Frontiers in Cardiovascular Medicine最新文献

{"title":"Prognostic value of inflammatory indices for atrial fibrillation recurrence after cryoablation: a cohort study.","authors":"Qiqiang Jie, Weichun Qian, Haibo Jia, Fengfu Zhang, Jianping Wang","doi":"10.3389/fcvm.2025.1637255","DOIUrl":"10.3389/fcvm.2025.1637255","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory markers have emerged as potential prognostic markers of atrial fibrillation (AF) recurrence following cryoablation. However, comparative analyses of multiple systemic indices are limited. This study aimed to evaluate four inflammation-derived biomarkers-the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and panimmune-inflammation value (PIV)-for their prognostic value in post-cryoablation AF recurrence.</p><p><strong>Methods: </strong>We conducted a retrospective cohort of 757 patients undergoing first-time cryoablation at Nanjing First Hospital (January 2017-December 2023). We investigated the associations between the four systemic inflammatory markers and AF recurrence. Baseline characteristics were collected from medical records, and inflammatory marker levels were calculated from routine blood tests. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratios; restricted cubic splines (RCS) assessed potential nonlinearity; and time-dependent receiver operating characteristic (ROC) analyses quantified predictive performance at 12 and 24 months.</p><p><strong>Results: </strong>Compared with tertile 1, tertile 3 showed higher multivariable-adjusted hazards of recurrence (HR: NLR = 4.112, SII = 4.010, SIRI = 5.137, PIV = 5.298; all <i>P</i> < 0.001). The RCS revealed inflection points (logNLR = 1.0, logSII = 6.0), beyond which the risk slopes intensified. Time-dependent ROC analyses showed the highest AUCs for logPIV (AUC = 0.764 at 12 months; 0.741 at 24 months) compared with the other indices (AUC range = 0.715-0.742), with an optimal cutoff yielding 79.2% sensitivity and 68.3% specificity.</p><p><strong>Conclusion: </strong>Systemic inflammation indices-particularly the pan-immune-inflammation value (PIV)-show prognostic association with AF recurrence after cryoablation and may inform preprocedural risk stratification and postablation surveillance. Given the observational design, these findings are associative and do not evaluate whether biomarker-guided selection or management improves outcomes. External calibration and validation-including in radiofrequency (RF) and pulsed-field ablation (PFA) cohorts-are needed to establish generalizability and clinical utility.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1637255"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative transcriptomic analysis reveals diagnostic biomarkers for comorbidity of coronary artery disease and obstructive sleep apnea.","authors":"Qingquan Liu, Xiaoyu Chen, Shuhan Chen, Hongzhi Gao, Meiting He, Yingting Shi, Mingzhu Zhao, Liying Yu, Huili Lin","doi":"10.3389/fcvm.2025.1658016","DOIUrl":"10.3389/fcvm.2025.1658016","url":null,"abstract":"<p><strong>Background: </strong>The co-occurrence of coronary artery disease (CAD) and obstructive sleep apnea (OSA), termed CADOSA, leads to worse clinical outcomes than either condition alone, yet its molecular mechanisms remain unclear, necessitating biomarker discovery for improved diagnosis and personalized management.</p><p><strong>Methods: </strong>This study enrolled 96 age-matched participants (24 healthy controls, 25 CAD, 23 OSA, and 24 CADOSA) for clinical assessment and PBMC transcriptomic profiling. Integrated bioinformatics analyses included differential gene expression (edgeR/DESeq2), pathway enrichment, protein-protein interaction networks and topological analysis, machine learning-based biomarker selection, and immune cell infiltration evaluation.</p><p><strong>Results: </strong>CADOSA patients had more severe cardiac dysfunction (enlarged left ventricle), respiratory impairment (higher apnea-hypopnea index), and metabolic disturbances (elevated triglycerides/creatinine) compared to single-disease condition of CAD or OSA. Transcriptomics identified 832 CAD-specific, 166 OSA-specific, and 376 CADOSA-specific DEGs compared to the healthy control. The CADOSA exhibited both shared (impaired efferocytosis, neutrophil extracellular traps, and cytoskeletal abnormalities) and unique enriched pathways (NOD-like receptor/PPAR signaling pathway), predominantly associated with immune or metabolic dysregulation. Enhanced expression of S100A12 and MMP9 genes (AUC = 0.83 and 0.78, respectively) was identified as potential biomarkers for CADOSA, and their upregulation was further confirmed by qRT-PCR. Notably, S100A12 expression was correlated with increased monocyte infiltration, highlighting its role in inflammatory pathogenesis of CADOSA.