Food Science and Human Wellness最新文献_第4页

Facile SERS screening of melamine in bovine milk with 2D printed AgNPs/glass fabric filter paper as the flexible substrate 用二维印刷的 AgNPs/玻璃纤维滤纸作为柔性基底，对牛乳中的三聚氰胺进行简便的 SERS 筛选

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250208

{"title":"Facile SERS screening of melamine in bovine milk with 2D printed AgNPs/glass fabric filter paper as the flexible substrate","authors":"","doi":"10.26599/FSHW.2022.9250208","DOIUrl":"10.26599/FSHW.2022.9250208","url":null,"abstract":"<div><div>Melamine is one of the most frequently detected adulterants in dairy products. The current study proposes a surface-enhanced Raman spectroscopy (SERS)-based analytical tool for fast and reliable screening of melamine in bovine milk. A hand-held Raman spectrometer was used in conjunction with a substrate composed of silver nanoparticles (AgNPs) that was 2D printed onto glass fiber (GF) filter paper. Under optimized conditions, a sensitive and fingerprint-like signal at 674 cm<sup>−1</sup> was obtained. The AgNPs/GF substrate exhibited high sensitivity to melamine in milk down to 1.9498 × 10<sup>−5</sup> mg/mL, which is well below the USA and EU safety limits (2.5 × 10<sup>−3</sup> mg/mL). Remarkably, the proposed technology was also highly reproducible, showing spot-to-spot and block-to-block variations below 3.3 % and 4.9 % at 674 cm<sup>−1</sup> in Raman intensity, respectively. The characteristic peak intensity and concentration of melamine showed an acceptable linear relationship (<em>R</em><sup>2</sup> = 0.9909) within the range of 0.0001–1 mg/mL. Overall, the method established in this study can provide an efficient and effective method for the quantitative target screening and detection of melamine in dairy products.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2595-2600"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of phytoconstituents on oral health practices: a post COVID-19 observation 植物成分对口腔卫生做法的影响：COVID-19 后的观察结果

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250197

{"title":"Impact of phytoconstituents on oral health practices: a post COVID-19 observation","authors":"","doi":"10.26599/FSHW.2022.9250197","DOIUrl":"10.26599/FSHW.2022.9250197","url":null,"abstract":"<div><div>Appropriate oral hygiene significantly reduces the possibility of oral infections. However, dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral health. Recently, herbal compounds have gained interest in maintaining oral health. Extracts of burdock root (<em>Arctium)</em>, noni fruit (<em>Morinda citrifolia)</em>, and neem leaf (<em>Azadirachta indica</em>) are now used as intracanal medicaments in endodontics and periodontics. <em>Plectranthus amboinicus</em> species and other plants produces essential oil like <em>β</em>-caryophyllene, <em>p</em>-cymene, and <em>γ</em>-terpinene can exhibit antibacterial activity; highlighting phytoconstituents plays a vital role in oral health. The COVID-19 pandemic highlighted the importance of hygiene and sanitization, to curb SARS-CoV-2. Oral cavity is among the gateways for virus entry into saliva. Saliva is a potential reservoir of SARS-CoV-2, and there is an increased risk of infection if there is any fissure in the mouth. This enables entry of virus into the vascular system through gingival or periodontal pocket, possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial dysfunction. This review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2386-2400"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oligomeric procyanidins combined with Parabacteroides distasonis ameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and bile acid metabolism in ApoE−/− mice 通过调节载脂蛋白E-/-小鼠的脂质代谢、炎症反应和胆汁酸代谢，低聚原花青素与副嗜酸杆菌结合可改善高脂饮食引起的动脉粥样硬化

