Food Science and Human Wellness最新文献

{"title":"Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway","authors":"Jiaxin Zhang ,&nbsp;Jinjing Zhong ,&nbsp;Zhengying Cui ,&nbsp;Yu Shen ,&nbsp;Yaping Zheng ,&nbsp;Yu Zhang ,&nbsp;Chaoxin Man ,&nbsp;Yanmei Hou ,&nbsp;Qianyu Zhao ,&nbsp;Yujun Jiang","doi":"10.26599/FSHW.2023.9250044","DOIUrl":"10.26599/FSHW.2023.9250044","url":null,"abstract":"<div><div>Branched-chain fatty acids (BCFAs) are new bioactive fatty acids with anti-inflammatory properties. However, the role of BCFAs in alleviating ulcerative colitis has not been clarified. Herein, we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate (DSS) and explored the corresponding mechanism. These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice, and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response. These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4 (TLR4)/ nuclear factor κB p65 (NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-18 in colon tissue, and significantly increase the expression of the anti-inflammatory factor IL-10. In conclusion, these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis. This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3624-3632"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model","authors":"Qiang Xie ,&nbsp;Chenglong Liu ,&nbsp;Wenhui Fu ,&nbsp;Chen Chen ,&nbsp;Dan Luo ,&nbsp;Shimin Gu ,&nbsp;Wentong Xue","doi":"10.26599/FSHW.2023.9250049","DOIUrl":"10.26599/FSHW.2023.9250049","url":null,"abstract":"<div><div>Intestinal immune homeostasis plays a critical role in the pathogenesis of food allergy. However, the association between intestinal microenvironment factors and food allergy severity is not well studied. In this study, we established a gluten allergy (GA) BALB/c mouse model and revealed the intestinal luminal factor-mediated alterations in phenotypes and endotypes of GA, combined with untargeted metabolomic profiling of the colonic contents. Our results showed that gluten sensitization induced severe allergic responses in BALB/c mice, characterized by exacerbated clinical allergic and diarrheal symptoms, increased histamine, elevated gluten-specific immunoglobulin (Ig)E and IgG2a levels, and increased mast cell degranulation. In response to GA, T-cell balance was disrupted, with aberrant production of interleukin (IL)-4, interferon (IFN)-γ, IL-10, and IL-2 in the spleen. GA led to a disrupted intestinal microenvironment homeostasis, including increased pH and water content, impaired intestinal antioxidant capacity and epithelial barrier function, decreased short-chain fatty acid production, and microbial dysbiosis, which was strongly correlated with GA severity. By metabolomic profiling, we found 29 differential expressed metabolites (DEMs) associated with GA, with 9 down-regulated and 20 up-regulated. A total of 11 out of all DEMs were classified into dipeptides, and 10 of them were up-regulated in the GA mice. Pathway enrichment analysis showed that most of the DEMs were enriched into the bile secretion metabolic route.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3680-3696"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community","authors":"Shuiling He ,&nbsp;Ruipeng Yang ,&nbsp;Jiangying Shi ,&nbsp;Ning An ,&nbsp;Shuhua Shan ,&nbsp;Zhuoyu Li ,&nbsp;Xiushan Dong","doi":"10.26599/FSHW.2023.9250019","DOIUrl":"10.26599/FSHW.2023.9250019","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process. Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD. Our previous findings indicated that polyphenol of the inner shell (BPIS) from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer (CRC). In the present study, we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate (DSS)-induced mouse colitis model. Data suggested that BPIS alleviated experimental colitis by restoring body weight, colonic length and protecting the epithelial architecture from damage by DSS. Moreover, we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/<em>β</em>-catenin pathway. Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts, including 1 phylum and 9 genera. Interestingly, BPIS significantly increased the abundance of <em>Aspergillus ruber</em>. It further verified that BPIS significantly promoted the growth of <em>A. ruber in vitro</em>. Collectively, BPIS has great potential to develop into an effective against IBD drug.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3339-3350"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study","authors":"Mirco Vacca ,&nbsp;Eduardo Maria Sommella ,&nbsp;Marina Liso ,&nbsp;Giulio Verna ,&nbsp;Aurelia Scarano ,&nbsp;Annamaria Sila ,&nbsp;Margherita Curlo ,&nbsp;Mauro Mastronardi ,&nbsp;Katia Petroni ,&nbsp;Chiara Tonelli ,&nbsp;Bruno Di Jeso ,&nbsp;Angelo Santino ,&nbsp;Vincenzo Vestuto ,&nbsp;Fabrizio Merciai ,&nbsp;Gianluigi Giannelli ,&nbsp;Pietro Campiglia ,&nbsp;Maria De Angelis ,&nbsp;Marcello Chieppa ,&nbsp;Francesco Maria Calabrese","doi":"10.26599/FSHW.2023.9250036","DOIUrl":"10.26599/FSHW.2023.9250036","url":null,"abstract":"<div><div>Nowadays, inflammatory bowel disease (IBD)-patient therapies are mainly based on corticosteroid, thiopurine, and immunomodulator treatments. Patients with active disease, that do not respond to corticosteroid and/or thiopurine treatment, can switch to the usage of the chimeric monoclonal antibody infliximab (IFX). However, to date, no treatment appeared to be conclusive in lowering the incidence of IBD relapses. With the aim to increase the effectiveness of IFX treatment, we combined it with an adjuvant purple corn supplementation enriched in anthocyanins. IBD-patients were enrolled before they underwent to the IFX-infusion, and they were allocated in 2 different study arms. Patients in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract, whereas control patients had a daily consumption of red fruit tea. 16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples, respectively.