Frontiers in Cardiovascular Medicine最新文献

{"title":"Hotspots and frontiers in patent foramen ovale research: a bibliometric and visualization analysis from 2003 to 2023.","authors":"Ying He, Zhaoxia Pu","doi":"10.3389/fcvm.2025.1483873","DOIUrl":"10.3389/fcvm.2025.1483873","url":null,"abstract":"<p><strong>Background: </strong>Patent foramen ovale (PFO) is among the most common congenital heart defects. Over the last two decades, the number of research publications on PFO has increased. This study aims to identify and describe the current state, hotspots, and emerging trends in PFO research over the previous 20 years using bibliometric analysis and visual mapping.</p><p><strong>Methods: </strong>The Web of Science Core Collection was searched for all publications on PFO research, which were then included in the study. CtieSpace, VOSviewer, and Excel software were used to visualize general information, publication output, countries/regions, authors, journals, influential papers, and keyword trends in this field.</p><p><strong>Results: </strong>This comprehensive analysis included 14,495 publications from 6,190 institutions across 115 countries. The United States dominated with the highest number of publications (2,407) and international collaborations. Mas JL made significant contributions to the PFO field, while Meier B emerged as a leading author, publishing 81 articles during the past 20 years. There were strong international collaborations among countries, institutions, and authors. <i>Stroke</i>, <i>Circulation</i>, and <i>the New England Journal of Medicine</i> were the most cited journals, with 13,124, 10,136, and 9,867 citations, respectively.</p><p><strong>Conclusions: </strong>This bibliometric study revealed that recent research frontiers primarily focused on the diagnosis and clinical management of patients with PFO. Future studies are expected to delve deeper into the biological mechanisms by which PFO contributes to stroke, the efficacy and limitations of PFO closure techniques, and the exploration of genetic variations associated with PFO and their roles in disease susceptibility.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1483873"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction.","authors":"Zi-Qi Xie, Qing Xie, Xiao-Ye Zheng, Xiao-Juan Wu, Wei-Hua Liu, Ru Li, Hong-Yan Zhu, Qi Zhou","doi":"10.3389/fcvm.2025.1525389","DOIUrl":"10.3389/fcvm.2025.1525389","url":null,"abstract":"<p><strong>Background: </strong>Heart failure with preserved ejection fraction (HFpEF) is characterized by normal ejection fraction and diastolic dysfunction. The role of plasma homocysteine (Hcy) levels in HFpEF has been understudied, though elevated levels are known to affect cardiovascular health.</p><p><strong>Methods: </strong>This retrospective observational study analyzed 80 HFpEF patients and 80 matched controls without HFpEF. Fasting plasma Hcy levels were measured using a dual-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Standard echocardiographic evaluations were performed to measure interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), and the early-to-late diastolic mitral inflow velocity ratio (E/A). Statistical analyses included independent sample t-tests, chi-square tests, Pearson's correlation, and Spearman's rank correlation.</p><p><strong>Results: </strong>HFpEF patients exhibited significantly higher plasma Hcy levels (45.17 µmol/L) compared with controls (33.85 µmol/L, <i>p</i> < 0.001). Although LVEDD and LVEF did not differ significantly between groups, HFpEF patients demonstrated increased IVST, LVPWT, LAD, and a higher E/A ratio (<i>p</i> < 0.01 for all). Plasma Hcy levels were inversely correlated with LVEF (<i>r</i> = -0.375, <i>p</i> = 0.012) and positively correlated with IVST (<i>r</i> = 0.53), LVPWT (<i>r</i> = 0.45), LAD (<i>r</i> = 0.43), and E/A ratio (<i>r</i> = 0.56; <i>p</i> < 0.01 for each). A strong positive correlation was also observed between Hcy levels and New York Heart Association (NYHA) classification (<i>r</i> = 0.824, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The findings indicate that elevated plasma homocysteine is associated with myocardial remodeling and impaired diastolic function in HFpEF patients. These results support the potential role of homocysteine as a biomarker for HFpEF severity and progression, warranting further investigation into its utility for risk stratification and targeted therapy.