Frontiers in Cardiovascular Medicine最新文献

{"title":"Lipoproteins predicting coronary lesion complexity in premature coronary artery disease: a supervised machine learning approach.","authors":"Marta Marcinkowska, Agnieszka Kuchta, Petra Małgorzata Grešner, Tomasz Figatowski, Piotr Kasprzyk, Radosław Targoński, Wojciech Sobiczewski, Miłosz Jaguszewski, Marcin Fijałkowski, Marcin Gruchała, Agnieszka Mickiewicz","doi":"10.3389/fcvm.2025.1470500","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1470500","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to assess the usefulness of lipoprotein(a) [Lp(a)] and LDL-C levels as potential predictors of coronary lesions' complexity in patients with premature coronary artery disease (pCAD).</p><p><strong>Methods: </strong>This study enrolled 162 consecutive patients with pCAD undergoing coronary angiography. The SYNTAX score (SS) was used to assess coronary lesions' complexity. Linear discriminant analysis (LDA) was employed to construct a multivariate classification model enabling the prediction of coronary lesions' complexity in SS.</p><p><strong>Results: </strong>The Lp(a) levels among patients with SS ≥ 23 and with SS 1-22 were significantly higher than those with SS = 0 (<i>p</i> = 0.021 and <i>p</i> = 0.027, respectively). The cut-off point for the Lp(a) level of 63.5 mg/dl discriminated subjects with SS ≥ 23 from those with SS ≤ 22 (sensitivity 0.546, specificity 0.780; AUC 0.620; <i>p</i> = 0.027). An LDA-based model involving the Lp(a) level, age, sex and LDL-C provided improved discrimination performance (sensitivity 0.727, specificity 0.733, AUC 0.800; <i>p</i> = 0.0001).</p><p><strong>Conclusions: </strong>Lp(a) levels in pCAD patients are associated with the advancement of coronary artery lesions in SS patients. An Lp(a) level of 63.5 mg/dl can be the cut-off point for the identification of subjects with SS ≥ 23. LDA-based modelling using Lp(a), LDL-C, age and gender may be an applicable tool for the preliminary identification of patients at risk of more complex coronary artery lesions.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1470500"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of lymphocyte-to-C-reactive protein ratio for left ventricular thrombus in patients with ST-segment elevation myocardial infarction.","authors":"Xinjia Du, Jiahua Liu, Zeqing Zhang, Yanfei Ren, Lei Chen, Yuan Lu, Zhuoqi Zhang","doi":"10.3389/fcvm.2025.1465350","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1465350","url":null,"abstract":"<p><strong>Background and purpose: </strong>Current evidence suggested a correlation between inflammation and Left Ventricular Thrombus (LVT). The lymphocyte to C-reactive protein ratio (LCR) has been established as be a reliable inflammation marker and is associated with the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). However, its relationship with the occurrence of LVT remains unclear. This study aims to evaluate the effectiveness of LCR in predicting LVT in patients with STEMI after undergoing primary percutaneous coronary intervention (pPCI).</p><p><strong>Methods: </strong>A total of 564 STEMI patients who underwent pPCI at the Affiliated Hospital of Xuzhou Medical University from September 2019 to June 2024 were included. Cardiac magnetic resonance imaging (CMR) was used to assess myocardial infarction characteristics and the presence of LVT. The definition of LCR is the lymphocyte to C-reactive protein ratio.</p><p><strong>Results: </strong>Out of 564 patients, 57 were diagnosed with LVT. The median time for CMR testing was 5 (4, 6) days. Univariate regression analysis showed significant differences in left ventricular ejection fraction (LVEF), peak N-terminal pro B-type natriuretic peptide (peak NT-proBNP), peak high-sensitivity troponin T (peak hsTnT), LCR, Late Gadolinium Enhancement% (LGE%), and Microvascular Obstruction% (MVO%) (<i>p</i> < 0.05). Multivariate regression analysis indicated that LCR was an independent predictor for LVT (<i>P</i> = 0.007, OR: 0.001 95% CI: 0.00-0.123). Receiver operating characteristic (ROC) curve analysis showed that LCR has good predictive ability for LVT (Area under the curve: 0.704, <i>p</i> < 0.001). Integration of integral LCR could significantly improve the discrimination and reclassification accuracy for LVT after STEMI (NRI = 0.517, IDI = 0.030; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Lower LCR is independently associated with the risk of LVT in patients with STEMI after pPCI. Integration of LCR can significantly improve the risk model for LVT.