</div><div>As a result, the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific lipids. Focusing on IBD patient annotated taxa, a significant decrease in <em>Lactobacillus</em> and <em>Bifidobacterium</em> relative abundances was found.</div><div>As far as it concerns the ulcerative colitis patient subset, the experimental intervention led to a decrease in <em>Alistipes</em> and Erysipelotrichaceae UCG-003 genus abundances and a concomitant <em>Parabacteroides</em> increase. On the contrary, after treatment, Crohn’s disease patients did not exhibit metataxonomics differences at the genus level.</div><div>At the end of the treatment that led to a reshaped microbiota community, the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3536-3543"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The meat of the matter: plant-based meat analogue versus traditional meat product nutritional quality","authors":"Arshia Shireen,&nbsp;Amanda J. Wright","doi":"10.26599/FSHW.2023.9250003","DOIUrl":"10.26599/FSHW.2023.9250003","url":null,"abstract":"<div><div>Plant-based meat analogues (PBMA) are formulated to mimic the sensory characteristics of traditional meat products (TMP) using vegetarian ingredients and are increasingly popular with the trend towards plant-based diets, even among meat-eating consumers. This narrative review compared the nutritional quality of PBMA and TMP to broaden the discussion on the suitability of simulated meat products to substitute TMP, while exploring other attributes for their comparison. The complexity of PBMA and TMP means they are not entirely interchangeable. Importantly, PBMA health effects extend beyond their basic nutrient content and quality. Postprandial metabolism and satiety, for example, can be affected by product formulation, ingredient interactions, and thermomechanical processing involved in producing organoleptically acceptable PBMA. There are specific opportunities for low-sodium PBMA products to contribute to a healthy shift toward plant-based diets. In conclusion, PBMA cannot be assumed to be healthier than TMP. They should be designed with comprehensive consideration of composition and processing to ensure they support consumers who are adopting plant-based diets in realizing the theoretical health benefits.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3110-3125"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140467236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways","authors":"Hong Duan ,&nbsp;Wei Wang ,&nbsp;Shu Li ,&nbsp;Han Li ,&nbsp;Ghulam Jilany Khan ,&nbsp;Yong Ma ,&nbsp;Fawang Liu ,&nbsp;Kefeng Zhai ,&nbsp;Henggui Hu ,&nbsp;Zhaojun Wei","doi":"10.26599/FSHW.2023.9250011","DOIUrl":"10.26599/FSHW.2023.9250011","url":null,"abstract":"<div><div>Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. <em>Isodon suzhouensis</em> has good anti-inflammatory and antioxidant stress effects, which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with <em>I. suzhouensis</em> and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets, and lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from <em>I. suzhouensis</em> and 1 194 COVID-19 related targets were selected. Among these, 164 common targets were obtained from the intersection of <em>I. suzhouensis</em> and COVID-19. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enriched 582 function targets and 87 target proteins pathways, respectively. The results from molecular docking studies revealed that rutin, vitexin, isoquercitrin and quercetin had significant binding ability with 3 chymotrypsin like protease (3CLpro) and angiotensin converting enzyme 2 (ACE2). <em>In vitro</em> studies showed that <em>I. suzhouensis</em> extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of epidermal growth factor receptor (EGFR) in RAW264.7 cells induced by LPS. In addition, ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall, the network pharmacology and <em>in vitro</em> studies conclude that active components from <em>I. suzhouensis</em> have strong therapeutic potential against COVID-19 through multi-target, multi-pathway dimensions and can be a promising candidate against COVID-19.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3245-3255"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled coupling and characterization of oyster (Crassostrea gigas) ferritin with gold nanostars","authors":"Han Li ,&nbsp;Xiaoyu Xia ,&nbsp;Shuzhen Cheng ,&nbsp;Jiachen Zang ,&nbsp;Zhenyu Wang ,&nbsp;Xianbing Xu ,&nbsp;Ming Du","doi":"10.26599/FSHW.2023.9250007","DOIUrl":"10.26599/FSHW.2023.9250007","url":null,"abstract":"<div><div>Ferritin has good thermal stability, resistance to certain acids and bases, and targeting, and has broad application prospects in the synthesis of gold nanostars (AuNS). In this study, we screened monodisperse AuNS with uniform particle size and morphology through a one-step synthesis method and coupled the synthesized AuNS with oyster ferritin (GF1). The results showed that the surface plasmon resonance (SPR) peaks of the coupled GF1@AuNS changed significantly, and the changes in infrared spectra and potential confirmed the success of the synthesis, while the microscopic morphology showed an increase in particle size and surface peak coverage. Furthermore, GF1@AuNS does not induce cell death in the 100 µmol/L range, is highly stable in physiological environments, and exhibits good X-ray attenuation in micro-computed tomography. Due to the unique functional activity of ferritin and AuNS, GF1@AuNS has potential applications in food detection and drug development in the future.