Frontiers in Cardiovascular Medicine最新文献

{"title":"Pulsed field ablation for atrial fibrillation: clinical applications and research advances.","authors":"Meng Sun, XiaoHong Fu, Jia Gao, Min Guo, Wenjie Yin, Rui Wang","doi":"10.3389/fcvm.2025.1679578","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1679578","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with increased risks of stroke, heart failure, and mortality. With the advancement of catheter ablation technology, pulsed field ablation (PFA), a novel nonthermal ablation modality, has garnered growing attention due to its myocardial selectivity and favorable safety profile. This review systematically summarizes the biophysical principles, clinical advantages, catheter systems, special population applications, limitations, and future directions of PFA based on the latest evidence.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1679578"},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to bedside: investigating SGLT2 inhibitors as a novel strategy against chemotherapy-induced cardiomyopathy.","authors":"Rade Jibawi Rivera, Faris Muaref, Sulaiman Paika, Abdullah Ruyyashi, Christopher S Gondi","doi":"10.3389/fcvm.2025.1647747","DOIUrl":"10.3389/fcvm.2025.1647747","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Anthracyclines are essential components of chemotherapeutic regimens for a broad spectrum of malignancies, yet their utility is constrained by cumulative, dose-dependent cardiotoxicity, often culminating in non-ischemic cardiomyopathy and heart failure. The pathogenesis involves oxidative stress, mitochondrial dysfunction, and topoisomerase IIβ-mediated DNA damage in cardiomyocytes. While ACE inhibitors and angiotensin receptor blockers (ARBs) have demonstrated modest cardioprotective effects, the efficacy of newer heart failure therapies remains underexplored. Sodium-glucose co-transporter-2 (SGLT2) inhibitors, endorsed as Class I therapy for heart failure with reduced ejection fraction (HFrEF) per 2022 AHA/ACC/HFSA guidelines, have shown robust cardioprotective effects in large cardiovascular outcomes trials. However, their potential to prevent or attenuate anthracycline-induced cardiotoxicity has not been systematically evaluated. This study aimed to assess preclinical and clinical evidence supporting their use in anthracycline-exposed populations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic review was conducted by PRISMA 2020 guidelines. Comprehensive searches of major medical databases and clinical trial registries were performed through March 2025. Eligible studies investigated SGLT2 inhibitors, β-blockers, or ACE inhibitors in adult patients receiving anthracycline-based chemotherapy or in animal models replicating this exposure. Primary outcomes included changes in LVEF, GLS, and incidence of heart failure. Studies involving pre-existing heart failure or non-anthracycline-related cardiotoxicity were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Preclinical studies (&lt;i&gt;n&lt;/i&gt; = 4) consistently demonstrated that SGLT2 inhibitors mitigated cardiomyocyte injury, fibrosis, and oxidative stress, preserving cardiac function in anthracycline-exposed models. In one study, LVEF was significantly higher in animals treated with SGLT2 inhibitors (61.3% ± 11%) vs. controls (49.2% ± 8%, &lt;i&gt;p&lt;/i&gt; = 0.007). Additional studies corroborated reduced histopathological damage and improved myocardial performance. No clinical trials to date have specifically assessed SGLT2 inhibitors in oncology populations. Nevertheless, major cardiovascular trials (e.g., EMPA-REG OUTCOME, DECLARE-TIMI 58) have demonstrated substantial reductions in heart failure events among non-cancer cohorts. In contrast, ACE inhibitors and β-blockers have shown variable efficacy during chemotherapy, with inconsistent findings across studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;SGLT2 inhibitors exhibit consistent cardioprotective effects in preclinical models of anthracycline cardiotoxicity and possess well-established efficacy in broader cardiovascular populations. These findings underscore the critical need for prospective trials evaluating their safety and therapeutic potential in cardio-oncology, with implications for reshaping current preventive strategies.&lt;/","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1647747"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment and treatment of left ventricular pseudoaneurysm due to wire injury in transcatheter aortic valve implantation: a case report.","authors":"Fumiko Yoshimachi, Tomohiko Shindo, Shigeo Godo, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Yasuda","doi":"10.3389/fcvm.2025.1676337","DOIUrl":"10.3389/fcvm.2025.1676337","url":null,"abstract":"<p><p>Transcatheter aortic valve implantation (TAVI) has recently become a minimally invasive alternative to surgical aortic valve replacement. However, it remains associated with potentially life-threatening complications. Among these, left ventricular pseudoaneurysm is a rare but serious event. Although infrequently reported, its occurrence may be followed by rapid clinical deterioration and fatal outcomes. We report the case of an 84-year-old woman with severe aortic stenosis (AS), who developed a left ventricular pseudoaneurysm following TAVI. Pre-procedural echocardiography showed a heavily calcified and immobile aortic valve, with a peak velocity of 4.0 m/s, an aortic valve area of 1.17 cm², and a mean pressure gradient of 38 mmHg. A self-expandable valve was selected to optimize supra-annular deployment. One day after the procedure, imaging revealed a pseudoaneurysm at the left ventricular apex. This case highlights a rare but critical complication of TAVI. We discuss potential mechanisms, preventive considerations, and management strategies for such events.