Frontiers in Cardiovascular Medicine最新文献

{"title":"Macrophages and cardiac lesion in zebrafish: what can single-cell RNA sequencing reveal?","authors":"Rebeca Bosso Dos Santos Luz, André Guilherme Portela Paula, Andressa Pacheco Czaikovski, Bruno Sime Ferreira Nunes, Jordana Dinora De Lima, Lais Cavalieri Paredes, Thais Sibioni Berti Bastos, Rebecca Richardson, Tarcio Teodoro Braga","doi":"10.3389/fcvm.2025.1570582","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1570582","url":null,"abstract":"<p><p>Unlike mammals, zebrafish can regenerate their heart after cardiac insult. There are several ways to perform cardiac injury in zebrafish, but cryoinjury most closely resembles human myocardial infarction (MI). Studies demonstrated that macrophages are essential cells from the beginning to later stages of cardiac injury throughout the regenerative process in zebrafish. These cells have phenotypic plasticity; hence, overly sensitive techniques, such as single-cell RNA sequencing (scRNAseq), are essential for uncovering the phenotype needed for zebrafish cardiac injury regeneration, from inflammatory profile initiation to scar resolution. This technique enables the RNA sequencing of individual cells, thus generating clusters of cells with similar gene expression and allowing the study of a particular cell population. Therefore, in this review, we focused on discussing data obtained by scRNAseq of macrophages in the context of cardiac injury. We found that from 1 to 7 days post-injury (dpi), macrophages are present with inflammatory and reparative functions in either cryoinjury or ventricular resection. At 14 dpi, there were differences between the injury models, especially in the expression profile of inflammatory cytokines, and studies with later time points are needed to understand the gene expression that enrolls the collagen scar resorption dynamic.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1570582"},"PeriodicalIF":2.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of caesarean section for a pregnant woman with Sjögren's disease and pulmonary embolism: a case report.","authors":"Fanghao Liu, Xiaohui Wang, Shu Yuan, Lin Xu, Kaiyue Shan, Longfei Wang, Jianting Huang, Qiang Zheng","doi":"10.3389/fcvm.2025.1467309","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1467309","url":null,"abstract":"<p><strong>Background: </strong>Sjögren's disease (SjD) is a chronic inflammatory autoimmune disease with significant female predominance, characterised by lymphocyte proliferation and progressive damage to exocrine glands. The complexity of the condition of women with SjD and the incidence of complications substantially increase during pregnancy, which undoubtedly has consequences on both maternal health and neonatal outcomes. Pulmonary embolism (PE) is associated with increased perinatal mortality. However, PE has rarely been reported in pregnant women with SjD.</p><p><strong>Case presentation: </strong>A 40-year-old pregnant woman was diagnosed as having SjD. During admission, she experienced chest tightness and suffocation and was scheduled for caesarean section under combined spinal-epidural anaesthesia because of sustained low oxygen saturation and foetal distress. Postoperative pulmonary artery computed tomography angiography confirmed that the patient had developed a pulmonary embolism during the perioperative period. After multidisciplinary consultation, the patient underwent inferior vena cava filter implantation, anticoagulation, oxygen therapy, and anti-infection therapy; both the mother and neonate recovered and were discharged.</p><p><strong>Conclusion: </strong>Early identification and comprehensive perioperative monitoring during the prenatal period are vital in patients with SjD complicated by PE.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1467309"},"PeriodicalIF":2.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylations in dilated cardiomyopathy and heart failure.","authors":"Cong Qin, Yansong Qin, Shanshan Zhou","doi":"10.3389/fcvm.2025.1559550","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1559550","url":null,"abstract":"<p><p>Dilated cardiomyopathy (DCM) is characterized by impaired expansion or contraction of the left or both ventricles in the absence of abnormal load conditions (such as primary valve disease) or severe coronary artery disease that can lead to ventricular remodeling. Genetic mutations, infections, inflammation, autoimmune diseases, exposure to toxins, and endocrine or neuromuscular factors have all been implicated in the causation of DCM. Cardiomyopathy, particularly DCM, often has genetic underpinnings, with established or suspected genetic origins. Up to 40% of DCM cases involve probable or confirmed genetic variations. The significance of RNA modification in the pathogenesis of hypertension, cardiac hypertrophy, and atherosclerosis is well-established. Of late, RNA methylation has garnered attention for its involvement in DCM. This review examines the biological mechanisms and effects of RNA methylation in DCM and heart failure.