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1465350"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into the association between organ damage and inflammatory response in preoperative abdominal aortic aneurysms.","authors":"Huan Wen, Bo Su, Jinbo Liu, Hongyu Wang","doi":"10.3389/fcvm.2025.1511112","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1511112","url":null,"abstract":"<p><strong>Background: </strong>Abdominal aortic aneurysm (AAA) is a life-threatening condition in the elderly population. The insidious nature of AAA onset makes early detection difficult. Currently, there are few studies on changes in laboratory parameters during AAA development.</p><p><strong>Methods: </strong>This study included 55 elderly patients with AAA who were admitted to the Department of Vascular Medicine, Shougang Hospital, Peking University 2021-2022. Propensity score matching (PSM) in a 1:1 ratio was performed to match the 55 patients and 1,031 controls. In this population of AAA, correlation and regression analyses were used to explore the association between the level of inflammation and each laboratory parameter.</p><p><strong>Results: </strong>Compared to the control group, significant differences in inflammatory markers, transaminase and bilirubin levels, blood urea nitrogen (BUN) and creatinine (Cr) levels, and ankle-brachial index were found in the aneurysm group. After PSM, the differences between the two groups for each parameter remained statistically significant. Correlation and regression analyses showed a weak positive correlation between the inflammatory index and the BUN and Cr levels (correlation coefficient = 0.22).</p><p><strong>Conclusions: </strong>Our study demonstrates the presence of a highly inflammatory state and damage to various organs in patients with AAA. This hyperinflammatory state may be associated with kidney injury and is a cause of concern.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1511112"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-lowering therapy (LLT) in 1,100 cardiac rehabilitation patients with coronary heart disease: the LLT-R(ehabilitation) registry.","authors":"Frank Noack, Kristina Eckrich, Heinz Völler, Bernhard Schwaab, Viktoria Heinze, Christa Bongarth, Manju Guha, Michael Richter, Nadja Schwark, Alexandra Strobel, Axel Schlitt","doi":"10.3389/fcvm.2025.1549935","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1549935","url":null,"abstract":"<p><strong>Background: </strong>Cardiac rehabilitation (CR) improves quality of life and prognosis in patients with coronary heart disease (CHD). The aim of the study was to evaluate effects of lipid-lowering therapy (LLT) in patients with CHD during and after CR.</p><p><strong>Methods: </strong>Data from prospective, multicenter registry including 1,100 patients with CHD undergoing CR in 6 German cardiac rehabilitation centers between 2016 and 2018 were analyzed.</p><p><strong>Results: </strong>The rate of statin-treated patients increased from 1,048 (96.3%) on admission to 1,062 (98.4%) at discharge (<i>p</i> < 0.001), falling to 644 (96.3%) and 609 (94.1%) at 3 and 12 months, respectively. Combination treatment with ezetimibe was effective in 8.9% of patients at admission and 28.5% at discharge (<i>p</i> < 0.001), and 23.5% and 25.8% after 3 month and 12 months, respectively. Titration of LLT during CR resulted in median LDL-C-values of 2.27 mmol/L at admission, 1.97 mmol/L at discharge (<i>p</i> < 0.001), 1.94 mmol/L after 3 months, and 1.94 mmol/L after 12 months, respectively.</p><p><strong>Conclusions: </strong>During CR, LLT was effectively instituted and titrated, resulting in a high rate of statin-treated patients and a significant reduction in LDL-C. From this study, we hypothesize that CR is efficacious for adherence to LLT.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1549935"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effects of extreme air pollutant concentrations on coronary heart disease hospitalization in Henan province: a time-stratified case-crossover study.","authors":"Shuming Liu, Yongbin Wang, Lujie Wang, Xuefang Li, Menghui Fei, Pingshuan Dong, Kan Yang, Hui Liu, Na Xie, Hengwen Chen, Guang Chen, Huan Li, Xiayan Zang, Jun Li, Zhigang Chen, Fei Lin, Guoan Zhao","doi":"10.3389/fcvm.2025.1538788","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1538788","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary heart disease (CHD) is a leading cause of cardiovascular mortality, with air pollution serving as a significant risk factor. Henan Province, characterized by both a high incidence of CHD and severe air pollution, faces substantial health and economic challenges. However, limited research has explored the relationship between air pollution and CHD in this region.