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1676337"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the monocyte-to-albumin ratio with cardiovascular disease and with all-cause and cardiovascular mortality in the general population.","authors":"Yingju Jin, Xiaoyue Wang, Yinlian Chen, Xiaomei Li, Xueqing Wu, Yunxue Tian, Juan Li","doi":"10.3389/fcvm.2025.1645793","DOIUrl":"10.3389/fcvm.2025.1645793","url":null,"abstract":"<p><strong>Objective: </strong>This investigation examined the links of monocyte-to-albumin ratio (MAR) with cardiovascular disease (CVD), alongside all-cause and CVD mortality in the general population, employing records from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018, connected to the National Death Index (NDI).</p><p><strong>Methods: </strong>Participants were split into three cohorts based on MAR. The link between MAR and CVD was examined by multivariable logistic regression analysis. Curve-fitting techniques investigated potential nonlinear associations. Receiver operating characteristic (ROC) curves determined the predictive capability of MAR regarding CVD. The links of MAR with all-cause and CVD mortality were investigated utilizing Cox regression modeling. Restricted cubic splines (RCS) curves illustrated the dose-dependent relationships. The weighted Kaplan-Meier method assessed survival distinctions among MAR tertile categories. Sensitivity and stratified analyses were performed to assess the robustness and stability of the results. Further, NRI analysis was conducted to quantify the predictive performance of MAR.</p><p><strong>Results: </strong>Multivariable logistic regression identified a notable positive link between MAR and CVD (<i>p</i> < 0.05), with a nonlinear trend confirmed by smoothing curves (nonlinear <i>p</i> = 0.019). Subgroup analyses indicated the consistency of this association (interaction <i>p</i> > 0.05). Through ROC evaluation, MAR exhibited robust predictive capability for CVD. Increased MAR measurements correlated with heightened risk of all-cause mortality [hazard ratio (HR): 1.25, 95% CI: 1.08-1.44] and CVD mortality (HR: 1.46, 95% CI: 1.10-1.93). RCS evaluation determined a nonlinear connection between MAR and all-cause mortality (nonlinear <i>p</i> < 0.05). The results maintained stability throughout sensitivity and stratified assessments.</p><p><strong>Conclusions: </strong>MAR demonstrated a positive correlation with CVD, and higher MAR levels were notably connected to an occurrence rate of both all-cause and CVD mortality. Further exploration of the feasibility and predictive capabilities of MAR as an emerging inflammatory marker is warranted.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1645793"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An explainable machine learning model for predicting chronic coronary disease and identifying valuable text features.","authors":"Weipeng Gan, Peipei Wang, Xiangrong Xie, Lingfei Yang, Dasheng Lu, Sheng Ye, Mingquan Ye","doi":"10.3389/fcvm.2025.1559831","DOIUrl":"10.3389/fcvm.2025.1559831","url":null,"abstract":"<p><strong>Background: </strong>Chronic Coronary Disease (CCD) is a leading global cause of morbidity and mortality. Existing Pre-test Probability (PTP) models mainly rely on in-hospital data and clinician judgment. This study aims to construct machine learning (ML) models for predicting CCD by using easily accessible text data and baseline characteristics, and to evaluate the contribution of text data to the diagnostic model.</p><p><strong>Methods: </strong>The chief complaints, present illness, past medical history and vital signs of the patients from the internal medicine departments of the First Affiliated Hospital and the Second Affiliated Hospital of Wannan Medical College were gathered. The text data of the research subjects were structured by using text mining technology. A customized \"stop words\" list and \"custom dictionary\" for cardiovascular medicine were created to optimize the processing of text data. Then, ML algorithms were employed to establish CCD prediction models. Finally, the Shapley additive explanation (SHAP) algorithm was used to interpret the models.</p><p><strong>Results: </strong>We enrolled a total of 21,855 patients in this study, with 7,449 in the CCD group and 14,406 in the non-CCD group. Patients in the CCD group were generally older and had a higher male proportion. After conducting feature engineering, we successfully constructed a Random Forest model. The model achieved an area under the ROC curve (AUC) of 0.93 (95% CI, 0.93-0.94), demonstrating excellent performance in horizontal comparisons. Using the SHAP algorithm, valuable text features like \"chest pain\", \"chest tightness\" and structured features such as age, which are crucial for CCD judgment, were identified. Additionally, an illustration of how these features influenced the model's decision-making process was provided.