</p><p><strong>Conclusions: </strong>These findings reveal immune-metabolic dysregulation underlying CADOSA and provide potential diagnostic biomarkers and targeted therapeutic targets (S100A12 and MMP9) for CADOSA patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1658016"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The role of electrocardiogram in prediction of cardiovascular and non-cardiovascular health outcomes.","authors":"Elsayed Z Soliman, Dexter Canoy","doi":"10.3389/fcvm.2025.1694071","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1694071","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1694071"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics.","authors":"Kiyoon Moon, Yosep Lee, Junseong Lee, Youngki Son, Youngje Woo, Eunju Jang, Sangseob Yun, Suncheol Park, Jangyong Kim","doi":"10.3389/fcvm.2025.1690884","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1690884","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fcvm.2025.1633938.].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1690884"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoadsorption contribution in neonatal cardiac surgery.","authors":"Isabella Molinari, Enrico Aidala, Maria Teresa Cascarano, Maria Stella Di Carlo, Cristina Rivoldini, Enrico Bonaveglio, Carlo Pace Napoleone","doi":"10.3389/fcvm.2025.1615697","DOIUrl":"10.3389/fcvm.2025.1615697","url":null,"abstract":"<p><strong>Background: </strong>Cardiopulmonary bypass (CPB) in paediatric open-heart surgery is challenging, especially in neonates and aortic arch surgery. It induces a systemic inflammatory response that can lead to significant postoperative complications, including multiorgan dysfunction, prolonged mechanical ventilation, and intensive care unit (ICU) stay. Blood purification with hemoadsorbers integrated into CPB has been proposed as a strategy to reduce these side effects. These devices adsorb cytokines from the bloodstream, trying to modulate their negative systemic effect.</p><p><strong>Methods: </strong>This retrospective study evaluates 33 neonates who underwent complex cardiac surgeries between January 2022 and January 2025 at Regina Margherita Children's Hospital. 17 of them had been treated with Jafron HA60 hemoadsorber during CPB. Biomarkers of organ damage (creatinine, lipase, aspartate transaminase, and alanine transaminase), C-reactive protein, lactates, inotropic drugs doses and a wide range of pro- and anti-inflammatory cytokines were analysed during surgery and in the intensive care unit.</p><p><strong>Results: </strong>The results showed a decrease in biomarkers of organ damage and inflammation, accompanied by a tendency toward reduction in the required dose of inotropes, ICU stays, days of mechanical ventilation, and duration of required open chest time in the treated group. A similar downward pattern was observed in cytokine levels.</p><p><strong>Conclusions: </strong>Hemoadsorption may be associated with improved clinical parameters in neonates undergoing high-risk cardiac surgery. Further large-scale studies are needed to explore these observations.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1615697"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of inflammatory burden index for new-onset atrial fibrillation in STEMI patients.","authors":"Kun Liu, Zhiwen Tao, Gonghao Li, Mingzhu Li, Jiayu Yin, Lei Zhou","doi":"10.3389/fcvm.2025.1599152","DOIUrl":"10.3389/fcvm.2025.1599152","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory burden index (IBI) is a novel and useful inflammatory marker. However, the association between IBI and new-onset atrial fibrillation (<i>N</i>OAF) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. This study focuses on exploring the predictive ability of IBI for NOAF after percutaneous coronary intervention (PCI) in STEMI patients.</p><p><strong>Materials and methods: </strong>This study is a single-center retrospective observational study. Patients diagnosed with STEMI and undergoing primary PCI between October 2022 and February 2025 were continuously enrolled. All enrolled patients received continuous electrocardiogram (ECG) monitoring (>72 h) and were grouped according to whether NOAF occurred during hospitalization. Logistic regression analysis was used to identify potential risk factors for NOAF. Meanwhile, restricted cubic spline (RCS) analysis was employed to thoroughly investigate the possible dose-response relationship between IBI and NOAF.