Frontiers in Cardiovascular Medicine最新文献

{"title":"Autophagy fine-tuning by angiotensin-(1-9) in cultured rat cardiomyocytes.","authors":"Mario Bustamante, Clara Quiroga, Georthan Mancilla, Wileidy Gomez, Anita Tapia, Reinaldo Figueroa, David Mondaca-Ruff, Ingrid Oyarzún, Hugo E Verdejo, Sergio Lavandero, Pablo Castro","doi":"10.3389/fcvm.2025.1408325","DOIUrl":"10.3389/fcvm.2025.1408325","url":null,"abstract":"<p><strong>Background: </strong>The renin-angiotensin system (RAS) plays a pivotal role in regulating blood volume, systemic vascular resistance, and electrolyte balance, serving as a key component of cardiovascular health. Recent findings highlight the role of angiotensin II (Ang II) in inducing autophagy through angiotensin II receptor type 1 (AT1R). Autophagy, a process of self-degradation and turnover of cellular components, is a homeostatic response that eliminates superfluous materials. Abnormal autophagy promotes cardiomyocyte loss and is critical in hypertrophy and heart failure progression. The RAS's non-canonical axis, which includes the angiotensin 1-9 peptide [Ang-(1-9)], has an anti-hypertrophic effect in cardiomyocytes via an unknown mechanism<b>.</b> In the present study, we aimed to elucidate the effect of Ang-(1-9) on cardiomyocyte autophagy.</p><p><strong>Methods: </strong>We <b>i</b>solated and cultured neonatal ventricular cardiomyocytes and then <b>co-</b>treated them with Ang-(1-9) in the presence of chloroquine (CQ), Ang-II, and chemical inhibitors of different signaling pathways. After treatment, total RNA and protein extracts were obtained to analyze the abundance of different autophagy markers. Likewise, cells were fixed, and autophagy was analyzed through epifluorescence microscopy.</p><p><strong>Results: </strong>Our findings show that CQ leads to a reduction in autophagy markers, such as microtubule-associated protein 1 light chain 3-II (LC3-II) and total LC3, suggesting Ang-(1-9)'s regulatory role in basal autophagy levels. Furthermore, Ang-(1-9) opposes Ang-II-induced autophagy and induces the phosphorylation of the S234 residue of Beclin-1 (BCN1) via an angiotensin II receptor type 2 (AT2R)/Akt-dependent pathway.</p><p><strong>Conclusions: </strong>This reduction of Ang-II-induced autophagy by Ang-(1-9) unveils a novel aspect of its action, potentially contributing to its cardioprotective effects.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1408325"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering.","authors":"Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig","doi":"10.3389/fcvm.2025.1532661","DOIUrl":"10.3389/fcvm.2025.1532661","url":null,"abstract":"<p><strong>Objective: </strong>Relaxation-Enhanced Angiography without Contrast and Triggering (REACT) is a novel 3D isotropic flow-independent non-contrast-enhanced MRA (non-CE-MRA) and has shown promising results in imaging of the thoracic aorta, primarily in patients without prior aortic surgery. The purpose of this study was to evaluate the performance of REACT after surgery of the aortic root and/or ascending aorta by performing an intraindividual comparison to CE-MRA.</p><p><strong>Material and methods: </strong>This retrospective single center study included 58 MRI studies of 34 patients [mean age at first examination 45.64 ± 11.13 years, 31 (53.44%) female] after ascending aortic surgery. MRI was performed at 1.5T using REACT (ECG- and respiratory-triggering, Compressed SENSE factor 9, acquired spatial resolution 1.69 × 1.70 × 1.70 mm³) and untriggered 3D CE-MRA. Independently, two radiologists measured maximum and minimum vessel diameters (inner-edge) and evaluated image quality and motion artifacts on 5-point scales (5 = excellent) for the following levels: mid-graft, distal anastomosis, ascending aorta, aortic arch, and descending aorta. Additionally, readers evaluated MRAs for the presence of aortic dissection (AD) and graded the quality of depiction as well as their diagnostic confidence using 5-point scales (5 = excellent).