</p><p><strong>Conclusion: </strong>Clinicians can leverage text data to construct a prediction model for CCD and apply the SHAP approach to pinpoint valuable text features and elucidate the model's decision-making mechanism.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1559831"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the culprit lies outside the coronary artery: dual case report of coronary sinus of valsalva dissection presenting as STEMI.","authors":"Kun Chen, Mengjiao Yu, Youpeng Ling","doi":"10.3389/fcvm.2025.1670164","DOIUrl":"10.3389/fcvm.2025.1670164","url":null,"abstract":"<p><p>Located sinus of Valsalva (SOV) dissection is a rare but critical condition that presents as inferior ST-segment elevation myocardial infarction (STEMI). We present two cases in which computed tomography angiography (CTA) was essential in identifying SOV dissection. In the first case, CTA confirmed a localized dissection of the right SOV. Surgical revascularization was delayed owing to initial diagnostic challenges and the family's hesitation, which ultimately led to a fatal outcome. In the second, intravascular ultrasound (IVUS) confirmed extrinsic compression of the right coronary artery (RCA), and following emergency stent implantation, coronary blood flow was restored, conservative treatment achieved a favorable clinical outcome. These cases highlight the pivotal role of early CTA when angiographic findings are incongruent with the clinical presentation, the utility of IVUS in determining the etiology of coronary artery occlusion, and the critical importance of timely revascularization.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1670164"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 inhibitor failure in a statin-intolerant FH patient with a novel LDLR variant: a case report.","authors":"Yuan Li, Huiyan Jiang, Yajuan Xiong, Simin Yan, Xin Chen","doi":"10.3389/fcvm.2025.1644145","DOIUrl":"10.3389/fcvm.2025.1644145","url":null,"abstract":"<p><strong>Background: </strong>Approximately 3.8 million patients in China suffer from familial hypercholesterolemia (FH). Statins and PCSK9 inhibitors are recommended by guidelines as therapeutic agents. Nevertheless, cases in which patients demonstrate statin intolerance and an abnormal response to PCSK9 inhibitors present a significant challenge to the clinical treatment of the condition.</p><p><strong>Case presentation: </strong>We report a 56-year-old Chinese female diagnosed with heterozygous familial hypercholesterolemia (HeFH). After taking simvastatin, she had elevated transaminases and creatine kinase levels, leading to a transition to PCSK9 inhibitor therapy. Unfortunately, the patient exhibited an absence of the desired response to three different PCSK9 inhibitors. A novel heterozygous missense variant in the LDLR gene (exon 11, c.1700C > T, p.Thr567Ile) was identified through related gene sequencing and genetic testing also revealed a heterozygous variant in the HTR7 gene. In light of the findings, she was treated with a combination of rosuvastatin and ezetimibe. This treatment resulted in the achievement of target lipid levels. During the follow - up, no adverse events were reported.</p><p><strong>Conclusion: </strong>The study highlights that genetic testing should be considered for FH patients who experience failure with PCSK9 inhibitors, as novel LDLR variants may account for resistance and inform personalized treatment.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1644145"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gut microbiota and its metabolites in diabetic cardiomyopathy: from pathogenesis to interventions.","authors":"Zheng Ji, Xinrou Yu, Haodi Gu, Ping Wang, Liping Meng, Hui Lin, Haitao Lv","doi":"10.3389/fcvm.2025.1677684","DOIUrl":"10.3389/fcvm.2025.1677684","url":null,"abstract":"<p><p>Diabetic cardiomyopathy (DCM), a prevalent cardiovascular complication and the principal driver of mortality among patients with diabetes, represents a significant clinical challenge. The gut microbiota, which reside a complex ecosystem within the human intestinal tract, play a fundamental role in host metabolism and systemic physiology. Mounting evidence underscores a critical link between gut microbial dysbiosis, microbial-derived metabolites, and DCM pathogenesis mediated through the gut-heart axis. This comprehensive review systematically synthesizes the current research elucidating the multifaceted interplay between the gut microbiota, their bioactive metabolites (e.g., short-chain fatty acids, bile acids, and branched-chain amino acids), and the development and progression of DCM. By critically evaluating the mechanisms underlying the gut-heart crosstalk, we provide novel insights into the etiopathogenesis of DCM. Furthermore, we evaluated emerging therapeutic strategies aimed at mitigating DCM by targeted modulation of the gut microbiota and their metabolic output, highlighting promising avenues for future research and clinical translation.