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Regulation of cancer cell ferroptosis by PTRF/Cavin-1. PTRF/Cavin-1 对癌细胞铁突变的调控。
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-08-07 DOI: 10.1080/10715762.2024.2386457
Hui Xiang, Miao Wang, Yi-Fang Chen, Hao-Ming Wu, Ming-Ge Li, Lei Guo, Ying-Yi Zhang, He-Zhe Lu
{"title":"Regulation of cancer cell ferroptosis by PTRF/Cavin-1.","authors":"Hui Xiang, Miao Wang, Yi-Fang Chen, Hao-Ming Wu, Ming-Ge Li, Lei Guo, Ying-Yi Zhang, He-Zhe Lu","doi":"10.1080/10715762.2024.2386457","DOIUrl":"10.1080/10715762.2024.2386457","url":null,"abstract":"<p><p>Ovarian cancer, marked by high rate of recurrence, novel therapeutic strategies are needed to improve patient outcome. One of the potential strategies is inducing ferroptosis in ovarian cancer cells. Ferroptosis is an iron-dependent, lipid peroxidation-driven mode of cell death primarily occurring on the cell membrane. PTRF, an integral component of the caveolae structures located on the cell membrane, is involved in a multitude of physiological processes, including but not limited to, endocytosis, signal transduction, and lipid metabolism. This study elucidates the relationship between PTRF and ferroptosis in ovarian cancer, offering a fresh perspective for the development of new therapeutic strategies. We knocked down PTRF employing siRNA in the ovarian cancer cell lines HEY and SKOV3, following which we stimulated ferroptosis with Erastin (Era). Our research indicates that the lack of PTRF sensitizes cancer cells to ferroptosis, likely by altering membrane stability and tension, thereby affecting signal pathways related to ferroptosis, such as lipid and atherosclerosis, fluid shear stress, and atherosclerosis. Our findings provide new insights for developing new treatments for ovarian cancer.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant properties of α-amino acids: a density functional theory viewpoint. α-氨基酸的抗氧化特性：密度泛函理论观点。
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-08-05 DOI: 10.1080/10715762.2024.2385338
Andrey A Buglak
{"title":"Antioxidant properties of α-amino acids: a density functional theory viewpoint.","authors":"Andrey A Buglak","doi":"10.1080/10715762.2024.2385338","DOIUrl":"10.1080/10715762.2024.2385338","url":null,"abstract":"<p><p>The antioxidant properties of 21 proteinogenic amino acids (AAs) and 3,4-dioxophenylanine (DOPA) have been studied in implicit water using density functional theory (DFT). All the calculations have been performed according to three oxidation mechanisms: (1) hydrogen-atom transfer (HAT); (2) single electron transfer followed by proton transfer (SET-PT); and (3) sequential proton-loss electron transfer (SPLET). As a result, five AAs with the highest antioxidant capacity have been established: DOPA, selenocysteine (Sec), tyrosine (Tyr), cysteine (Cys), and tryptophan (Trp). Also, global reactivity in terms of hardness/softness has been evaluated, as well as Fukui indices of local reactivity. Trp has been determined as the most reactive molecule, whereas selenium atom of Sec has been established as the most reactive atom. All the findings are in agreement with the recent literature on both experimental and theoretical studies of amino acids antioxidant activity. However, to the best of my knowledge, the calculations for one electron redox reactions of zwitterionic amino acids in implicit water have been performed for the first time.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice. 有氧运动时间对小鼠骨骼肌中 BMAL1 蛋白表达和抗氧化反应的影响
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-07-01 DOI: 10.1080/10715762.2024.2348789
Lei Xu, Jie Jia, Jingjing Yu, Shudan Miao, Ying Zhang