</p><p><strong>Methods: </strong>This study employs a case-crossover design combined with a distributed lag non-linear model (DLNM) to examine the short-term effects of extreme concentrations of air pollutants (PM₂.₅, PM₁₀, NO₂, SO₂, CO, and O₃) on CHD hospitalizations in Henan. Data on 133,294 confirmed CHD patients from seven large hospitals across five cities (2016-2021) were collected, with patients' addresses linked to nearby air quality monitoring stations to assess exposure to air pollutants and meteorological factors. The time-stratified case-crossover design and DLNM were used to calculate relative risks (RRs) for pollutant exposure on CHD hospitalizations, and subgroup analyses were conducted to identify sensitive groups.</p><p><strong>Results: </strong>Significant increases in CHD hospitalizations were associated with extremely high concentrations of NO₂, SO₂, and PM₁₀, with maximum RRs of 1.768 for NO₂, 2.821 for SO₂, and 1.728 for PM₁₀ on the 7th cumulative day, while high O₃ levels showed a protective effect. Younger individuals (≤64y) and males were more sensitive to these effects, and high CO concentrations only increase the risk of CHD incidence in the younger (≤64y) subgroup. Synergistic interactions were observed between certain pollutants, such as CO and NO₂/SO₂/PM₁₀, suggesting that the negative impact of CO on CHD is amplified in a multi-pollutant environment due to interactions with other pollutants.</p><p><strong>Discussion: </strong>These findings highlight the significant public health impact of air pollution on CHD in Henan Province.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1538788"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 receptor agonists: a review from a cardiovascular perspective.","authors":"Yosra Turkistani","doi":"10.3389/fcvm.2025.1535134","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1535134","url":null,"abstract":"<p><strong>Introduction: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are novel agents with proven cardiovascular (CV) benefits. GLP-1 RAs have been used for diabetes and found to improve CV outcomes in diabetic and nondiabetic patients. They are authorized for treating obesity. Our narrative review discussed the CV benefits of GLP-1 RAs in terms of controlling CV risk factors and improving CV outcomes in diabetic and nondiabetic patients regardless of their CV history, and the CV perspectives related to their use in clinical practice.</p><p><strong>Areas covered: </strong>Literature was searched with no limits on date or language, using various combinations of keywords. Data on the CV benefits of GLP-1 RAs and their use in clinical practice were summarized.</p><p><strong>Results: </strong>Several studies have discussed the CV beneficial effects of GLP-1 RAs in terms of reducing blood pressure, lipid levels, body weight, risk for arrhythmias, reducing the risk of major adverse CV events, and hospital admission for heart failure.</p><p><strong>Conclusion: </strong>The cardioprotective effects and low risk of hypoglycemia of GLP-1 RAs make them preferred agents in any multidisciplinary approach aiming to reduce CV disease burden and improve prognosis. Cardiologists are encouraged to strongly consider the CV benefits of GLP-1 RAs in their risk-reduction strategies.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1535134"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liberal versus restrictive red blood cell transfusion strategy in acute coronary syndrome and anemia: an updated systematic review and meta-analysis.","authors":"Sinda Hidri, Wajeeh Ur Rehman, Karam Gardezi, Jassim Zaheen Shah, Sai Venkata Siddhartha Masetti, Naiela E Almansouri, Arslan Maan, Tirth Dave, Sumeja Catic, Simranjeet Singh Nagoke, Mohammad Ebad Ur Rehman, Huzaifa Ahmad Cheema, Adeel Ahmad, Raheel Ahmed, Abdelhamid Ben Selma, Mouhamed Amr Sabouni, Nabil Braiteh, Alon Yarkoni, Keyoor Patel, Afzal Ur Rehman","doi":"10.3389/fcvm.2025.1457400","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1457400","url":null,"abstract":"<p><strong>Background: </strong>It is uncertain whether a liberal red blood cell (RBC) transfusion strategy is superior to a restrictive approach in patients with acute coronary syndrome (ACS) and anemia.