 95% CI: 0.156-0.515, <i>P</i> < 0.001; <i>r</i> = 0.328, 95% CI: 0.133-0.497, <i>P</i> = 0.001, respectively), and a negative correlation with LVEF values (<i>r</i> = -0.285, 95% CI: -0.460 to -0.087, <i>P</i> = 0.006). Receiver operating characteristic (ROC) analysis identified an LRP1 expression threshold of 0.79 for predicting MACE within six months post-PCI, with a sensitivity of 81.8% (95% CI: 61.5-92.7%), a specificity of 70% (95% CI: 58.5-79.5%), and an area under the curve (AUC) of 0.789 (95% CI: 0.688-0.890, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>LRP1 expression appears to be an independent predictor of MACE in STEMI patients and may have prognostic value for short-term outcomes following PCI.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1520696"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Dual-chamber pacemaker for hypertrophic cardiomyopathy with bradyarrhythmia and idiopathic pericardial effusion: a report of two cases and literature review.","authors":"Chang Liu, Fei Zheng, Yuxia Gao, Zheming Wang, Xinyu Zhang, Xiuqing Tian","doi":"10.3389/fcvm.2025.1518000","DOIUrl":"10.3389/fcvm.2025.1518000","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by asymmetric hypertrophy of the ventricles and the ventricular septum, leading to subsequent left ventricular outflow tract (LVOT) obstruction and diastolic dysfunction. Typically, patients with HCM experience sinus tachycardia and sinus arrest relatively infrequently. In addition, the concurrent occurrence of HCM with non-surgically induced (ablation or myectomy) bradyarrhythmia and idiopathic pericardial effusion in adult patients has not been previously reported.</p><p><strong>Case summary: </strong>In this report, we present two elderly female patients with HCM who exhibited sinus bradycardia and sinus arrest, one of whom also presented with moderate pericardial effusion, they all presented with chest tightness. To manage the complex comorbidities, we opted for dual-chamber pacemaker implantation. Subsequent examinations and follow-up revealed that pacing significantly reduced LVOT obstruction and corrected heart rhythm. Additionally, there was no significant progression of pericardial effusion.</p><p><strong>Discussion: </strong>The primary strategies for alleviating LVOT obstruction involve altering the structure of the septum, including septal myectomy (SME), alcohol septal ablation (ASA), and septal radiofrequency ablation. Meanwhile, a dual-chamber pacemaker can treat HCM by changing the sequence of myocardial contraction. Although pacemakers have been considered an inferior alternative due to their relatively large residual obstruction, their benefits may be significantly underestimated. This report underscores the additional efficacy of dual-chamber pacemakers in managing HCM, particularly in patients complicated by sinus node dysfunction and idiopathic pericardial effusion.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1518000"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic polymer based patches for congenital cardiac surgery: future development of implants.","authors":"Emma Richert, Linda Grefen, Alexandra Zorin, Julian Hubrich, Stefan Simon, Christian P Sommerhoff, Christian Hagl, Christopher Herz, Dominik Obrist, Jürgen Hörer, Thierry Carrel, Maximilian Grab, Paul Philipp Heinisch","doi":"10.3389/fcvm.2025.1540826","DOIUrl":"10.3389/fcvm.2025.1540826","url":null,"abstract":"<p><strong>Objective: </strong>Despite advancements in surgical techniques, many patients born with congenital heart defects (CHD) require repeated reinterventions due to the limitations of materials used in congenital cardiac surgery (CCS). Traditional biogenic polymers, such as bovine or equine pericardium, are prone to calcification, have limited durability, and fail to adapt to the growth of infants. This study aims to address these challenges by investigating bacterial cellulose (BC) as a promising material for CCS.</p><p><strong>Methods: </strong>Variability in patch quality from previous studies was addressed by refining the production protocol taking advantage of optical density (OD) measurements. After a 72 h incubation, patches were harvested and tested mechanically with burst pressure and uniaxial strain testing. BC's biomechanical properties were further explored by modifying nutrient concentrations, creating different media groups (N10, N30, N50). Hybrid patches combining BC with electrospun polyurethane (ESP-PU) were developed using a specially designed 3D-printed flask to ensure uniform coating and integration.