Frontiers in Cardiovascular Medicine最新文献

{"title":"Cardiac events and dynamic echocardiographic and electrocardiogram changes following osimertinib treatment in lung cancer.","authors":"Jonathan N Le, Jordan O Gasho, Olivia Peony, Asneh Singh, Katrina D Silos, Sungjin Kim, Anthony T Nguyen, Mitchell Kamrava, Amin Mirhadi, Behrooz Hakimian, Karen L Reckamp, Kamya Sankar, Raymond H Mak, Andriana P Nikolova, Katelyn M Atkins","doi":"10.3389/fcvm.2024.1485033","DOIUrl":"10.3389/fcvm.2024.1485033","url":null,"abstract":"<p><p>Osimertinib is first-line treatment for epidermal growth factor (EGFR)-mutated non-small cell lung cancer (NSCLC) and has been associated with cardiotoxicity. However, the nature of cardiac remodeling and associated risk factors remains incompletely understood. Retrospective analysis of NSCLC patients with ≥1 echocardiogram post-osimertinib between 2007 and 2022 was performed. The cumulative incidence of grade ≥2 cardiac common terminology criteria for adverse events (CTCAE) was estimated and Fine and Gray regressions performed (non-cardiac death as competing risk). Eighty-five patients [mean [interquartile range, IQR], 68 [60-75] years; 67% female; 12% with pre-existing heart conditions] met inclusion criteria. With a median follow up of 34.7 months, the 2-year cumulative incidence of grade ≥2 and grade ≥3 cardiac events were 19.2% and 8.5%, respectively. There was an increased risk of grade ≥2 cardiac CTCAE with pre-existing arrhythmia [hazard ratio(HR) 3.90, 95%CI, 1.11-13.72; <i>p</i> = 0.034] and higher body mass index (HR 1.07, 95%CI, 1.00-1.14; <i>p</i> = 0.04). Following osimertinib (vs. baseline), the median QTc was prolonged (451 vs. 437 ms; <i>p</i> < 0.001) and LVEF ≤50% was more common (10.6% vs. 5.3%; <i>p</i> = .046). Osimertinib treatment was associated with QTc prolongation and reduced LVEF. BMI was identified as a potentially modifiable risk factor for osimertinib-associated cardiotoxicity, worthy of further study.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1485033"},"PeriodicalIF":2.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of glucagon-like peptide-1 (GLP-1) in coronary artery disease: a comprehensive review.","authors":"Alicja Skrobucha, Patryk Pindlowski, Natalia Krajewska, Marcin Grabowski, Szymon Jonik","doi":"10.3389/fcvm.2024.1446468","DOIUrl":"10.3389/fcvm.2024.1446468","url":null,"abstract":"<p><p>Coronary artery disease (CAD)-cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries-is responsible for disabilities of millions of people worldwide and remains the most common single cause of death. Inflammation is the primary pathological mechanism underlying CAD, since is involved in atherosclerotic plaque formation. Glucagon-like peptide-1 (GLP-1) is a peptide hormone which role extends beyond well-known carbohydrates metabolism. In <i>in vitro</i> studies GLP-1 receptor agonism is associated with regulation of several inflammatory pathways, including cytokine production, lypotoxicity and macrophages differentiation. In this review, we aimed to provide a comprehensive summary of the potential relationship between anti-inflammatory effects of GLP-1 and CAD. We have described a well-established association of anti-inflammatory properties of GLP-1 and atherosclerosis in animals. Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response. Human studies in this area are limited by small sample size and often nonrandomized character. However, beneficial impact of GLP-1 on endothelial function and microcirculatory integrity in patients with CAD have been described. Understanding atherosclerosis as a chronic inflammatory disease offers new opportunities for the prevention and treatment of CAD. Therefore, we emphasize the need for larger randomized controlled trials focusing on cardiovascular morbidity and mortality to verify the cardioprotective properties of GLP-1R agonists in patients with CAD.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1446468"},"PeriodicalIF":2.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Cardiovascular complications of emerging oncological therapies.","authors":"Isaac Ho, Yee-Tat Lee, Tsun-Ho Lam, Chun-Ka Wong","doi":"10.3389/fcvm.2024.1530705","DOIUrl":"10.3389/fcvm.2024.1530705","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1530705"},"PeriodicalIF":2.