</p><p><strong>Methods: </strong>We searched MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.gov from inception to April 2024 for randomized controlled trials (RCTs) comparing liberal and restrictive transfusion strategies in ACS patients with concurrent anemia.</p><p><strong>Results: </strong>Five RCTs (4,510 patients) were included in this meta-analysis. There was no significant difference between the liberal and restrictive RBC transfusion strategy groups in the risk of major adverse cardiovascular events (MACE) (RR 0.91, 95% CI: 0.68-1.21; <i>I</i> ² = 63%) and all-cause mortality (RR 0.85, 95% CI: 0.72, 1.00; <i>I</i> ² = 0%). A liberal transfusion strategy reduced the risk of myocardial infarction (MI) (RR 0.80, 95% CI: 0.66, 0.98; <i>I</i> ² = 0%). There were no significant differences between the two strategies in the risk of revascularization, heart failure, stroke, cardiac mortality, acute kidney injury or failure, and pneumonia, bacteremia, or infection. Liberal transfusion increased the risk of acute lung injury (RR 8.97, 95% CI: 1.65, 48.65; <i>I</i> ² = 0%).</p><p><strong>Conclusions: </strong>Our meta-analysis demonstrated that a liberal RBC transfusion strategy reduced the risk of MI and increased the risk of acute lung injury but did not affect other clinical outcomes compared to a restrictive approach in patients with mainly acute MI and anemia. New large-scale multicenter RCTs are required to confirm or refute our findings and provide more reliable results.</p><p><strong>Systematic review registration: </strong>PROSPERO (CRD42024506844).</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1457400"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of coronary artery calcium scoring in the prediction of coronary artery disease based on non-contrast non-cardiac chest CT scans in airline pilots.","authors":"Lin Zhang, Li Li Liu, Zheng Bin Zhu, Yan Xu, Kai Chen, Qing Qing Duan, Yu Kai Li, Jie Gao, Meng Song, Qiu Yu Shen, Shao Jie Zhu, Qing Qing Jin, Jian Ping Wen, Shuo Feng, Ying Lu, Run Du, Bin Ren, Rui Yan Zhang","doi":"10.3389/fcvm.2025.1511358","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1511358","url":null,"abstract":"<p><strong>Background: </strong>The aim of the present study was to explore the value of coronary artery calcium score (CACS) using non-gated, non-contrast chest computed tomography (NCCT) to predict coronary artery disease (CAD) in airline pilots.</p><p><strong>Methods: </strong>Pilots with coronary calcification found on NCCT were consecutively enrolled into this study. All received a coronary computed tomography angiography (CCTA) examination. The coronary artery calcium score (CACS) was evaluated on NCCT using the Agatston method. CCTA images were analyzed using a semi-automated software. Coronary Artery Disease Reporting and Data System (CAD-RADS) scoring categorized coronary stenosis.</p><p><strong>Results: </strong>A total of 217 male pilots were included, of which 49 were diagnosed with significant CAD (CAD-RADS category 3 or higher). Pilots with significant CAD had much higher CACS (324.28 ± 389.02 vs. 39.16 ± 68.88; <i>p</i> < 0.001). Plaque volumetric measurements showed that total plaque volume (1,103.50 ± 285.51 mm³ vs. 913.18 ± 277.45 mm³; <i>p</i> < 0.001) and calcified plaque volume (149.77 ± 160.71 mm³ vs. 36.42 ± 26.86 mm³; <i>p</i> < 0.001) were more pronounced in individuals in the significant CAD group than those in the non-significant CAD group. A multivariate analysis demonstrated that CACS (odds ratio 1.01; 95% confidence interval 1.005-1.014; <i>p</i> < 0.001) was the only independent risk factor of significant CAD but traditional cardiovascular risk factors, pre-existing medication regimens, or prolonged flight duration were not. CACS positively correlated with total plaque volume (<i>r</i> = 0.156; <i>p</i> = 0.027) and calcified plaque volume (<i>r</i> = 0.434; <i>p</i> < 0.001). Receiver operating characteristic curve analysis showed the area under the curve for the CACS in diagnosing significant CAD was 0.891 (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>CACS assessed using NCCT was significantly associated with CAD-RADS category 3 or higher, as confirmed by CCTA, which indicates that it may serve as a robust predictor for diagnosing significant CAD among airline pilots.