</p><p><strong>Results: </strong>Vessel diameters were comparable between CE-MRA and REACT (total acquisition time: 05:42 ± 00:38 min) with good to excellent intersequence agreement (ICC = 0.86-0.96). At the distal anastomosis (minimum/maximum, <i>p</i> < .001/<i>p</i> = .002) and at the ascending aorta (minimum/maximum, <i>p</i> = .002/<i>p</i> = .06), CE-MRA yielded slightly larger diameters. Image quality for all levels combined was higher in REACT [median (IQR); 3.6 (3.2-3.93) vs. 3.9 (3.6-4.13), <i>p</i> = .002], with statistically significant differences at mid-graft [3.0 (2.5-3.63) vs. 4.0 (4.0-4.0), <i>p</i> < .001] and ascending aorta [3.25 (3.0-4.0) vs. 4.0 (3.5-4.0), <i>p</i> < .001]. Motion artifacts were more present in CE-MRA at all levels (<i>p</i> < .001). Using CE-MRA as the standard of reference, readers detected all 25 cases of residual AD [Stanford type A: 21 (84.0%); Stanford type B: 4 (16.0%)] in REACT with equal quality of depiction [4.0 (3.0-4.5) vs. 4.0 (3.0-4.0), <i>p</i> = .41] and diagnostic confidence [4.0 (3.0-4.0) vs. 4.0 (3.0-4.0), <i>p</i> = .81) in both sequences.</p><p><strong>Conclusions: </strong>This study indicates the feasibility of REACT for assessment of the thoracic aorta after ascending aortic surgery and expands its clinical use for gadolinium-free MRA to these patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1532661"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Females with Fabry disease: an expert opinion on diagnosis, clinical management, current challenges and unmet needs.","authors":"Antonino Tuttolomondo, Cristina Chimenti, Vittoria Cianci, Maurizio Gallieni, Chiara Lanzillo, Antonella La Russa, Giuseppe Limongelli, Renzo Mignani, Iacopo Olivotto, Federico Pieruzzi, Antonio Pisani","doi":"10.3389/fcvm.2025.1536114","DOIUrl":"10.3389/fcvm.2025.1536114","url":null,"abstract":"<p><p>Females with Fabry disease (FD) often have a milder phenotype, later symptom onset, and slower disease progression than males, causing delayed diagnosis and undertreatment. A survey was conducted at nine Italian FD centers to evaluate routine management of females with FD; results were discussed at a meeting of eleven Italian specialists and recommendations developed. Of the 227 females managed by the physicians surveyed, 85% were diagnosed through family screening and 38.5% were symptomatic at presentation. Female patients usually underwent cardiac, renal, and neurologic monitoring, and measurement of plasma lyso-globotriaosylsphingosine (Gb3) levels at 6- or 12-month intervals. Treatment was initiated in 54%, mostly enzyme replacement therapy. Experts recommended screening all female relatives of index cases and evaluating all potentially affected organ systems. Diagnosis should be based on genetic analysis. Individualized monitoring of asymptomatic females must balance the need to detect organ damage while maintaining adherence. Treatment decisions should be based primarily on signs/symptoms of FD, but age, family screening results, <i>GLA</i> mutations, Gb3/lyso-Gb3 accumulation, and organ damage should be considered in asymptomatic females. More research on FD in females is needed and physicians should be aware of differences in the diagnosis, monitoring, and management of females vs. males with FD.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1536114"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for long-term outcome of pulmonary valve perforation and balloon valvuloplasty in neonates with critical pulmonary valve stenosis or pulmonary valve atresia with intact ventricular septum.","authors":"Tariq Abu-Tair, Ines Willershausen, Melanie Friedmann, Kai Rubarth, Annika Weigelt, Claudia Martin, Sven Dittrich, Christoph Kampmann","doi":"10.3389/fcvm.2025.1527832","DOIUrl":"10.3389/fcvm.2025.1527832","url":null,"abstract":"<p><strong>Introduction: </strong>Percutaneous balloon valvuloplasty is the treatment of choice for critical pulmonary valve stenosis (CPS) and pulmonary valve atresia with intact ventricular septum (PA/IVS) if the ventricle has a suitable size. This study aimed to evaluate the long-term outcomes and predictors for surgical intervention and pulmonary valve replacement in patients with CPS or with PA/IVS after PBV, considering different morphological and hemodynamic parameters.