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Avoiding misdiagnosis in amyloidosis-navigating transthyretin genopositivity and monoclonal gammopathy in a patient with advanced heart failure and spinal stenosis.","authors":"Xia Wu, Denis Toskic, Ping Zhou, Stephanie Scalia, Xun Ma, Parva Bhatt, Teresa Fogaren, Monika Pilichowska, Knarik Arkun, Jainith Patel, Ron I Riesenburger, Daniel P Larson, Raymond L Comenzo","doi":"10.3389/fcvm.2024.1479676","DOIUrl":"10.3389/fcvm.2024.1479676","url":null,"abstract":"<p><strong>Background: </strong>A 63-year-old Black woman presented with progressive exertional dyspnea and chronic lower back pain. The course and findings in her case are instructive.</p><p><strong>Case report: </strong>Family history was notable for cardiac deaths. An echocardiogram demonstrated ventricular wall thickening with diastolic dysfunction. The patient's N-terminal pro b-type natriuretic peptide level was 1,691 pg/ml with a troponin I level of 0.36 ng/ml. Transthyretin (TTR) sequencing detected a heterozygous V122I variant. The patient's free <i>κ</i> light chain level in serum was 664 mg/L with a ratio of 16.5. Bone marrow analysis showed 20%-30% κ-restricted plasma cells with amyloid deposits. A technetium-99m sodium pyrophosphate scan was performed and was negative. Magnetic resonance imaging of the total spine showed ligamentum flavum (LF) thickening at L4-5, causing severe spinal stenosis. In both the abdominal fat and the LF, liquid chromatography-coupled tandem mass spectrometry confirmed κ-type immunoglobulin light chain (AL) amyloidosis; the quantitative estimate of amyloid content in the LF was 5%. She was diagnosed with AL amyloidosis with Mayo Stage IIIA cardiac and soft tissue involvement, enrolled in the Aquarius trial (NCT05250973) in Cohort 2, and received daratumumab, cyclophosphamide, bortezomib, and dexamethasone. She achieved a partial hematological response with a cardiac response and is now pain-free and fully functional.</p><p><strong>Conclusion: </strong>In patients with amyloidosis who have both monoclonal gammopathy and a TTR variant, it is imperative to discern the tissue type of the amyloid to deduce the correct diagnosis. ATTR and AL amyloidosis can both cause spinal stenosis with minimal degenerative changes. The LF tissue must be stained for amyloids and, if present, typing must be performed.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1479676"},"PeriodicalIF":2.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of postoperative stroke in patients experienced coronary artery bypass grafting surgery: a machine learning approach.","authors":"Shiqi Chen, Kan Wang, Chen Wang, Zhengfeng Fan, Lizhao Yan, Yixuan Wang, Fayuan Liu, JiaWei Shi, QianNan Guo, NianGuo Dong","doi":"10.3389/fcvm.2024.1448740","DOIUrl":"10.3389/fcvm.2024.1448740","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary artery disease. However, its postoperative complications can have a significant effect on long-term patient outcomes. A retrospective study was conducted to identify before and after surgery that contribute to postoperative stroke in patients undergoing CABG, and to develop predictive models and recommendations for single-factor thresholds.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;We utilized data from 1,200 patients who undergone CABG surgery at the Wuhan Union Hospital from 2016 to 2022, which was divided into a training group (&lt;i&gt;n&lt;/i&gt; = 841) and a test group (&lt;i&gt;n&lt;/i&gt; = 359). 33 preoperative clinical features and 4 postoperative complications were collected in each group. LASSO is a regression analysis method that performs both variable selection and regularization to enhance model prediction accuracy and interpretability. The LASSO method was used to verify the collected features, and the SHAP value was used to explain the machine model prediction. Six machine learning models were employed, and the performance of the models was evaluated by area under the curve (AUC) and decision curve analysis (DCA). AUC, or area under the receiver operating characteristic curve, quantifies the ability of a model to distinguish between positive and negative outcomes. Finally, this study provided a convenient online tool for predicting CABG patient post-operative stroke.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included a combined total of 1,200 patients in both the development and validation cohorts. The average age of the participants in the study was 60.26 years. 