{"title":"The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice.","authors":"Lei Xu, Jie Jia, Jingjing Yu, Shudan Miao, Ying Zhang","doi":"10.1080/10715762.2024.2348789","DOIUrl":"10.1080/10715762.2024.2348789","url":null,"abstract":"<p><p>It is well known that the adaptations of muscular antioxidant system to aerobic exercise depend on the frequency, intensity, duration, type of the exercise. Nonetheless, the timing of aerobic exercise, related to circadian rhythms or biological clock, may also affect the antioxidant defense system, but its impact remains uncertain. Bain and muscle ARNT-like 1 (BMAL1) is the core orchestrator of molecular clock, which can maintain cellular redox homeostasis by directly controlling the transcriptional activity of nuclear factor erythroid 2-related factor 2 (NRF2). So, our research objective was to evaluate the impacts of aerobic exercise training at various time points of the day on BMAL1 and NRF2-mediated antioxidant system in skeletal muscle. C57BL/6J mice were assigned to the control group, the group exercising at Zeitgeber Time 12 (ZT12), and the group exercising at ZT24. Control mice were not intervened, while ZT12 and ZT24 mice were trained for four weeks at the early and late time point of their active phase, respectively. We observed that the skeletal muscle of ZT12 mice exhibited higher total antioxidant capacity and lower reactive oxygen species compared to ZT24 mice. Furthermore, ZT12 mice improved the colocalization of BMAL1 with nucleus, the protein expression of BMAL1, NRF2, NAD(P)H quinone oxidoreductase 1, heme oxygenase 1, glutamate-cysteine ligase modifier subunit and glutathione reductase in comparison to those of ZT24 mice. In conclusion, the 4-week aerobic training performed at ZT12 is more effective for enhancing NRF2-mediated antioxidant responses of skeletal muscle, which may be attributed to the specific activation of BMAL1.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells. 源自胱氨酸的细胞外分泌半胱氨酸可调节 HepG2 细胞的氧化和亲电压力。
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-05-11 DOI: 10.1080/10715762.2024.2350524
Hanako Aoki, Yasuhiro Shinkai, Masahiro Akiyama, Satoshi Yamazaki, Motohiro Nishida, Yoshito Kumagai
{"title":"Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells.","authors":"Hanako Aoki, Yasuhiro Shinkai, Masahiro Akiyama, Satoshi Yamazaki, Motohiro Nishida, Yoshito Kumagai","doi":"10.1080/10715762.2024.2350524","DOIUrl":"10.1080/10715762.2024.2350524","url":null,"abstract":"<p><p>While cysteine (CysSH) is known to be exported into the extracellular space, its biological significance is not well understood. The present study examined the movement of extracellular CysSH using stable isotope-labeled cystine (CysSSCys), which is transported into cells and reduced to CysSH. Exposure of HepG2 cells to 100 µM stable isotope-labeled CysSSCys resulted in 70 µM labeled CysSH in cell medium 1 h after CysSSCys exposure. When the cell medium was collected and incubated with either hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) or atmospheric electrophiles, such as 1,2-naphthoquinone, 1,4-naphthoquinone and 1,4-benzoquinone, CysSH in the cell medium was almost completely consumed. In contrast, extracellular levels of CysSH were unaltered during exposure of HepG2 cells to H<sub>2</sub>O<sub>2</sub> for up to 2 h, suggesting redox cycling of CysSSCys/CysSH in the cell system. Experiments with and without changing cell medium containing CysSH from HepG2 cells revealed that oxidative and electrophilic modifications of cellular proteins, caused by exposure to H<sub>2</sub>O<sub>2</sub> and 1,2-naphthoquinone, were significantly repressed by CysSH in the medium. We also examined participation of enzymes and/or antioxidants in intracellular reduction of CysSSCys to CysSH. These results provide new findings that extracellular CysSH derived from CysSSCys plays a role in the regulation of oxidative and electrophilic stress.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate. 亚油酸酯 9-过氧化氢（9-HPODE）在血红素催化下降解，通过一个拟议的假对称二环氧自由基中间体形成两个烯丙基环氧酮。
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-08-04 DOI: 10.1080/10715762.2024.2386459
Saori Noguchi, William E Boeglin, Ned A Porter, Alan R Brash