</p><p><strong>Results: </strong>A total of 696 STEMI patients were finally included in this study. The incidence of NOAF during hospitalization was 62/696 (8.9%). After adjusting for potential confounding factors, the results of multivariate logistic regression analysis showed that left ventricular ejection fraction (OR = 0.928, 95% CI: 0.895-0.962), age (OR = 1.048, 95% CI: 1.022-1.075), and IBI (OR = 1.007, 95% CI: 1.003-1.011) were independent factors for NOAF in STEMI patients (<i>P</i> < 0.05). RCS results suggested that there was a non-linear dose-response relationship between IBI and NOAF. After integrating IBI, the ability of the new model to predict NOAF was significantly improved (<i>N</i>RI = 0.617, 95% CI: 0.360-0.873, <i>P</i> < 0.01; IDI = 0.026, 95% CI: 0.007-0.046, <i>P</i> = 0.008).</p><p><strong>Conclusions: </strong>Elevated IBI is an independent risk factor for NOAF after PCI in STEMI patients. Integrating IBI can improve the risk stratification for NOAF in STEMI patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1599152"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative voltage index: a novel tailored method to identify left atrial low voltage areas in non-paroxysmal AF.","authors":"Guoshu Yang, Shiqiang Xiong, Yan Luo, Duan Luo, Michael Shehata, Zhen Zhang, Lin Cai, Xunzhang Wang, Ashkan Ehdaie, Hanxiong Liu","doi":"10.3389/fcvm.2025.1656983","DOIUrl":"10.3389/fcvm.2025.1656983","url":null,"abstract":"<p><strong>Background: </strong>The optimal voltage threshold for determining low voltage areas (LVA) in non-paroxysmal atrial fibrillation (<i>N</i>PAF) is unclear. This study aims to evaluate a patient-specific voltage measurement using the left atrial appendage (LAA) as a benchmark to establish a normalized threshold for detecting LVA in NPAF.</p><p><strong>Methods: </strong>Bipolar LA and LAA voltage in 40 NPAF and 42 patients with no AF (control group) were studied in sinus rhythm (SR) and AF (NPAF group) and SR only in the control group. Bipolar LA and LAA voltage distribution were compared between the NPAF and control groups. Fibrotic regions identified by late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) was used as the reference standard comparison in the NPAF group.</p><p><strong>Results: </strong>The median, 5th percentile (V_LA5%), and the 95th percentile of bipolar voltage in the LA were significantly lower in NPAF patients than controls. No significant LAA voltage differences between groups [median = 3.303 (1.796) vs. 3.100 (1.045); V_LAA95% = 8.089 (3.571) vs. 7.604 (3.404), all <i>p</i> > 0.05]. A strong linear correlation between V_LA5% and V_LAA95% was observed in the control group. The standardized relative voltage index (RVI) factor of 0.1324 was identified as the threshold for defining LVA and calculated as V_LA5% = 0.1324 × V_LAA95%. The correlation between LVA guided by RVI was superior to the universal threshold for detecting LVA in sinus and AF rhythms using LGE-MRI as the gold standard.</p><p><strong>Conclusion: </strong>A patient-tailored low voltage threshold can be obtained using a simplified equation and provides more accurate representation of LVA in NPAF than universal thresholds.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1656983"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of left atrial strain in significant aortic valve disease: a systematic review and meta-analysis.","authors":"Na Chen, Wenhui Gu, Jun Wu","doi":"10.3389/fcvm.2025.1667871","DOIUrl":"10.3389/fcvm.2025.1667871","url":null,"abstract":"<p><strong>Background: </strong>Previous studies on aortic valve disease have mainly focused on the left ventricle, but increasing evidence suggests that left atrial strain also has prognostic value in significant aortic valve disease.</p><p><strong>Objective: </strong>To systematically evaluate the prognostic value of left atrial strain in significant aortic valve disease.</p><p><strong>Methods: </strong>Multiple electronic databases were searched for studies evaluating significant aortic stenosis (AS) or aortic regurgitation (AR) using peak left atrial longitudinal strain (PALS) from the inception of each database to 1 February 2025. There were no language or regional restrictions. The primary endpoint was a composite outcome comprising all-cause mortality, hospitalization for heart failure, aortic valve replacement, pulmonary hypertension, and postoperative new-onset atrial fibrillation.</p><p><strong>Results: </strong>A total of 25 studies were included, involving 7,195 patients, with 2,039 (28%) patients experiencing primary endpoint events. The PALS was lower in the positive group (EVENT+) compared to the negative group (EVENT-) (SMD = -1.03, 95% CI [-1.22, -0.84], <i>p</i> < 0.05). For each unit increase in PALS, the risk of the primary endpoint event decreased by 7% (HR = 0.93, 95% CI [0.91, 0.96], <i>p</i> < 0.001). PALS exhibited consistent incremental predictive value in both the AR and AS cohorts, although the strength of its effect and the underlying mechanisms varied between groups.</p><p><strong>Conclusion: </strong>PALS is an independent predictor of adverse cardiovascular events in patients with significant aortic valve disease. PALS has certain value in the prognosis of significant aortic valve disease.