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1677684"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When can coronary computed tomography angiography in patients with calcified plaque be accurate?","authors":"Qisheng Ran, Diyou Chen, Huiru Zhang, Letian Zhang","doi":"10.3389/fcvm.2025.1570517","DOIUrl":"10.3389/fcvm.2025.1570517","url":null,"abstract":"<p><strong>Aim: </strong>To identify a new method to indicate when coronary computed tomography angiography (CCTA) in patients with calcified plaque can be accurate.</p><p><strong>Methods: </strong>Prospective analysis on 105 cases of coronary artery stenosis with calcified plaque underwent both CCTA and invasive coronary angiography (ICA). The Hounsfield unit (Hu) values of calcified plaque and adjacent blood were measured, and then the ratio (R <i>_Hu</i> ) was subsequently calculated. The ICA data served as the gold standard for defining obstructive stenosis (≥ 50%) and were utilized to create a two-dimensional receiver operating characteristic (ROC) curve. The cut-off value was employed to categorize the CCTA data. Additionally, a Bland-Altman plot was used to analyze discrepancies in stenosis degree detection between CCTA and ICA. An <i>in vitro</i> experiment was designed to assess the practicability of R <i>_Hu</i> .</p><p><strong>Results: </strong>The R <i>_Hu</i> was correlated with the concordance of CCTA and ICA for stenosis evaluation (<i>r</i> = 0.509, <i>p</i> < 0.001). ROC analysis suggested a cut-off value of 0.36. The Bland-Altman plot indicated that stenosis evaluation by CCTA demonstrates good concordance when R <i>_Hu</i> exceeds 0.36; however, significant bias occurs when R <i>_Hu</i> is below 0.36 in comparison to ICA. <i>In vitro</i> experiments confirmed that the R <i>_Hu</i> parameter can be easily adjusted to enhance the accuracy of CCTA. In validation experiments, the R <i>_Hu</i> achieved a prediction accuracy of 74.0%.</p><p><strong>Conclusion: </strong>Our study suggests that the accuracy of detection of stenosis with CCTA in calcified vessels is related to the difference in Hu values between calcified plaques and blood.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1570517"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yiqi Huoxue Tongluo decoction combined with conventional medicine therapy: effects on restenosis rates and clinical efficacy in patients with coronary heart disease undergoing percutaneous coronary intervention.","authors":"Xing Zhao, Lihua Zhang, Zhijie Liu","doi":"10.3389/fcvm.2025.1600189","DOIUrl":"10.3389/fcvm.2025.1600189","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effect of Yiqi Huoxue Tongluo decoction (YHTD) in combination with conventional medicine therapy on restenosis rates and clinical efficacy in patients with coronary heart disease undergoing percutaneous coronary intervention.</p><p><strong>Methods: </strong>A total of 80 patients with coronary artery disease who underwent PCI between August 2019 and February 2021 were selected, and the patients were assigned to either the control group (<i>n</i> = 40) or the observation group (<i>n</i> = 40) according to a randomized numerical table. The control group received conventional medicine treatment, while the observation group took YHTD alongside conventional medicine treatment. Coronary angiography was performed after 6 months of treatment to compare the changes in coronary restenosis, TCM syndrome scores, Seattle Angina Questionnaire (SAQ) scores, cardiac function indexes, and related serum biomarkers between the two groups.</p><p><strong>Results: </strong>After treatment, the TCM syndrome scores of patients in both groups were lower than those before treatment, and the post-treatment TCM syndrome scores of the observation group were significantly lower than those of the control group. Similarly, the SAQ scores of patients in both groups were significantly higher than those before treatment, and the SAQ scores of the observation group were significantly higher than those of the control group. After treatment, both groups showed significant reductions in the LVEDD and LVESD compared with those before treatment, and the LVEDD and LVESD values of the observation group were significantly lower than those of the control group. Similarly, the LVEF and SV of patients in both groups increased compared with those before treatment; however, the LVEF and SV values of the observation group were significantly higher than those of the control group, and the difference was statistically significant. After treatment, hs-CRP, Hcy, and sST2 were significantly reduced in both groups, and the levels of hs-CRP, Hcy, and sST2 in the observation group were significantly lower than those in the control group.</p><p><strong>Conclusion: </strong>YHTD combined with conventional medicine therapy can significantly reduce the rate of coronary restenosis in post-PCI patients, improve the TCM symptoms, alleviate angina symptoms, enhance cardiac function indexes, and effectively regulate serum biomarker levels, which offers a better choice for the treatment of post-PCI coronary artery disease.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1600189"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}