{"title":"Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate.","authors":"Saori Noguchi, William E Boeglin, Ned A Porter, Alan R Brash","doi":"10.1080/10715762.2024.2386459","DOIUrl":"10.1080/10715762.2024.2386459","url":null,"abstract":"<p><p>Heme-initiated decomposition of unsaturated fatty acid hydroperoxides creates alkoxyl radicals that propagate a complex series of reactions to hydroxy, keto, epoxy and aldehydic products. Herein, among the products from the hematin-catalyzed degradation of 9-hydroperoxy-linoleic acid (9-HPODE), we observed a double peak on normal-phase HPLC that resolved on RP-HPLC into equal proportions of two epoxy-allylic ketones with identical UV spectra. Their proton NMR spectra were also indistinguishable and consistent with 9,10-<i>trans</i>-epoxy-11<i>E</i>-13-keto- and 9-keto-10<i>E</i>-12,13-<i>trans</i>-epoxy-octadecenoic acids. Acid hydrolysis to the corresponding dihydroxy-ketones and GC-MS analysis identified the earlier eluting product on RP-HPLC as the 9,10-epoxy regio-isomer. Starting from the C9-hydroperoxide, recovery of the two epoxy-ketones in equal proportions suggests their formation from a common intermediate. Earlier work has proposed formation of a pseudo-symmetrical diepoxy radical (9,10-epoxy-11(•)-12,13-epoxy, derived from an epoxy allylic hydroperoxide precursor) in the carbon chain fragmentation leading to aldehydic products. This intermediate in pathways of alkoxyl radical reactions forms equal pairs of aldehydes, and now also a pair of epoxy-ketones, and based on mechanism the same products arise from either 9-HPODE or 13-HPODE. Our results point to the intermediacy of this diepoxy-carbinyl radical in the origin of at least two classes of linoleate peroxidation products, and it should be considered as a viable intermediate for homo-conjugated diene peroxidation in general. The reactions could contribute to the aldehydes and epoxy-ketones in tissues undergoing oxidative transformations of polyunsaturated fatty acids.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indole-3-carbinol loaded-nanocapsules modulated inflammatory and oxidative damages and increase skin wound healing in rats. 负载吲哚-3-甲醇的纳米胶囊可调节炎症和氧化损伤，促进大鼠皮肤伤口愈合。
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-07-04 DOI: 10.1080/10715762.2024.2375200
Daniel Vargas, Hecson Segat, Mailine Gehrcke, Vinicius Costa Prado, Karine Roversi, Sabrina Grendene Muller, Patrícia Severo do Nascimento, Cristina Wayne Nogueira, Marilise Escobar Burger, Fabiana Elias, Leonardo Gruchouskei, Letícia Cruz, Daniel Curvello de Mendonça Muller
{"title":"Indole-3-carbinol loaded-nanocapsules modulated inflammatory and oxidative damages and increase skin wound healing in rats.","authors":"Daniel Vargas, Hecson Segat, Mailine Gehrcke, Vinicius Costa Prado, Karine Roversi, Sabrina Grendene Muller, Patrícia Severo do Nascimento, Cristina Wayne Nogueira, Marilise Escobar Burger, Fabiana Elias, Leonardo Gruchouskei, Letícia Cruz, Daniel Curvello de Mendonça Muller","doi":"10.1080/10715762.2024.2375200","DOIUrl":"10.1080/10715762.2024.2375200","url":null,"abstract":"<p><p>This study evaluated the effects of topically applied hydrogels (HG) containing nanoencapsulated indol-3-carbinol (I3C) and its free form in a rat model of skin wounds. Formulations were topically applied twice a day for five days to the wounds. On days 1, 3, and 6, the wound area was measured to verify the % of regression. On the sixth day, the animals were euthanized for the analysis of the inflammatory and oxidative profile in wounds. The nanocapsules (NC) exhibited physicochemical characteristics compatible with this kind of suspension. After five hours of exposure to ultraviolet C, more than 78% of I3C content in the suspensions was still observed. The NC-I3C did not modify the physicochemical characteristics of HG when compared to the HG base. In the <i>in vivo</i> study, an increase in the size of the wound was observed on the 3rd experimental day, which was lower in the treated groups (mainly in HG-NC-I3C) compared to the control. On the 6th day, HG-I3C, HG-NC-B, and HG-NC-I3C showed lower regression of the wound compared to the control. Additionally, HG-NC-I3C exhibited an anti-inflammatory effect (as observed by decreased levels of interleukin-1B and myeloperoxidase), reduced oxidative damage (by decreased reactive species, lipid peroxidation, and protein carbonylation levels), and increased antioxidant defense (by improved catalase activity and vitamin C levels) compared to the control. The current study showed more satisfactory results in the HG-NC-I3C group than in the free form of I3C in decreasing acute inflammation and oxidative damage in wounds.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways. 非热大气等离子体抗肿瘤的机制：影响细胞内 RONS 并调节信号通路
IF 3.6 3区 生物学