910 (75.8%) of the patients were men, and 153 (12.8%) patients were in NYHA class III and IV. Subsequently, LASSO model was used to identify 11 important features, which were mechanical ventilation time, preoperative creatinine value, preoperative renal insufficiency, diabetes, the use of an intra-aortic balloon pump (IABP), age, Cardiopulmonary bypass time, Aortic cross-clamp time, Chronic Obstructive Pulmonary Disease (COPD) history, preoperative arrhythmia and Renal artery stenosis in descending order of importance according to the SHAP value. According to the analysis of receiver operating characteristic (ROC) curve, AUC, DCA and sensitivity, all seven machine learning models perform well and random forest (RF) machine model was found to perform best (AUC-ROC = 0.9008, Accuracy: 0.9008, Precision: 0.6905; Recall: 0.7532, F1: 0.7205). Finally, an online tool was established to predict the occurrence of stroke after CABG based on the 11 selected features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Mechanical ventilation time, preoperative creatinine value, preoperative renal insufficiency, diabetes, the use of an intra-aortic balloon pump (IABP), age, Cardiopulmonary bypass time, Aortic cross-clamp time, Chronic Obstructive Pulmonary Disease (COPD) history, preope","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1448740"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between \"Life's Essential 8\" cardiovascular health and apparent treatment-resistant hypertension among US adults from the NHANES, 2005 to 2018.","authors":"Zhong-Jiao Xu, Ru-Ming Shen, Wu-Ming Hu, Jia-Yi Shen, Xiao-Yan Wu, Ling-Chun Lv","doi":"10.3389/fcvm.2024.1453563","DOIUrl":"10.3389/fcvm.2024.1453563","url":null,"abstract":"<p><strong>Background: </strong>The association between healthy lifestyle and American Heart Association (AHA) Life's Essential 8 (LE8) score and apparent treatment-resistant hypertension(aTRH)remains uncertain. We aimed to explore the association between healthy lifestyle and higher LE8 score and apparent treatment-resistant hypertension in the general population.</p><p><strong>Methods: </strong>Using NHANES data from 2005 to 2018, we included and analyzed information on 7,474 participants eligible for this study. The association between LE8 and aTRH was explored using logistic regression models, and the association between LE8 and antihypertension drugs uncontrolled hypertension was further explored using logistic regression models.</p><p><strong>Results: </strong>Participants with higher LE8 scores tended to be non-Hispanic white and married or living with a partner; have low income and higher education; and be without Chronic kidney disease (CKD)(all <i>p</i>-values <0.001). Compared to subjects with low CVH, participants with moderate and high CVH exhibited lower risks of 47% and 76%, respectively. After adjusting for covariates, there was no evidence of a nonlinear association between LE8 and aTRH (<i>p</i> for nonlinearity = 0.456). Physical activity (PA), body mass index (BMI), and blood glucose were associated with aTRH (all <i>p</i>-values < 0.05), while diet, nicotine exposure, sleep, and blood lipids were not significantly associated with aTRH. Compared to the low LE8 group, the ORs for the high LE8 group were 0.46 (95% CI, 0.28 to 0.76) and 0.07 (95% CI, 0.02 to 0.20) for uncontrolled hypertension with 1-2 and 3-4 antihypertensive drugs, respectively. In the sensitivity analysis, subgroup analyses were performed on all covariates, and the results remained stable.</p><p><strong>Conclusion: </strong>In our study, we found a significant association between higher LE8 scores and a lower risk of aTRH. Our findings suggest that implementing various healthy lifestyle practices and managing known cardiovascular risk factors could be a feasible comprehensive preventive approach to aTRH.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1453563"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional printing-guided percutaneous transcatheter replacement in coarctation of the aorta: a retrospective study.","authors":"Qing He, Chennian Xu, Yang Liu, Ping Jin, Mengen Zhai, Rui Qiao, Zhiyuan Tian, Bin Cui, Jian Yang","doi":"10.3389/fcvm.2024.1429470","DOIUrl":"10.3389/fcvm.2024.1429470","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the feasibility, effectiveness and assistant effect of 3D printed aortic model in the treatment on congenital coarctation of the aorta (CoA) in adolescents and adults.</p><p><strong>Methods: </strong>From December 2018 to December 2023, a total of 10 patients with congenital coarctation of aorta underwent percutaneous balloon dilatation covered stent implantation in the department of cardiovascular surgery, Xijing Hospital. There were 6 males and 4 females whose average age was (27.68 ± 13.45) years. One case complicated with ventricular septal defect (VSD). The CT data of aorta were collected before operation, and the aorta was reconstructed by Mimics software and printed with 3D printing technology. The operation simulation was performed before operation to determine the best operation plan. The clinical data during hospitalization and follow-up were analyzed.