</p><p><strong>Methods: </strong>Neonates with PA/IVS or CPS who were admitted to the University Medicine Mainz and University Hospital Erlangen between November 1994 and March 2013 and underwent successful PBV as an initial procedure, with a follow-up of at least 5 years (median 13.1 years), were included. The <i>Z</i>-scores of pulmonary valve diameter, balloon/annulus ratio, number of cusps, and persisting stenosis were analyzed. The endpoint was the need for surgical procedures or valve replacement.</p><p><strong>Results: </strong>A total of 62 neonates (median age at intervention 5 days) were included. Among them, 15 patients (24.2%) reached the endpoint. The mean time of freedom from surgery differed according to the number of cusps (<i>P</i> < 0.001), pulmonary valve diameter <i>Z</i>-scores (<i>P</i> = 0.04), and degree of persisting stenosis (<i>P</i> = 0.008), but did not differ according to the balloon/annulus ratio (≤1.2 vs. >1.2).</p><p><strong>Conclusion: </strong>Pulmonary valve perforation and PBV achieved favorable long-term outcomes in neonates with PA/IVS and CPS. A small pulmonary valve diameter, reduced number of cusps, and persisting gradient of >40 mmHg increased the risk for reduced time of freedom from surgical intervention and/or pulmonary valve replacement.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1527832"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A universal model for predicting coronary artery lesions in subgroups of kawasaki disease in China: based on cluster analysis.","authors":"Chuxiong Gong, Feng Li, Zhongjian Su, Yanan Fu, Xing Zhang, Qinhong Li, Xiaomei Liu, Lili Deng","doi":"10.3389/fcvm.2025.1532768","DOIUrl":"10.3389/fcvm.2025.1532768","url":null,"abstract":"<p><strong>Objective: </strong>Coronary artery lesions (CAL) represent the most severe complication of Kawasaki disease (KD). Currently, there is no standardized method for predicting CAL in KD, and the predictive effectiveness varies among different KD patients. Therefore, our study aims to establish distinct predictive models for CAL complications based on the characteristics of different clusters.</p><p><strong>Methods: </strong>We employed principal component clustering analysis to categorize 1,795 KD patients into different clustered subgroups. We summarized the characteristics of each cluster and compared the occurrence of CAL components within each cluster. Additionally, we utilized LASSO analysis to further screen for factors associated with CAL. We then constructed CAL predictive models for each subgroup using the selected factors and conducted preliminary validation and assessment.</p><p><strong>Results: </strong>Through PCA analysis, we identified three clusters in KD. We developed predictive models for each of the three clusters. The AUCs of the three predictive models were 0.789 (95% CI: 0.732-0.845), 0.894 (95% CI: 0.856-0.932), and 0.773 (95% CI: 0.727-0.819), respectively, all demonstrating good predictive performance.</p><p><strong>Conclusion: </strong>Our study identified the existence of three clusters among KD patients. We developed KD-related CAL predictive models with good predictive performance for each cluster with distinct characteristics. This provides reference for individualized precision treatment of KD patients and aids in the health management of coronary arteries in KD.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1532768"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of electrophysiological left bundle branch pacing characteristics in different bilateral electrode pacing vector configurations.","authors":"Hao Wu, Longfu Jiang, Jiabo Shen, Lu Zhang","doi":"10.3389/fcvm.2025.1500196","DOIUrl":"10.3389/fcvm.2025.1500196","url":null,"abstract":"<p><strong>Introduction: </strong>Left bundle branch pacing (LBBP) in bipolar pacing with anodal capture produces a more balanced ventricular activation than conventional unipolar pacing but need high pacing output. The present study aimed to compare the electrophysiological characteristics of LBBP in different bilateral electrode pacing vector configurations.