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1559550"},"PeriodicalIF":2.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate and CO₂-derived parameters are not predictive factors of major postoperative complications after cardiac surgery with cardiopulmonary bypass: a diagnostic accuracy study.","authors":"Xiao-Fen Zhou, Han Chen, Jun Ke, Shi-Rong Lin, Ting-Feng Huang, Bing-Ying Chen, Xin-Da Jiang, Feng Chen","doi":"10.3389/fcvm.2025.1504431","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1504431","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the performance of lactate and CO₂-derived parameters in predicting major postoperative complications (MPC) after cardiac surgery with cardiopulmonary bypass.</p><p><strong>Methods: </strong>Lactate and CO₂-derived parameters, including the venous-arterial difference in CO₂ partial pressure (Pv-aCO₂), the venous-arterial difference in CO₂ partial pressure to arterial-venous O₂ content ratio (Pv-aCO₂/Ca-vO₂), and the venous-arterial difference in CO₂ content to arterial-venous O₂ content ratio (Cv-aCO₂/Ca-vO₂) at ICU admission, 3 h, 6 h, and 12 h later were collected. Receiver-operating characteristics (ROC) curve analysis was carried out to assess the predictive performance. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of MPC.</p><p><strong>Results: </strong>MPC occurred in 77 (54.2%) of 142 patients. No significant difference was observed between the MPC and no-MPC groups regarding lactate and CO₂-derived parameters. The area under the curves (AUCs) were 0.532 (0.446-0.616) for lactate, 0.559 (0.473-0.642) for Pv-aCO₂, 0.617 (0.532-0.697) for Pv-aCO₂/Ca-vO₂, and 0.625 (0.540-0.705) for Cv-aCO₂/Ca-vO₂, respectively, and there was no significant difference between the parameters. In the <i>post-hoc</i> analysis, all parameters' AUCs were lower than 0.75 in predicting acute renal failure, and there was no significant difference between these parameters. Cv-aCO₂/Ca-vO₂ at 12 h yielded the highest AUC of 0.853 (0.784-0.907) in predicting mortality and the highest AUC of 0.808 (0.733-0.869) in predicting delirium. In multivariate analysis, hypertension, surgery duration, and PaO₂/FiO₂ were identified as independent predictors of MPC, while lactate and CO₂-derived parameters lost statistical significance after adjustment for covariates.</p><p><strong>Conclusions: </strong>Lactate and CO₂-derived parameters cannot be used as reliable indicators to predict the occurrence of MPC after cardiopulmonary bypass. Instead, traditional clinical factors such as hypertension, extended surgical duration, and impaired oxygenation emerged as the most reliable risk indicators.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1504431"},"PeriodicalIF":2.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Mechanisms by which statins protect endothelial cells from radiation-induced injury in the carotid artery.","authors":"Karima Ait-Aissa, Linette N Leng, Nathanial R Lindsey, Xutong Guo, Denise Juhr, Olha M Koval, Isabella M Grumbach","doi":"10.3389/fcvm.2025.1523371","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1523371","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fcvm.2023.1133315.].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1523371"},"PeriodicalIF":2.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing.","authors":"Raphael Schoch, Jonathan Wagner, Max Niemeyer, Fabienne Bruggisser, Denis Infanger, Justin Carrard, Benedikt Gasser, Arno Schmidt-Trucksäss, Raphael Knaier","doi":"10.3389/fcvm.2025.1531027","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1531027","url":null,"abstract":"<p><strong>Background: </strong>Bioimpedance cardiography offers a non-invasive and time-efficient method to measure hemodynamic parameters. Previous studies only investigated its reliability under steady-state conditions and at maximum load but not at ventilatory thresholds (VTs). This is the first study that assesses the reliability of measured hemodynamic parameters at different exercise stages during cardiopulmonary exercise testing (CPET) using prespecified strict criteria to assess reliability.