</p><p><strong>Results: </strong>The initial bacterial concentration significantly influenced cellulose yield and growth rate, with static cultures outperforming shaken ones. Nutrient-enriched media (N10, N30, N50) produced cellulose with greater elasticity and strength compared to standard C-Medium, with stiffness correlating to nutrient concentration. Inflation tests showed that N10 and N30 samples withstood higher pressures than N50, which, despite being stiffer, performed worse under rapid inflation. All samples, however, maintained pressures above physiological levels. Scanning electron microscopy analysis confirmed effective BC coating of PU fibres without altering BC fibre orientation or bacterial activity.</p><p><strong>Conclusion: </strong>BC patches demonstrated burst pressure resistance above 1,400 mmHg. BC's elasticity can be tailored, and in combination with ESP-PU, an innovative hybrid material can be produced, positioning BC as a promising biomaterial for future CCS implant development.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1540826"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigued with Friedewald: why isn't everyone onboard yet with the new LDL-C equations?","authors":"Madhusudhanan Narasimhan, Jing Cao, Jeffrey W Meeusen, Alan T Remaley, Seth S Martin, Alagarraju Muthukumar","doi":"10.3389/fcvm.2025.1534460","DOIUrl":"10.3389/fcvm.2025.1534460","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1534460"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial dysfunction caused by MyBPC3 P459fs mutation in hypertrophic cardiomyopathy: evidence from multi-omics approaches and super-resolution imaging.","authors":"Yupeng Wu, Yuzhu Zhang, Qirui Zheng, Qiyuan Wang, Xingyu Fang, Zaihan Zhu, Jing Lu, Dandan Sun","doi":"10.3389/fcvm.2025.1529921","DOIUrl":"10.3389/fcvm.2025.1529921","url":null,"abstract":"<p><strong>Introduction: </strong>Mutations in the sarcomere protein, particularly in cardiac myosin binding protein C gene (<i>MyBPC3</i>), were the most frequent genetic cause of hypertrophic cardiomyopathy (HCM). The pathogenic MyBPC3 P459fs mutation has been reported in HCM patients. However, there was limited knowledge of the structure-function relationships and potential pathways in clinical HCM with MyBPC3 P459fs mutation.</p><p><strong>Methods: </strong>We used multi-omics approaches and super-resolution imaging to explore the effects of MyBPC3 P459fs mutation on humans and cells. HCM patients carrying MyBPC3 P459fs mutation (MyBPC3-P459fs HCMs) and healthy controls (HCs) were evaluated for myocardial function using both conventional and advanced echocardiography. In parallel, H9C2 myocardial cells infected with either MyBPC3 P459fs mutation (P459fs cells) or its wild type (WT cells) were investigated for myocardial fiber formation and the potential pathways behind this using super-resolution imaging and metabolomics and proteomics.</p><p><strong>Results: </strong>First, conventional and advanced echocardiography showed that MyBPC3-P459fs HCMs exhibited left ventricular diastolic and systolic dysfunction. Subsequently, super-resolution imaging indicated that P459fs cells formed fewer and shorter myocardial fibers in the cytoplasm compared to WT cells. Moreover, our metabolomic and proteomic data suggested several key components of mitochondrial membrane integrity, myocardial remodeling, myocardial energy metabolism, oxidative stress, inflammation, and actin binding capacity were significantly altered in response to P459fs mutation.</p><p><strong>Conclusions: </strong>This investigation indicated myocardial dysfunction and myocardial fiber disarray in clinical HCMs with MyBPC3 P459fs mutation and added potential pathways underlying this. These findings provided a link between the observed structural and functional disorders in MyBPC3 P459fs mutation and its onset of HCM pathogenesis and might have a significant translational contribution to effective treatment in HCM patients with MyBPC3 P459fs mutation.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1529921"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}