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250230

{"title":"Oligomeric procyanidins combined with Parabacteroides distasonis ameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and bile acid metabolism in ApoE−/− mice","authors":"","doi":"10.26599/FSHW.2022.9250230","DOIUrl":"10.26599/FSHW.2022.9250230","url":null,"abstract":"<div><div>Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases. Hence, the prevention and treatment strategies of AS have attracted great research attention. As a potential probiotic, <em>Pararabacteroides distasonis</em> has a positive regulatory effect on lipid metabolism and bile acids (BAs) profile. Oligomeric procyanidins have been confirmed to be conducive to the prevention and treatment of AS, whose anti-atherosclerotic effect may be associated with the promotion of gut probiotics. However, it remains unclear whether and how oligomeric procyanidins and <em>P. distasonis</em> combined (PPC) treatment can effectively alleviate high-fat diet (HFD)-induced AS. In this study, PPC treatment was found to significantly decrease atherosclerotic lesion, as well as alleviate the lipid metabolism disorder, inflammation and oxidative stress injury in ApoE<sup><strong>−/−</strong></sup> mice. Surprisingly, targeted metabolomics demonstrated that PPC intervention altered the BA profile in mice by regulating the ratio of secondary BAs to primary BAs, and increased fecal BAs excretion. Further, quantitative polymerase chain reaction (qPCR) analysis showed that PPC intervention facilitated reverse cholesterol transport by upregulating <em>Srb1</em> expression; In addition, PPC intervention promoted BA synthesis from cholesterol in liver by upregulating <em>Cyp7a1</em> expression via suppression of the farnesoid X receptor (FXR) pathway, thus exhibiting a significant serum cholesterol-lowering effect. In summary, PPC attenuated HFD-induced AS in ApoE<sup><strong>−/−</strong></sup> mice, which provides new insights into the design of novel and efficient anti-atherosclerotic strategies to prevent AS based on probiotics and prebiotics.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2847-2856"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model 辣椒素缓解昼夜节律紊乱小鼠模型中的肝脏时钟基因紊乱和肠道微生物群失调

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250238

{"title":"Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model","authors":"","doi":"10.26599/FSHW.2022.9250238","DOIUrl":"10.26599/FSHW.2022.9250238","url":null,"abstract":"<div><div>As the body’s internal clock, the circadian rhythm regulates the energy expenditure, appetite, and sleep. There exists a close relationship between the host circadian rhythm and gut microbiota. In this work, a circadian disorder mouse model induced by constant darkness (CD) was constructed to investigate the regulating effects of capsaicin (CAP) on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms. Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue. The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP. Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness, diversity and composition, and restored diurnal oscillations of gut microbes at the phylum and family level. These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice, providing theoretical basis for CAP to be used as a muti-functional ingredient with great health-promoting effects.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2947-2958"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization and anti-inflammatory activities of novel polysaccharides obtained from Pleurotus eryngii 从刺五加中提取的新型多糖的结构特征和抗炎活性

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250245

{"title":"Structural characterization and anti-inflammatory activities of novel polysaccharides obtained from Pleurotus eryngii","authors":"","doi":"10.26599/FSHW.2022.9250245","DOIUrl":"10.26599/FSHW.2022.9250245","url":null,"abstract":"<div><div>Natural polysaccharides named PEP-0.1-1, PEP-0-1 and PEP-0-2 from edible mushroom species <em>Pleurotus eryngii</em> were obtained in the present study. Results showed that molecular weights of these polysaccharides were 3235, 2041 and 23933 Da, respectively. Further, structural characterization revealed that PEP-0.1-1 had a →4-<em>α</em>-<em>D</em>-Glc<em>p</em>-1→ backbone and contained →4)-<em>α</em>-<em>D</em>-Glc<em>p</em> and →4)-<em>β</em>-<em>D</em>-Glc<em>p</em> reducing end groups. PEP-0-1 backbone contained →4-<em>α</em>-<em>D</em>-Glc<em>p</em>-1→ and →6-<em>α</em>-3-<em>O</em>-Me-<em>D</em>-Gal<em>p</em>-1→, and the side chains contained <em>α</em>-<em>D</em>-Glc<em>p</em>, <em>β</em>-<em>D</em>-Man<em>p</em>-1→ and <em>α</em>-<em>D</em>-Glc<em>p</em>-3→. However, PEP-0-2 backbone consisted of →4-<em>α</em>-<em>D</em>-Glc<em>p</em>-1→ and →6-<em>α</em>-3-<em>O</em>-Me-<em>D</em>-Gal<em>p</em>-(1→6)-<em>α</em>-<em>D</em>-Gal<em>p</em>-1→ while the side chains contained <em>α</em>-<em>D</em>-Glc<em>p</em> and <em>β</em>-<em>D</em>-Man<em>p</em>-1→. Biological activity analysis was then carried out and found that all these polysaccharides could significantly suppress the relative mRNA expression of toll-like receptor 4, nitric oxide, tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in lipopolysaccharide (LPS)-induced inflammation of RAW264.7 cells, as well as the over secretion of the above cell cytokines. Moreover, Western blotting analysis revealed that all these purified fractions displayed significant inhibition effects on the expression of c-Jun N-terminal kinases protein protein induced by LPS in mitogen activated protein kinase pathway, along with the relieving on the inhibition effect of LPS on IκB-α protein expression. In summary, the information generated by the present study could provide a theoretical basis for the exploration of novel healthy food materials from edible mushroom with anti-inflammation activities.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 3031-3042"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis 通过尿液代谢组学分析揭示地瓜多糖的特征及对 2 型糖尿病大鼠的抗糖尿病作用