</p><p><strong>Methods: </strong>Data from 31 healthy, well-trained adults were analyzed. Each participant completed two CPETs, both following the same ramp protocol, with a 7-day interval between them. Hemodynamic parameters were measured with the PhysioFlow® (Manatec Biomedical, Poissy, France) at characteristic phases and thresholds [VT1, VT2, and peak oxygen uptake (V̇O_2peak)]. To ensure comparability, the wattage (power) corresponding to the thresholds in Test 1 (P_VT1, P_VT2, and P_V̇O2peak) was used for Test 2.</p><p><strong>Results: </strong>Heart rate, stroke volume, and cardiac output demonstrated good reliability on a group level (mean intraclass correlation >0.75) at both thresholds (0.91, 0.80, and 0.77 at P_VT1; 0.92, 0.80, and 0.77 at P_VT2) and at P_V̇O2peak (0.93, 0.82, and 0.80). For stroke volume at P_V̇O2peak, both individual differences (-39.0 to 36.9 mL for the women and -39.9 to 45.2 mL for the men) and mean detectable change (17.5 mL) were larger than the <i>a priori</i> defined acceptable ranges of agreement (-3.6 to 3.8 mL for the women and -4.5 to 3.3 mL for the men).</p><p><strong>Conclusion: </strong>The PhysioFlow® reliably measures heart rate, stroke volume, and cardiac output during CPET on a group level. However, as shown by the Bland-Altman plots, the reliability is too low to be used for individual comparisons.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1531027"},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Surgical resection of giant ventricular fibroma in an infant utilizing 3D imaging guidance.","authors":"Jin Lu, Yu Chen, Xingchen Lian, Peipei Chang, Ping Wen, Na Zou, Lin Ma, Yuhang Liu","doi":"10.3389/fcvm.2025.1492727","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1492727","url":null,"abstract":"<p><p>Primary cardiac tumors are extremely rare, with fibromas being one of the more prevalent type primary cardiac tumors in infants and children. Cardiac fibromas present a high risk of fatal arrhythmia and sudden death, hence more aggressive surgical treatment approaches are typically employed. However, certain populations, such as asymptomatic infants and young children in the early stages, require extra caution. We present the case of a patient with a giant fibroma of the heart detected during fetal development, who was followed up until the age of 5 months before undergoing surgical resection. Prior to surgery, we employed three-dimensional (3D) imaging technology to acquire a deeper understanding of the anatomical nature of cardiac tumors. We then devised a comprehensive surgical strategy to minimize the risk of damage to large blood vessels during surgery and maximize preservation of myocardial tissue. Following surgical resection of the tumor, cardiac dysfunction was managed with extracorporeal membrane oxygenation (ECMO) continuous adjuvant therapy, and conventional vasodilators such as dopamine and nitroglycerin were ad. The patient recovered well without any serious complications. This case highlights the significance of timely surgical intervention, combined with 3D imaging to develop a meticulous surgical plan and early use of ECMO to maintain cardiac function in patients with postoperative cardiac dysfunction. This can help to ensure the safety and effectiveness of giant cardiac fibromas resection in infants and young children.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1492727"},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary fiber intake and all-cause and CVD-caused mortality among heart failure survivors: a cohort study from the NHANES database.","authors":"Shulin Wang, Yun Ruan, Yuliang Zhang","doi":"10.3389/fcvm.2024.1406511","DOIUrl":"https://doi.org/10.3389/fcvm.2024.1406511","url":null,"abstract":"<p><strong>Aim: </strong>Heart failure (HF) is a severe manifestation or late stage of various heart diseases. As an anti-inflammatory nutrient, dietary fiber has been shown to be associated with the progression and prognosis of cardiovascular diseases (CVDs). However, little is known about the relationship between dietary fiber intake and mortality in HF survivors. This study evaluated the association between dietary fiber intake and all-cause and CVD-caused mortality among HF survivors.</p><p><strong>Methods: </strong>Data for the study were extracted from the National Health and Nutrition Examination Survey 1999-2018. Dietary fiber intake information was obtained by a 24-h dietary recall interview. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2019. Covariates, including sociodemographic, lifestyle, disease history, and laboratory data, were extracted from the database. The weighted univariate and multivariate Cox proportional hazard models were utilized to explore the association between dietary fiber intake and mortality among HF survivors, with hazard ratios and 95% confidence intervals. Further stratified analyses were performed to explore this association based on age, gender, a history of diabetes and dyslipidemia, and duration of HF.