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1525389"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report and literature review: fetal diagnosis of vascular ring with circumflex right aortic arch and unique aortic arch branching pattern.","authors":"Tyler Langenfeld, Yumna Ali, Chetan Sharma, Arpit Agarwal","doi":"10.3389/fcvm.2025.1523356","DOIUrl":"10.3389/fcvm.2025.1523356","url":null,"abstract":"<p><p>Circumflex right aortic arch is a rare aortic arch anomaly where the arch extends in a retro-esophageal pattern with a left-sided descending thoracic aorta. In the setting of circumflex right aortic arch with the ductus arteriosus connecting the left descending aorta and left pulmonary artery, a vascular ring is present and can cause compressive symptoms of the aerodigestive tract. A 33-year-old G4P3 patient underwent fetal echocardiography after obstetric ultrasound showed concern for double aortic arch. Fetal echocardiogram was suspicious for vascular ring with presumptive diagnosis of double aortic arch vs. circumflex right aortic arch. The child was born at 38 weeks gestation via induced vaginal delivery and had an uneventful postnatal course. Post-natal echocardiogram was able to diagnose vascular ring but could not fully assess the arch or branching pattern. Cardiac computed tomography angiography (CCTA) was able to definitively diagnose right aortic arch and characterize the branching pattern. To our knowledge, this is the first case reported in the literature of a circumflex right aortic arch suspected on fetal echocardiogram and postnatal echocardiogram and subsequently confirmed with CCTA. Fetal echocardiogram provides a unique opportunity to assess the aortic arch as the trachea is filled with fluid. However, circumflex aortic arch and double aortic arch can be difficult to delineate on fetal or post-natal echocardiography. CCTA is an effective modality for evaluation of the aortic arch and its branching pattern in the setting of non-diagnostic echocardiography.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1523356"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosuppressant adherence after heart transplantation: a review on detection, prevention, and intervention strategies in a multidisciplinary.","authors":"Ziying Fan, Yong Han, Guojun Sun, Zuojun Dong","doi":"10.3389/fcvm.2025.1558082","DOIUrl":"10.3389/fcvm.2025.1558082","url":null,"abstract":"<p><p>Heart transplantation is an effective treatment for end-stage heart disease, and postoperative patients' medication adherence is crucial for transplantation outcomes and long-term survival. By reviewing a large amount of related literature, this review summarizes the current status, evaluation methods, influencing factors, and intervention strategies of medication adherence after heart transplantation, emphasizes the important role of multidisciplinary teams in improving medication adherence, and discusses the importance of transplantation multidisciplinary teams and holistic management. By integrating the research results from various fields such as medicine, pharmacy, psychology, and sociology, it provides a more comprehensive theoretical support and practical guidance for improving medication adherence in heart transplant patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1558082"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Complete AV block in two patients with a congenital absence of the right coronary artery: an unusual correlation.","authors":"Ruihui Lai, Shuai Sun, Yanjun Chen, Tan Xu","doi":"10.3389/fcvm.2025.1556188","DOIUrl":"10.3389/fcvm.2025.1556188","url":null,"abstract":"<p><strong>Background: </strong>Congenital absence of the right coronary artery (RCA) is an extremely rare coronary anomaly with a very low incidence in the general population. The prevalence of complete atrioventricular (AV) block also appears to be low. No previous reports have documented the coexistence of congenital absence of the RCA and complete AV block in the same patient.</p><p><strong>Case summaries: </strong>Case 1 was a 52-year-old man with no significant past medical history who experienced syncope. The initial ECG revealed complete AV block with a non-specific ST-T segment. Coronary angiography showed mild, non-obstructive atherosclerosis in the dominant left circumflex artery (LCx), which continued along the anatomical course of the RCA. The patient underwent a dual-chamber pacemaker implantation for complete AV block. Case 2 was a 79-year-old man with a history of hypertension and coronary heart disease who presented with gradually worsening fatigue lasting 6 h. ECG showed complete AV block with a non-specific ST-T segment. Coronary angiography revealed an abnormal origin of the RCA arising from the distal portion of a dominant LCx, which retrogradely followed the course of a normal RCA to the base of the heart. The patient also underwent a dual-chamber pacemaker implantation for complete AV block.