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1511358"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding immune cell interactions during cardiac allograft vasculopathy: insights derived from bioinformatic strategies.","authors":"Edward B Thorp, Aparnaa Ananthakrishnan, Connor W Lantz","doi":"10.3389/fcvm.2025.1568528","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1568528","url":null,"abstract":"<p><p>Chronic allograft vasculopathy (CAV) is a major cause of late graft failure in heart transplant recipients, characterized by progressive intimal thickening and diffuse narrowing of the coronary arteries. Unlike atherosclerosis, CAV exhibits a distinct cellular composition and lesion distribution, yet its pathogenesis remains incompletely understood. A major challenge in CAV research has been the limited application of advanced \"-omics\" technologies, which have revolutionized the study of other vascular diseases. Recent advancements in single-cell and spatial transcriptomics, proteomics, and metabolomics have begun to uncover the complex immune-endothelial-stromal interactions driving CAV progression. Notably, single-cell RNA sequencing has identified previously unrecognized immune cell populations and signaling pathways implicated in endothelial injury and vascular remodeling after heart transplantation. Despite these breakthroughs, studies applying these technologies to CAV remain sparse, limiting the translation of these insights into clinical practice. This review aims to bridge this gap by summarizing recent findings from single-cell and multi-omic approaches, highlighting key discoveries, and discussing their implications for understanding CAV pathogenesis.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1568528"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity.","authors":"Jian Yu, Jiangtao Wang, Xinya Liu, Cancan Wang, Li Wu, Yuanming Zhang","doi":"10.3389/fcvm.2025.1566782","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1566782","url":null,"abstract":"<p><strong>Background: </strong>Doxorubicin-induced cardiotoxicity (DIC) significantly impacts the survival and prognosis of cancer patients. Ferroptosis is involved in the pathogenesis of DIC, but its specific mechanisms remain unclear. This study aims to explore key genes of ferroptosis in DIC and potential therapeutic drugs using various bioinformatics methods.</p><p><strong>Methods: </strong>This study obtained the GSE106297 and GSE157282 datasets from the GEO database, conducted differential gene expression screening and GSEA enrichment analysis using R software. Subsequently obtained ferroptosis-related genes from FerrDb V2, Genecards, Geneontology, and GSEA databases, performed GO and KEGG enrichment analysis after intersecting them with the differentially expressed genes using a Venn diagram. Utilized LASSO regression, SVM-RFE, and RF algorithms to identify key genes, followed by validation using external datasets (GSE232331, GSE230638) and ROC curve plotting to determine the diagnostic value of key genes. Further validation of the expression levels of key genes were conducted through the establishment of a cell damage model. Constructed an mRNA-miRNA-lncRNA network diagram, and performed immune cell composition analysis using CIBERSORT. Finally, predicted potential drugs for key genes using the DSigDB database.</p><p><strong>Results: </strong>We obtained 119 genes after intersecting 1380 Differentially Expressed Genes (DEGs) with Ferroptosis-Related Genes (FRGs). Three key genes (KLHDC3, NDRG1, SPHK1) were identified through further analysis using LASSO, SAM-RFE and RF. The ROC analysis demonstrated that KLHDC3 and NDRG1 have significant diagnostic value, and qRT-PCR verification results also showed statistical significance. We constructed miRNA-lncRNA networks by identifying target miRNAs for KLHDC3 (hsa-miR-24-3p, hsa-miR-486-3p, hsa-miR-214-3p) and NDRG1 (hsa-miR-4510, hsa-miR-182-5p, hsa-miR-96-5p). Immunoinfiltration analysis revealed the relationship between KLHDC3, NDRG1 and immune cells. Anisomycin emerges as a promising small molecule drug for treating DIC, exhibiting good relative binding with KLHDC3 and NDRG1.</p><p><strong>Conclusion: </strong>KLHDC3 and NDRG1 serve as ferroptosis biomarkers implicated in DIC and demonstrate good diagnostic value. In addition, anisomycin may also be a potential drug for treating DIC.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1566782"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}