</p><p><strong>Systematic review registration: </strong>[www.crd.york.ac.uk/prospero/], identifier [CRD 42024623883].</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1667871"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon vs. balloon-comparison of hemolysis and renal markers after cryoballoon vs. ballon-in-basket pulsed field pulmonary vein isolation.","authors":"Jan-Per Wenzel, Raed Abdessadok, Sascha Hatahet, Charlotte Eitel, Julius Nikorowitsch, Roman Mamaev, Sorin Popescu, Samuel Reincke, Anna Traub, Behnam Subin, Suzanne de Waha, Tanja Zeller, Karl-Heinz Kuck, Roland Richard Tilz","doi":"10.3389/fcvm.2025.1681098","DOIUrl":"10.3389/fcvm.2025.1681098","url":null,"abstract":"<p><strong>Background and aims: </strong>Single-shot ablation systems are widely used for pulmonary vein isolation (PVI) in atrial fibrillation (AF). Cryoballoon ablation (CBA) ablation is a well-established thermal method, while balloon-in-basket pulsed field ablation (BiB-PFA) represents a novel non-thermal modality. Both may elicit systemic effects, including hemolysis and renal stress. This study aimed to compare biomarker changes indicative of hemolysis and renal function following CBA vs. BiB-PFA.</p><p><strong>Methods: </strong>In this prospective, non-randomized, single-center study, patients undergoing first-time PVI with either CBA or BiB-PFA were enrolled. Venous blood samples were collected before PVI and at day 1 post procedure. Laboratory analyses included lactate dehydrogenase (LDH), haptoglobin, hemoglobin, myoglobin, total bilirubin, creatinine, and estimated glomerular filtration rate (eGFR).</p><p><strong>Results: </strong>A total of 100 patients were included (CBA: <i>n</i> = 50; BiB-PFA: <i>n</i> = 50). Acute and first-pass PVI was achieved in all cases. CBA resulted in a significantly greater increase in LDH (Δ+60 vs. + 47 U/L; <i>p</i> = 0.038) and a more pronounced decline in haptoglobin (Δ-13 vs. -3 mg/dl; <i>p</i> = 0.003). Hemoglobin decreased after BiB-PFA (Δ-0.62 g/dl) but slightly increased after CBA (Δ+0.18 g/dl; <i>p</i> < 0.001). Myoglobin and bilirubin changes were comparable. There was no significant difference in kidney function change between the groups (CBA: Δ-2.0 vs. BiB-PFA: glomerular filtration rate -1.0 ml/min; <i>p</i> = 0.522).</p><p><strong>Conclusion: </strong>While CBA was associated with more pronounced hematologic changes, kidney function did not differ between groups. These findings emphasize the systemic effects of catheter design and energy modality while supporting the renal safety of both techniques.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1681098"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin A deficiency attenuates cardiac rupture in <i>Stra6-</i>deficient hearts following ischemic injury.","authors":"Yannick Smolenski, Natali Froese, Paolo Galuppo, Christopher Werlein, Anna Gigina, Steven R Talbot, Sergej Erschow, Dirk Wedekind, Robert Geffers, Norbert B Ghyselinck, Heike Bähre, Jan C Kamp, Lavinia Neubert, Melanie Ricke-Hoch, Johann Bauersachs, Christian Riehle","doi":"10.3389/fcvm.2025.1626769","DOIUrl":"10.3389/fcvm.2025.1626769","url":null,"abstract":"<p><strong>Background: </strong>Stimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development. We hypothesized that <i>Stra6</i> expression attenuates ischemic injury-induced heart failure following myocardial infarction (MI) by vitamin A-dependent mechanisms.</p><p><strong>Methods: </strong>MI was induced in mice with <i>Stra6</i> germline deletion, vitamin A deficiency (VitAD) by combined <i>lecithin-retinol acyltransferase (Lrat)</i> germline deletion and feeding with a vitamin A-deficient diet. Contractile function was determined by transthoracic echocardiography, cardiac structure was assessed by histological analysis, and gene profiling was performed by RNA sequencing.</p><p><strong>Results: </strong><i>Stra6</i> deletion and VitAD did not impact contractile function and cardiac structure under basal conditions. <i>Stra6</i> deficiency resulted in myocardial rupture, with the majority of mice dying by 4 days post-MI, which additional VitAD attenuated. Interestingly, contractile function, mRNA expression of heart failure markers, and cardiac structure were not different between groups 3 days post-MI. Gene profiling 3 days post-MI revealed decreased Wnt signaling in <i>Stra6</i>-deficient relative to wildtype hearts, which was reversed by VitAD.</p><p><strong>Conclusion: </strong>The present study identifies an unexpected role for VitAD, which preserves Wnt signaling and attenuates cardiac rupture in <i>Stra6</i>-deficient hearts following ischemic injury.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1626769"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}