</p><p><strong>Conclusion: </strong>These two cases represent the first reported instances of complete AV block coexisting with congenital absence of the RCA, where the LCx supplied the territory of the RCA without evidence of myocardial infarction.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1556188"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal hematoma following transradial percutaneous coronary intervention: case report and literature review.","authors":"Qiangsong Jin, Jiamin Wang, Xiaogang Hu, Xianqing Hu, Shenwen Fu","doi":"10.3389/fcvm.2025.1414907","DOIUrl":"10.3389/fcvm.2025.1414907","url":null,"abstract":"<p><p>Mediastinal hematoma due to transradial PCI is rare. We reported a case of chest tightness, dyspnea, progressive neck swelling after transradial PCI. Clinical examinations such as chest computer tomography were completed and identified as mediastinal hematoma caused by a rupture of the subclavian artery branch and occlude the artery under digital subtraction angiography guidance, the artery was considered to be a collateral vessel of non-bronchial arterial circulation. This case highlights the necessity of exercising extreme caution when utilizing hydrophilic-coated curved-tip guidewires during the advancement process in peripheral vascular procedures. Mediastinal hematoma is a life-threatening complication and progresses rapidly, we need timely identification and diagnosis based on symptoms and appropriate clinical examination, interventional embolization therapy is critical for patients with poor response of conservative treatment.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1414907"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial.","authors":"Yuan Wen, Yuanyuan Zhang, Qingquan Lv, Weiqun Lan, Yi Shu, Qiuhuan Qi, Hongping Hu, Othman Zakaria Saleh","doi":"10.3389/fcvm.2025.1421923","DOIUrl":"10.3389/fcvm.2025.1421923","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) is a pervasive chronic condition that poses a significant threat to global health and mortality worldwide. Given the severity of this disease, it is imperative to consider pivotal factors such as age, concurrent diseases, and physical frailty of patients diagnosed with ischemic non-obstructive CHD prior to initiating cardiopulmonary rehabilitation. Consequently, the objective of this study is to investigate the impact of an individualized exercise rehabilitation program, on the ischemic burden in patients suffering from ischemic non-obstructive CHD.</p><p><strong>Methods: </strong>From February 2019 to July 2021, a cohort of one hundred patients diagnosed with ischemic non-obstructive CHD were recruited and randomly allocated into two groups. The control group underwent a standard rehabilitation program, while the intervention group participated in an individualized exercise rehabilitation program. This program was tailored to each patient, with a 50% power intensity exercise prescription derived from the results of the patient's Cardiopulmonary Exercise Testing (CPET) evaluation. The therapeutic effect, total myocardial ischemic burden (TIB), the effective rate of TIB reduction, pulmonary function indices, cardiac function, and the incidence of adverse events compared between the two groups.</p><p><strong>Results: </strong>The intervention group demonstrated a higher effective rate. TIB in the intervention group was significantly reduced at the 1,2, and 4-week marks post-intervention and exhibited a higher effective rate of total myocardial ischemia load reduction. Post-intervention, there were improvements in the Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and the FEV1/FVC ratio, with the intervention group showing higher values for these parameters. Cardiac function was enhanced following the intervention, with the intervention group displaying higher Left Ventricular Ejection Fraction (LVEF) and Carbon Monoxide (CO) levels, and a lower Left Ventricular End-Diastolic Dimension (LVEDD) compared to the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>An individualized exercise rehabilitation regimen for patients diagnosed with ischemic non-obstructive CHD can effectively compensate for the lack of physical activity. This regimen has demonstrated its ability to enhance the clinical therapeutic effect, reduce the total load of myocardial ischemia, improve pulmonary function indices and cardiac function, and decrease the incidence of cardiovascular adverse events.</p><p><strong>Clinical trial registration: </strong>identifier (TJ-IRB20210716).