</p><p><strong>Methods: </strong>A total of 57 patients who met the criteria for left bundle branch (LBB) capture and underwent three bilateral electrode pacing vector configuration test were enrolled. The electrocardiogram (ECG) and electrogram (EGM) parameters were evaluated and other electrophysiological characteristics were analyzed using a three-electrode configuration test.</p><p><strong>Results: </strong>Seven capture modes [right ventricular septal (RVS) + left ventricular septal (LVS) + LBB, RVS + LBB, LVS + LBB, RVS + LVS, RVS, LVS, and LBB] were utilized in the study. The thresholds of full fusion mode (RVS + LVS + LB) in Bilateral Cathodes and Ring Bipolar were all lower than that in Tip Bipolar (1.2 ± 0.5 V vs. 2.7 ± 1.0 V, <i>P</i> < 0.001; 1.6 ± 0.6 V vs. 2.7 ± 1.0 V, <i>P</i> < 0.001). Full fusion mode had the shortest P-QRS (116.9 ± 12.8 ms) and V1 RWPT (94.5 ± 12.3 ms), V6 RWPT remain the shortest (64.9 ± 9.7 ms).</p><p><strong>Conclusion: </strong>Changing the bilateral electrode pacing vector configuration to Bilateral Cathodes and Ring Bipolar can reduce the full fusion mode capture threshold compared to conventional bipolar pacing.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1500196"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of severe myocarditis combined with erythema multiforme caused by herpes simplex virus-1.","authors":"Anwu Huang, Bin Lin, Xiaojun Ji, Shanjiang Chen","doi":"10.3389/fcvm.2025.1421364","DOIUrl":"10.3389/fcvm.2025.1421364","url":null,"abstract":"<p><p>Herpes simplex virus-1 (HSV-1) is a recognised pathogen that is primarily associated with skin mucosal infection. However, in rare cases, it has been observed to lead to skin extramucosal manifestations, including myocarditis. The present case report documents the occurrence of severe myocarditis in a 35-year-old female patient, attributed to HSV-1 infection. She received cardiac support in the form of VA-ECMO (Venoarterial Extracorporeal Membrane Oxygenation). Concurrently, the patient exhibited cutaneous manifestations of erythema multiforme, which demonstrated a favourable response to antiviral and hormonal therapy. This case underscores the significance of HSV-1 as a causative agent of myocarditis and underscores the necessity for vigilance and expeditious treatment of potential cardiac complications caused by HSV-1.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1421364"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes of nurses towards telenursing in cardiac care in Al-Ahsa, Saudi Arabia: a cross-sectional study.","authors":"Dalal Abdulrahman Alsultan, Sahbanathul Missiriya Jalal","doi":"10.3389/fcvm.2025.1506441","DOIUrl":"10.3389/fcvm.2025.1506441","url":null,"abstract":"<p><strong>Objectives: </strong>Telenursing in cardiac care leverages technology to support self-care and optimize outcomes for heart failure patients during and beyond the pandemic. This study aims to explore nurse's knowledge and attitudes towards telenursing in cardiac care, examine the correlation between knowledge and attitude, and associate knowledge levels with selected demographic variables.</p><p><strong>Methods: </strong>A cross-sectional study was conducted, and 149 nurses from Prince Sultan Cardiac Care Center hospitals were randomly selected. The data were collected through a structured questionnaire, including socio-demographic characteristics, knowledge, and attitudes about telenursing.</p><p><strong>Results: </strong>The mean age of the nurses was 36.17 ± 6.5 years. Most nurses (64.4%) held a bachelor's degree, with 71.8% working as staff nurses. Nearly half (47.6%) had 6-9 years of professional experience. Among them, 15.4% had good knowledge, 63.8% had average knowledge, and 20.8% had poor knowledge, with a total mean knowledge score of 14.92 ± 3.2. Overall, nurses had positive attitudes towards telenursing (<i>p</i> < 0.05). Knowledge scores were significantly associated with age, education, and professional experience (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Strengthening nurse's understanding of telenursing is vital. Focused educational and training programs are imperative to enhance knowledge about telenursing in cardiac care and alleviate the healthcare system's economic burden.