</p><p><strong>Results: </strong>A total of 1,510 patients were included. Up to 31 December 2019, 859 deaths had occurred over a mean follow-up of 70.00 months. After multivariable adjustment, a higher dietary fiber intake was associated with a lower risk of all-cause and CVD-caused mortality in HF survivors, especially in male patients, those aged <60 years old, and those with a history of diabetes and dyslipidemia.</p><p><strong>Conclusion: </strong>Among HF survivors, higher dietary fiber intake levels may be associated with a good health outcome. More large-scale prospective cohort studies are needed to further explore this benefit relationship.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1406511"},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing ablation outcomes: vein of Marshall ethanol infusion in persistent atrial fibrillation with severe left atrial enlargement.","authors":"Tao Luo, Tao Liu, Bo Cui, Chenggang Deng, Yanhong Chen, Xiong Xiong, Jinlin Zhang, Gang Wu","doi":"10.3389/fcvm.2025.1554321","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1554321","url":null,"abstract":"<p><strong>Background: </strong>Left atrial (LA) enlargement is a widely recognized factor that increases the risk of ablation failure in patients with atrial fibrillation (AF). This retrospective, observational study aimed to assess the influence of vein of Marshall (VOM) ethanol infusion (VOM-EI) on persistent atrial fibrillation (PsAF) ablation among patients with severe LA enlargement.</p><p><strong>Methods: </strong>In this research, 178 patients underwent the VOM-EI followed by the radiofrequency (RF) ablation procedure, which was based on circumferential pulmonary vein antrum (CPVA) ablation and linear ablation of the roof of the LA and the mitral isthmus (MI). In comparison, 83 patients only underwent the RF ablation procedure.</p><p><strong>Results: </strong>In the VOM + RF ablation group, the duration of left CPVA ablation was shorter compared to the RF ablation group (20.3 ± 8.7 minutes vs. 27.1 ± 8.1 minutes, <i>P</i> < 0.0001). The rate of MI block was higher (94.9% vs. 85.5%, <i>P</i> = 0.01) in the VOM + RF ablation group, with a shorter MI ablation time (23.2 ± 10.8 minutes vs. 30.5 ± 11.8 minutes, <i>P</i> < 0.0001), and a lower need for coronary sinus vein ablation compared to the RF ablation group (64.0% vs. 78.3%, <i>P</i> = 0.02). Throughout the one-year observation period, the VOM + RF ablation group exhibited a notably superior survival rate without recurrence compared to the RF ablation group (78.7% vs. 65.1%, <i>P</i> = 0.02). As compared to the RF ablation group, the VOM + RF ablation group had a lower rate of recurrence with atrial tachycardia (8.4% vs. 19.3%, <i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>The VOM-EI facilitated the left CPVA and the MI ablation and improved the ablation outcomes in patients with severe LA enlargement for treating PsAF.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1554321"},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of the left atrioventricular coupling index in cardiovascular disease.","authors":"Xu Liu, Jing Wang, Yan Tong, Shuai Wang","doi":"10.3389/fcvm.2025.1567856","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1567856","url":null,"abstract":"<p><p>The left atrioventricular coupling index (LACI) has emerged as a novel and transformative biomarker in cardiovascular research, addressing long-standing limitations in traditional cardiac function assessments. By quantifying the ratio of left atrial to left ventricular end-diastolic volumes, LACI offers unprecedented prognostic insights into a wide range of cardiovascular diseases, including atrial fibrillation, heart failure, and myocardial infarction, as well as other conditions such as hypertension and cardiomyopathies. Recent evidence highlights its unique ability to integrate atrial and ventricular dynamics, offering a more comprehensive perspective on cardiac health and disease progression. This review synthesizes the latest advancements in LACI research, elucidates its underlying pathophysiological mechanisms, and explores its expanding clinical applications as a pivotal tool for risk stratification, precision diagnostics, and personalized therapy in cardiovascular medicine.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1567856"},"PeriodicalIF":2.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}