Free Radical Research Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.1080/10715762.2024.2358026
Wenjie Wang, Peijia Zheng, Liang Yan, Xiaoman Chen, Zhicheng Wang, Qi Liu
{"title":"Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways.","authors":"Wenjie Wang, Peijia Zheng, Liang Yan, Xiaoman Chen, Zhicheng Wang, Qi Liu","doi":"10.1080/10715762.2024.2358026","DOIUrl":"10.1080/10715762.2024.2358026","url":null,"abstract":"<p><p>Non-thermal atmospheric plasma (NTAP) has been proven to be an effective anti-tumor tool, with various biological effects such as inhibiting tumor proliferation, metastasis, and promoting tumor cell apoptosis. At present, the main conclusion is that ROS and RNS are the main effector components of NTAP, but the mechanisms of which still lack systematic summary. Therefore, in this review, we first summarized the mechanism by which NTAP directly or indirectly causes an increase in intracellular RONS concentration, and the multiple pathways dysregulation (i.e. NRF2, PI3K, MAPK, NF-κB) induced by intracellular RONS. Then, we generalized the relationship between NTAP induced pathways dysregulation and the various biological effects it brought. The summary of the anti-tumor mechanism of NTAP is helpful for its further research and clinical transformation.</p>","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca2+-induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress 限制热量的抗肥胖效应与线粒体含量的提高、Ca2+ 诱导的线粒体损伤的阻断以及反向电子传递介导的氧化应激的降低有关
IF 3.3 3区 生物学
Free Radical Research Pub Date : 2024-04-17 DOI: 10.1080/10715762.2024.2342962
Aline Maria Brito Lucas, Plinio Bezerra Palacio, Pedro Lourenzo Oliveira Cunha, Heberty Tarso Facundo
{"title":"Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca2+-induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress","authors":"Aline Maria Brito Lucas, Plinio Bezerra Palacio, Pedro Lourenzo Oliveira Cunha, Heberty Tarso Facundo","doi":"10.1080/10715762.2024.2342962","DOIUrl":"https://doi.org/10.1080/10715762.2024.2342962","url":null,"abstract":"Calorie restriction is a nutritional intervention that reproducibly protects against the maladaptive consequences of cardiovascular diseases. Pathological cardiac hypertrophy leads to cellular grow...","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140615666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis 低强度激光疗法对桥本氏甲状腺炎患者氧化应激水平和生活质量的影响
IF 3.3 3区 生物学
Free Radical Research Pub Date : 2024-04-16 DOI: 10.1080/10715762.2024.2339892
Sümeyye Tunç, Şükriye Leyla Altuntaş, Murat Atmaca, Çağrı Çakıcı, Türkan Yiğitbaşı, Yeong‑Cheng Liou, Wei-An Chang
{"title":"The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis","authors":"Sümeyye Tunç, Şükriye Leyla Altuntaş, Murat Atmaca, Çağrı Çakıcı, Türkan Yiğitbaşı, Yeong‑Cheng Liou, Wei-An Chang","doi":"10.1080/10715762.2024.2339892","DOIUrl":"https://doi.org/10.1080/10715762.2024.2339892","url":null,"abstract":"This study aimed to examine the effects of low-level laser therapy (LLLT) combined with levothyroxine replacement therapy on thyroid function, oxidative stress (OS), and quality of life in patients...","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140615693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling 人参皂苷 Re 通过激活信号转导子和转录激活子 3 信号转导，减轻线粒体功能障碍，从而保护小鼠免受凯因酸盐诱发的神经毒性影响
IF 3.3 3区 生物学
Free Radical Research Pub Date : 2024-04-13 DOI: 10.1080/10715762.2024.2341885
YenNhiDoan Nguyen, JiHoon Jeong, Naveen Sharma, Ngoc KimCuong Tran, Hoang-Yen Phi Tran, Duy-Khanh Dang, JungHoon Park, Jae Kyung Byun, Sung Kwon Ko, Seung-Yeol Nah, Hyoung-Chun Kim, Eun-Joo Shin
{"title":"Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling","authors":"YenNhiDoan Nguyen, JiHoon Jeong, Naveen Sharma, Ngoc KimCuong Tran, Hoang-Yen Phi Tran, Duy-Khanh Dang, JungHoon Park, Jae Kyung Byun, Sung Kwon Ko, Seung-Yeol Nah, Hyoung-Chun Kim, Eun-Joo Shin","doi":"10.1080/10715762.2024.2341885","DOIUrl":"https://doi.org/10.1080/10715762.2024.2341885","url":null,"abstract":"It was demonstrated that ginsenosides exert anti-convulsive potentials and interleukin-6 (IL-6) is protective from excitotoxicity induced by kainate (KA), a model of temporal lobe epilepsy. Ginseno...","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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