</p><p><strong>Results: </strong>All the patients of CoA were successfully treated with percutaneous balloon dilatation covered stent implantation. The narrowest average diameter of CoA increased from (4.35 ± 2.61) mm before operation to (16.84 ± 1.99) mm immediately after operation (<i>P</i> < 0.05). The mean transconstrictive systolic pressure difference decreased from (81.29 ± 18.72) mmHg before operation to (15.52 ± 7.47) mmHg after operation (<i>P</i> < 0.05). The mean systolic blood pressure of the right upper limb decreased from (182.05 ± 38.99) mmHg preoperatively to (141.95 ± 32.11) mmHg postoperatively (<i>P</i> < 0.05). The mean systolic blood pressure of the lower limb increased from (121.52 ± 27.84) mmHg preoperatively to (131.81 ± 32.39) mmHg postoperatively (<i>P</i> < 0.05). Two patients with PDA and VSD underwent interventional occlusion at the same time without shunt. During the period of hospitalization and follow-up, there were significant cardiovascular complications.</p><p><strong>Conclusions: </strong>Percutaneous balloon dilatation covered stent implantation is effective in the treatment of adolescents and adults with CoA in the short and medium term, with fewer complications, and the long-term effect needs furthshdie1er study.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1429470"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Loeffler endocarditis as a cause of left ventricular thrombosis in young women: a case study and literature review.","authors":"Yue Cui, Yugen Shi, Xiaojun Wang","doi":"10.3389/fcvm.2024.1456788","DOIUrl":"10.3389/fcvm.2024.1456788","url":null,"abstract":"<p><p>It is unusual for young patients without any underlying diseases to experience sudden cerebral infarction and heart failure. Here, we report a rare case of a 28-year-old female patient who presented with chest tightness and dizziness. Left ventricular thrombus formation and cardiac insufficiency were evident on echocardiogram, while multiple acute or subacute cerebral infarctions were visible on brain magnetic resonance imaging. We preliminarily determined that this was a different manifestation of the same disease. After investigating the cause, we diagnosed the patient with Loeffler endocarditis caused by idiopathic eosinophilia syndrome involving the heart. Although no endocardial biopsy was performed, this diagnosis was confirmed through cardiac magnetic resonance imaging (CMR). After drug treatment consisting of corticosteroids and anticoagulants, the eosinophil count decreased significantly; however, the thrombus did not completely disappear, as assessed in multiple follow-up echocardiogram sessions. Further exploration of the tissue composition of the patient's left ventricular mass suggested that the mass was a mixture of thrombus and eosinophilic granulation tissue. The addition of imatinib to the treatment plan had a good therapeutic effect, and the patient's left ventricular mass completely disappeared. Loeffler endocarditis progresses rapidly and requires early identification and intervention by clinicians. This case emphasizes that, despite the lack of an endocardial biopsy, the early diagnosis of Loeffler endocarditis can be made through CMR, while avoiding the occurrence of irreversible endocardial fibrosis. We also explored the nature of the patient's cardiac mass and proposed different insights. The nature of cardiac mass varies in different stages of Loeffler endocarditis, and individualized treatment strategies are needed.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1456788"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of abdominal aortic aneurysm (2014-2024).","authors":"Shao-Jia Liu, Xin-Qing Yang, Hong-Qiao Lu, Kun-Chi Zhang, Yong-Jiang Tang, Yu Xu","doi":"10.3389/fcvm.2024.1436600","DOIUrl":"10.3389/fcvm.2024.1436600","url":null,"abstract":"<p><strong>Background: </strong>Abdominal aortic aneurysm (AAA) is a localized bulge of the abdominal aorta, which mainly manifests as a pulsatile mass in the abdomen. Once an abdominal aortic aneurysm ruptures, the patient's life is seriously endangered. Surgery is the preferred treatment for abdominal aortic aneurysm. At present, there has been no comprehensive review of the current status of abdominal aortic aneurysm research. Therefore, this study aimed to identify global trends in abdominal aortic aneurysm research over the last 10 years through bibliometric analysis and to inform clinical practice, research funding allocation, and decision-making.