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250237

{"title":"Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis","authors":"","doi":"10.26599/FSHW.2022.9250237","DOIUrl":"10.26599/FSHW.2022.9250237","url":null,"abstract":"<div><div>The present study reports the structural characteristics of 3 polysaccharide fractions (SPS-F1, SPS-F2 and SPS-F3) isolated and purified from squash. SPS-F1 (molecular weight (<em>Mw</em>) = 12.30 kDa) and SPS-F2 (<em>Mw</em> = 19.40 kDa) were likely to contain HG and RG-I domain of pectic polysaccharide, respectively. SPS-F2 (<em>Mw</em> = 270.4 kDa) was mainly composed of rhamnose, galactose and arabinose. The treatment with SPS decreased body weight gain, glucose and TG levels in type 2 diabetes rats. Besides, 25 differential metabolites were identified based on urinary metabolomics analysis, which are crucial to the anti-diabetic effect of SPS. The regulation of nicotinamide <em>N</em>-oxide, histamine, <em>cis</em>-aconitate, citrate, <em>L</em>-malic acid, 3-(3-hydroxyphenyl) propanoic acid and <em>N</em>-acetyl-<em>L</em>-aspartic acid were mainly associated with energy metabolism, gut microbiota and inflammation. Study of surface plasmon resonance revealed the binding kinetics with galectin-3 (Gal-3) and fibroblast growth factor 2 (FGF2). The <em>K</em><sub>D</sub> values of SPS-F2 and SPS-F3 to Gal-3 were 4.97 × 10<sup>-3</sup> and 1.48 × 10<sup>-3</sup> mol/L, indicating a weak binding affinity. All 3 fractions showed moderate binding to FGF2 and the affinity was SPS-F3 > SPS-F2 > SPS-F1. Thus, the metabolomics and SPR approach were proved to be a promising tool in exploring the anti-diabetes effects of SPS and provided a deep understanding of the mechanisms.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2937-2946"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional values, bioactive compounds and health benefits of purslane (Portulaca oleracea L.): a comprehensive review 马齿苋（Portulaca oleracea L.）的营养价值、生物活性化合物和健康益处：综述

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250203

{"title":"Nutritional values, bioactive compounds and health benefits of purslane (Portulaca oleracea L.): a comprehensive review","authors":"","doi":"10.26599/FSHW.2022.9250203","DOIUrl":"10.26599/FSHW.2022.9250203","url":null,"abstract":"<div><div><em>Portulaca oleracea</em> L., commonly known as purslane, is a worldwide weed species belonging to the family Portulacaceae and has been known as “Global Panacea”. As one of the most widely consumed green vegetables and medicinal plants around the world, it has recently been re-evaluated as a potential “new crop” due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid (<em>α</em>-linolenic acid), as well as a variety of nutrients and phytochemicals. Accordingly, emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory, anti-hyperglycemic, antioxidant, neuroprotective, and immunomodulatory. These findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional medicine. This review systematically summarizes the up-to-date research carried out on purslane, including the nutritional compositions, bioactive compounds, and health benefits it exerts as well as limitations, challenges, and future directions of research. Finally, we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2480-2501"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations 基因组比较分析表明，饮食习惯影响了双歧杆菌对不同地域人群肠道的适应性