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3202-3209"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway","authors":"Hu Zhang ,&nbsp;Ye Zhang ,&nbsp;Jiling Liang ,&nbsp;Jiahang Li ,&nbsp;Miao He ,&nbsp;Xin Liu ,&nbsp;Jielun Huang ,&nbsp;Minghui Wang ,&nbsp;Jingjing Fan ,&nbsp;Ning Chen","doi":"10.26599/FSHW.2023.9250053","DOIUrl":"10.26599/FSHW.2023.9250053","url":null,"abstract":"<div><div>Obesity, caused by excessive energy, leads to body weight gain and various diseases, including cognitive impairment. Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity. However, further exploration is needed to understand the specific mechanisms of high fat diet (HFD)-induced cognitive decline in obesity. In the present study, 4-month-old mice were subjected to HFD feeding for 18 weeks, followed by aerobic exercise and high-intensity intermittent exercise, regular diet feeding, and intermittent fasting for 8 weeks, and then used to evaluate cognitive capacity, inflammation, compromised insulin signaling pathway, and apoptosis in hippocampal tissue, as well as AMPK/SIRT1 and TLR4 signal pathways. Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets. In contrast, aerobic exercise, high-intensity intermittent exercise, regular diet, and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway, thereby rescuing the cognitive impairment of obese mice. Therefore, diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3171-3180"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141050914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of moderate beer consumption with the gut microbiota","authors":"Zhaoxi Liu ,&nbsp;Jinming Shi ,&nbsp;Lushan Wang ,&nbsp;Jianjun Dong ,&nbsp;Junhong Yu ,&nbsp;Min Chen","doi":"10.26599/FSHW.2023.9250004","DOIUrl":"10.26599/FSHW.2023.9250004","url":null,"abstract":"<div><div>Beer is a fermented beverage prepared from water, malted barley, hops, and yeast that has been around for centuries. Alcoholic beverages alter the composition of the gut microbiota, which in turn causes oxidative stress brought on by alcohol, increases intestinal permeability to luminal bacterial products. However, beer has been shown to contain several intriguing non-alcoholic chemicals. Recent research demonstrates that moderate beer drinking could have positive impacts on human health. Beer's non-alcoholic ingredients have a significant impact on gut microbiota, and this type of diet is known to modulate gut microbiota, which has a variety of effects on the body, including effects on intestinal permeability, mucosal immune function, intestinal motility, antioxidant activity, and anti-inflammatory activity. Although the negative consequences of excessive alcohol intake are widely known, it is still debatable whether or not some non-alcoholic components, such as polyphenols and carbohydrates, have any positive benefits. In this review, we explain the primary benefits of moderate beer consumption on the gut microbiota, which are mostly attributable to non-alcoholic components such polyphenols. Despite any potential advantages of moderating consumption of alcoholic beverages, the lowest alcohol intake is the most secure.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3126-3138"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of free amino acids, biogenic amines and volatile compounds in fermented sausages inoculated with Lactiplantibacillus plantarum and Staphylococcus simulans","authors":"Xuefei Shao,&nbsp;Huhu Wang,&nbsp;Xiangyu Song,&nbsp;Mingyuan Huang,&nbsp;Jian Sun,&nbsp;Xinglian Xu","doi":"10.26599/FSHW.2023.9250046","DOIUrl":"10.26599/FSHW.2023.9250046","url":null,"abstract":"<div><div>Lactic acid bacteria and coagulase-negative staphylococci play an important role in the production of fermented sausages, such as inhibiting the growth of undesirable bacteria and antioxidant. In this study, the effects of inoculation with different starter cultures (<em>Lactiplantibacillus plantarum</em> HN108 and <em>Staphylococcus simulans</em> NJ209) on the free amino acids (FAAs), biogenic amines (BAs) and volatile compounds of fermented sausages were investigated using an amino acid analyzer, ultra performance liquid chromatography and gas chromatography-ion mobility spectrometry, respectively. The pH and carbonyl content of the inoculated group was significantly lower than those in the control group (<em>P</em> &lt; 0.05). <em>L. plantarum</em> HN108 significantly reduced the content of FAAs and BAs in fermented sausage production (<em>P</em> &lt; 0.05), while <em>S. simulans</em> NJ209 promoted the formation of FAAs (especially bitter amino acids) and exhibited slight BAs-reducing activity. In addition, <em>L. plantarum</em> HN108 promoted the formation of volatile compounds such as ketones, alcohols and alkenes in sausages. In conclusion, <em>L. plantarum</em> HN108 could contribute to reducing the content of putrescine and tyramine and forming the desirable flavor compounds in fermented sausages. Thus, <em>L. plantarum</em> HN108 is expected to be a starter culture that can improve the safety and flavor of fermented sausages.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3642-3651"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}