</p><p><strong>Methods: </strong>We downloaded research articles and reviews on abdominal aortic aneurysm from 1 January 2014, to 1 March 2024, from the Web of Science core collection. CiteSpace (version 6.2.1), RStudio and VOSviewer (version 1.6.18) were used for visual analysis of regional distribution, institutions, authors, keywords and other information.</p><p><strong>Results: </strong>The number of documents on abdominal aortic aneurysm research increased continuously and has stabilized in recent years. A total of 9,905 publications from 67 countries were published from 1 January 2014, to 1 March 2024. A total of 2,142 (29.52%) studies were from the United States, 1,293 (13.05%) were from China, and 919 (9.28%) were from the United Kingdom. A total of 205 studies were conducted at Stanford University, 172 were conducted at Harvard Medical School, and 165 were conducted at the Mayo Clinic. The top three coauthorship authors were Schermerhorn, Marc L (114); Golledge, Jonathan (102); and De Vries, Jean Paul P.M. (74). The most cocited reference was Chaikof EL, 2018, J Vasc Surg, v67, p. 2; the most cocited journal was the Journal of Vascular Surgery; and the most cocited author was Lederle, FA. \"Abdominal aortic aneurysm\" was the most frequently used author keyword (2,492). Twenty-five references with strong citation bursts were identified by \"CiteSpace\". \"Artificial intelligence\", \"clinical outcomes\" and \"bridging stent\" were the primary keywords of emerging research hotspots.</p><p><strong>Conclusion: </strong>This is the first bibliometric study to comprehensively summarize the research trends in abdominal aortic aneurysm research. This information can help us to identify the current research hotspots and directions. This study will provide extensive help for future research.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1436600"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: The unrelenting journey-successful resolution of catecholaminergic polymorphic ventricular tachycardia (CPVT) through right cardiac sympathetic denervation in a teenager after left cardiac sympathetic denervation.","authors":"Hei-To Leung, Sit-Yee Kwok, Ming Lau, Lucius Kwok-Fai Lee, Sabrina Tsao","doi":"10.3389/fcvm.2024.1477359","DOIUrl":"10.3389/fcvm.2024.1477359","url":null,"abstract":"<p><strong>Background: </strong>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia disorder characterized by ventricular arrhythmia triggered by adrenergic stimulation.</p><p><strong>Case presentation: </strong>A 9-year-old boy presented with convulsions following physical exertion. Bidirectional ventricular tachycardia (VT) during a treadmill test led to the diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT). Genetic testing revealed a pathogenic variant of <i>RYR2:c.720G>A (p.ArG2401His)</i>. Nadolol was initially started. However, he experienced aborted VT arrest three years later. Flecainide was thus added as dual therapy and he underwent left cardiac sympathetic denervation (LCSD). Subsequently, a transvenous implantable cardioverter-defibrillator (ICD) was implanted because he still had several episodes of bidirectional VT. Despite a good compliance to medication, the patient still had exercise induced VT episodes with new onset of atrial fibrillation. High dose nadolol was required and amiodarone was added. Despite maximizing the dosage of these three antiarrhythmics, the patient continued to experience multiple episodes of ventricular fibrillation with appropriate ICD shocks and persistent atrial arrhythmias. Right cardiac sympathetic denervation (RCSD) was performed as the last modality of treatment. Patient had a total elimination of VT post bilateral sympathectomy. He remained asymptomatic on follow up. A follow-up treadmill test showed no recurrence of exercise-induced PVCs and VT.</p><p><strong>Conclusion: </strong>We illustrated the challenges and the complex decision-making process encountered in managing refractory CPVT. In patients unresponsive to conventional therapies, RCSD in additional to LCSD is a safe and effective alternative treatment. A history of LCSD should not preclude physicians from considering RCSD in children with refractory CPVT.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1477359"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}