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250243

{"title":"Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations","authors":"","doi":"10.26599/FSHW.2022.9250243","DOIUrl":"10.26599/FSHW.2022.9250243","url":null,"abstract":"<div><div>Recent research on the genome of <em>Bifidobacterium bifidum</em> has mainly focused on the isolation sources (intestinal tract niche) recently, but reports on the isolation region are limited. This study analyzed the differences in the genome of <em>B. bifidum</em> isolated from different geographical populations by comparative genomic analysis. Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates. The phylogenetic tree, based on 919 core genes showed that <em>B. bifidum</em> might be related to the geographical characteristics of isolation region. Furthermore, functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes (CAZys) involved in the degradation of polysaccharide from plant and host sources in <em>B. bifidum</em> were high, and 18 CAZys showed significant differences across different geographical populations, indicating that <em>B. bifidum</em> had adapted to the human intestinal environment, especially in the groups with diets rich in fiber. Dietary habits were one of the main reasons for the differences of <em>B. bifidum</em> across different geographical populations. Additionally, <em>B. bifidum</em> exhibited high diversity, evident in glycoside hydrolases, the CRISPR-Cas system, and prophages. This study provides a genetic basis for further research and development of <em>B. bifidum</em>.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 3006-3017"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health effects of fruit juices and beverages with varying degrees of processing 不同加工程度的果汁和饮料对健康的影响

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250202

{"title":"Health effects of fruit juices and beverages with varying degrees of processing","authors":"","doi":"10.26599/FSHW.2022.9250202","DOIUrl":"10.26599/FSHW.2022.9250202","url":null,"abstract":"<div><div>The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages (FJBs) consumption. In fact, the consumption of ultra-processed foods has been shown to pose health risks. In this study, we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories, low (minimal), moderate and high. Second, we compared the differences in attitudes towards FJBs in dietary guidelines. Third, we integrated the results of existing epidemiological surveys, randomized controlled trials, and animal experiments to explore the health risks associated with consuming FJBs. Deepening the processing of FJBs has been found to lead to an increased risk of diseases. Dietary pattern, nutrients, addition agents and consumer preferences may be influential factors. Finally, we investigated whether there were any changes in the health benefits of 100 % fruit juices produced by different processing methods. In conclusion, minimally/moderately processed 100 % fruit juices provide more health benefits than highly processed fruit beverages. The results support the need to consider the extent of FJBs processing in future studies to adjust official nutritional recommendations for beverage consumption.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2456-2479"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of gut microbiome composition on effect variations of anti-cholesterol treatment among individual mice 肠道微生物群组成对小鼠个体间抗胆固醇治疗效果变化的影响

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250252

Hyemin Oh , Yohan Yoon

{"title":"Influence of gut microbiome composition on effect variations of anti-cholesterol treatment among individual mice","authors":"Hyemin Oh , Yohan Yoon","doi":"10.26599/FSHW.2022.9250252","DOIUrl":"10.26599/FSHW.2022.9250252","url":null,"abstract":"<div><div>This study investigated if the variation in the effect of anti-cholesterol (AC) treatment on individual mice are related to gut microbiome composition. The bile salt hydrolase (BSH) activity of 23 commercial fermented milk products was examined to select a fermented milk product for AC treatment. Mice were fed to different diets for 6 weeks: high-fat (660 % of total calories from fat; D1), high-dietary fibre (20 % cellulose; D2), and low-fat (17.2 % of total calories from fat; D3) diets to change their gut microbiomes. Subsequently, faecal microbiome was transplanted (FMT) into mice treated with high cholesterol diet contained 2 % cholesterol, followed by AC or non-AC (sterile tap water, STW) treatments. Control groups with normal (NC) and high-cholesterol diets (PC) were prepared for both AC and STW treatment. All experimental groups were subjected to serum and liver cholesterol, cholesterol metabolism-related (CMR) gene expression, and intestinal microbiome analyses. D3-FMT mice showed the most significant enhancements in cholesterol ratio and decreased hepatic cholesterol levels with AC treatment. Moreover, upregulation of the <em>Cyp7a1</em> gene expression was observed in this group. Furthermore, the intestinal microbiome analysis indicated higher abundances of BSH-producing <em>Eubacterium</em>, <em>Bifidobacterium</em>, and <em>Parabacteroides</em> in the D3-FMT + AC group compare to others, potentially contributing to increased bile acid synthesis.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 3054-3065"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0