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1506441"},"PeriodicalIF":2.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computerized tomography angiography in diagnosing an obtuse marginal branch perforation after pericardiocentesis: a case report.","authors":"A Ostojic, Z Antonic, I Ilic","doi":"10.3389/fcvm.2025.1535797","DOIUrl":"10.3389/fcvm.2025.1535797","url":null,"abstract":"<p><strong>Background: </strong>Pericardiocentesis is both therapeutic and diagnostic invasive procedure, guided by echocardiography and/or angiography. It can be done using subcostal or apical approach. One of the major complications of pericardiocentesis is coronary artery laceration with an incidence of less than 1%. Diagnosis of such lacerations is often made by invasive coronary angiography or urgent thoracotomy. Computed tomography angiography is used to determine the extent of bleeding and hemopericardium, but its potential for detailed evaluation of bleeding site is somewhat underestimated.</p><p><strong>Case presentation: </strong>We present a rare case of distal obtuse marginal (OM) artery perforation resulting from apical pericardiocentesis that was diagnosed with CT angiography (CTA) further treated with coronary guidewire particle embolization. A 49-year-old male patient who had undergone ascending aorta and aortic arch reconstruction after an aortic dissection Type A was evaluated with echocardiography before being discharged from our hospital. A loculated pericardial effusion was identified, necessitating pericardiocentesis. The clinical course was further complicated by hemopericardium due to coronary laceration. The hemorrhage was managed with coronary guidewire segment embolization which led to immediate improvement in hemodynamic status. The patient was discharged seven days after intervention.</p><p><strong>Conclusion: </strong>Coronary artery perforation is a rare, albeit life-threatening complication of pericardiocentesis that requires urgent surgical or percutaneous intervention. CTA can provide important diagnostic information on perforation location and help in deciding whether embolization or open-heart surgery is needed to address ongoing bleeding.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1535797"},"PeriodicalIF":2.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of MitoQ on prevention and management of cardiometabolic diseases: a scoping review.","authors":"Mingli Pang, Shidi Wang, Tianyi Shi, Jinsong Chen","doi":"10.3389/fcvm.2025.1506460","DOIUrl":"10.3389/fcvm.2025.1506460","url":null,"abstract":"<p><strong>Background: </strong>The exploration of mitochondrial-targeted antioxidants represented a burgeoning field of research with significant implications for cardiometabolic diseases (CMD). The studies reviewed in this scoping analysis collectively highlighted the effect of MitoQ on prevention and management of CMD and underlying mechanisms were discussed, mainly including cardiovascular diseases (CVDs), liver health and others.</p><p><strong>Methods: </strong>This scoping review aimed to synthesize current research on the health impacts of MitoQ on CMD, focusing primarily on human-based clinical trials. While the primary focus was on human trials, <i>in vivo</i> and <i>in vitro</i> studies were referenced as supplementary material to provide a broader understanding of MitoQ's mechanisms and potential effects.</p><p><strong>Results: </strong>This scoping review had synthesized the findings that collectively contributed to the understanding of mitochondrial-targeted antioxidants and their role in CMD.</p><p><strong>Conclusion: </strong>The synthesis of these findings illustrated a broad spectrum of benefits ranging from enhanced insulin secretion to improved lipid profiles and mitochondrial function, yet the path to clinical application required further investigation on appropriate doses and populations.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1506460"},"PeriodicalIF":2.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}