</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1421923"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of post-PCI nomogram in elderly patients with acute coronary syndromes.","authors":"Xing-Yu Zhu, Zhi-Meng Jiang, Xiao Li, Fei-Fei Su, Jian-Wei Tian","doi":"10.3389/fcvm.2025.1529476","DOIUrl":"10.3389/fcvm.2025.1529476","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to create and validate a clinical prediction model for the incidence of major adverse cardiovascular events (MACE) within one year after percutaneous coronary intervention (PCI) in elderly patients diagnosed with acute coronary syndromes (ACS).</p><p><strong>Methods: </strong>The study will use 70% of the 738 patients for model training and the remaining 30% for model validation. The feature recursive elimination algorithm (RFE) and the least absolute shrinkage selection operator (LASSO) regression technique will be used to identify the best combination of features. We compare the clinical prediction model we constructed with GRACE in terms of discrimination, calibration, recall, and clinical impact.</p><p><strong>Results: </strong>We used the RFE and LASSO regression technique to select 8 key variables from 44 candidates for our predictive model. The predictive model was found to have a good fit based on the Hosmer-Lemeshow test results (<i>χ</i> ² = 6.245). Additionally, the Brier score of the clinical prediction model was 0.1502, confirming its accuracy. When comparing our clinical prediction model to the widely used GRACE scoring system, the results showed that our model had slightly better predictive efficacy for the dataset involved in this study. The NRI was 0.6166, NRI + was 0.2262, NRI- was 0.3904, and IDI was 0.1272, with a <i>P</i> value of <0.001. The validation set's AUC was 0.787, indicating the prediction model has high differentiation and discriminative ability.</p><p><strong>Conclusion: </strong>This model assists in the early identification of the risk of MACE within one year after PCI for ACS in elderly patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1529476"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time technical support for guiding remotely ICD/CRT-D implantation.","authors":"Antonio Curcio, Letizia R Romano, Florinda M Augusto, Giovanni Canino, Elisa Coluccio, Alberto Polimeni, Ciro Indolfi","doi":"10.3389/fcvm.2025.1525151","DOIUrl":"10.3389/fcvm.2025.1525151","url":null,"abstract":"<p><strong>Background: </strong>In the electrophysiologic (EP) lab, technical support for implantable cardioverter/defibrillators (ICD) and cardiac resynchronization therapy (CRT-D) procedures is often limited by the availability and costs of field clinical specialist (FCS) bioengineers.</p><p><strong>Methods: </strong>This study explores the viability of using remote support through an internet-based platform for ICD and CRT-D implantation procedures, aiming to enhance efficiency and overcome geographical or pandemic-related barriers. After preclinical phases, thirty patients underwent ICD/CRT-D guided either remotely or with on-site FCS implantation at two primary cardiac care centers, with ten procedures guided remotely and twenty cases with on-site FCS.</p><p><strong>Results: </strong>All procedures in both study arms were successfully completed (100% of cases). Procedural time was shorter in the telemedicine group (<i>P</i> = 0.031). Although fluoroscopic time was slightly reduced in the remote guided group, the difference did not reach statistical significance (<i>P</i> = 0.5). No major adverse events occurred.</p><p><strong>Conclusion: </strong>The study demonstrates the feasibility of remotely supported ICD and CRT-D implantation procedures.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1525151"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Surgical correction of pulmonary artery sling causing tracheal obstruction in infancy: rapid and complete recovery.","authors":"Hüseyin Sicim, Daniel A Velez, Mohamad Alaeddine","doi":"10.3389/fcvm.2025.1558779","DOIUrl":"10.3389/fcvm.2025.1558779","url":null,"abstract":"<p><p>Pulmonary artery sling (PAS) is an uncommon congenital anomaly in which the left pulmonary artery (LPA) originates abnormally from the posterior aspect of the right pulmonary artery (RPA). The LPA then traverses between the trachea and esophagus, resulting in compression of the lower trachea. This compression can lead to respiratory symptoms, including wheezing and stridor, and in some cases, airway obstruction. In addition, bronchial compression-commonly affecting the right bronchus-can result in air trapping, pneumonia, and atelectasis. In this report, we present postoperative rapid relief of a symptomatic case in which LPA transection and reimplantation to the main pulmonary artery were performed successfully on cardiopulmonary bypass.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1558779"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}